Neo YIR-2013-14-v0 MEU - the Department of Pediatrics

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Year in Review
Division of Neonatology
2013-2014
University of California San Francisco
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UCSF Division of Neonatology•www.neonatology.ucsf.edu
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UCSF Division of Neonatology•www.neonatology.ucsf.edu
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UCSF Division of Neonatology
Annual Review News Letter
2013 - 2014
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Johns Clements receives the first
Mary Ellen Avery Award from the PAS/SPR on May
2014. Pictured (left to right) Richard
Bland, Roberta Ballard, John Clements, Margo Clements, Philip Ballard.
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Dear Faculty, Fellows, Co-workers, Alumni and other Friends,
Welcome to the 7th edition of the UCSF Division of Neonatology Year in Review. This year
has seen significant changes in division administration, as we have moved to the UCSF clinical enterprise model and a system of more rational division budget allocation. We have also
been successful in hiring new faculty both at UCSF Moﬃtt and our community hospitals
and we anticipate further growth. The ICN has had an exceptionally high census, which reflects in part increased activity of L&D, as well as a robust referral network. We are looking
forward to the move-in to the new UCSF Benioﬀ Children’s Hospital Intensive Care Nursery
at Mission Bay in February of 2015. Hold on to your hats as the division grows and adapts
to these new opportunities and challenges. The following sections detail progress in specific
areas relevant to the clinical and research enterprise of the division. But first I want to highlight special distinctions achieved by division faculty.
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John Clements, MD, was awarded the first annual Mary Ellen Avery Neonatal Research
Award from the PAS/SPR at the recent meetings in Vancouver (see photo above). He was
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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presented this award by Dick Bland and Roberta Ballard, pictured below. John gave a touching address highlighting the spirit of discovery that characterized the CVRI and Division of
Neonatology.
Sam Hawgood, MBBS, was named the 10th Chancellor of UCSF by UC President Janet
Napolitano on July 17th 2014; please check the following link for details. http://www.ucsf.edu/news/2014/07/115926/uc-regents-confirm-sam-hawgood-ucsf%E2%80%99s-10thchancellor. Sam served as Chief of the Division of Neonatology from 1994 to 2006, Interim
Chair of the Department of Pediatrics 2003-2004, Chair of the Department of Pediatrics
from 2004 to 2009, Interim Dean of UCSF School of Medicine 2007-2009 and Dean of
UCSF School of Medicine from 2009 to 2014.
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We extend our congratulations to John and Sam on these significant achievements!
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Sam Hawgood, former Chief of Neonatology, was confirmed as new Chancellor of UCSF.
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Major events of the 2014 include the new association of USCF Benioﬀ
Children’s Hospitals in San Francisco and Oakland (formerly, ‘Children’s
Hospital and Research Center Oakland’). In 2015 we look forward to the
big move to the new58-bed ICN in at UCSF Benioﬀ Children’s Hospital
San Francisco at Mission Bay. The division continues to show excellent
productivity in terms of research publications and our faculty and fellows
have been successful in achieving distinguished training awards. For all
these reasons (described further below), I am very proud of the terrific eﬀorts of our fellows,
faculty and staﬀ. What follows is a summary of significant events and developments in the
division in the past academic year 2013-2014.
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I. Faculty News
New Faculty
We are pleased to welcome Drs. James McGuire, Martha Douglas-Escobar, Luke
Judge, Deborah Stern, Martina Steurer-Muller and Mark Petersen, as new faculty members in the Division.
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Dr. James McGuire received his undergraduate degree from Harvard, his
medical degree from UCSD and his master’s in public health from UCLA,
where he also completed a residency in pediatrics and a fellowship in neonatology. His interests include team harmony and collaboration. After practicing
neonatology for the last fourteen years in Oregon, including service as a medical director, Dr. McGuire is excited to join UCSF and the Washington Special Care Nursery in Fremont. Dr. McGuire is fond of the Bay Area, having
grown up in the East Bay and on the Peninsula.
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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Dr. Martha Douglas-Escobar is an assistant professor of clinical pediatrics
in the UCSF Division of Neonatology. She received her medical degree and
pediatric from Universidad del Valle, Colombia where she worked as professor for 10 years. She moved to US in 2000 and did her Pediatric Residency
at UCSF. She completed her neonatology fellowship at University of Florida
and had worked at Baylor College of Medicine and at University of Florida
as an Assistant Professor of Pediatrics. Dr. Douglas-Escobar will be the medical co-director of the Intensive Care Nursery at Natividad Hospital. !
Dr. Luke Judge completed his MD, PhD at University of Washington School
of Medicine, Seattle, in the Medical Scientist Training Program. He was a resident in Pediatrics and fellow Neonatology within the Molecular Medicine
Training Program. Luke’s research in the laboratory of Dr. Bruce Conklin
models the impact of cardiomyopathy genetic mutations using induced
pluripotent stem cells. He has been supported by a training grant from the
California Institute of Regenerative Medicine (CIRM).
Dr. Deborah Stern is a graduate of the UCSF Medical School and continued her training in Pediatrics at UCLA. Prior to entering neonatology, Dr.
Stern worked as a general pediatrician and administrator, heading pediatric
practices in Novato, CA; Maui, HI and East Hampton, NY. She made the
courageous mid-career decision to return to complete a fellowship in
Neonatal-Perinatal Medicine at SUNY Stonybrook. She conducted and
published clinical research on non-invasive positive pressure ventilation. After fellowship she returned to the Bay Area and did newborn and pediatric care at Marin
General Hospital before joining the UCSF staﬀ as a neonatologist at Washington Hospital in
June.
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Dr. Martina Steurer-Muller completed pediatric residency and neonatology fellowship at the Children's Hospital in Lucerne, Switzerland. She then
moved to San Francisco to complete her pediatric critical care fellowship at
UCSF. She is currently working in the ICN at SFGH and in the PICU at
UCSF. She completed the Master's Degree in Clinical Research and her research interests concern infants with congenital diaphragmatic hernia, pulmonary hypertension and prediction models. !
Dr. Mark Petersen received his medical degree from the University of Iowa
and he completed his Pediatric Residency Training at Stanford University.
He began his Fellowship in Neonatology at UCSF in 2009. With mentorship from Dr. Katerina Akasaglou, Mark investigates the impact of inflammatory signaling on myelination. Mark was successful in obtaining support
from the Physician Scientist Development Program (PSDP).
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UCSF Division of Neonatology•www.neonatology.ucsf.edu
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Transitions
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”Fritzi” Drosten (pictured with (left) Tom Shimotake and
(right) Yao Sun) retired after a long career at UCSF as a lactation consultant. She was a constant presence in the ICN and
constant source of parental support. She was instrumental in
helping make a new policy of breast milk availability to all
patients and other quality improvements.
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Andrea Mostny, RN. The
ICN was devastated this year
by the sudden and unexpected
passing of our dear friend and
colleague Andrea Mostny. Andrea was an extraordinary
ICN nurse, educator, resource, mentor, and a great
friend to many of us over the
past several decades. She was
known for her kindness, generous and loving spirit, and quirky good humor. She was a huge part of the spirit and identity of the UCSF ICN, which she always saw as part of her family. She was very much loved
and we will miss her dearly.
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II.
Fellowship Program News
Fellowship Program 2013-14. Drs. Larry
Shiow, Leslie Lusk and graduating fellow Eunice Rhee at the 2014 Tooley Lecture.
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Graduating Fellows
Luke Judge, MD, PhD—See, New Faculty.
Eunice Rhee, MD – Dr. Rhee, under the combined mentorship of Dr. McCune and
Dr. Trevor Burt developed a project (SILVER) designed to test the hypothesis that the human immune system may not develop in a linear fashion but in a layered manner instead.
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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She has accepted a clinical faculty position at the University of Colorado where she will have
combined teaching and clinical responsibilities in the NICU. She was recently married and
her husband will be part of the anesthesia training program at the University of Colorado.
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New Fellows. We welcome three outstanding fellows to the program:
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James Anderson, MD Jim did his undergraduate training at the University
of Richmond, then at the University of Massachusetts Amherst in the
Commonwealth College Honors Program, where he studied Economics. He
worked for two years prior to medical school as a mental health counselor
to children ages 5-16, then as a research associate in private industry developing cellular assays. He returned to medical school at the Univ of Massachusetts. In 2011 he started in the UCSF Pediatric Residency Program
under the Global Heath Clinical Scholars Pathway. With a long-standing
interest in neonatology and infant outcomes, Jim will work with experienced global health
mentors Dr. Colin Partridge and Dr. George Rutherford, to establish a network of high-risk
infant follow-up clinics in Hanoi.
