Jinping Lai, M.D., Ph.D.:CV - Department of Pathology

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CURRICULUM VITAE
Jinping Lai, M.D., Ph.D.
Department of Pathology, Saint Louis University
1402 S. Grand Blvd., St Louis, MO 63104
E-mail: [email protected]
Tel: 314-268-7165
Pager: 314-419-2281
PRESENT POSITION: Assistant Professor, Surgical pathology/GI and Hepatic
Pathology, Department of Pathology, Saint Louis University
EDUCATION
MD, 1987,
Hunan Medical University, Changsha, Hunan, China.
PhD, 1994
Hunan Medical University (Now named: Xiangya School of Medicine,
Central South University), Changsha, Hunan, China.
AMERICAN BOARD OF ANATOMIC PATHOLOGY
Certified on 08/02/2012
USMLE
ECFMG certified (ECFMG ID: 06853170)
PREVIOUS PROFESSIONAL POSITIONS AND MAJOR APPOINTMENTS
07/2013-06/2014: GI/liver pathology fellow at Cedars-Sinai Medical Center
07/2012-06/2013: Surgical pathology fellow (chief fellow) at Cedars-Sinai
Medical Center
07/2011-06/2012: Chief resident, Pathology, NCI/NIH.
07/2009-06/2012: Pathology resident (AP only) at NCI/NIH
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10/2004-06/2009 : Assistant Professor (Research), Division of
Gastroenterology & Hepatology, Miles & Shirley Fiterman Center for
Digestive Diseases, Mayo Clinic Cancer Center, Mayo Clinic.
Research areas: Molecular pathogenesis of hepatocellular carcinoma: The
roles of novel sulfatase genes SULF1 and SULF2 in hepatocellular
carcinoma.
PI/Mentors: Lewis R Roberts, MD, PhD (Laboratory Director)
Gregory J Gores, MD (Director of GI research Center and
Chairman of Division of GI, Mayo Clinic)
03/2001-10/2004 : Senior Research Fellow/Research Associate, Division
of Gastroenterology & Hepatology, Mayo Clinic Rochester.
Research areas: Molecular pathogenesis of hepatocellular carcinoma: The
role of a novel sulfatase gene (SULF1) in hepatocellular carcinoma,
ovarian, breast, pancreas and head and neck cancer.
PI/Mentors: Lewis R Roberts, MD, PhD
09/2000 – 03/2001: Research Scientist, Dept. of Otolaryngology - Head
and Neck Surgery, University of Munich, Germany.
Research area: Molecular pathogenesis of photodynamic therapy-induced
tumor cell death
PI/Mentor: Andreas Leunig, MD
07/1997 – 08/2000: Surgeon and Associate Professor, Dept. of
Otolaryngology - Head and Neck Surgery, Hunan Medical University,
Changsha, China.
09/1996 – 07/1997: Research Fellow, Dept. of Otolaryngology - Head &
Neck Surgery, University of Vienna Medical School, Vienna, Austria
Research area: Molecular pathogenesis and photodynamic therapy in
head and neck cancer
PI/Mentor: Martin Burian, MD, PhD
07/1994 – 08/1996: Surgeon and Assistant Professor, Dept. of
Otolaryngology - Head and Neck Surgery, Hunan Medical University,
China
Dept. Chair: Jianyun Xiao, MD
08/1993 – 07/1994: Research fellow, Cancer Research Institute, Hunan
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Medical University.
Mentors: Zhengde Tao, MD /Jianyun Xiao, MD / Hecheng Zhu, PhD
09/1987 – 07/1993: Resident, chief resident, Dept. of Surgical
Otolaryngology, Hunan Medical University, Changsha, China.
Mentors: Zhengde Tao, MD (Dept. Chair) /Jianyun Xiao, MD
HONORS/AWARDS
1. Distinguished Young investigator award- “Minimal invasive laser
therapy for early stage laryngeal carcinoma”, the Ministry of Education,
China, 2000
2. Distinguished Young Scientist award-“Diagnosis and treatment of
nasopharyngeal carcinoma”, the Government of Hunan Province, 1999.
3. Distinguished Young Investigator award-“Early diagnosis and
photodynamic therapy for nasopharyngeal carcinoma”, the Ministry of
Public Health, China, 1998.
4. Second prize Award “Studies of operative methods for treatment of
otorhinopharyngeal tumor invading the to skull base”, the Committee of
Science and Technology of Hunan Province, China, in 1999, (No:
9913210).
5. Third prize Award “Fiberoptic laryngosopic YAG laser therapy for
diseases of the pharynx and larynx”, the Committee for Science and
technology of Hunan Province, China, in 1998. (No: 9813224).
6. Second prize award-“Basic and clinical studies of photodynamic
therapy for nasopharyngeal carcinoma”, the Committee for Science and
Technology of Hunan Province, China, in 1994. (No: 940162).
7. Second prize award “The significance of early stage diagnosis of the
specific EB virus DNA polymerase”, the Committee for Science and
Technology of Hunan Province, China, in 1995. (No: 950144).
RESEARCH GRANTS/FUNDING AWARD:
NIH R21 Grant CA128633 “Dysregulation of the Tumor
Microenviroment in Hepatocellular Carcinoma” (2009-2011)
PI: Roberts, LR, CI: Lai, JP
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NIH R01 Grant CA100882-01A) “Molecular pathogenesis of
hepatocellular carcinoma” (2004-2009). PI: Roberts, LR. CI: Lai,
JP.
