IMB NEWS September 2013—May, 2014 Department of Immunobiology Newsletter Departmental News You can’t be everywhere at once. Here is a quick recap of what’s been happening lately in the IMB Department. Prelim Milestone Success! We are so happy all three of the graduate students who took their prelim exams passed!! Congratulations to Christy Harrison—Kiela Lab, Matthew Bronnimann—Campos Lab and Shraddha Tuladhar—Koshy Lab! Donut Tuesday—Totally Awesome! Donut Tuesday has been a success ever since Dr. Koshy introduced all of us to the carb-loading, sugar rush of a good time! Check the IMB Social Calendar for the details on where Donut Tuesday will be held in the future. “Department of Immunobiology at the University of Arizona College of Medicine is growing into a nationally and internationally recognized research and educational center.” Janko Nikolich-Žugich, M.D., Ph.D. Tea Time Department Head, Bowman Professor and Chair Department of Immunobiology The IMB department had its first “Tea Time” on Thursday, May 15th. Thank you to everyone who participated! We look forward to seeing you every Third Thursday of the month for some delicious tea and IMB camaraderie. Potluck A special thank you to Dr. Goodrum for hosting the April IMB Potluck. We appreciate her opening up her home to us! The next potluck will be in August. If there are any faculty members willing to host please contact Nicole. In This Issue Departmental News Changes in Faculty/Staff 2014 Symposium Department Outreach Grants Publications And More... Enjoying an evening with colleagues at the IMB Potluck! 1 “To improve is to change; to be perfect is to change often.” –Winston Churchill Enjoying the school spirit at the AHSC appreciation lunch! Changes in Staff There have been a lot of changes lately! (+ is for people who joined IMB, - is for people who left IMB. ) September Our Extended Family +Kristian Doyle: Assistant Professor, +Lydia Lutes: Undergrad Lab Assistant, Nikolich Lab +Jennifer Frye: Research Specialist, Sr., Doyle Lab +Jason Buehler: Postdoctoral Research Associate I, Goodrum Lab October +Vivian Nguyen: Research Scientist, Doyle Lab +Daniel Powell: Postdoctoral Research Associate I, Frelinger Lab November +Dominik Schenten: Assistant Professor December +Nicole Swinteck: Program Coordinator, IMB Admin -Samantha Chiquette, Undergraduate Researcher, Campos Lab January +Kevin Holt: Research Technician, Schenten Lab February -Sherilen Clark: Department Administrator, retired after 5 years with the IMB department Brianna was born on February 11th: 8 lbs 12 oz, 22 inches long (Proud Parents: Kristin & Graham Renkema) March +Iris Man Cheong: Graduate Student, So Lab, +Krysta Felix: Graduate Student, Wu Lab, +Marvin O’Ketch: Graduate Student, Schenten Lab, +Sarah Bughio: CMM Graduate Student, Goodrum Lab, +Sebastian Zeltzer: CMM Graduate Student, Goodrum Lab +Heather Thompson: Postdoctoral Research Associate I, Nikolich Lab, +Wazir Abdullahi: Research Specialist, Nikolich Lab April +Christy Wright: Office Specialist, Sr., IMB Admin -Janice Chapman, Research Technician, Campos Lab May -Andrew Nelson, our student worker for 4 years graduated and is moving to California. -Hannah Ledvina is going to begin graduate school at the University of Washington -Lydia Roberts will continue her Postdoctoral work at the National Institutes of Health Rocky Mountain Laboratories in Hamilton, Montana +Nicole Congrove: Research Specialist, Schenten Lab +Madeline Keenen: Research Lab Assistant, Kuhns Lab -Marcella Berumen, Undergraduate Researcher, Campos Lab Amelia was born April 5th: 8 lbs 12 oz, 21 inches long (Proud Parents: Jennifer & Jamie Uhrlaub) 2 2014 Symposium The Ninth Annual Frontiers in Immunobiology and Immunopathogenesis Symposium was held on Friday, March 7th. The Symposium featured scientific talks by researchers in the fields of Immunology, Viral Pathogenesis, and Bacteriology Pathogenesis, as well as a poster session highlighting work in these, and related fields. Graduate Students and Postdoctoral Fellows were invited to present