Melissa Catenacci, MD Melissa received her undergraduate degree from
the Univ of Vermont but moved back to her native Florida for medical
school at Florida State University. She came to UCSF for her Pediatric Residency, which she completed in 2012. During Residency, Melissa found
time to conduct research into hydrocortisone use and ROP under the mentorship of Ron Clyman. During her year after residency, Melissa worked as
one of our ICN moonlighters. Her hobbies include running marathons,
snowboarding, hiking and trekking.
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Emily Stieren, MD, PhD. Emily completed her undergraduate work in
2002, receiving a BS in Psychobiology from the University of Miami. She
was accepted into the MD/PhD program at the University of Texas, Galveston where she worked with Darren
Boehning, Ph.D. elucidating the molecular mechanisms by which the
ubiquilin protein contributes to
Alzheimer’s disease pathogenesis. She
completed her MD in 2012 and received numerous
awards for her scholarship. She was accepted into the
UCSF Molecular Medicine Training Program as a FastTrack resident (2+4) and enters our Fellowship program
this year. During fellowship, she will work under the
Mentorship of Peter Walter at the Mission Bay Campus.
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1974 training memento provided by Victor Baum, MD
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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C.
Other Fellowship and Training News. Our
fellowship selection process for the 2014 Match is
again in process with a new record number of applicants. The Fellowship Program is undergoing expansion to three fellows every year for a total of 9
ACGME fellows. The Annual Fellows Retreat occurred in June and was an opportunity to enjoy some
well-deserved time together outside the hospital setting, as well as providing important feedback that
was incorporated into the Annual Program review.
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Simulation laboratory training 2014 (above), and
teaching session with Phil Ursel, MD, Chief of Pediatric Pathology (below).
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This section acknowledges junior
faculty that have
achieved distinguished career development
awards within the past five years
(2009-2014):
1. Magda Petryniak, MD, NIH KO8, “Genetic Mechanisms of Oligodendrogenesis and Remyelination.” Current position: OHSU
2. Mike Kuzniewicz, MD, NIH K23, “Genetic Epidemiology of Respiratory Distress Syndrome.” Current position: Kaiser Permanente and UCSF
3. Ann Zovein, MD, Burroughs Wellcome Fund Career Award for Medical Scientists,
“Hematopoietic stem cell emergence from the vasculature.” Current position: UCSF
4. Trevor Burt, MD, NIH KO8, “Defining the transition from fetal to adult T cell
predominance in the human fetus and neonate.” Current position: UCSF
5. Fernando Gonzalez, MD, NIH KO8, ““Erythropoietin and Neurogenesis after
Neonatal Stroke.” Current position: UCSF
6. Henry Lee, MD, NIH K23, “Maternal, Clinician & Hospital Factors in Breast
milk for Premature Infants.” Current position: Stanford
7. Sonia Bonifacio, MD, NIH K23, “Multi-modal neuromonitoring, serum GFAP,
and MRI as early biomarkers of outcome in neonates with encephalopathy.” Current position: UCSF
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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8. Cindy Tran, MD, NIH KL2, “Role of the type III secretion system in
Pseudomonas aeruginosa biofilm formation at the epithelial barrier.” Current position: UCSF
III.
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Division Progress Report
The leadership has generated an inclusive plan for organization of major clinical and research eﬀorts within the Division to provide pathways of career development, falling into two broad categories: 1) clinical services and 2) clinical-translational and basic science research.
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1) !
A.
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Clinical Service News
William H. Tooley ICN at Moffitt-Long Hospital Patient census in the ICN was significantly higher this year compared to the previous
year. The higher census reflects increasing deliveries at UCSF as well as robust transport activity from our partner Outreach institutions. In March 2014, Washington Hospital in Fremont transitioned from a satellite nursery of Lucile Packard Hospital to a level II nursery fully owned and operated by Washington Hospital and staﬀed by UCSF Neonatologists. Because of the new relationship between Washington Hospital and UCSF, perinatal and neonatal referrals from the East Bay have increased.
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The aﬃliation between Children’s Hospital Oakland and UCSF is now complete,
and with a large philanthropic gift from Lynne and Marc Benioﬀ, the hospitals are now
known as UCSF Benioﬀ Children’s Hospital Oakland and UCSF Benioﬀ Children’s Hospital
San Francisco. Although the two Neonatology groups remain separate entities, East Bay
Neonatology and the UCSF Division of Neonatology continue to work on ways to integrate
clinical guidelines and research projects.
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Exacting dress codes for teams during rounds (left) and X-mas 2014 (right)
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After years of planning, anticipation, and hard work, construction of the new Mission Bay hospital has been completed and the building will formally be turned over to UCSF
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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in the next month. Equipment installation and patient care simulations including “Day in
the Life” scenarios are taking place now, and patients will move from Parnassus ICN to Mission Bay on opening day, February 1, 2015.
Use the link below to read more about our exciting new home.
http://missionbayhospitals.ucsf.edu/our-facilities/childrens-hospital
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UCSF Benioﬀ Children’s Hospital San
Francisco (today, left) and January, 2015 (right).
UCSF Benioﬀ Children’s Hospital ICN “Destination Programs”:
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The Pediatric Pulmonary Hypertension Program provides care to children with
primary and secondary pulmonary hypertension (PH) in all settings, from the ICU to the
clinic. We care for infants and children with acute chronic problems resulting from bronchopulmonary dysplasia, congenital diaphragmatic hernia, and other cardiopulmonary
anomalies. The evaluation and treatment of these infants involves consideration of the contribution of structural and functional cardiac, pulmonary vessel and pulmonary vascular abnormalities, as well as lung function, to the infant’s overall status. Our multi-disciplinary
team is composed of pediatric physicians from Neonatology, Critical Care, Cardiology, Imaging, Interventional Cardiology and Pulmonology, who work together to address this need.
The program is staﬀed by a Pediatric Nurse Practitioner, focused on the care of infants and
children with PH, as well as a dedicated social worker. We work with the family and referring
physicians to develop specific care plans for the patient, based on her/his functional status
and co-morbidities and the family’s wishes. As an uncommon pediatric disorder, broader experience with PH is necessary to continue to advance our level of understanding of management and treatment. From our work, we have identified the natural history of the echocardiographic diagnosis of pulmonary hypertension in newborns with CDH, and the biochemical biomarkers associated with adverse outcomes. In addition, we participate in a national
registry of referral pediatric pulmonary hypertension centers. Data from this registry helps
identify the course of PH from a variety of etiologies, and should also provide insight into
the most eﬀective treatments for particular subsets of patients. If
you would like to refer a patient to the UCSF Pediatric Pulmonary
Hypertension program in the Intensive Care Nursery, you can
contact Emma Olson, PNP at 415-476-6795 or Roberta Keller,
MD at 415-514-3192 or the Intensive Care Nursery attending
physician at 415-353-1565. We are also happy to arrange referrals
for older children with PH. UCSF Division of Neonatology•www.neonatology.ucsf.edu
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2014 Annual ICN Halloween Reunion
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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The Neuro-Intensive Care Nursery (NICN) at the UCSF Benioﬀ Children’s Hospital San Francisco was established in 2008 as the first dedicated Neonatal Neurocritical Care
Service (NNCS) in the United States. Our broad mission is to improve neurodevelopmental
outcomes in critically ill newborns at risk for brain injury, and to increase awareness regarding the impact of critical care on the vulnerable developing brain. The NICN is comprised of
a multi-disciplinary team with participation from Neonatology, Child Neurology, Neurophysiology, and Nursing. Unique features of this program include a co-management model
of care with daily involvement of the NNCS, specially trained NICN bedside nurses, 24/7
availability of brain monitoring for diagnosis and treatment of seizures, the ability to perform
brain MRIs on the smallest and sickest patients, and access to research studies including neuroprotection trials and imaging studies. The NICN cares for almost 150 newborns each year
with Hypoxic-Ischemic Encephalopathy (HIE), Stroke, Seizures, Genetic & Metabolic Disorders, Vascular Malformations, CNS Infections, Intracranial Hemorrhage, Neonatal Onset
Epilepsies, and neurologic complications associated with critical illness and prematurity.
Highlights include the treatment of more than 200 newborns with therapeutic hypothermia,
the only clinically available treatment to reduce the risk of death or significant disability in
neonates with HIE. The NICN has garnered a reputation both nationally and internationally
as a leading innovator in providing neurocritical care and access to the latest neuroprotective
research. If you would like to refer a patient to the NICN, you may contact the Intensive
Care Nursery attending physician at 415-353-1565 24/7. For consults and interest in our
educational outreach program please contact Sue Peloquin RN, 415-353-1565 or Mary
Ulman, RN at 415-476-7242 during normal business hours. !