NIH R01 Grant CA95683-01A1 “Improved MRI guided thermal
treatment of cancer” (2003-2007). PI: Felmlee, JP. CI: Lai, JP.
National Nature Science Foundation of China (Grant No. 39800030)
(1999 - 2001). “The role of Bak and Cyclin D1 in photodynamic
therapy- induced apoptosis of NPC”. PI: Lai, JP.
Ministry of Education of China (1998-2000). “Proliferation and
apoptosis of nasopharyngeal carcinoma.” PI: Lai, JP.
National Natural Science Foundation of China (Grant No.
30010210142). “International exchange program on
nasopharyngeal carcinoma.” (2000), PI: Lai, JP.
Ministry of Education of China (Grant No. 20027). “Microinvasive laser
therapy of laryngeal carcinoma.” PI: Lai, JP.
Ministry of Public Health of China (Grant No. 9808). “Cyclins
expression in nasopharyngeal carcinoma and its effect on
radiosensitivity”. PI: Lai, JP.
American-Chinese Medical Board (1991-1995). “Photodynamic
therapy for nasopharyngeal carcinoma (NPC).” PI: Xiao,JY; Co-PI:
Lai, JP.
MEMBER OF ACADEMIC SOCIETY
2009-date: Member of the USCAP
2009-date: Member of ASCP
2007-date: Member of the International Liver Cancer Association
2004-date: Member of the American Association for Cancer Research
2004-date: Member of the American Gastroenterological Association
2000 - 2004: Member, Standing Committee of Chinese Society for Laser
Medicine and Surgery. Vice chair of Laser Medicine and Surgery in
Otorhinolaryngology of China
7. 2000: Member of the American Society for Laser Medicine & Surgery.
8. 1998 - 2004: Member, Committee of Hunan Medical Association.
9. 1995 - 2004: Chief of the Committee of Laser Medical Association in Hunan
Province, China.
10. 1994 - 2004: Member, Committee of Chinese Society for Laser Medicine and
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Surgery.
TEACHING ACTIVITIES
2013-2014: Residents, surgical fellows and clinical GI fellows teaching- GI and
hepatic pathology. Cedars-Sinai Medical Center, Los Angeles, CA
2012-2013: Residents teaching- Surgical Pathology. Cedars-Sinai Medical
Center, Los Angeles, CA
2011-2012: Residents and rotating medical school student teachingAnatomic Pathology. NIH/NCI, Bethesda, MD
2005-2009: Clinical Fellow and Resident Lab teaching-Cellular and
Molecular Biology Laboratory sessions. Center for Basic
Research in Digestive Diseases, College of Medicine, Mayo Clinic
Rochester MN
2002-2004: Research fellow and summer medical student Lab teachingCellular and Molecular Biology. Center for Basic Research in
Digestive Diseases, College of Medicine, Mayo Clinic Rochester
MN
1987-2000: Lectures: Medical students / graduate students/ and ENT
residents, Otolaryngology, Hunan Medical University, China
REVIEWER OR EDITORIAL BOARDS
1. 2012- Journal of Hepatology
2. 2008- 2009: Hepatology
2. 2008- 2009: Journal of Proteome Research
3. 2004- 2007: Chinese Journal of Otolaryngol-Skull Base Surgery
4. 2000- 2004: Chinese Journal of Laser Medicine and Surgery
5. 1999- 2004: The Journal of Chinese Physician
6. 1997- 2004: Acta Laser Biology Sinica
GRANT REVIEWER FOR
National Natural Science Foundation of China (1998-2000).
Natural Science Foundation of Hunan Province of China (1999-2000
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PUBLICATIONS
Original study articles
Lai JP, Fan X, Guindi M, Balzer B, and Rutgers JK. Endoscopic ultrasound
guided - fine needle aspiration (EUS-FNA), in comparison with gross and
histologic diagnoses of pancreatic lesions. Am J Digest Dis. 2014 (in press)
Mohanty SK, Lai JP, Gordon OK, Bose S, and Dadmanesh F. BRCA-mutated
Invasive Breast Carcinomas: Immunohistochemical Analysis of insulin-like
Growth Factor II mRNA-binding Protein (IMP3), Cytokeratin 8/18, and
Cytokeratin 14. Breast J. 2014 (in Press)
Lai JP, Chen ZM, Lok T, Chan OT, Himmelfarb E, Zhai Q, Lin F, Wang
HL.Immunohistochemical stains of proliferating cell nuclear antigen, insulinlike growth factor 2 and clusterin help distinguish malignant from benign liver
nodular lesions. J Clin Pathol. 2014 Jun;67(6):464-9.
Lai JP, Liu YC, Alimchandani M, Liu Q, Aung PP, Matsuda K, Lee CC, Tsokos
M, Hewitt S, Rushing EJ, Tamura D, Levens DL, Digiovanna JJ, Fine HA,
Patronas N, Khan SG, Kleiner DE, Oberholtzer JC, Quezado MM, Kraemer
KH. The influence of DNA repair on neurological degeneration, cachexia, skin
cancer and internal neoplasms: autopsy report of four xeroderma
pigmentosum patients (XP-A, XP-C and XP-D). Acta Neuropathol Commun.
