Potassium Channels Potassium channels are crucial regulators of membrane excitability. They control the frequency and shape of action potentials, regulate secretion of hormones and neurotransmitters and establish cell plasma membrane potential. Below you will find a sample of Tocris products related to potassium channels. Product Description KV7.2/KV7.3 Channel Opener ICA 069673 Cat. No. 4305 N Cl O N N H F ICA 069673 is a selective KV7.2/KV7.3 (KCNQ2/3) potassium channel opener (EC50 = 0.69 µM). The compound is 20-fold selective for KV7.2/KV7.3 over KV7.3/KV7.5 with no measurable activity over a panel of cardiac ion channels (IC50 >30 µM for KV11.1 (hERG), NaV1.5, L-type channels and KV7.1). ICA 069673 is orally active in several animal models of epilepsy. Product Description AM 92016 hydrochloride (0876) KV channel blocker Flupirtine maleate (2867) KV7 channel activator 10 mg 50 mg GW 542573X (4311) Selective activator of KCa2.1 channels 10 mg 50 mg Iberiotoxin (1086) KCa channel blocker (high conductance) F Size 10 mg 50 mg Size 100 µg ICA 069673 (4305) KV7.2/KV7.3 channel opener 10 mg 50 mg JNJ 303 (3899) Potent and selective IKs blocker 10 mg 50 mg Kaliotoxin (3564) KV and KCa channel blocker 100 µg L-364,373 (2660) KV7.1 channel activator, activates IKs 10 mg 50 mg Levcromakalim (1378) Kir6 (KATP) channel opener. Active enantiomer of cromakalim (Cat. No. 1377) 10 mg 50 mg Linopirdine dihydrochloride (1999) KV7 channel blocker 10 mg 50 mg Apamin (1652) KCa2 channel blocker (small conductance) 1 mg BL 1249 (3797) Putative K2P2.1 (TREK-1) channel opener 10 mg 50 mg Margatoxin (3563) Potent Kv1.3 channel blocker 100 µg BMS 191011 (2665) Potent BKCa (KCa1.1) channel opener 10 mg 50 mg ML 133 hydrochloride (4549) Kir2 channel blocker 10 mg 50 mg Charybdotoxin (1087) KCa channel blocker (high conductance) 10 µg ML 213 (4519) KV7.2 and KV7.4 channel opener 10 mg 50 mg Cromakalim (1377) Kir6 (KATP) channel opener 10 mg 50 mg Nateglinide (4231) Kir6 (KATP) blocker; displays high affinity for SUR1/Kir6.2 channels 10 mg 50 mg CyPPA (2953) Activator of KCa2.2 and KCa2.3 channels 10 mg 50 mg NS 1619 (3804) Activator of BKCa (KCa1.1) channels 10 mg DMP 543 (2330) K+ channel blocker and potent ACh release enhancer 10 mg 50 mg NS 1643 (3062) Kv11.1 (hERG) channel activator. Antiarrhythmic 10 mg 50 mg E-4031 dihydrochloride (1808) KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) 10 mg 50 mg NS 309 (3895) Positive modulator of KCa2 and KCa3.1 channels 10 mg 50 mg 1-EBIO (1041) Activator of epithelial KCa channels 10 mg 50 mg NS 3623 (4462) KV11.1 (hERG) channel activator. Antiarrhythmic 10 mg 50 mg For a complete list of available products, please visit www.tocris.com Product Description KV4.3 Channel Activator NS 5806 Cat. No. 4166 H N F3C O Br HN CF3 N Br N N NH NS 5806 is a KV4.3 channel activator that mediates the transient outward K+ current (Ito). The compound increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 µM). NS 5806 inhibits KV1.4-mediated currents independently of KChIP2. The compound also slows the decay of KV4.2 and KV4.3 currents in the presence of KChIP2. Product Description Size NS 5806 (4166) KV4.3 channel activator 10 mg 50 mg Penitrem A (4617) Potent and selective BKCa (KCa1.1) channel blocker 1 mg PD 118057 (2830) Selective KV11.1 (hERG) K+ channel activator 10 mg 50 mg PNU 37883 hydrochloride (2095) Vascular Kir6 (KATP) channel blocker 10 mg 50 mg Psora 4 (4367) Potent KV1.3 channel blocker 10 mg 50 mg RuBi-4AP (3557) Caged 4-aminopyridine; non-selective KV channel blocker 10 mg SKA 31 (3670) Activator of KCa3.1 and KCa2 channels 10 mg 50 mg Tenidap (2580) Opener of Kir2.3. Also cyclooxygenase (COX-1) inhibitor 10 mg 50 mg Tertiapin LQ (4339) Selective Kir1.1 blocker; derivative of tertiapin-Q (Cat. No. 1316) 1 mg Tertiapin-Q (1316) Potent, selective blocker of inward-rectifier K+ channels 1 mg Tetraethylammonium chloride (3068) Non-selective K+ channel blocker Size TRAM 34 (2946) Highly selective KCa3.1 channel blocker 10 mg 50 mg UCL 2077 (2661) Slow afterhyperpolarization (sAHP) channel blocker 10 mg 50 mg UK 78282 hydrochloride (3829) Blocker of KV1.3 and KV1.4 channels 10 mg 50 mg VU 0240551 (3888) KCC2 inhibitor 10 mg 50 mg VU 590 dihydrochloride (3891) Inhibitor of Kir1.1 (ROMK) and Kir7.1 10 mg 50 mg VU 591 hydrochloride (4197) Selective Kir1.1 (ROMK) inhibitor 10 mg 50 mg XE 991 dihydrochloride (2000) Potent, selective KV7 (KCNQ) channel blocker; blocks M-current 10 mg 50 mg Zatebradine hydrochloride (2202) Bradycardic agent; blocks If pacemaker current 10 mg 50 mg ZD 7288 (1000) Sino-atrial node function modulator (If inhibitor) 10 mg 50 mg Potent and Selective IKs Blocker JNJ 303 Cat. No. 3899 Cl 50 mg H N O O NHSO2Me Scan this QR code with your smartphone to view all products for potassium channels on the Tocris website. JNJ 303 is a potent IKs blocker (IC50 = 64 nM). The compound displays no effects on other cardiac channels (IC50 values are 3.3, >10, 11.1 and 12.6 µM for INa, ICa, Ito and IKr currents respectively). JNJ 303 prolongs QT and causes unprovoked torsades de pointes (TdP). (Sold with the permission of Janssen Pharmaceutica NV) To keep up-to-date with Tocris news and events, follow @Tocris on Twitter © 2013 Tocris Cookson, Ltd. Tocris is an R&D Systems company
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