2014 Kern Lipid Conf. Cover Page

Molecular model of nascent HDL
“The meeting features named lecutres in memory of (left to right) David L. Williams, Fred Kern, and Roger Davis,
preeminent scientists in lipid metabolism and longtime supporters of the meeting.”
2014 Kern Lipid Conference
Evolving Concepts of HDL Function in Cardiometabolic Diseases and Beyond
Vail, Colorado, August 4 - 7, 2014 ● Vail Marriott Mountain Resort
Conference Co-Chairs: John Parks, Ph.D., Sudha Biddinger, M.D., Ph.D., Richard Gregg, M.D.
Decades of animal and human studies have demonstrated that high levels of high density lipoproteins (HDL) are associated with
decreased risk for atherosclerotic vascular disease and that HDL augments reverse cholesterol transport. However, efforts to reduce
cardiovascular disease by raising HDL concentrations have failed so far. At the 2014 Kern Lipid Conference, leading scientists will present cutting edge research in the areas of cellular HDL and cholesterol metabolism, in vivo HDL metabolism, HDL therapeutic strategies,
genetic regulation of HDL, and emerging new protective roles for HDL in chronic diseases. This highly interactive meeting will foster
discussion between academic and industrial scientists on novel roles and strategies for HDL as a therapeutic agent.
Registration
Complete program information and on-line registration is available at www.kernconference.org. Attendance at the conference is limited to 150
participants and a waiting list will be implemented once maximum capacity has been reached. Early application is advised. Breakfast will be
provided during morning sessions. Lunches, evening poster session reception, and reception dinner are also included in the registration fee.
General Information
Vail is at an altitude of 8,150 feet. Summer days are warm and the evenings cool, with frequent late afternoon showers. Dress is informal.
Sweaters or jackets are often needed in the evenings.
There are direct flights to Vail. You may also rent a car at Denver International Airport for the two-hour scenic drive. For information and links
regarding travel, airport shuttle discounts, lodging arrangements, and summer events in Vail, visit our conference
website: www.kernconference.org
A copy of the full program and additional program information is available at the conference website: www.kernconference.org
Session 1
Session 3
Cellular HDL and Cholesterol Metabolism
Monday, August 4, 2014 • 1:30 pm - 7:30 pm
HDL as a Therapeutic Target
Wednesday, August 6, 2014 • 7:30 am - 4:00 pm
Introduction and Comments by Moshe Levi, M.D., President, Kern Lipid
Conference, (University of Colorado Anschutz Medical Campus, Aurora, CO)
• David Atkinson, Ph.D. - “AopA-I structural models and implications for function”
(Boston, MA)
• Jonathan Smith, Ph.D. -“Mechanisms of apoA-I lipidation by ABCA1”
(Cleveland, Ohio)
Philip Shaul, M.D. - “Regulation of cellular signal transduction by HDL”
(Dallas, TX)
4:10 pm - 4:30 pm - Break
Alan Chait, M.D. - “Anti-inflammatory effects of HDL on adipocytes”
(Seattle, WA)
Introduction and Presentation of the Roger Davis Lecturer
Robert Eckel, M.D. (Aurora, CO)
Roger Davis Lecture: TBD
6:00 - 7:30 pm - Poster Session & Reception
Session 2
In vivo HDL Metabolism
Tuesday, August 5, 2014 • 7:30 am - 10:00 pm
Sean Davidson, Ph.D. - “Human plasma HDL speciation and the proteome”
(Cincinnati, OH)
Henry Ginsburg, M.D. - “HDL metabolism in normal and insulin resistant states”
(New York, NY)
10:10 am - 10:30 am - Break
Daisy Sahoo, Ph.D. - “SR-B1 and HDL metabolism” (Milwaukee, WI)
Christina Christoffersen, M.D., Ph.D. - “HDL, apoM, and S1P signaling”
(Copenhagen, DK)
12:10 pm - 2:00 pm - Lunch & Round Table Discussion - “Careers in Industry”
2:00 pm - 3:30 pm - Poster Session
Session 2 - Evening (6:00 pm - 10:00 pm)
Introduction and Presentation of the Kern Lectureship Award Moshe Levi, M.D. (Aurora, CO)
6:00 pm - Kern Lecture: Daniel Rader, M.D. - (Philadelphia, PA)
7:15 pm - 10:00 pm - Reception & Dinner
Gregory Schwartz, M.D., Ph.D. - “Update on HDL clinical trials”
(Aurora, CO)
Rosanne Crooke, Ph.D. - “Apo-CIII inhibition with ASOs” (Carlsbad, CA)
10:10 am - 10:30 am - Break
Todd Kirchgessner, Ph.D. - “Update on development of LXR agonists”
(Princeton, NJ)
Douglas Johns, Ph.D. - “Will CETP inhibitors be cardioprotective?”