2013 May 8;1(1):4. doi: 10.1186/2051-5960-1-4.
Alimchandani M, Lai JP, Aung PP, Khangura S, Kamal N, Gallin JI, Holland SM,
Malech HL, Heller T, Miettinen M, Quezado MM. Gastrointestinal
histopathology in chronic granulomatous disease: a study of 87 patients. Am
J Surg Pathol. 2013 Sep;37(9):1365-72.
Bodogai M, Chang CL, Wejksza K, Lai J, Merino M, Wersto RP, Gress RE, Chan
AC, Hesdorffer C, and Biragyn A. Anti-CD20 antibody promotes cancer
escape via enrichment of tumor-evoked regulatory B cells expressing low
levels of CD20 and CD137L. Cancer Res. 2013;73(7):2127-38.
Lai JP, Cowen EW, Stern JB, Ballester LY, Chu EY, Chirinos RE, Childs RW,
Lee CC. Zoon’s balanitis with mucinous metaplasia: a case report and review
of literature. Open J Clinic Diagnostics. 2013; 3(2):33-36.
Ballester LY, Aung PP, Lai JP, Digiovanna JJ, Abdullaev Z, Pack S, W Linehan
WM, Stern JB, Pinto PA, and Lee CC. An unusual presentation of
glomeruloid hemangioma in a patient with VHL syndrome: A case report and
review of literature. Open J Clinic Diagnostics 2013; 3(2):63-66.
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Vanderver A, Tonduti D, Bernard G, Lai J, Rossi C, Carosso G, Quezado M,
Wong K, Schiffmann R. More Than Hypomyelination in Pol-III Disorder. J
Neuropathol Exp Neurol. 2013 Jan;72(1):67-75.
Lai JP, Rosenberg AZ, Miettinen MM, Lee CC. NY-ESO-1 expression in
sarcomas: A diagnostic marker and immunotherapy target.
Oncoimmunology. 2012 Nov 1;1(8):1409-1410.
Lai JP, Robbins PF, Raffeld M, Aung PP, Tsokos M, Rosenberg SA,
Miettinen MM, Lee CC. NY-ESO-1 expression in synovial sarcoma and other
mesenchymal tumors: significance for NY-ESO-1-based targeted therapy and
differential diagnosis. Mod Pathol. 2012 Jun;25(6):854-8.
Aung PP, Sarlomo-Rikala M, Lasota J, Lai JP, Wang ZF, Miettinen M. KBA62
and PNL2: 2 new melanoma markers-immunohistochemical analysis of 1563
tumors including metastatic, desmoplastic, and mucosal melanomas and their
mimics. Am J Surg Pathol. 2012 Feb;36(2):265-72.
Yang JD, Sun Z, Hu C, Lai J, Dove R, Nakamura I, Lee JS, Thorgeirsson SS,
Kang KJ, Chu IS, Roberts LR. Sulfatase 1 and sulfatase 2 in hepatocellular
carcinoma: associated signaling pathways, tumor phenotypes, and survival.
Genes Chromosomes Cancer. 2011 Feb;50(2):122-35.
Lai JP, Oseini A, Moser CD, Yu C, Hu C, Adeca I, Shire AM, Adjer AA,
Sanderson S, Fernandez-Zapico M,Roberts LR. The oncogenic effect of
sulfatase 2 (SULF2) in hepatocellular carcinoma is mediated in part by
glypican 3 (GPC3)-dependent Wnt activation. Hepatology, 2010; 52:16801689.
Lai JP, Sandhu D, Moser CD, Yu C, Hu C, Shire AM, Adeca I, Adjer AA,
Sanderson S, Roberts LR*. Sulfatase 2 (SULF2) protects hepacellular
carcinoma cells against apoptosis induced by PI3K inhibitor LY294002, MEK
and JNK kinase inhibitors. Liver International, 2010; 30:1522-1528 (Cover
page).
Lai JP* (* corresponding author), Sandhu D, Moser CD, Sanderson S, Roberts
LR*. Addictive effects of apicidin and doxorubicin in SULF1-expressing
hepatocellular carcinoma. J Hepatology 2009; 50(6):1112-1121
Lai JP* (* corresponding author), Sandhu D, Yu C, Han T, Moser CD, Guerrero
RB, Aderca I, Isomoto H, Garrity-Park MM, Zou H, Sanderson S, Nagorney D,
Adjei AA, Lee JS, ThorgeirssonSS, Roberts LR*. SULF2 up-regulates
glypican 3, promotes fibroblast growth factor signaling and decreases survival
in hepatocellular carcinoma. Hepatology; 2008; 47: 1211-1222 (Mayo Clinic
Cancer Center News, Science Daily News; Innovations Report, Life
Science News).
Chien J, Narita K, Rattan R, Giri S, Shridhar R, Staub J, Lai J, Roberts L , Molina
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J, Kaufmann SH, Prendergast GC, Shridhar V. A Role for Candidate Tumor
Suppressor Gene TCEAL7 in the Regulation of c-Myc Activity, Cylin D1
Levels and Cellular Transformation. Oncogene 2008 Dec 11;27(58):722334.
Aderca I, Moser CD, Bani-Hani AH, Bonilla-Guerrero R, Ahmed K, Shire A,
Cazanave SC, Montoya DP, Mettler TA, Burgart LJ, Nagorney DM,
Thibodeau SN, Cunningham JM, Lai JP * (* corresponding author) and
Roberts LR*. The JNK inhibitor SP600129 enhances apoptosis of HCC cells
induced by the tumor suppressor WWOX. J Hepatology; 2008; 49:373-383.