posters. Each year, this event brings together researchers from across campus to present and discuss their latest findings and provide networking opportunities with other labs. The program was kicked-off with a brief welcome from IMB Department Head, Janko Nikolich-Žugich M.D., Ph.D., BIO5 Institute Director, Fernando Martinez, M.D., and CoM Deputy Dean for Research, Anne Cress, Ph.D. This year’s Symposium featured plenary addresses by: Michael Starnbach, Ph.D., Harvard Medical School Stanley Lemon, M.D., University of North Carolina at Chapel Hill Matthew Krummel, Ph.D., University of California San Francisco The Symposium was a huge success with more than 100 attendees. A big thank you to everyone on the Symposium Committee! We had great participation during Science City at the Festival of Books! Thanks everyone!! Frelinger Lab Updates In November 2014 Daniel Powell joined our lab as a Postdoctoral Fellow. He comes to us from the University of Maryland where he got his Ph.D. with Bob Ernst studying the effect of LPS on Francisella pathogenesis. Since joining the lab Daniel has been working on some Salmonella typhimurium projects and we are very happy to have him with us. At the end of May, two of our troops will be heading off to their next steps in life. Lydia Roberts has received a great position at National Institutes of Health Rocky Mountain Laboratories in Hamilton, Montana as a Postdoctoral Fellow. Lydia received her Ph.D. with Jeff last June and has been working for him since 2009. During her time with him she has published four papers with two more still in the works studying the immune response to Francisella tularensis. In Montana, she will be working with Katy Bosio studying the immune response to virulent Francisella. Lydia has been a wonderful asset to the Frelinger lab and her presence will be greatly missed. We wish her nothing but the best in her future studies and hope she will be back to visit! Hannah Ledvina will be leaving us to attend graduate school at the University of Washington, pursuing her Ph.D. in microbiology. She has been the lab manager for the Frelinger lab for about a year and has been a great asset. Hannah received her BS in microbiology at the University of Arizona and did her undergraduate research with Dr. Viswanathan. We wish her the best of luck and want to remind her to always have an umbrella handy in Seattle! Deepa Jamwal celebrated her baby boys first birthday on April 22nd and he is happy and healthy! Adam Buntzman has done a wonderful job promoting science throughout our community. He recently headed a huge volunteer weekend for the department at the Tucson Festival of Books to which we brought the Science Bus! It was a huge success and a major hit of the festival. 3 Grants Dr. Samuel Campos, Assistant Professor: Awarded R01 Grant from the National Institute of Allergy and Infectious Diseases: “Mechanisms of L2-Mediated Membrane Translocation of the Papillomaviral Genome” Period: 2014-2019 Dr. Felicia Goodrum, Associate Professor: Received a new grant from the Flinn Foundation. Dr. Goodrum is the Co-PI as she is working collaboratively with Dr. Matt Sullivan and Dr. Kenneth Knox (both at the University of Arizona). Title: Defining the Pulmonary Virome and the Impact of Human Cytomegalovirus Persistence Period: 2013-2015 R01 grant was renewed! Title: Mechanisms of Human Cytomegalovirus Latency in Primary Human Hematopoietic Cells Period: 2014-2019 Dr. Janko Nikolich-Žugich, Bowman Professor and IMB Department Head Was awarded a R21 NIH Grant from the National Institute of Aging. Title: Longevity extension and immune function in aging Period: 2014-2016 Publications Ahmad, N. 2014 Sherris Medical Microbiology, Sixth edition. ed. McGraw-Hill Education Medical, New York. Ryan, K.J., Ray, C.G. (Eds.). Chapters 1-13 in Sherris Medical Microbiology: Viruses: Basic Concepts Pathogenesis of Viral Infection Influenza and Other Respiratory Viruses Mumps, Measles and Other Childhood Exanthums Poxviruses Enteroviruses Hepatitis Viruses Viruses of Diarrhea Arthropod-Borne