(New York, NY)
Introduction of the David L Williams Lecture
Mary Sorci-Thomas, Ph.D. (Winston-Salem, NC)
David L. Williams Lecture: TBD
1:00 pm - 2:00 pm - Lunch & Small Group Discussions
2:00 pm - 4:00 pm - Poster Session
Session 4
Genetic Regulation of HDL and Cholesterol Transport/Storage
Wednesday, August 6, 2014 • 5:00 pm - 7:30 pm
Kasey Vickers, Ph.D. - “HDL and microRNA transport” (Nashville, TN)
Anne Tybjaerg-Hansen, M.D., DMSc - “Using Mendelian randomization to determine
causality of HDL cholesterol in ischemic heart diseae” (Copenhagen, DK))
Laura Michael, Ph.D. - “Genome-wide modulation of hepatic apoA-I secretion”
(Indianapolis, IN)
Session 5
Emerging Roles of HDL Beyond Atherosclerosis
Thursday, August 7, 2014 • 7:00 am - 12:00 pm
Joseph DiDonato, Ph.D. - “ApoA-I and its potential role as an anti-tumor agent”
(Cleveland, OH)
Introduction of the Journal of Lipid Research Lectureship
Ira J. Goldberg, M.D. (New York, NY)
Journal of Lipid Research Lecture: Alan Tall, M.D. - “Cholesterol efflux pathways
in atherosclerosis and thrombosis” (New York, NY)
9:45 am - 10:00 am - Break
Cheryl Wellington, Ph.D. - “ABCA1, HDL and Alzheimer’s disease”
(British Columbia)
Joachim Herz, M.D. - “Lipoproteins and receptors in the brain” (Dallas, TX)
11:40 - 12:00 pm - Closing Remarks - Conference Adjourns
Registration Fees & Hotel Accomodations
Hotel Accomodations:
A discounted rate is available for Kern Conference attendees at the Vail Marriott.
Conference attendees
(excluding award winners and speakers) are responsible for making their own hotel reservations. A link for online reservations will
be provided at time of registration. You may also call Marriott Reservations toll free at 877-622-3140 and use group reference: Kern
Lipid. The group rate is available three days pre and post conference for any attendees who wish to extend their stay in Vail. The
discounted conference rate is guaranteed for reservations made on or before July 12, 2014. If your reservation is cancelled
after July 14, 2014, you will forfeit a room deposit equal to one night’s room and tax.
Established Investigators
This category applies to all academic investigators, at or
above the rank of Assistant Professor and those below the
rank of Assistant Professor who do not wish to compete for
the ECI award. Fee is $900.
Graduate Students & Postdocs
A reduced registration fee is available for these attendees.
Fee is $250. Please refer to the conference website for
lodging information.
Industry Participants
Applies to individual persons from the pharmaceutical and/or biotechnology industry. Fee is $1,900. Refer to the website
(under Registration) or contact Susan Hayes at 214-648-1636 or [email protected] for information on
industry/corporate sponsorship levels.
Programs & Awards
Early Career Investigators
Postdoctoral fellows and graduate students who wish to
apply need to submit an abstract, a letter from their department chair, and a CV, to compete for a $750 travel stipend.
Roger Davis Investigator Award for
Transitional Faculty
Faculty appointed as Instructor or Assistant Professor with at
least two years of prior postdoctoral work but no more than
three years in first faculty position, with clear evidence of
progress in developing independence.
David L. Williams Memorial
Lectureship Award
Instructor or Assistant Professor faculty working in the general
area of lipid and lipoprotein metabolism and atherosclerosis are
eligable to apply.
Francis R. Simon, M.D. Outstanding
Poster Award
The winner of this award will be chosen by the Conference Board
during the conference and will be selected from the Early Career
Investigator poster presenters. The winner will receive a $1,000
cash award.
Please refer to the conference website for all submission requirements,
or contact Holly Smith, Registration Coordinator at [email protected]
Deadline for submission for awards: April 30, 2014

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