Yu C, Friday BB, Lai JP, McCollum A, Atadja P, Roberts LR, Kaufmann SH,
Adjei AA. Abrogation of MAPK and Akt signaling by multiple receptor tyrosine
kinase inhibitor AEE788 synergistically potentiates histone deacetylase
inhibitor-induced apoptosis through reactive oxygen species generation.
Clinical Cancer Research; 2007; 13:1140-1148.
Lai JP, Yu C, Moser CD, Aderca I, Han T, Garvey TD, Murphy LM, Garrity- Park
MM, Shridhar V, Adjei AA, Roberts LR. SULF1 inhibits tumor growth and
potentiates the effects of histone deacetylase inhibitors in hepatocellular
carcinoma. Gastroenterology. 2006;130:2130-2144.
Yu C, Friday BB, Lai JP, Yang L, Sarkaria J, Kay NE, Carter CA, Roberts LR,
Kaufmann SH, Adjei AA. Cytotoxic synergy between the multikinase inhibitor
sorafenib and the proteasome inhibitor bortezomib in vitro: induction of
apoptosis through Akt and c-Jun NH2-terminal kinase pathways. Mol Cancer
Ther. 2006; 5:2378-2387.
Rouviere O, Reynolds C, Le Y, Lai J, Roberts LR, Felmlee JP, Ehman RL.
Fiducial markers for MR histological correlation in ex vivo or short-term in vivo
animal experiments: a screening study. J Magn Reson Imaging. 2006;23:5059.
Lai JP, Chien JR, Moser DR, Staub JK, Aderca I, Montoya DP, Matthews TA,
Nagorney DM, Cunningham JM, Smith DI, Greene EL, Shridhar V, Roberts
LR. hSulf1 sulfatase promotes apoptosis of hepatocellular cancer cells by
decreasing heparin-binding growth factor signaling. Gastroenterology. 2004;
126:231-248.(AGA news)
Lai JP, Strome S, Chien J, Staub J, Dong HD, Montoya D, Smith DI, Roberts LR,
Shridhar V. HSulf1 modulates HGF mediated tumor cell invasion and
signaling in head and neck cancer. Oncogene. 2004; 23:1439-1447.
Wang F, Denison S, Lai JP, Philips LA, Montoya D, Kock N, Schule B, Klein C,
Shridhar V, Roberts LR, Smith DI. Parkin gene alterations in hepatocellular
carcinoma. Genes Chromosomes Cancer. 2004;40:85-96.
Lai J, Chien J, Staub J, Avula R, Greene EL, Mathews TA, Smith DI, Kaufmann
SH, Roberts LR, Shridhar V. Loss of hSulf1 up-regulates heparin binding
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growth factor signaling in carcinoma. J. Biol. Chem. 2003; 278 (25): 2310723117.
Betz CS*, Lai JP* (* equal contribution), Xiang W, Stepp H, Baumgartner R,
Leunig A. In vitro photodynamic therapy for nasopharyngeal carcinoma using
5-aminolevulinic acid. Photochemical Photobiological Science 2002; 1(5):
315-319.
Lai JP, Tong CL, Hong C, et al. Association of the initial tissue Cyclin D1 level
and the recurrence of Nasopharyngeal carcinoma. Laryngoscope 2002; 112
(2): 402-408.
Lai J, Tao Z, Xiao J, et al. Effect of photodynamic therapy on the expression of
pro-apoptotic gene Bak in nasopharyngeal carcinoma. Lasers Surg. Med.
2001; 29(1): 27-32.
Lai JP, Tao Z, Xiao J, et al. Microinvasive Nd:YAG laser therapy of early glottic
carcinoma and its effect on soluble interleukin-2 receptor, interleukin-2, and
natural killer cells. Laryngoscope. 2001; 111(9):1585-1588.
Wang CL, Lai JP, Wang XW, et al. Photodynamic therapy induced apoptosis in
nasopharyngeal carcinoma and its effect on the expression of Bax mRNA.
Chin J Physiological Medicine and Therapy. 2001, 23(3): 144-146. (in
Chinese).
Lai J, Tao Z, Xiao J, Luo J, Chen X, Zhao S, Betz C. Microinvasive laser surgery
for laryngeal carcinoma. Proc. SPIE 2001;4427:36-40.
Lai JP, Wang CL, Tang FQ et al. Apoptosis of mouse HNE1 nasopharyngeal
carcinoma cells induced by photodynamic therapy with 630 nm
semiconductor laser. International J of Modern Cancer Therapy 2000, 3(1):
55-58.
Lai J, Neuchrist C., Tong W., Issue H., Burian M. Relationship between protoapoptotic gene Bak and cell cycle regulational gene CyclinD1 in primary
laryngeal squamous cell carcinoma. Chin J Cell Biology 2000; 23(suppl): 5458. (in Chinese)
Lai J, and Xiao J. Microinvasive Nd:YAG laser therapy of early glottic carcinoma
and its effect on cellular immune function of the patients. Chin J Lasers Med
Surg 2000; 9(5):312-314. (in Chinese)
Wang CL, Lai JP, Tang FQ, et al. Ultrastructural study of HNE1 apoptosis
induced by photodynamic therapy in vitro. Chin. J. Otolaryngol-Skull Base
Surg. 2000, 6(1):20-23. (in Chinese)
Lai J, and Xiao J. Effect of photodynamic therapy on the expression of proapoptotic gene Bak in nasopharyngeal carcinoma. J. Optoelectronics. Laser
1999; 10 (suppl.):175-178. (in Chinese)
Lai J, and Xiao J. By fibro-laryngoscope YAC laser therapy for early stage
cancer of larynx. J. Optoelectronics . Laser 1999; 10(suppl.):179-182. (in
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Chinese)
Lai J, Neuchrist C, Burian M. Expression of bcl-2, bcl-x, bak and bax in human
tonsil. Chin J Otolaryngol Skull Base Surg. 1999; 5(3):337-341. (in Chinese)
Lai JP, and Li YB. Apoptotic inhibitor Bcl-X protein expression in nasal polyp.