Viruses and Other Viral Zoonoses Rabies Retroviruses Papilloma and Polyoma Viruses Persistent Viral Infection Having fun at SGK Race for the Cure Harris, D.T., Stem Cell Banking for Regenerative and Personalized Medicine. Biomedicines 2014. Biomedicines 2014, 2, 50-79; doi:10.3390/ biomedicines2010050 Badowski, M., Shultz, C.L., Eason, Y., Ahmad, N., Harris, D.T., 2014. The influence of intrinsic and extrinsic factors on immune system aging. Immunobiology 219, 482–485. doi:10.1016/j.imbio.2014.02.008 Badowski, M., Muise, A., Harris, D.T., 2014. Mixed effects of long-term frozen storage on cord tissue stem cells. Cytotherapy 16, 1313–1321. doi:10.1016/j.jcyt.2014.05.020 Calton, C.M., Wade, L.K., So, M., 2013. Upregulation of ATF3 inhibits expression of the pro-inflammatory cytokine IL-6 during Neisseria gonorrhoeae infection. Cell. Microbiol. 15, 1837–1850. doi:10.1111/cmi.12153 Cekanaviciute, E., Dietrich, H.K., Axtell, R.C., Williams, A.M., Egusquiza, R., Wai, K.M., Koshy, A.A., Buckwalter, M.S., 2014a. Astrocytic TGF -β Signaling Limits Inflammation and Reduces Neuronal Damage during Central Nervous System Toxoplasma Infection. J. Immunol. doi:10.4049/jimmunol.1303284 Cekanaviciute, E., Fathali, N., Doyle, K.P., Williams, A.M., Han, J., Buckwalter, M.S., 2014b. Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice. Glia. doi:10.1002/glia.22675 Choudhery, M.S., Badowski, M., Muise, A., Harris, D.T., 2013. Utility of cryopreserved umbilical cord tissue for regenerative medicine. Curr Stem Cell Res Ther 8, 370–380. Choudhery, M.S., Badowski, M., Muise, A., Pierce, J., Harris, D.T., 2014a. Cryopreservation of whole adipose tissue for future use in regenerative medicine. J. Surg. Res. 187, 24–35. doi:10.1016/j.jss.2013.09.027 Choudhery, M.S., Badowski, M., Muise, A., Pierce, J., Harris, D.T., 2014b. Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation. J Transl Med 12, 8. doi:10.1186/1479-5876-12-8 Doyle, K.P., Buckwalter, M.S., 2014. A mouse model of permanent focal ischemia: distal middle cerebral artery occlusion. Methods Mol. Biol. 1135, 103–110. doi:10.1007/978-1-4939-0320-7_9 Dupont, C.D., Christian, D.A., Selleck, E.M., Pepper, M., Leney-Greene, M., Harms Pritchard, G., Koshy, A.A., Wagage, S., Reuter, M.A., Sibley, L.D., Betts, M.R., Hunter, C.A., 2014. Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii. PLoS Pathog. 10, e1004047. doi:10.1371/journal.ppat.1004047 Funk, J.L., Frye, J.B., Davis-Gorman, G., Spera, A.L., Bernas, M.J., Witte, M.H., Weinand, M.E., Timmermann, B.N., McDonagh, P.F., Ritter, L., 2013. Curcuminoids limit neutrophil-mediated reperfusion injury in experimental stroke by targeting the endothelium. Microcirculation 20, 544–554. doi:10.1111/micc.12054 4 Publications Continued... Griffiths, S.J., Riddell, N.E., Masters, J., Libri, V., Henson, S.M., Wertheimer, A., Wallace, D., Sims, S., Rivino, L., Larbi, A., Kemeny, D.M., Nikolich-Zugich, J., Kern, F., Klenerman, P., Emery, V.C., Akbar, A.N., 2013. Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA. J. Immunol. 190, 5363–5372. doi:10.4049/jimmunol.1203267 Harris, D.T., 2013. Umbilical cord tissue mesenchymal stem cells: characterization and clinical applications. Curr Stem Cell Res Ther 8, 394– 399. Harris, D.T., Badowski, M., 2014. Long term human reconstitution and immune aging in NOD-Rag (-)-γ chain (-) mice. Immunobiology 219, 131–137. doi:10.1016/j.imbio.2013.08.013 Harris, D.T., Badowski, M., Balamurugan, A., Yang, O.O., 2013. Long-term human immune system reconstitution in non-obese diabetic (NOD)-Rag (-)-γ chain (-) (NRG) mice is similar but not identical to the original stem cell donor. Clin. Exp. Immunol. 174, 402–413. doi:10.1111/ cei.12192 Heger, K., Fierens, K., Vahl, J.C., Aszodi, A., Peschke, K., Schenten, D., Hammad, H., Beyaert, R., Saur, D., van Loo, G., Roers, A., Lambrecht, B.N., Kool, M., Schmidt-Supprian, M., 2014. A20-deficient mast cells exacerbate inflammatory responses in vivo. PLoS Biol. 12, e1001762. doi:10.1371/journal.pbio.1001762 Hess, S.M., Young, E.F., Miller, K.R., Vincent, B.G., Buntzman, A.S., Collins, E.J., Frelinger, J.A., Hess, P.R., 2013. Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance. Transpl. Immunol. 29, 138–145. doi:10.1016/j.trim.2013.10.005 Holmes, J.C., Holmer, S.G., Ross, P., Buntzman, A.S., Frelinger, J.A., Hess, P.R., 2013. Polymorphisms and tissue expression of the feline leukocyte antigen class I loci FLAI-E, FLAI-H, and FLAI-K. Immunogenetics 65, 675–689. doi:10.1007/s00251-013-0711-z Knowles, J.K., Simmons, D.A., Nguyen, T.-V.V., Vander Griend, L., Xie, Y., Zhang, H., Yang, T., Pollak, J., Chang, T., Arancio, O., Buckwalter, M.S., Wyss-Coray, T., Massa, S.M., Longo, F.M., 2013. Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer’s mouse model. Neurobiol. Aging 34, 2052–2063. doi:10.1016/j.neurobiolaging.2013.02.015 Kusne, Y., Goldberg, E.L., Parker, S.S., Hapak, S.M., Maskaykina, I.Y., Chew, W.M., Limesand, K.H., Brooks, H.L., Price, T.J., Sanai, N., Nikolich-Zugich, J., Ghosh, S., 2014. Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice. Age (Dordr) 36, 199–212. doi:10.1007/s11357-013-9572-5 Li, G., Rak, M., Nguyen, C.C., Umashankar, M., Goodrum, F.D., Kamil, J.P., 2014. An Epistatic Relationship between the Viral Protein Kinase UL97 and the UL133-UL138 Latency Locus during the Human Cytomegalovirus Lytic Cycle. J. Virol. 88, 6047–6060. doi:10.1128/JVI.00447-14 Lopez, J., Lomen-Hoerth, C., Deutsch, G.K., Kerchner, G.A., Koshy, A., 2014. Influenza-associated global amnesia and hippocampal imaging abnormality. Neurocase 20, 446–451. doi:10.1080/13554794.2013.791864 Mohler, M.J., Fain, M.J., Wertheimer, A.M., Najafi, B., Nikolich-Žugich, J., 2014. The Frailty syndrome: clinical measurements and basic underpinnings in humans and animals. Exp. Gerontol. 54, 6–13. doi:10.1016/j.exger.2014.01.024 Neely, C.J., Kartchner, L.B., Mendoza, A.E., Linz, B.M., Frelinger, J.A., Wolfgang, M.C., Maile, R., Cairns, B.A., 2014. Flagellin treatment prevents increased susceptibility to systemic bacterial infection after injury by inhibiting anti-inflammatory IL-10+ IL-12- neutrophil polarization. PLoS ONE 9, e85623. doi:10.1371/journal.pone.0085623 Nish, S.A., Schenten, D., Wunderlich, T., Pope, S.D., Gao, Y., Hoshi, N., Yu, S., Yan, X., Lee, H.K., Pasman, L., Brodsky, I., Yordy, B., Zhao, H., Brüning, J., Medzhitov, R., 2014. T cell-intrinsic role of IL-6 signaling in primary and memory responses. Elife e01949. doi:10.7554/ eLife.01949 Palm, N.W., Rosenstein, R.K., Yu, S., Schenten, D.D., Florsheim, E., Medzhitov, R., 2013. Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity 39, 976–985. doi:10.1016/ j.immuni.2013.10.006 Pollow, D.P., Uhrlaub, J., Romero-Aleshire, M.J., Sandberg, K., Nikolich-Zugich, J., Brooks, H.L., Hay, M., 2014. Sex Differences in TLymphocyte Tissue Infiltration and Development of Angiotensin II Hypertension. Hypertension. doi:10.1161/HYPERTENSIONAHA.114.03581 Rendón, M.A., Hockenberry, A.M., McManus, S.A., So, M., 2013. Sigma factor RpoN (σ54) regulates pilE transcription in commensal Neisseria elongata. Mol. Microbiol. 90, 103–113. doi:10.1111/mmi.12350 Renkema, K.R., Li, G., Wu, A., Smithey, M.J., Nikolich-Žugich, J., 2014. Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging. J. Immunol. 192, 151–159. doi:10.4049/jimmunol.1301453 Roberts, L.M., Davies, J.S., Sempowski, G.D., Frelinger, J.A., 2014a. IFN-γ, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis Live Vaccine Stain infection. Vaccine. doi:10.1016/j.vaccine.2014.05.013 Roberts, L.M., Tuladhar, S., Steele, S.P., Riebe, K.J., Chen, C.-J., Cumming, R.I., Seay, S., Frothingham, R., Sempowski, G.D., Kawula, T.H., Frelinger, J.A., 2014b. Identification of Early Interactions between Francisella and the Host. Infect. Immun. 82, 2504–2510. doi:10.1128/ IAI.01654-13 Rudd, B.D., Venturi, V., Smith, N.L., Nzingha, K., Goldberg, E.L., Li, G., Nikolich-Zugich, J., Davenport, M.P., 2013. Acute neonatal Infections “lock-in” a suboptimal CD8+ T cell repertoire with impaired recall responses. PLoS Pathog. 