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2014 Annual ICN Halloween Reunion
Family Support: a multidisciplinary team that includes physicians, nurses, social
workers, spiritual care, ICN families, and faculty from the Department of Pediatrics and the
School of Nursing are in the formative stages of a research project to bring Family Integrated
Care (FICare) to UCSF. Variations of family integrated care, where parents are taught how
to take care of their babies in the intensive care nursery, are practiced throughout the world,
and Canadian neonatology researchers are now in a nationwide clinical trial to investigate the
eﬀects of FICare in Canada. UCSF will adapt strategies from our Canadian colleagues, but
will need to craft some new approaches to FICare due to diﬀerences in the patient population, funding, and family leave policies between the United States and Canada. The new
Mission Bay hospital, with its single family patient rooms, will be an ideal environment to
investigate the eﬀects of FICare in the United States.
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William H. Tooley ICN and Neonatal Medical Leadership:
•Sonia Bonifacio, MD, Neonatal Director, NICN
•Roberta Keller, MD, Leader for ECMO-PPHN Programs and
Clinical Investigation.
•Liz Rogers, MD, HRIF Clinic Director, Associate Clinical Director
•David Rowitch, MD, PhD, Chief of Neonatology
•Tom Shimotake, MD, Fellowship Director, Associate Clinical DiUCSF Division of Neonatology•www.neonatology.ucsf.edu
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B.
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rector
Yao Sun, MD, PhD, Director of Neonatal Clinical Programs
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Community ICNs & Outreach
As outlined previously in the New Faculty section, UCSF has been busy hiring staﬀ
for the Parnassus campus and our aﬃliated community hospitals. Santa Rosa Memorial
Hospital and Natividad Medical Center have been joined by Washington Hospital as UCSF
Neonatology staﬀed hospitals. ValleyCare Medical Center will remain staﬀed by UCSF
Neonatology this coming year, but is expected to transition to a relationship with Lucile
Packard Hospital due to an expected aﬃliation with Stanford University Medical Center. We
have enhanced our support of Marin General Hospital. Finally, the aﬃliation of UCSF Benioﬀ Children’s Hospital Oakland and San Francisco promises new opportunities for clinical
and research collaborations that will significantly enhance the Division’s profile.
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Community Aﬃliate Neonatal Medical Leadership:
• Roberta Bruni, MD, Natividad Nursery Director
• Olivier Danhaive, MD, SFGH Nursery Director
• Monica Dawson, MD, ValleyCare Hospital Nursery Director
• James McGuire, MD, Washington Hospital Nursery Director
• Colin Partridge, MD, Marin General Hospital Nursery Director
• Alan Shotkin, MD, Santa Rosa Memorial Hospital Nursery Director
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High Risk Infant Follow-Up (HRIF) Clinic
It has been another big year in the ICN Follow-Up Program, with lots of changes and many more to anticipate in the
coming year. As many of you know or remember, the program has
long had a commitment to providing outreach to our outlying
communities that include Eureka, Modesto, Salinas, and many
others. This should evoke images of Dr. Bob Piecuch pulling up to
the side of Hwy 101 to examine kids from Ukiah, Clear Lake,
Willits on northward! We are coming in to the modern age, and
with it, we have had to adjust our practices to also adjust to our new referral patterns, legal
implications of the electronic medical record, etc. To that end, we are working hard to solidify our outreach presence at a few key sites and have had to say goodbye to the days of roadside stand neurologic exams. We are adding clinics in Marin, Fremont at Washington Hospital, and transitioning to the UCSF pediatric space in Modesto, and are working hard to create oﬃcial UCSF clinic sites in Salinas and Eureka. We are looking forward to our transition
to Mission Bay and will continue to expand our very busy San Francisco and Santa Rosa
practices.
We said goodbye to our administrative assistant Gabe McMIllan, a longtime ICN
presence, as he moved on to bigger pastures, and this summer have welcomed to our ICN
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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family Daisy Parra-Padilla who has already made herself completely invaluable. Our pediatric nurse practitioner Suzanne Golden, who was an ICN bedside nurse prior to becoming
the program PNP, retired from UCSF this summer and we are currently in transition to new
PNP leadership in the program. We are sad but doing our best to be optimistic that we continue to put together the best team possible for our families.
We continue to be a mixed mandate program, balancing our clinical responsibilities as a CCS High Risk Infant Follow-Up (HRIF) program with our research commitments
to our ICN research studies and trials. Clinical eligibility of the CCS HRIF program have
altered slightly to be more inclusive as a response to decreased early intervention screening in
the community. The highest impact change to us several years ago was inclusion of infants
born with neonatal encephalopathy to our transitional preterm population. In the coming
year, our clinical program will also start screening infants born with critical congenital heart
disease who are cared for in our ICN and PCICU. We hope very much this will be a benefit
to our patients and families, as well as to the scientific community in terms of measuring the
neurodevelopmental impact of cardiac disease and surgery in the neonatal period.
Our families are so appreciative of the ICN staﬀ and we hear at every visit a chorus
of “thank yous” and “Say hi tos.” We feel that our program is a true testament to the fact
that we don’t send our patients oﬀ into the big world without taking advantage of the opportunity to continue to learn from them. Please join us at the ICN Reunion on October 18you will make the day of kids and parents, as well as your own!
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2) Summary of Division Research
http://neonatology.ucsf.edu/research/default.aspx
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Research in the Division falls into two broad categories: (A) Clinical Investigation,
Epidemiology, Informatics & Health Science Policy, (B) Basic/Lab-based Investigation. The
following sections outline current activities and plans to expand these programs.
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A) Clinical Investigation
Clinical investigation in the Division is lead by Roberta Keller, MD. Division investigators remain active in clinical research in the intensive care nursery and the high-risk infant follow-up clinic. Faculty and fellows continue to publish their findings from prospective
and retrospective studies. The “NEATO” trial, funded by the Thrasher Foundation, with
Yvonne Wu (pediatric neurology) as PI, has almost completed enrollment at 5 centers. Infants with hypoxic ischemic encephalopathy undergoing therapeutic hypothermia are randomized to erythropoietin or placebo. Follow up, which continues to one year of age, is unUCSF Division of Neonatology•www.neonatology.ucsf.edu
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derway. Additional prospective studies include The NINDS-funded BAMRI (PI- Donna Ferriero) and PREMRI (PI- Jim Barkovich) studies, focused on neuroimaging as it relates to later neurodevelopmental outcomes in these high-risk infant populations. Other studies enrolling infants with hypoxic ischemic encephalopathy include an early imaging study, funded
by Sonia Bonifacio’s K23 award, and an investigation of morphine pharmacokinetics during
therapeutic hypothermia. Martina Steurer is continuing her work in evaluating biomarkers in
CDH. In preterm infants, Ron Clyman is investigating the best approach to management of
PDA, and one- and two-year pulmonary and neurodevelopmental follow up is ongoing in
the NHLBI-funded PROP (PI- Roberta Keller/Phil Ballard) and TOLSURF (PI- Roberta
Ballard) studies. We have ongoing collaborations with colleagues at CHRCO and Alta Bates
hospital in the PROP study. They have additional eﬀorts in other multi-center centers to
study new protocols in management of neonatal seizures, cooling on transport and
Omegaven for TPN-associated liver disease.
In the previously mentioned studies and others, collaborations with our UCSF colleagues in Surgery, Radiology, Neurology and the School of Nursing remain exciting and
productive. Neurodevelopmental Follow up of children enrolled in the NIH-funded management of myelomeningocoele (MOMS) trial is ongoing. In addition, our engagement in
the growing UC Fetal consortium (UCfC) has added new opportunities for research collaboration across the five UC medical campuses, with a focus on junior faculty and fellow involvement in these endeavors. One of The UCSF goals is to have a rapid and direct impact
on patient care. We anticipate a lot of education around these eﬀorts, based on rigorous evaluation of practices and outcomes. gastroschisis was the first disorder tackled within the
group, and these eﬀorts have yielded 2 publications with “best practice” development in
progress.
Prospective Research in the ICN has relied heavily on the expertise and direct support of the Neonatal/Critical Care clinical research nurses for many years. These positions
were most recently funded through the UCSF clinical translational sciences institute. Due to
changes in the CTSI budget, this support will be shifting to a research coordinator, so less
research nursing expertise will be directly available within the unit for unanticipated needs.
We are very sorry to lose such a wonderful resource, but are committed to the success of our
ongoing and new research eﬀorts.
We are always interested in new collaborative eﬀorts and are eager to talk about research, so please contact any of us if you are interested in discussing ideas in these, or other,
areas!
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B) Basic/Lab-Based Investigation
Dr. Rowitch leads development of lab-based investigation in the Division. We plan
development of integrated programs for translational research, which incorporate both basic
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UCSF Division of Neonatology•www.neonatology.ucsf.edu
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science and clinical research components. This idea is demonstrated by the historical links of
the CVRI to the ICN. Given the very competitive nature of NIH and other extra-mural
funding, the Division of Neonatology implemented a trial research incentive payment to
clinically active faculty with academic series appointments. This will help to ensure protected
time for research despite less overall salary support from grants.