Chin. J. Otolaryngol-Skull Base Surg. 1998, 4(4):230-232. (in Chinese)
Lai JP, Tao ZD, Xiao JY, et al. Effect of photodynamic therapy on selected
laboratory values of patients with nasopharyngeal carcinoma. Ann. Otol.
Rhinol. Laryngol. 1997; 106(8):680-682.
Liang X, Qi Z, Cao P, Xiao J, Tang G, Li X, Lai J. Studies on purging leukemic
cells by photosensitizer PSD-007 laser photoradiation in vitro. Bulletin of
Hunan Medical University 02/1997; 22(3):199-202.
Lai J, Tao ZD, Xiao JY, et al. Apoptosis induced by photodynamic therapy in
nasopharyngeal carcinoma in vitro. J. Med. Laser 1996, 10(2): 46-48. (in
Chinese)
Lai J, Tao ZD, Xiao JY, et al. Photodynamic therapy-induced change of the
expression of C-myc and H-ras gene in NPC (a preliminary in vitro study).
Chin. J. Modern Med. 1995, 5(1):17-19. (in Chinese)
Xiao JY, Luo JL, Tao ZD, Lai JP. P53 protein expression in laryngeal carcinoma
and its surrounding lesions. Chin. J. Otolaryngol-Skull Base Surg. 1995, 1(1):
47-49. (in Chinese)
Lai J, Tao ZD, Xiao JY, et al. YAG laser vaporization plus photodynamic therapy
in treatment of nasopharyngeal carcinoma and its effects on SIL-2R, IL-2 and
NK. Chin. J. Otolaryngol-Skull Base Surg. 1995, 1(2): 83-86. (in Chinese)
Lai JP, Tao ZD, Zhu HC, et al. In vitro photodynamic effect of three photosensitizers with pulsed copper vapor laser on 5 human NPC cell lines. Chin.
J. Laser Med. Surg. 1994, 3(2): 100-103 (in Chinese)
Lai JP, Tao ZD, Xiao JY, et al. Detection of circulating SIL-2R and IL-2 in
patients with nasal and nasopharyngeal tumors and its clinical significance.
Clin. J. Otorhinolaryngol. 1994, 8(6): 351-53 (in Chinese)
Lai J, Tao ZD, Xiao JY, et al. Preliminary study on SIL-2R levels in both serum
and nasal secretion of the patients with rhinitis or nasal polypus. Chin. J.
Otorhinolaryngol.1994, 8(6): 292-295. (in Chinese)
Lai J, Tao ZD, Xiao JY, et al. Soluble IL-2 receptor- A prognostic indicator of
laryngeal cancer. Chin. Arch Otolaryngol-Head Neck Surg. 1994,1(1):48-50.
(in Chinese)
Lai J, Tao ZD, Xiao JY, et al. Effect of hematoporphyrin derivative on the
radiosensitivity of nasopharyngeal carcinoma (in vitro and in vivo). Chin. J.
Modern Med. 1994, 4(suppl): 58-60. (in Chinese)
Lai J, Tao ZD, Xiao JY. Misdiagnosis of acoustic neuroma (A retrospective
analysis of 72 cases). Chin.J. Otorhinolaryngol. 1994, 29(4): 198-200. (in
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Chinese)
Review articles
Lai JP, Thompson J, Sandhu DS and Roberts LR. Heparin-degrading Sulfatases
in Hepatocellular Carcinoma: roles in pathogenesis and therapy targets.
Future Oncology; 2008; 4(6):803-814.
Lai JP, Sandhu DS and Roberts LR. Tumor suppressor function of Sulfatases 1
in cancers. J Gastroenterology Cancer; 2008;39(1-4):149-58. Review.
Sandhu DS, Tharayil VS, Lai JP and Roberts LR. Treatment options for
hepatocellular carcinoma. Expert Rev Gastroenterol Hepatol; 2008; 2: 8192.
Lai J, and Xiao J. Fibro-laryngoscopic laser therapy for the diseases of pharynx
and larynx. Chin J Lasers Med Surg 2000; 9:47-49. (in Chinese) (Expert
experience)
Book chapters
1. Marchevsky A, Lai J, and McKenna R. Diagnostic problems of frozen
section during thoracic surgery: mediastinum, lung and plura. In
Marchevsky A, Abdul-Karim FW, Balzer B, editors. Intraoperative
consultation. Philadelphia (PA): Elsevier, Philadelphia (PA), 2014 - (in
press)
2. Lai J, Giuliano A, and Dadmanesh F. Diagnostic problems of frozen
section during breast surgery. In Marchevsky A, Abdul-Karim FW, Balzer
B, editors. Intraoperative consultation. Philadelphia (PA): Elsevier,
Philadelphia (PA), 2014- (in press)
3. Lai J, Brien E, and Balzer B. Diagnostic problems of frozen section during
orthopedic surgery. In Marchevsky A, Abdul-Karim FW, Balzer B, editors.