9, e1003572. doi:10.1371/ journal.ppat.1003572 5 Publications Continued... Sansoni, P., Vescovini, R., Fagnoni, F.F., Akbar, A., Arens, R., Chiu, Y.-L., Cičin-Šain, L., Dechanet-Merville, J., Derhovanessian, E., Ferrando -Martinez, S., Franceschi, C., Frasca, D., Fulöp, T., Furman, D., Gkrania-Klotsas, E., Goodrum, F., Grubeck-Loebenstein, B., Hurme, M., Kern, F., Lilleri, D., López-Botet, M., Maier, A.B., Marandu, T., Marchant, A., Matheï, C., Moss, P., Muntasell, A., Remmerswaal, E.B.M., Riddell, N.E., Rothe, K., Sauce, D., Shin, E.-C., Simanek, A.M., Smithey, M.J., Söderberg-Nauclér, C., Solana, R., Thomas, P.G., van Lier, R., Pawelec, G., Nikolich-Zugich, J., 2014. New advances in CMV and immunosenescence. Exp. Gerontol. 55, 54–62. doi:10.1016/ j.exger.2014.03.020 Schenten, D., Nish, S.A., Yu, S., Yan, X., Lee, H.K., Brodsky, I., Pasman, L., Yordy, B., Wunderlich, F.T., Brüning, J.C., Zhao, H., Medzhitov, R., 2014. Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells. Immunity 40, 78–90. doi:10.1016/j.immuni.2013.10.023 Striemer, G., Krovi, H., Akoglu, A., Vincent, B., Hopson, B., Frelinger, J., Buntzman, A., 2014. Overcoming the Limitations Posed by TCRbeta Repertoire Modeling Through a GPU-Based In-Silico DNA Recombination Algorithm, in: Proceedings of the 2014 IEEE 28th International Parallel and Distributed Processing Symposium, IPDPS ’14. IEEE Computer Society, Washington, DC, USA, pp. 231–240. doi:10.1109/ IPDPS.2014.34 Umashankar, M., Goodrum, F., 2014. Hematopoietic long-term culture (hLTC) for human cytomegalovirus latency and reactivation. Methods Mol. Biol. 1119, 99–112. doi:10.1007/978-1-62703-788-4_7 Umashankar, M., Rak, M., Bughio, F., Zagallo, P., Caviness, K., Goodrum, F.D., 2014. Antagonistic determinants controlling replicative and latent States of human cytomegalovirus infection. J. Virol. 88, 5987–6002. doi:10.1128/JVI.03506-13 Vescovini, R., Fagnoni, F.F., Telera, A.R., Bucci, L., Pedrazzoni, M., Magalini, F., Stella, A., Pasin, F., Medici, M.C., Calderaro, A., Volpi, R., Monti, D., Franceschi, C., Nikolich-Žugich, J., Sansoni, P., 2014. Naïve and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus. Age (Dordr) 36, 625–640. doi:10.1007/s11357-013-9594-z Wellensiek, B, Ramakrishnan, R., Bashyal, B. Eason, Y., Gunatilaka, L and Ahmad, N. Inhibition of HIV-1 replication by secondary metablolites from endophytic desert plants. The Open Journal Of Virology 7:41-49, 2013. Wertheimer, A.M., Bennett, M.S., Park, B., Uhrlaub, J.L., Martinez, C., Pulko, V., Currier, N.L., Nikolich-Žugich, D., Kaye, J., NikolichŽugich, J., 2014. Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. J. Immunol. 192, 2143–2155. doi:10.4049/jimmunol.1301721 Oral Presentations Dr. Adam Buntzman, Research Associate, Frelinger Lab May 2014—Presented “Overcoming the Limitations Posed by TCRb Repertoire Modeling through a GPU-based In-Silico DNA Recombination Algorithm" at Proceedings of Institute of Electrical and Electronic Engineers 28th International Parallel and Distributed Processing Symposium, Phoenix, AZ Farah Bughio, CMM Graduate Student, Goodrum Lab June 2014—Presented “ Human Cytomegalovirus pUL135 and pUL136 Are Required for Endothelial Cell Specific Tropism: at American Society for Virology 33rd Annual Meeting at Colorado State University, Fort Collins, CO. Dr. Samuel Campos, IMB Assistant Professor September 2013—Presented “Sorting and Translocation of the Papillomavirus Genome by the Minor Capsid Protein L2” at the Joint Departmental Retreat, Biosphere 2 in Oracle, AZ. May 2014—Presented “How the Papillomavirus Genome Breaches the Limiting Membrane During Infection- Mechanism and Implications” at The University of Arizona College of Medicine-Phoenix, Department of Basic Medical Sciences in Phoenix, AZ Katie Caviness, Genetics Graduate Student, Goodrum Lab September 2013—Presented “A novel human cytomegalovirus ULb’ encoded viral protein” at the University of Arizona Biosphere Joint Departmental Retreat, Oracle, AZ. June 2014—Presented "Interplay of UL136 isoforms in balancing states of human cytomegalovirus infection" at the American Society