The Newborn Brain Research Institute (NBRI) is supported by HHMI, NIH RO1
and Program Project (PO1, UO1) awards to Drs. Ferriero and Rowitch. The newest award
will provide support for a team of basic and translational investigator to study human brain
development in the third trimester-term post-mortem specimens collected in the UCSF Pediatric Research Neuropathology Laboratory< http://ucpnc.pathology.ucsf.edu/>.
Stephen Fancy, DVM PhD. The newest member to the NBRI is Dr.
Steve Fancy. Steve obtained his Doctorate in Veterinary Medicine and his PhD at University
of Cambridge, UK. He completed his postdoctoral training at UCSF under the mentorship
of David Rowitch. His research focused on the nature of oligodendrocyte remyelination and
how this becomes dysregulated in multiple sclerosis and newborn white matter injuries leading to cerebral palsy. Dr. Fancy was the successful candidate selected in a joint open search
from the departments of Pediatrics and Neurology as an investigator of the Newborn Brain
Research Institute. He will be establishing his laboratory in the new Sandler Neurosciences
building at Mission Bay and will join the BMS and PIBS graduate programs. Apart from the
lab, he is an avid cyclist and enjoys biking Marin trails.
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Our progress will be measured by traditional metrics such as papers
published by the Division, extramural-funding obtained, honors and awards, and most importantly, new opportunities for fully independent lab-based investigators. The following
section lists current faculty, their areas of interest and current PI/co-PI extramural grants.
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Phil Ballard, MD, PhD Human lung physiology and surfactant biology
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NIH/NHLB U01 – Trial Of Late SURFactant (TOLSURF) to Prevent BPD
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NIH/NHLB U01 – Program Project Grant in Alveolar Stability
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UCSF Dickson Emeritus Professorship Award
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NIH – U01 Clinical Research Center for Prematurity and Respiratory Outcome Program
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University of Pennsylvania - multicenter site (DCC)
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Roberta Ballard, MD Clinical investigation of BPD and newborn neurological injury
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INO Therapeutics LLC – Clinical trials to prevent BPD
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NIH/NHLB U01 – Trial of Late SURFactant (TOLSURF) to Prevent BPD
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UCSF Division of Neonatology•www.neonatology.ucsf.edu
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Sonia Bonifacio, MD Neonatal Neurointensive care and Neuroprotection
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NIH/NINDS K23 -- Early Biomarkers in Neonatal Brain Injury
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Trevor Burt, MD
Biology of the human fetal immune system
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NIH/NICHD K08 -- Defining the Transition from Fetal to Adult T Cell Predominance in
the Human Fetus
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Burroughs Wellcome Fund – Preterm Birth Initiative Award - Fetal Immune Activation and
Lineage Switching Preterm Birth
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UCSF REAC Award – A novel approach to study human fetal T cell diﬀerentiation and
function in vitro using induced pluripotent stem cells
!
Ron Clyman, MD
Basic and clinical investigation of Patent Ductus Arteriosus
•
NIH – RO1 Genes Contributing to Patent Ductus Arteriosus Susceptibility in Preterm
Newborns
•
Gerber Foundation – Patent Ductus Arteriousus: Trial of Conservative versus E
!
Stephen Fancy, DVM, PhD
Oligodendrocyte developmental biology and impact of newborn
brain injury
•
National Multiple Sclerosis Society – Remyelination Failure in MS – Mediators and Control
Mechanisms of Pathological Wnt Activity
!
Fernando Gonzalez, MD
Biology of neonatal stroke and EPO neuroprotection
•
NIH/NINDS K08 -- Erythropoeitin and Neurogenesis after Neonatal Stroke
!
Roberta Keller, MD
Evaluation of prognostic factors, biomarkers and consequences of lung
disease related to extreme prematurity or birth defects
•
NIH – U01 Clinical Research Center for Prematurity and Respiratory Outcome Program
!
Emin Maltepe, MD, PhD
Regulation of placental diﬀerentiation by hypoxia and impact
of human disease
•
NIH/NHLBI RO1 – Integrating Environmental Cues at the Maternal – Fetal Interface
!
David Rowitch, MD, PhD
Overlapping mechanisms of CNS development and disease
•
NIH/NINDS RO1 -- Oligodendrocyte Lineage Gene Function in the CNS
•
NIH/NINDS RO1 -- Cellular and Developmental Origins of Astrocytes
•
NIH/NINDS PO1 -- Cellular Pathways of Human Brain Development
•
NIH/NICHD T32 -- Translational Research Training Program in Neonatology
•
HHMI -- Rational Understanding and Treatment of Cerebral Palsy
•
European Leukodystrophy Assoc. – Dlx genes as regulators of oligodendrocyte production
•
Pediatric Brain Tumor Foundation – Wnt signaling in pediatric glioma angiogenesis
•
UH Harrington Discovery Institute – Sonic Hedgehog Agonist (SAG) for Neonatal
Neuroprotection
•
National Multiple Sclerosis Society – Oligodendrocyte-Mediated Vascular Remodeling of
White Matter
!
Ann Zovein, MD, PhD Vascular and hematopoietic development
•
Burroughs Wellcome Fund -- Career Awards for Medical Scientists
•
NIH DP2 -- New Innovator Award
•
March of Dimes Foundation -- Basil O’Connor Starter Scholar Award
•
CIRM--New Faculty Physician Scientist Translational Research Award
UCSF Division of Neonatology•www.neonatology.ucsf.edu
"17
Division Productivity 2013-present
In the past 18 months the fellows have published 5 papers and reviews and the faculty (combined San Francisco and Oakland) has published 94 papers and reviews. See the Appendix below for
further details. These numbers indicated that the Division continues to be a leader in
academic productivity amongst our peer institutions in Neonatology in the country.
!
17th William H. Tooley Professor – Robin Steinhorn and first
Tooley-CVRI Research Symposium
In June, we held the first William H. Tooley Memorial Research Symposium for all academic
and clinical staﬀ. Joe Kitterman gave a history of the Cardiovascular Research Institute
(CVRI), and the roots of Neonatology at UCSF since 1964. We heard from Shaun Coughlin
about the future of the CVRI and from current faculty, fellows and trainees about the many
exciting directions in both basic and clinical research that are ongoing. We were visited this
year by external reviewer, Dr. Robin Steinhorn, Chair of Pediatrics and a neonatologist at
UC Davis. In her words, UCSF Division of Neonatology is a leader in research, training and
innovation.
!
2014 William H. Tooley Memorial Research Symposium. (left to right) Drs. Tom Shimotake, Phil
Ballard, Roberta Ballard, Robin Steinhorn, David Rowitch, Roberta Keller and Ann Zovein.
Staff Appreciation
The support of our outstanding staﬀ is essential to smooth operations of the
Division and we are very thankful to Jenny Quach, Division Administrator, Mary
Ulman (assistant to Dr. Rowitch), Cheryl Fong (assistant to Dr. Sun), and Sara
Hoover (fellowship program coordinator).
In Closing
The Division continues to expand, make progress in research and clinical care
and we have a terrific pipeline of very talented fellows. Extramural grant support is
UCSF Division of Neonatology•www.neonatology.ucsf.edu
"18
keeping pace and allowing for growth and research productivity is exceptional. We
have made progress in terms of quality improvement and new models of clinical
practice (e.g., the NICN and PPHN programs), which further distinguish the
William H. Tooley ICN as a place of clinical innovation. And, we even still take care
of gorillas (see final page; as many of you know, Bill Tooley and ICN nurses cared for
Coco the gorilla, who went on to show remarkable sign language skills)! The opening
of the new ICN at the Benioﬀ Children’s Hospital Mission Bay in February 2015 will
mark a new chapter in the Division’s evolution.
For current fellows and faculty, I’d like to say thanks to all of you for your
superb work in the ICN and in your research, and to our alumni, thanks for your
ongoing interest in the Division, comments and contributions.
Sincerely,
!
David H. Rowitch, MD, PhD, Professor of Pediatrics & Neurological Surgery, Chief
of Neonatology, UCSF
!
!
!
!
2014 William H. Tooley
Memorial Research
Symposium. UCSF Division of Neonatology•www.neonatology.ucsf.edu
"19
!
!
!
!
!
Division of Neonatology
Faculty/Fellows publications from 2013 to present
The Fellows
Melissa Catenacci
Catenacci M, Miyagi S, Wickremasinghe AC, Lucas SS, de Alba Campomanes AG, Good
WV, Clyman RI. Dopamine-resistant hypotension and severe retinopathy of prematurity. J
Pediatr. 2013 Aug;163(2):400-5. doi: 10.1016/j.jpeds.2013.01.054. Epub 2013 Mar 1.