Intraoperative consultation. Philadelphia (PA): Elsevier, Philadelphia
(PA), 2014- (in press)
4. Fan X, Lai J, Adashek K and Gangi A. Diagnostic problems of frozen
section during thyroid and parathyroid surgery. In Marchevsky A, AbdulKarim FW, Balzer B, editors. Intraoperative consultation. Philadelphia
(PA): Elsevier, Philadelphia (PA), 2014- (in press)
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ORAL OR POSTER PRESENTATIONS AT INTERNATIONAL
CONFERENCES:
Lai JP, Koo J, Chung F, Mendez AB, Kahn M, Mertens R, Dhall D. Comparison
of PAX6 and PAX8 as Markers for Pancreatic Neuroendocrine Tumors
(NETs). Poster presentation at the USCAP annual meeting, Baltimore, MD,
March 2-8, 2013
Lai J, Larson BK, Thakur S, Sahu SS, Agarwal S, Guindi M, Kalra K, Dhall D,
and Pillai PK. Differential Expression of miR-196a and miR-216a in
Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma Poster
presentation at the USCAP annual meeting, San Diego, CA, March 1-6,
2014
Lai JP, Knudsen BS, and Guindi M. Can Hypoxia after Transarterial
Chemoembolization (TACE) Trigger a Progenitor/Cholangiocytic Cell
Phenotype in Hepatocellular Carcinoma? Poster presentation at the USCAP
annual meeting, San Diego, CA, March 1-6, 2014
Lai JP, Fan X, Ljubimova J, Ljubimov A, Bose S. Laminin b1 and Laminin b2
Expression in Invasive Breast Carcinoma. Poster presentation at the
USCAP annual meeting, Baltimore, MD, March 2-8, 2013
Lai JP, Aung PP, Khangura S, Kamal N , Gallin JI, Holland SM , Malech HL ,
Kleiner DE, Heller T, Quezado M. Chronic granulomatous disease involving
gastrointestinal tract (pathology study of 87 cases). Poster presentation at
the USCAP annual meeting, Vancouver, Canada. March 17-23, 2012.
Lai JP, Aung PP, Wang Z, Rosenberg A, Kleiner DE, Roberts LR, Miettinen M.
Oncogenic SULF2 protein expression is associated with pathogenesis of
cirrhosis and hepatobiliary carcinoma. Poster presentation at the USCAP
annual meeting, Vancouver, Canada. March 17-23, 2012.
Lai JP, Beatriz Walter, Aung P, LinehanWM , Merino MJ. Mixed Epithelial
and Stromal Tumor of Kidney. Molecular and IHC findings of a Possible
New Hereditary Syndrome. Platform presentation at the USCAP
annual meeting, Vancouver, Canada. March 17-23, 2012.
Lai JP, Robbins P, Raffeld M, Aung PP, Tsokos M, Rosenberg SA, Miettinen M,
Lee CC. NY-ESO differentiates synovial sarcoma from other sarcomas.
ASCP annual meeting. Las Vegas, Oct. 18-22, 2011.
Lai JP, Oberholtzer C, Liu YC, Hewitt S, Kraemer K, and Kleiner D. Xeroderma
pigmentosum (XP-D) with neurologic degeneration (an autopsy case report).
Oral presentation at the International workshop on Xeroderma pigmentosum
and other diseases of human premature aging and DNA repair: Molecules to
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patients. Chantilly, VA. September 21-24, 2010.
Lai JP, Sandhu DS, Moser CD, Sanderson S and Roberts LR. Sulfatase 2
(SULF2) protects hepatocellular carcinoma cells against apoptosis induced by
PI3K inhibitor LY294002. Poster presentation at the 2010 Annual meeting of
American Society of Clinical Pathology (ASCP). San Francisco, CA, October
27-31, 2010.
Merino MJ, Lai J, Killian K, and Linehan M. Smooth muscle rich, tubulo-cystic
papillary renal cell carcinoma. A new reanl tumor? Immunohistochemical and
genetic chracteristics. Poster presentation at the 99th USCAP annual
meeting (section III #162). Washington DC, March 20-24, 2010.
Lai JP, Yu C, Moser CD, Lee JS, Adjer AA, Thorgeirsson SS, Sanderson SO,
Roberts LR. SULF2 sulfatase promotes tumor growth of hepatocellular
carcinoma through activation of Wnt signaling pathway. Oral presentation in
the Annual meeting of Digestive Diseases Week (DDW). Chicago, IL, May 31
to June 4, 2009. (Highlighted in the DDW Daily News, May 31)
Lai JP, Han T, Moser CD, Lee JS, Thorgeirsson SS, Roberts LR. SULF2
sulfatase functions as a novel oncogenic protein in hepatocellular carcinoma.
Oral presentation at the tumor molecular marker section of the 100 th Annual
meeting of American Association for Cancer Research (AACR). Denver, CO,
April 18-22, 2009.
Lai JP, Sandhu D, Moser CD, Shire R, Sanderson S, Roberts LR. Synergistic
effects of apicidin and doxorubicin in SULF1-expressing hepatocellular
carcinoma. Poster presentation in the Annual Meeting of American
Association for the Study of Liver Disease, San Francisco, Oct 28 – Nov 2,
2008.