for Virology 33rd Annual Meeting at Colorado State University, Fort Collins, CO. Dr. Jeffrey Frelinger, IMB Professor January 2014—Presented “Bacterial attenuation by failure to inhibit host responses” as an invited Speaker, Rutgers University, New Brunswick, NJ April 2014—Presented “Screening spherule cell walls for protective vaccine antigens” at the COCCI Study Group 58th Annual Meeting, Phoenix, AZ Dr. Felicia Goodrum, IMB Associate Professor March 2014—Presented a Jamie McNew Endowed Lecturer at the University of Minnesota in Minneapolis, MN. May 2014—Graduate student invited speaker for SUNY Upstate Medical University, ogy, Syracuse, NY. Department of Microbiology and Immunol6 Announcements: The joint IMB/CBC/MCB/CMM retreat will be October 25th and 26th. The keynote speaker will be Denise Montell whose lab studies apoptosis and anastasis (coming back from the brink of death.) More details to come over the summer. - Anita Koshy, M.D. Funding has been continued for the calendar 2014 year for the BioTech Express Educational Outreach Mobile Lab. Special thanks to all of the Science City participants who made this years event very successful. The student, faculty, and staff participation from the Department of Immunobiology was very high. - Adam Buntzman, Ph.D. Our graduate students are extraordinary! Oral Presentations Continued... Dr. Janko Nikolich-Žugich, Bowman Professor and IMB Department Head Seminar Presentations: March 2014—The Doherty Institute, University of Melbourne, Melbourne, Australia April 2014—Queensland Institute for Medical Research, Brisbane, Australia April 2014—-University of New South Wales, Sydney, Australia, Upcoming Faculty Meetings: July 21st @ 12 pm August 25th @ 12 pm September 15th @ 12 pm October 20th @ 1 pm November 17th @ 1 pm December 15th @ 12 pm May 2014—Memorial Sloan-Kettering Cancer Center, New York, NY, September 2013—Invited Speaker, British Society for Research on Ageing Annual meeting, Norwich, UK September 2013—Invited Speaker and Session Chair, 6th SENS Foundation Meeting, Cambridge, UK November 2013—Invited Speaker, 1st Vaccine and Gene Therapy Institute-Florida Symposium: “Integrative approaches to the Immunotherapy of Cancer and Infectious Diseases”, Port St. Lucie, FL Dr. Janko Nikolich-Žugich, Bowman Professor and IMB Department Head Conference and workshop presentations: November 2013—Invited Panelist, “Societal Implications of Delaying Aging” panel, Gerontological Society of America 2013 Annual meeting, New Orleans, LA April 2014—Invited Speaker and Scientific Committee Member, 5th International T cell conference "ThymOz", Heron Island, Australia April 2014—Organizer and Speaker, UA Miraval Institute Symposium “Preparing for an Aging World : Living Beyond 100”, Miraval Resort, Catalina, AZ November 2013—RERF-NIAID Workshop “Radiation and Age-associated Immunosenescence“, Tokyo, Japan Dr. Goodrum and Dr. Frelinger on Valentine’s Day May 2014—NIAID Workshop “Immune protection in Special da, MD Populations”, Bethes7 Oral Presentations Continued... Katie Caviness, Genetics Graduate Student, Goodrum Lab September 2013— Presented “A novel human cytomegalovirus ULb’ encoded viral protein” at the University of Arizona Biosphere Multi-Departmental Retreat, Oracle, AZ. Neha Deshpande, IMB Graduate Student in Kuhns Lab November 2013—Presented “The CD4 T-cell repertoire becomes poly-specific with age” at the Gerontological Society of America's 66th Annual Scientific Meeting, New Orleans, LA Jason Pugh, Genetics Graduate Student in Nikolich Lab November 2013—Presented “Radiation and Immunity in the Context of Aging and Cytomegalovirus. ” at the Gerontological Society of America's 66th Annual Scientific Meeting, New Orleans, LA Some of the Immunobiology family members Mike Rak, CMM Graduate Student, Goodrum Lab March 2014—15 minute talk at the Frontiers in Immunobiology Symposium, describing our research and findings on CMV protein UL135 and its relationship to viral latency and replication. University of Arizona, Tucson, AZ Poster Presentations Dr. Adam