PubMed PMID: 23465406; PubMed Central PMCID: PMC3676698.
!
Luke Judge
1. Miyaoka Y, Chan AH, Judge LM, Yoo J, Huang M, Nguyen TD, Lizarraga PP, So PL,
Conklin BR. Isolation of single-base genome-edited human iPS cells without antibiotic
selection. Nat Methods. 2014 Mar;11(3):291-3. doi: 10.1038/nmeth.2840. Epub 2014
Feb 9. PMID: 24509632
Leslie Lusk
1. Martina Steurer, Anita Moon-Grady, Jeﬀrey Fineman, Christine Sun, Leslie Lusk, Katherine Wai, and Roberta Keller. B-type natriuretic peptide: a prognostic marker in congenital
diaphragmatic hernia. Pediatric Research, in press.
2. Lusk LA, et. al.. Multi-institutional practice patterns and outcomes in uncomplicated gastroschisis: a report from the University of California Fetal Consoritium. Journal of Pediatric
Surgery, in press.
!
Larry Shiow
1. Fancy SP, Harrington EP, Baranzini SE, Silbereis JC, Shiow LR, Yuen TJ, Huang EJ,
Lomvardas S, Rowitch DH. Parallel states of pathological Wnt signaling in neonatal brain
injury and colon cancer. Nat Neurosci. 2014 Apr;17(4):506-12. doi: 10.1038/nn.3676.
Epub 2014 Mar 9
!
UCSF Division of Neonatology•www.neonatology.ucsf.edu
"20
!
!
The Faculty: UCSF BCH San Francisco
Phil Ballard
1. Ballard PL, Keller RL, Black DM, Durand DJ, Merrill JD, Eichenwald EC, Truog WE,
Mammel MC, Steinhorn R, Ryan RM, Courtney SE, Horneman H, Ballard RA; Investigators of TOLSURF Pilot and TOLSURF. Inhaled Nitric Oxide Increases Urinary Nitric
Oxide Metabolites and Cyclic Guanosine Monophosphate in Premature Infants: Relationship to Pulmonary Outcome. Am J Perinatol. 2014 Jun 26. [Epub ahead of print]
PMID: 24968129 [PubMed - as supplied by publisher]
1. Lafemina MJ, Sutherland KM, Bentley T, Gonzales LW, Allen L, Chapin CJ, Rokkam D,
Sweerus KA, Dobbs LG, Ballard PL, Frank JA. Claudin-18 deficiency results in alveolar
barrier dysfunction and impaired alveologenesis in mice. Am J Respir Cell Mol Biol. 2014
May 1. [Epub ahead of print] PMID: 24787463 [PubMed - as supplied by publisher]
Roberta Ballard
1. Ballard PL, Keller RL, Black DM, Durand DJ, Merrill JD, Eichenwald EC, Truog WE,
Mammel MC, Steinhorn R, Ryan RM, Courtney SE, Horneman H, Ballard RA; Investigators of TOLSURF Pilot and TOLSURF. Inhaled Nitric Oxide Increases Urinary Nitric
Oxide Metabolites and Cyclic Guanosine Monophosphate in Premature Infants: Relationship to Pulmonary Outcome. Am J Perinatol. 2014 Jun 26. [Epub ahead of print]
PMID: 24968129 [PubMed - as supplied by publisher]
Sonia Bonifacio
1. Frymoyer A, Meng L, Bonifacio SL, Verotta D, Guglielmo BJ. Gentamicin pharmacokinetics and dosing in neonates with hypoxic ischemic encephalopathy receiving hypothermia. Pharmacotherapy. 2013 Jul;33(7):718-26. doi: 10.1002/phar.1263. Epub 2013 Apr
1.PMID: 23553582 [PubMed - indexed for MEDLINE] Free PMC Article
Oishi PE, Klein OD, Keller RL; University of California San Francisco Neonatology and
Pediatric Critical Care Early Faculty Development Committee. Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an eﬀort to formulate a
departmental policy. J Pediatr. 2013 Sep;163(3):616-7.e1. doi: 10.1016/j.jpeds.2013.05.047.
No abstract available. PMID: 23973233 PubMed - indexed for MEDLINE]
UCSF Division of Neonatology•www.neonatology.ucsf.edu
"21
3. Orbach SA, Bonifacio SL, Kuzniewicz MW, Glass HC. Lower Incidence of Seizure
Among Neonates Treated With Therapeutic Hypothermia. J Child Neurol. 2013 Dec 11.
[Epub ahead of print]
PMID: 24334344 [PubMed - as supplied by publisher]
4. Ferriero DM, Bonifacio SL. The search continues for the elusive biomarkers of neonatal
brain injury. J Pediatr. 2014 Mar;164(3):438-40. doi: 10.1016/j.jpeds.2013.11.042. Epub
2013 Dec 31. No abstract available. PMID: 24388328 [PubMed - indexed for MEDLINE]
5. Glass HC, Wusthoﬀ CJ, Shellhaas RA, Tsuchida TN, Bonifacio SL, Cordeiro M, Sullivan
J, Abend NS, Chang T. Risk factors for EEG seizures in neonates treated with hypothermia: a multicenter cohort study. Neurology. 2014 Apr 8;82(14):1239-44. doi: 10.1212/
WNL.0000000000000282. Epub 2014 Mar 7. PMID: 24610326 [PubMed - indexed for
MEDLINE]
6. Jenster M, Bonifacio SL, Ruel T, Rogers EE, Tam EW, Partridge JC, Barkovich AJ, Ferriero DM, Glass HC. Maternal or neonatal infection: association with neonatal encephalopathy outcomes. Pediatr Res. 2014 Jul;76(1):93-9. doi: 10.1038/pr.2014.47.
Epub 2014 Apr 8. PMID: 24713817 [PubMed - in process]
Trevor Burt
1. Oishi PE, Klein OD, Keller RL; University of California San Francisco Neonatology and
Pediatric Critical Care Early Faculty Development Committee. Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an eﬀort to formulate a
departmental policy. J Pediatr. 2013 Sep;163(3):616-7.e1. doi: 10.1016/j.jpeds.2013.05.047.
No abstract available. PMID: 23973233 [PubMed - indexed for MEDLINE]
2. Krow-Lucal ER, Kim CC, Burt TD, McCune JM. Distinct functional programming of
human fetal and adult monocytes. Blood. 2014 Mar 20;123(12):1897-904. doi: 10.1182/
blood-2013-11-536094. Epub 2014 Feb 11. PMID: 24518760 [PubMed - indexed for
MEDLINE]
Highlighted paper: This study demonstrates that cells of the human fetal myeloid cell
lineage are transcriptionally and functionally distinct from adult myeloid
cells. Specifically, the response of fetal monocytes to inflammatory cytokines seems to
be tuned in such a way to avoid classical inflammatory responses. This may help prevent preterm labor at baseline, or contribute to its pathogenesis in the setting of significant intrauterine infection.
!
Ron Clyman
1. Catenacci M, Miyagi S, Wickremasinghe AC, Lucas SS, de Alba Campomanes AG, Good
WV, Clyman RI. Dopamine-resistant hypotension and severe retinopathy of prematurity. J
Pediatr. 2013 Aug;163(2):400-5. doi: 10.1016/j.jpeds.2013.01.054.
Epub 2013 Mar 1. PubMed PMID: 23465406; PubMed Central PMCID: PMC3676698.
UCSF Division of Neonatology•www.neonatology.ucsf.edu
"22
Highlighted paper: This study discovered a risk factor that can be used within the
first 2 weeks after birth to identify infants who have an 80% chance of developing
ROP that will require surgery at the end of their neonatal course. It also points out a
potential etiologic link between early vascular paralysis and the development of ROP.
2. Clyman R, Wickremasinghe A, Jhaveri N, Hassinger DC, Attridge JT, Sanocka U,
Polin R, Gillam-Krakauer M, Reese J, Mammel M, Couser R, Mulrooney N, Yanowitz
TD, Derrick M, Jegatheesan P, Walsh M, Fujii A, Porta N, Carey WA, Swanson JR;
Ductus Arteriosus Feed or Fast with Indomethacin or Ibuprofen (DAFFII)
Investigators. Enteral feeding during indomethacin and ibuprofen treatment of a
patent ductus arteriosus. J Pediatr. 2013 Aug;163(2):406-11. doi:
10.1016/j.jpeds.2013.01.057. Epub 2013 Mar 6. PubMed PMID: 23472765; PubMed
Central PMCID: PMC3683087.
