Updates on XtremeCT I & XtremeCT II Nicolas Vilayphiou SCANCO Medical AG Switzerland XtremeCT updates XtremeCT I Lower Leg Arterial Calcification Soft Tissue Analysis SPECTRA XtremeCT II Scan protocols MrOS Study & Proximal scanning LLAC Lower Leg Arterial Calcification Quantification of lower leg arterial calcifications by high-resolution peripheral quantitative computed tomography. Patsch JM, Zulliger MA, Vilayphiou N, Samelson EJ, Cejka D, Diarra D, Berzaczy G, Burghardt AJ, Link TM, Weber M, Loewe C. Published in Bone – January 2014 Installation on request !! Soft Tissue Analysis Muscle Segmentation Soft Tissue Analysis Muscle Segmentation Methods paper to be submitted soon in JCD Installation on request, after publication SPECTRA SPECTRA Chairs : Dr. Stephanie Finzel (University of Nuremberg-Erlangen) Dr. Cheryl Barnabe (University of Calgary) Dr. Kathryn Stok (ETH Zurich) Study Group @ American College of Rheumatology meeting ~ 40 participants OMERACT May 2014 in Budapest, Hungary. Encouraged to pursue a workshop application for OMERACT 2016. SPECTRA Last meeting June 2014, Lyon New members: Drs. Rosa Pereira (Brazil), and LS Tam (Hong Kong). Perfusion study : small cortical breaks seen by micro-CT that are linear in shape are in fact blood vessel channels. Development of an automated script to identify cortical breaks (Maastricht). Ongoing comparison of different joint space width assessment methods (Calgary, Lyon, UCSF). Work has begun on an image atlas (Maastricht) and a systematic literature review. SPECTRA Detection of cortical break > 0.5mm MCP joint of one case a. µCT image b. HR-pQCT image SPECTRA Upcoming events OMERACT Proposal due November 2014 Study Group at the American College of Rheumatology, Tuesday Nov 18 Next SPECTRA Meeting at the University of Maastricht, April 10-11 2015 New collaborators interested in the assessment of inflammatory arthritis using HR-pQCT are always welcome to join the group. XtremeCT II XtremeCT I * 82 µm XtremeCT II 91 µm µCT 100 XtremeCT II 25 µm 60 µm *Multicenter Precision of Cortical and Trabecular Bone… (Burghardt et.al JBMR 2013) XtremeCT II Scan Protocols XtremeCT I XtremeCT II Low res High res X-ray Tube Voltage [kV] 60 68 68 Intensity [µA] 900 1460 1460 Integration Time [ms] 100 36 43 Projections [#] 750 750 900 Radiation [µSv] <3 <3 <5 Scan time [min] 2.8 1.4 2 Voxel size[µm] 82 91 -> 82 61 MTF @10% [µm] 130 120 95 126 140 140 9 10 10 Number of slices [#] 110 110 164 Max scan length [mm] 150 200 200 Scan protocol Resolution Field of View Diameter [mm] Stack height [mm] XtremeCT II Scan Protocols Standard scan: 61 µm, 2 min scan time, Z = 168 slices ~ 10mm No change (yet ?) to the reference line positioning Standard Distal Radius, 9mm prox. to the ref. line Standard Distal Tibia, 22mm prox. to the ref. line XtremeCT I Radius offset : 9.5 mm Tibia offset : 22.5 mm XtremeCT II Scan Protocols XtremeCT II MrOS Male Osteoporosis ~ 6000 men over 65 yrs, at start in 1999 Visit 4 includes HR-pQCT, using XtremeCT II Multicentric study, 6 sites Central analysis Standard Distal Radius, 61 µm Standard Distal Tibia, 61 µm Proximal Tibia @ 30%, 61 µm XtremeCT II Proximal scanning XtremeCT II Proximal scanning XtremeCT II Proximal scanning XtremeCT II XtremeCT II XtremeCT II
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