Buntzman, Research Associate, Frelinger Lab October 2013—Presented "Serum Deprivation Blunts the Angiogenic Response to Hypoxia in Human Adipose Stem Cells" at the Plastic Surgery Conference in San Diego, CA John Davies, IMB Graduate Student, Nikolich Lab November 2013—Presented “Age Related Defects in Human Naïve T Cells” at GSA, in New Orleans, LA Neha Deshpande, IMB Graduate Student in Kuhns Lab January 2014—Presented “The CD4 T-cell repertoire becomes poly-specific with age” at the 53rd Midwinter Conference of Immunologists, Monterrey, CA. Emily Goldberg, Nutritional Science Graduate Student in Nikolich Lab January 2014—Presented “Immune memory-boosting dose of rapamycin curtails expansion of effector immunity against infection” at the 53rd Midwinter Conference of Immunologists, Monterrey, CA. Dr. Jeffrey Frelinger, IMB Professor January 2014—Presented “Revealing sub-dominant immune signaling pathways following Francisella tularensis infection” at the Midwinter Conference of Immunologist, Monterrey, CA Mike Rak, CMM Graduate Student, Goodrum Lab June 2014—Presented “Human Cytomegalovirus Proteins UL135 and UL138 Create a Functional Switch to Regulate Latency and Reactivation” at the American Society for Virology 33rd Annual Meeting at Colorado State University, Fort Collins, CO. Travel Awards Katie Caviness, Genetics Graduate Student, Goodrum Lab June 2014—The American Society for Virology Graduate Student Travel Award - $500 July 2014—University of Arizona Graduate Professional Student Council Travel Award - $500 Neha Deshpande, IMB Graduate Student, Kuhns Lab January 2014—Graduate School Professional Counsel Award (The University of Arizona, Tucson, AZ) to the 53rd Midwinter of Immunologists at Asilomar Conference in Pacific Grove, CA Conference Emily Goldberg, Nutritional Science Graduate Student, Nikolich Lab March 2013—Graduate and Professional Student Council Grant ($500) November 2014—Department of Nutritional Science Travel Grant ($400) Christy Harrison, IMB Graduate Student, Kiela Lab June 2014—NIH-sponsored award to the 2nd Annual Metabolomics Workshop at the University of Alabama in Birmingham, AL 8 Travel Awards Continued... Mike Rak, CMM Graduate Student, Goodrum Lab September 2013—Graduate and Professional Student Council Award ($500) June 2014—American Society of Virology Award ($500) Other Accomplishments Dr. Adam Buntzman, Research Associate, Frelinger Lab Recent Graduates!! February 2014—Attended Biological Collections Ontology and Population Collections Ontology Conference in Tucson, AZ. January 2014—Funding has been continued for the BioTech Express Educational Outreach Mobile Lab, Tucson, AZ. We are so happy to announce two department members in the Nikolich Lab GRADUATED!!! Dr. Nafees Ahmad, IMB Professor Jason Lyle Pugh, Ph.D., Fall 2013 Christy Harrison, IMB Graduate Student, Kiela Lab Dissertation Title: “Radiation and Immunity in the Context of Cytomegalovirus and Aging” Neha Deshpande, IMB Graduate Student in Kuhns Lab We are lucky enough to keep Jason here for his Postdoctoral work. He is continuing his work in the Nikolich lab. Emily Goldberg, Ph.D., Spring 2014 Dissertation Title: “Lifespan Extension and Immune Competence“ We are sad to see Emily leave but know she will be a fabulous addition to Dr. Vishwa Deep Dixit’s Lab at Yale University. *Both students were mentored by Janko Nikolich-Žugich, M.D., Ph.D. and Megan J. Smithey, Ph.D. November 2013—Life Time Achievement Educator of the Year Award, College of Medicine Year 1 and 2 medical school curriculum. May 201 4—Co-authored an abstract that was presented at the Digestive Disease Week International Conference in Chicago, IL. January 2014—Received the Ray Owen Poster Award sponsored by The American Association of Immunologist for outstand ing Graduate Student Poster at The 53rd Midwinter Conference of Immunologists at Asilomar Conference , Monterey, California. August 2013 Graduate student nominated by Dean Dr. Steven Goldschmid to participate in the AAAS/Science program for excellence in science. Reward: Two