3. Jelin AC, Kuppermann M, Erickson K, Clyman R, Schulkin J. Obstetricians'
attitudes and beliefs regarding umbilical cord clamping. J Matern Fetal Neonatal
Med. 2013 Dec 12. [Epub ahead of print] PubMed PMID: 24215582.
4. Yanowitz TD, Reese J, Gillam-Krakauer M, Cochran CM, Jegatheesan P, Lau J,
Tran VT, Walsh M, Carey WA, Fujii A, Fabio A, Clyman R. Superior mesenteric
artery blood flow velocities following medical treatment of a patent ductus
arteriosus. J Pediatr. 2014 Mar;164(3):661-3. doi: 10.1016/j.jpeds.2013.11.002.
Epub 2013 Dec 8. PubMed PMID: 24321538; PubMed Central PMCID: PMC4077598.
5. Clyman RI, Wickremasinghe A, Merritt TA, Solomon T, McNamara P, Jain A, Singh
J, Chu A, Noori S, Sekar K, Lavoie PM, Attridge JT, Swanson JR, Gillam-Krakauer
M, Reese J, DeMauro S, Poindexter B, Aucott S, Satpute M, Fernandez E, Auchus RJ;
Patent Ductus Arteriosus Ligation/Hypotension Trial Investigators. Hypotension
following patent ductus arteriosus ligation: the role of adrenal hormones. J
Pediatr. 2014 Jun;164(6):1449-55.e1. doi: 10.1016/j.jpeds.2014.01.058. Epub 2014
Mar 15. PubMed PMID: 24636853; PubMed Central PMCID: PMC4035426.
6. Heuchan AM, Clyman RI. Managing the patent ductus arteriosus: current
treatment options. Arch Dis Child Fetal Neonatal Ed. 2014 Jun 5. pii:
fetalneonatal-2014-306176. doi: 10.1136/archdischild-2014-306176. [Epub ahead of
print] Review. PubMed PMID: 24903455.
Olivier Danhaive
1. Salerno T, Peca D, Rossi FP, Menchini L, Danhaive O, Cutrera R. Bronchiectasis
and severe respiratory insuﬃciency associated with a new surfactant protein C
mutation. Acta Paediatr. 2013 Jan;102(1):e1-2. doi: 10.1111/apa.12043. PubMed
PMID: 23025826.
2. Cogo PE, Simonato M, Danhaive O, Verlato G, Cobellis G, Savignoni F, Peca D,
Baritussio A, Carnielli VP. Impaired surfactant protein B synthesis in infants
with congenital diaphragmatic hernia. Eur Respir J. 2013 Mar;41(3):677-82. doi:
10.1183/09031936.00032212. Epub 2012 Jun 14. PubMed PMID: 22700843.
3. Salerno T, Peca D, Menchini L, Schiavino A, Petreschi F, Occasi F, Cogo P, Danhaive O,
Cutrera R. Respiratory insuﬃciency in a newborn with congenital hypothyroidism due to a
new mutation of TTF-1/NKX2.1 gene. Pediatr Pulmonol. 2014 Mar;49(3):E42-4. doi:
10.1002/ppul.22788. Epub 2013 Sep 2.
PMID: 23997037 [PubMed - in process]
UCSF Division of Neonatology•www.neonatology.ucsf.edu
"23
4. Citti A, Peca D, Petrini S, Cutrera R, Biban P, Haass C, Boldrini R, Danhaive O Ultrastructural characterization of genetic diﬀuse lung diseases in infants and children: a cohort
study and review. Ultrastruct Pathol. 2013 Oct;37(5):356-65. doi:
10.3109/01913123.2013.811454. PMID: 24047351 [PubMed - indexed for MEDLINE]
Stephen Fancy
1. Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP,
Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC. "Expression
profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific
genes and direct Sox9-Nfe2l1 interactions". Glia. 2013 Sep;61(9):1518-32.
2. Feng Mei*, Fancy SP*, Yun-An A. Shen, Jianqin Niu, Chao Zhao, Bryan Presley, Edna
Miao, Seonok Lee, Sonia R. Mayoral, Stephanie A. Redmond, Ainhoa Etxeberria, Lan Xiao,
Robin J. M. Franklin, Ari Green, Stephen L. Hauser, Jonah R. Chan. “Fabricated micropillar
arrays as a novel high throughput screening platform for potential therapeutics in Multiple
Sclerosis”. Nature Medicine 2014 Jul 6 (PMID: 24997607)
Highlighted paper: This study describes a high throughput screen for pro-myelinating therapeutic drugs, and identifies muscarinic pathway agonists as potent regulators
of oligodendrocyte maturation. This is moving forward to clinical trials in MS patients and might also be beneficial in neonatal while matter injury.
3. Fancy SP, Emily P. Harrington, Sergio E. Baranzini, John C. Silbereis, Lawrence R. Shiow,
Tracy J. Yuen, Eric C. Huang, Stavros Lomvardas and David H. Rowitch. “Parallel states of
pathological Wnt signaling in neonatal brain injury and colon cancer”. Nature Neuroscience
2014 Apr;17(4):506-12 (PMID: 24609463)
4. Yuen TJ, Silbereis JC, Griveau A, Chang SM, Daneman R, Fancy SP, Zahed H, Maltepe
E, Rowitch DH. “Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination
and White Matter Angiogenesis”. Cell. 2014 Jul 17;158(2):383-96. doi: 10.1016/j.cell.
2014.04.052. Epub 2014 Jul 10 (PMID: 25018103).
!
Fernando Gonzalez (right, pictured
with Tom Shimotake (left), Jill Thorton (middle) at 2014 Swim Across America event.
1. van Velthoven C*, Gonzalez F*, Vexler Z, Ferriero D. Stem cells for neonatal stroke-the
future is here. Frontiers in Cellular Neuroscience, in press.
!
Roberta Keller
1. Amirnovin R, Oishi P, Fineman JR, Keller RL. Reply to the editor. J Thorac Cardiovasc
Surg. 2013 May;145(5):1416. doi: 10.1016/j.jtcvs.2013.01.002. No abstract available.
PMID: 23597627 [PubMed - indexed for MEDLINE]
2. Fleck S, Bautista G, Keating SM, Lee TH, Keller RL, Moon-Grady AJ, Gonzales K, Norris PJ, Busch MP, Kim CJ, Romero R, Lee H, Miniati D, MacKenzie TC. Fetal production
UCSF Division of Neonatology•www.neonatology.ucsf.edu
"24
of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia. Pediatr Res. 2013 Sep;74(3):290-8. doi: 10.1038/pr.2013.98.
Epub 2013 Jun 14. PMID: 23770923 [PubMed - indexed for MEDLINE]
3. Oishi PE, Klein OD, Keller RL; University of California San Francisco Neonatology and
Pediatric Critical Care Early Faculty Development Committee. Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an eﬀort to formulate a
departmental policy. J Pediatr. 2013 Sep;163(3):616-7.e1. doi: 10.1016/j.jpeds.2013.05.047.
No abstract available. PMID: 23973233 [PubMed - indexed for MEDLINE]
4. Radman M, Keller RL, Oishi P, Datar SA, Wellnitz K, Azakie A, Hanley F, Char D, Hsu
JH, Amrinovin R, Adatia I, Fineman JR. Preoperative B-type natriuretic peptide levels are
associated with outcome after total cavopulmonary connection (Fontan). J Thorac Cardiovasc Surg. 2014 Jul;148(1):212-9. doi: 10.1016/j.jtcvs.2013.08.009. Epub 2013 Sep 27.
PMID: 24079880 [PubMed - in process]
5. Rocha LA, Byrne FA, Keller RL, Miniati D, Brook MM, Silverman NH, Moon-Grady
AJ. Left heart structures in human neonates with congenital diaphragmatic hernia and the
eﬀect of fetal endoscopic tracheal occlusion. Fetal Diagn Ther. 2014;35(1):36-43. doi:
10.1159/000356437. Epub 2013 Dec 18. PMID: 24356206 [PubMed - in process]
6. Derderian SC, Trivedi S, Farrell J, Keller RL, Rand L, Goldstein R, Feldstein VA, Hirose
S, MacKenzie TC. Outcomes of fetal intervention for primary hydrothorax.
J Pediatr Surg. 2014 Jun;49(6):900-3; discussion 903-4. doi: 0.1016/j.jpedsurg.2014.01.020.