Lai JP, Sandhu DS, Han T, Moser CD, Shire A, Lee JS, Thorgeirsson SS,
Roberts LR. SULF2 up-regulates glypican 3, promotes FGF signaling, and
decreases survival of patients with hepatocellular carcinoma (HCC). Oral
presentation at the Young Investigator Plenary section of the Annual
meeting of Digestive Disease Week (DDW) in San Diego, May 17-22, 2008.
(Highlighted in the DDW Daily News)
Shire A, Lai JP, Zou H, Aderca I, Moser CD, Jenkins RB, Roberts LR. Downregulation of SULF1 by hypermethylation mediates resistance to
chemotherapy induced apoptosis of hepatocellular carcinoma. Oral
presentation at the Annual meeting of Digestive Disease Week (DDW) in San
Diego, May 17-22, 2008. (Highlighted in the DDW Daily News)
Lai JP, Moser CD, Zhao SP, Sandhu DS, Xiao JY, Qian CN, and Lewis R.
Roberts. High SULF2 expression predicts poor prognosis in nasopharyngeal
carcinoma (NPC) and knockdown of SULF2 decreases HGF signaling in NPC
cells. Poster presentation at the 99th AACR Annual Meeting, San Diego, April
14
12-16, 2008.
Lai JP, Han T, Moser C D, Aderca I, Lee JS, Thorgeirsson SS and Roberts LR
SULF2 - A novel oncogenic protein in hepatocellular carcinoma (HCC).
Poster presentation at the 1st annual meeting of International Liver Cancer
Association, Barcelona, Spain Oct 5-7, 2007.
Lai JP, Zhao SP, Moser CD, Xiao JY, Roberts LR. Overexpression of SULF2 is
associated with recurrence of nasopharyngeal carcinoma. Poster
presentation at the 98th AACR Annual Meeting, Los Angeles, CA, April 14-18,
2007. Mayo Clinic Cancer Center News, Science Daily News.
Lai JP, Yu C, Moser C, Aderca I, Han T, Garvey T, Murphy L, Garrity M,
Shridhar V, Adjei A, and Roberts LR. SULF1 inhibits histone deacetylase
(HDAC) and potentiates the efficacy of HDAC inhibitors in hepatocellular
carcinoma. Oral presentation at the Fifth International meeting of
hepatocellular carcinoma: Eastern and Western Experiences, Houston, TX,
Jan 11-13, 2007.
Lai JP, Yu C, Moser C, Aderca I, Han T, Garvey T, Murphy L, Garrity M,
Shridhar V, Adjei A, and Roberts LR. SULF1 inhibits tumorigenesis and
potentiates the efficacy of histone deacetylase inhibitors in hepatocellular
carcinoma in vitro and in vivo. AACR Meeting Abstracts, Apr 2006; 2006:
1183 - 1184. (poster presentation)
Primak S, Le Y, Lai J, Lewis Roberts1, Carol Reynolds1, Phil Rossman1,
Joel Felmlee. Pilot Study Correlating Tissue Stiffness and Gross
Pathology of MRgFUS Thermal Lesions in Human Liver Cancer
Xenoplant Tissue. Oral presentation at ISMRM annual meeting 2006.
Lai J, Moser C, Aderca I, Han T, and Roberts LR. The novel HDAC inhibitor
apicidin induces apoptosis of hepatocellular carcinoma (HCC) cells and
inhibitsangiogenesis in HCC xenografts. AACR Meeting Abstracts, Apr 2005;
2005: 1260 – 1261. (poster presentation)
Lai JP, Shridhar V and Roberts LR. Apoptosis induced by histone deacetylase
inhibitors in HCC cells is enhanced by hSulf1 sulfatase. Oral presentation at
the Annual Digestive Disease Week in New Orleans, May 15-20, 2004.
Xiao J, Zhao S, Tian Y, Jiang W, and Lai J. Infection status of Epstein-Barr
virusin nasopharyngeal carcinoma. AACR Meeting Abstracts, Apr 2005; 2005:
79 - 80. (poster presentation)
Lai JP, Moser CD, Aderca I, Shridhar V and Roberts LR. The hSulf1 sulfatase
inhibits migration of HCC cell lines and tumorigenesis in nude mice. Poster
presented in 55th Annual Meeting of American Association for the Study of
Liver Disease, Boston, MA, Oct 28 – Nov 2, 2004.
Lai JP, Chien J, Strome SE, Staub J, Smith DI, Shridhar V, Roberts LR. HSulf
15
modulates HGF-mediated tumor cell invasion and signaling in head and neck
squamous carcinoma. Proceedings of American Association for Cancer
Research 2004; Poster Presentation at 95th AACR Annual Meeting held at
Orlando, FL, March 26-31, 2004.
Lai JP, Chien JR, Staub JK, Aderca I, Montoya DP, Matthews TA, Smith DI,
Greene EL, Shridhar V, Roberts LR. A novel sulfatase, hSulf1, downregulates fibroblast growth factor (FGF) and hepatocyte growth factor (HGF)
signaling in human hepatocellular carcinoma. Poster presented in 54th
Annual Meeting of American Association for the Study of Liver Disease
(President’s Choice), Boston, MA, October 24-28, 2003. Abstract published
in Hepatology, 38:No.4, Suppl.1:562-563.
Lai JP, Chien J, Staub J, Smith DI, Roberts LR, Shridhar V. HSulf-1 induces cell
growth arrest in breast cancer by down modulation of cyclin E. Poster
presentation at the 2003 FASEB Summer Research Conference, Tucson,
Arizona, Aug. 2-7,2003.