year sponsored membership in AAAS/Science. September 2013—Received outstanding oral presentation prize at the Joint Biology Research Retreat (BMCB/CBC/CMM/IMB) Title: “The CD4 T-cell repertoire becomes polyspecific with age” University of Arizona, Biospehere2, Oracle, AZ August 2013—Graduate student nominated by the Immunobiology department to be highlighted on the research touch screen monitor in the College of Medicine, The University of Arizona, Tucson, AZ Mike Rak, CMM Graduate Student, Goodrum Lab March 2014—ARCS (Achievement Rewards for College Scientists) Award from the Phoenix ARCS chapter, including $2000 for research funding through the graduate college, a $500 travel award, and a cash award of $3500 per semester. Department Outreach Dr. Michael Badowski, Postdoctoral Research Associate III February, 2014—Judged and gave feedback to science fair students at Fruchthendler Elementary, Tucson, AZ. Dr. Samuel Campos, IMB Assistant Professor December 2013—Speaker at the local Tucson ACS chapter for the “Climb to Conquer Cancer” kickoff event. Briefly highlighted our research on HPV infection and emphasized the importance of ACS fundraising to cancer research and young researchers, Tucson, AZ Dr. Kristian Doyle, Assistant Professor March 2014—Tucson Festival of Books, Science City, Tucson, AZ Dr. Richard Friedman, Professor Semester Dates Aug. 25—Fall Classes Begin Dec. 10—Fall Classes End December 2013—Gave a presentation and had discussion with students at Pima Community College, Tucson, AZ Dr. Felicia Goodrum, Associate Professor December 2013—Presented at Career Day for St. Michael’s Middle School, Tucson, AZ February 2014—Judged a Science Fair at Sam Hughes School, Tucson, AZ 9 Upcoming Social Events Every Tuesday at 8:45 am is Donut Tuesday. Check the Social Calendar to see who is hosting each week. Every Third Thursday of each month we have Tea Time at 3 pm in the MRB 2nd Floor Lunch Room Check your inbox for updates on when the next IMB Potluck will be. Immunobiology Fun! Holidays July 4—Independence Day Sept. 1—Labor Day Nov. 11—Veterans Day Nov. 27-30—Thanksgiving Dec. 24-25—Christmas Department Outreach Continued... Dr. David Harris, Professor Monthly—Co-Chair of the Bioscience leadership Council for Southern Arizona, Tucson, AZ January 2014—Mentored a JBio student at the BIO5 Institute, Tucson, AZ February 2014—Interview with the University of Arizona to explain stem cells, Tucson, AZ February 2014—Stem Cell Banking Phone Interview with the New York Times, Tucson, AZ March 2014—Presented a poster at Festival of Books, Science City. Tucson, AZ. Contact Us Questions, Comments, Suggestions, Additions? Dr. Anita Koshy, Assistant Professor February 2014—Spoke at Science Day at Sunrise Drive Elementary School, Tucson, AZ March 2014—Speaker on behalf of BIO5 for the Tucson Festival of Books, Science City, Tucson, AZ Dr. Mike Kuhns, Assistant Professor Contact: Nicole Swinteck [email protected] 520-626-0710 IMB Department 1656 E. Mabel Street P.O. Box 245221 Tucson, AZ 85724-5221 (520) 626-6409 Visit us on the web at www.immunobiology. arizona.edu March, 2014—Judged the Southern Arizona Science and Engineering Fair, Tucson, AZ Dr. Janko Nikolich-Žugich, Bowman Professor and IMB Department Head January 2014—Presentation on Lifespan and Health Span and Biology of Aging at the Wiseguise Group, Phoenix, AZ. Vivian Nguyen, Research Scientist March 2014—Tucson Festival of Books, Science City, Tucson, AZ Dr. Megan Smithey, Research Assistant Professor March, 2014—Judged the Southern Arizona Science and Engineering Fair, Tucson, AZ Dr. Anne Wertheimer, Assistant Professor Sept-March, 2014—Co-Director of the Southern Arizona Science and Engineering Fair, Tucson, AZ Social Calendar Link: https://www.google.com/calendar/embed?src=qegdfljkgi27jea9ooglnf82bo% 40group.calendar.google.com&ctz=America/Phoenix Seminar Calendar Link: https://www.google.com/calendar/embed?src=p31frvjtmk1v5l1v1rsodejqfo% 40group.calendar.google.com&ctz=America/Phoenix 10
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