Epub 2014 Jan 31. PMID: 24888831 [PubMed - in process]
7. Ballard PL, Keller RL, Black DM, Durand DJ, Merrill JD, Eichenwald EC, Truog WE,
Mammel MC, Steinhorn R, Ryan RM, Courtney SE, Horneman H, Ballard RA; Investigators of TOLSURF Pilot and TOLSURF. Inhaled Nitric Oxide Increases Urinary Nitric Oxide Metabolites and Cyclic Guanosine Monophosphate in Premature Infants: Relationship to
Pulmonary Outcome. Am J Perinatol. 2014 Jun 26. [Epub ahead of print]
PMID: 24968129 [PubMed - as supplied by publisher]
8. Guay-Woodford LM, Bissler JJ, Braun MC, Bockenhauer D, Cadnapaphornchai MA,
Dell KM, Kerecuk L, Liebau MC, Alonso-Peclet MH, Shneider B, Emre S, Heller T, Kamath BM, Murray KF, Moise K, Eichenwald EE, Evans J, Keller RL, Wilkins-Haug L,
Bergmann C, Gunay-Aygun M, Hooper SR, Hardy KK, Hartung EA, Streisand R, Perrone
R, Moxey-Mims M. Consensus Expert Recommendations for the Diagnosis and Management of Autosomal Recessive Polycystic Kidney Disease: Report of an International Conference. J Pediatr. 2014 Jul 8. pii: S0022-3476(14)00532-0. doi: 10.1016/j.jpeds.2014.06.015.
[Epub ahead of print] No abstract available. PMID: 25015577 [PubMed - as supplied by
publisher]
!
A baby gorilla (patient) at SF Zoo.
UCSF Division of Neonatology•www.neonatology.ucsf.edu
"25
!
Michael Kuzniewicz
1. Wickremasinghe AC, Kuzniewicz MW, Newman TB. Black race is not protective
against hazardous bilirubin levels. J Pediatr. 2013 May;162(5):1068-9. doi:
10.1016/j.jpeds.2012.12.092. Epub 2013 Feb 10. PubMed PMID: 23403251.
2. Flaherman VJ, Kuzniewicz MW, Li S, Walsh E, McCulloch CE, Newman TB. First-day
weight loss predicts eventual weight nadir for breastfeeding newborns. Arch Dis Child
Fetal Neonatal Ed. 2013 Nov;98(6):F488-92. doi: 10.1136/archdischild-2012-303076.
Epub 2013 Jul 17. PMID: 23864443 [PubMed - indexed for MEDLINE]
3. Kuzniewicz MW, Wi S, Qian Y, Walsh EM, Armstrong MA, Croen LA. Prevalence and
neonatal factors associated with autism spectrum disorders in preterm infants. J Pediatr. 2014
Jan;164(1):20-5. doi: 10.1016/j.jpeds.2013.09.021. Epub 2013 Oct 22.
PMID: 24161222 [PubMed - indexed for MEDLINE]
4. Kuzniewicz MW, Parker SJ, Schnake-Mahl A, Escobar GJ. Hospital readmissions and
emergency department visits in moderate preterm, late preterm, and early term infants. Clin
Perinatol. 2013 Dec;40(4):753-75. doi: 10.1016/j.clp.2013.07.008. Epub 2013 Sep 20. Review. PMID: 24182960 [PubMed - indexed for MEDLINE]
5. Kuzniewicz MW, Wickremasinghe AC, Newman TB Invited commentary: does neonatal
hyperbilirubinemia cause asthma? Am J Epidemiol. 2013 Dec 15;178(12):1698-701. doi:
10.1093/aje/kwt249. Epub 2013 Oct 31. PMID: 24186968 [PubMed - indexed for MEDLINE]
6. Orbach SA, Bonifacio SL, Kuzniewicz MW, Glass HC. Lower Incidence of Seizure
Among Neonates Treated With Therapeutic Hypothermia. J Child Neurol. 2013 Dec 11.
[Epub ahead of print] PMID: 24334344 [PubMed - as supplied by publisher]
7. Escobar GJ, Puopolo KM, Wi S, Turk BJ, Kuzniewicz MW, Walsh EM, Newman TB,
Zupancic J, Lieberman E, Draper D. Stratification of risk of early-onset sepsis in newborns ≥
34 weeks' gestation. Pediatrics. 2014 Jan;133(1):30-6. doi: 10.1542/peds.2013-1689. Epub
2013 Dec 23. PMID: 24366992 [PubMed - indexed for MEDLINE]
!
Emin Maltepe
1. Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, Delay M, Donne M, Choi
HJ, Tormos KV, Yeghiazarians Y, Jeﬀrey SS, Rinaudo PF, Rowitch DH, Aghi M,
Maltepe E. Nuclear localization of the mitochondrial factor HIGD1A during
metabolic stress. PLoS One. 2013 Apr 30;8(4):e62758. doi:
10.1371/journal.pone.0062758. Print 2013. PubMed PMID: 23646141; PubMed Central
PMCID: PMC3639984.
2. Smith F, Hu D, Young NM, Lainoﬀ AJ, Jamniczky HA, Maltepe E, Hallgrimsson B,
Marcucio RS. The eﬀect of hypoxia on facial shape variation and disease
UCSF Division of Neonatology•www.neonatology.ucsf.edu
"26
phenotypes in chicken embryos. Dis Model Mech. 2013 Jul;6(4):915-24. doi:
10.1242/dmm.011064. Epub 2013 Apr 16. PubMed PMID: 23592613; PubMed Central
PMCID: PMC3701211.
3. Choi HJ, Sanders TA, Tormos KV, Ameri K, Tsai JD, Park AM, Gonzalez J, Rajah
AM, Liu X, Quinonez DM, Rinaudo PF, Maltepe E. ECM-dependent HIF induction
directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.
PLoS One. 2013;8(2):e56949. doi: 10.1371/journal.pone.0056949. Epub 2013 Feb 21.
PubMed PMID: 23437279; PubMed Central PMCID: PMC3578927.
4. Zeldovich VB, Clausen CH, Bradford E, Fletcher DA, Maltepe E, Robbins JR, Bakardjiev
AI. Placental syncytium forms a biophysical barrier against pathogen invasion. PLoS Pathog.
2013 Dec;9(12):e1003821. doi: 10.1371/journal.ppat.1003821. Epub 2013 Dec 12. PMID:
24348256 [PubMed - in process] Free PMC Article
5. Feuer SK, Liu X, Donjacour A, Lin W, Simbulan RK, Giritharan G, Piane LD, Kolahi K,
Ameri K, Maltepe E, Rinaudo PF. Use of a mouse in vitro fertilization model to understand
the developmental origins of health and disease hypothesis. Endocrinology. 2014 May;
155(5):1956-69. doi: 10.1210/en.2013-2081. Epub 2014 Mar 31. PMID: 24684304
[PubMed - indexed for MEDLINE]
6. Yuen TJ, Silbereis JC, Griveau A, Chang SM, Daneman R, Fancy SP, Zahed H, Maltepe
E, Rowitch DH. Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination
and White Matter Angiogenesis. Cell. 2014 Jul 17;158(2):383-96. doi: 10.1016/j.cell.
2014.04.052. Epub 2014 Jul 10. PMID: 25018103 [PubMed - in process]
7. Tache V, Ciric A, Moretto-Zita M, Li Y, Peng J, Maltepe E, Milstone DS, Parast MM Hypoxia and trophoblast diﬀerentiation: a key role for PPARγ. Stem Cells Dev. 2013 Nov
1;22(21):2815-24. doi: 10.1089/scd.2012.0596. Epub 2013 Jul 12. PMID: 23767827
[PubMed - indexed for MEDLINE
!
Colin Partridge (left, pictured with Mary Ulman)
1. Partridge JC, Robertson KR, Rogers EE, Landman GO, Allen AJ, Caughey AB.
J Matern Resuscitation of neonates at 23 weeks' gestational age: a cost-eﬀectiveness analysis.
Fetal Neonatal Med. 2014 Jul 24:1-10. [Epub ahead of print] PMID: 24684658 [PubMed as supplied by publisher]
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Mark Petersen
1. Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK,
Smirnoﬀ DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K. Early detection of
thrombin actvity in neuroinflamatory disease. Ann Neurol. 2014 Feb;75(2):303-8. doi:
10.1002/ana.24078. Epub 2014 Feb 24. PMID: 24740641 [PubMed - indexed for MEDLINE] Free PMC Article
UCSF Division of Neonatology•www.neonatology.ucsf.edu
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Liz Rogers
1. Wickremasinghe AC, Rogers EE, Johnson BC, Shen A, Barkovich AJ, Marco EJ. Children born prematurely have atypical sensory profiles. J Perinatol. 2013 Aug;33(8):631-5. doi:
10.1038/jp.2013.12. Epub 2013 Feb 14. PMID: 23412641 [PubMed - indexed for MEDLINE] Free PMC Article
2. Partridge JC, Robertson KR, Rogers EE, Landman GO, Allen AJ, Caughey AB.
J Matern Resuscitation of neonates at 23 weeks' gestational age: a cost-eﬀectiveness analysis.