Shridhar V, Lai JP, Chien J, Staub J, Greene EL, Matthews T, Smith DI,
Kaufmann SH, Roberts LR. Loss of hSulf1, a novel sulfatase, upregulates
heparin bending growth factor signaling in ovarian cancer. Proceedings of
American Association for Cancer Research 2003; 44:948-949. Poster
presentation at 94th AACR Annual Meeting at Washington D.C., July 10-14,
2003.
Lai JP, Strome SE, Chien J, Staub J, Smith DI, Shridhar V, Roberts LR. A novel
sulfatase, hSulf, promotes apoptosis in head and neck cancer by modulation
of FGF2 signaling. Proceedings of American Association for Cancer
Research 2003; 44:705. Poster presentation at 94th AACR Annual Meeting at
Washington D.C., July 10-14, 2003.
Lai JP, Chien J, Staub J, Smith DI, Shridhar V, Roberts LR. A novel sulfatase
promotes apoptosis in hepatocellular carcinoma by modulation of FGF2
signaling. Gastroenterology 2003; 124 (4:Suppl1): A-472. Poster presented
at DDW in Orlando, FL, May 17-22, 2003. (Poster).
Lai JP, Avula R, Montoya D, Tsuchiya N, Smith DI, Jenkins RB, Shridhar V,
Roberts LR. Increased expression of the novel sulfatase gene, hSulf, is
associated with gain of chromosome 8 or duplication of 8Q in human
hepatocellular carcinoma. Hepatology, 2002; 36(4):Pt.2:449A.
Lai JP, Avula R, Montoya D, Greene EL, Smith DI, Shridhar V, Roberts LR. A
novel sulfatase domain contaning protein, hSulf, promotes apoptosis in
hepatocellular carcinoma. Proceedings of 93th AACR Annual Meeting, San
Francisco, April 6-10, 2002. (Poster).
Lai JP, Staub J, Avula R, Chien J, Smith DI, Roberts LR, Shridhar V.
Chracrization of a novel sulfatase domain-contaning gene hSulf in ovarian
16
carcinoma. Proceedings of 93th AACR Annual Meeting, San Francisco, April
6-10, 2002. (Poster).
Lai JP, Avula R, Montoya D, Greene EL, Smith DI, Shridhar V, Roberts LR.
Proapoptotic effects of a novel sulfatase domain containing protein, hSulf, in
hepatocellular carcinoma. Proceedings of AACR Meeting on Apoptosis and
Cancer: Basic Mechanisms and Therapeutic Opportunities in the PostGenomic Era. Hawaii Feb 13-17, 2002. (Poster).
Lai JP, Staub J, Avula R, Chien J, Smith DI, Roberts LR, Shridhar V. A novel
sulfatase domain-contaning gene hSulf promotes apoptosis in ovarian
carcinoma. Proceedings of AACR Meeting on Apoptosis and Cancer: Basic
Mechanisms and Therapeutic Opportunities in the Post-Genomic Era. Hawaii
Feb 13-17, 2002. (Poster).
Strobele S, Lai J, Leunig A, Betz C, Baumbartner R. 5-ALA induced
photodynamic therapy of in vitro squamous cell carcinoma of the larynx and
oropharynx compared to fibroblasts. Presiding of IPA 8th world congress of
Photodynamic Medicine, Vancouver, June 5-9, 2001. (Oral presentation).
Lai JP, Avula R, Montoya D, Aderca I, Yu C, Bani-Hani A, Smith DI, Shridhar V,
Roberts LR. A novel differentially expressed gene promotes apoptosis of
hepatocellular carcinoma cells. Hepatology, 2001; 34(4): Pt.2: 503A.
(Poster).
Lai J et al. Effect of photodynamic therapy on the expression of pro-apoptotic
gene Bak in nasopharyngeal carcinoma. Lasers Surg Med 2000; Suppl 12
(abstract). Presented in the 20th Annual Meeting of the American Society for
Laser Medicine & Surgery on April 5-9,2000, at Reno, Nevada. (Oral
presentation).
Lai J et al. Fibrolaryngoscopic YAG laser therapy of glottic carcinoma and its
effect on cellular immune function. Lasers Surg Med 2000; Suppl 12.
Presented at the 20th Annual Meeting of the American Society for laser
Medicine & Surgery on April 5-9,2000, at Reno, Nevada. (Oral presentation).
Lai J, Tao Z, Xiao J, et al. YAG laser vaporization combination with
photodynamic therapy for recurrent and persistent nasopharyngeal
carcinoma. Proceedings of the 17th World Otolaryngology-Head and Neck
Surgery, Sydney, Australia, March 3-7, 1997. (Oral presentation).
Lai J, Tao ZD, Xiao JY, et al. Effects of hematoporphyrin derivative on the
radiosensitivity of 4 human NPC cell lines in vitro. Proceedings of the 12th
Asia Pacific Cancer Conference, Singapore, Oct. 22-27, 1995, pp596. (Oral
presentation).
Lai J, Tao ZD, Xiao JY, et al. YAG laser vaporization plus photodynamic therapy
in treatment of nasopharyngeal carcinoma and its effects on SIL-2R, IL-2 and
NK. Proceedings of the 12th Asia Pacific Cancer Conference, Singapore, Oct.
17
22-27, 1995, pp41. (Oral presentation).

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