Fetal Neonatal Med. 2014 Jul 24:1-10. [Epub ahead of print] PMID: 24684658 [PubMed as supplied by publisher]
3. Jenster M, Bonifacio SL, Ruel T, Rogers EE, Tam EW, Partridge JC, Barkovich AJ, Ferriero DM, Glass HC. Maternal or neonatal infection: association with neonatal encephalopathy outcomes. Pediatr Res. 2014 Jul;76(1):93-9. doi: 10.1038/pr.2014.47. Epub 2014 Apr 8.
PMID: 24713817 [PubMed - in process]
David Rowitch
1. Yuen TJ, Silbereis JC, Griveau A, Chang SM, Daneman R, Fancy SP, Zahed H, Maltepe
E, Rowitch DH. Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination
and White Matter Angiogenesis. Cell. 2014 Jul 17;158(2):383-96. doi: 10.1016/j.cell.
2014.04.052. Epub 2014 Jul 10. PMID: 25018103 [PubMed - in process]
Highlighted paper: This study shows that oligodendrocyte precursor cells (OPC) directly respond to oxygen via HIF signaling. HIF then activates production of Wnt
proteins, which have a dual eﬀect to block OPC maturation and induce angiogenesis
in white matter. Thus, OPCs have a novel angiogenic role and appear to use HIF signaling to synchronize myelination with adequate white matter vascularization.
2. Meijer DH, Sun Y, Liu T, Kane MF, Alberta JA, Adelmant G, Kupp R, Marto JA, Rowitch DH, Nakatani Y, Stiles CD, Mehta S. An amino terminal phosphorylation motif regulates intranuclear compartmentalization of olig2 in neural progenitor cells. J Neurosci. 2014
Jun 18;34(25):8507-18. doi: 10.1523/JNEUROSCI.0309-14.2014. PMID: 24948806
[PubMed - in process]
3. Pouwels PJ, Vanderver A, Bernard G, Wolf NI, Dreha-Kulczewksi SF, Deoni SC, Bertini
E, Kohlschütter A, Richardson W, Ffrench-Constant C, Köhler W, Rowitch D, Barkovich
AJ. Hypomyelinating leukodystrophies: Translational research progress and prospects. Ann
Neurol. 2014 Jul;76(1):5-19. doi: 10.1002/ana.24194. Epub 2014 Jun 24.
PMID: 24916848 [PubMed - in process]
4. Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR,
Baranzini SE, Ullian EM, Rowitch DH. Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 8;509(7499):189-94. doi: 10.1038/nature13161. Epub 2014 Apr 28. PMID: 24776795 [PubMed - indexed for MEDLINE]
5. Freeman MR, Rowitch DH.Evolving concepts of gliogenesis: a look way back and ahead
to the next 25 years. Neuron. 2013 Oct 30;80(3):613-23. doi: 10.1016/j.neuron.
2013.10.034. Review. PMID: 24183014 [PubMed - indexed for MEDLINE]
6. Otero JJ, Kalaszczynska I, Michowski W, Wong M, Gygli PE, Gokozan HN, Griveau A,
Odajima J, Czeisler C, Catacutan FP, Murnen A, Schüller U, Sicinski P, Rowitch D. Cerebellar cortical lamination and foliation require cyclin A2. Dev Biol. 2014 Jan 15;385(2):328-39.
UCSF Division of Neonatology•www.neonatology.ucsf.edu
"28
doi: 10.1016/j.ydbio.2013.10.019. Epub 2013 Oct 30. PMID: 24184637 [PubMed - indexed for MEDLINE]
7. Silbereis JC, Nobuta H, Tsai HH, Heine VM, McKinsey GL, Meijer DH, Howard MA,
Petryniak MA, Potter GB, Alberta JA, Baraban SC, Stiles CD, Rubenstein JL, Rowitch DH.
Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian
brain. Neuron. 2014 Feb 5;81(3):574-87. doi: 10.1016/j.neuron.2013.11.024.
PMID: 24507192 [PubMed - indexed for MEDLINE]
8. Fancy SP, Harrington EP, Baranzini SE, Silbereis JC, Shiow LR, Yuen TJ, Huang EJ,
Lomvardas S, Rowitch DH. Parallel states of pathological Wnt signaling in neonatal brain
injury and colon cancer. Nat Neurosci. 2014 Apr;17(4):506-12. doi: 10.1038/nn.3676.
Epub 2014 Mar 9.
PMID: 24609463 [PubMed - indexed for MEDLINE]
9. Achim K, Peltopuro P, Lahti L, Tsai HH, Zachariah A, Astrand M, Salminen M, Rowitch
D, Partanen J .The role of Tal2 and Tal1 in the diﬀerentiation of midbrain GABAergic neuron precursors. Biol Open. 2013 Aug 9;2(10):990-7. doi: 10.1242/bio.20135041. eCollection 2013. PMID: 24167708 [PubMed] Free PMC Article
10. Oishi PE, Klein OD, Keller RL; University of California San Francisco Neonatology and
Pediatric Critical Care Early Faculty Development Committee. Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an eﬀort to formulate a
departmental policy. J Pediatr. 2013 Sep;163(3):616-7.e1. doi: 10.1016/j.jpeds.2013.05.047.
No abstract available. PMID: 23973233 [PubMed - indexed for MEDLINE]
11. Stephan AH, Madison DV, Mateos JM, Fraser DA, Lovelett EA, Coutellier L, Kim L,
Tsai HH, Huang EJ, Rowitch DH, Berns DS, Tenner AJ, Shamloo M, Barres BA. A dramatic increase of C1q protein in the CNS during normal aging. J Neurosci. 2013 Aug
14;33(33):13460-74. doi: 10.1523/JNEUROSCI.1333-13.2013. PMID: 23946404
[PubMed - indexed for MEDLINE] Free PMC Article
12. Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP,
Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC. Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes
and direct Sox9-Nfe2l1 interactions. Glia. 2013 Sep;61(9):1518-32. doi: 10.1002/glia.
22538. Epub 2013 Jul 10. PMID: 23840004 [PubMed - indexed for MEDLINE] Free
PMC Article
13. Potter GB, Santos M, Davisson MT, Rowitch DH, Marks DL, Bongarzone ER, Petryniak MA Missense mutation in mouse GALC mimics human gene defect and oﬀers new insights into Krabbe disease. Hum Mol Genet. 2013 Sep 1;22(17):3397-414. doi: 10.1093/
hmg/ddt190. Epub 2013 Apr 24. PMID: 23620143 [PubMed - indexed for MEDLINE]
14. Potter GB, Santos M, Davisson MT, Rowitch DH, Marks DL, Bongarzone ER,
Petryniak MA. Missense mutation in mouse GALC mimics human gene defect and oﬀers
new insights into Krabbe disease. Hum Mol Genet. 2013 Sep 1;22(17):3397-414. doi:
10.1093/hmg/ddt190. Epub 2013 Apr 24. PubMed PMID: 23620143; PubMed Central
PMCID: PMC3736866.
!
Cindy Tran
1. *Tran CS, *Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T,
Metzger RJ, Mostov KE, Engel JN. Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host Microbe. 2014 May 14; 15(5):
636-43. PMID: 24832456.
UCSF Division of Neonatology•www.neonatology.ucsf.edu
"29
!
Highlighted paper: Pseudomonas aeruginosa subverts cell polarity during infection of
epithelial cells. In this work, we show that recruitment of critical cell polarity proteins is associated with activation of the innate immune response to infection.
Ann Zovein
1. Schmitt CE, Lizama CO, Zovein AC. From transplantation to transgenics: Mouse models
of developmental hematopoiesis. Exp Hematol. 2014 Jul 8. pii: S0301-472X(14)00501-3.
doi: 10.1016/j.exphem.2014.06.008. [Epub ahead of print] Review.
PMID: 25014737 [PubMed - as supplied by publisher]
!
!
UCSF Benioff Children’s Hospital Oakland
Jeanette Asselin
1. Murthy KM, Evans JR, Bhatia A, Rothstein D, Wadhawan R, Zaniletti I, Rao R, Thurm
C, Mathur A, Piazza A, Stein JE, Reber KM, Short BL, Padula MA, Durand DJ, Asselin
JA, Pallotto EK, Dykes FD: The association of type of surgical closure on length of stay
among infants with gastroschisis born ≥ 34 weeks’ gestation. J Ped Surg accepted for publication Dec 2013 (10.1016/j.jpedsurg.2013.12.020)
2. Murthy KM, Dykes FD, Padula MA, Pallotto, EK, Reber KM, Durand DJ, Short BL,
Asselin JM, Zaniletti I; Evans JR: The Children's Hospitals Neonatal Database: An Overview of Patient Complexity, Outcomes and Variation in Care (J Perinatol, accepted for
publication January 2014 epub ahead of print: http://www.nature.com/doifinder/
10.1038/jp.2014.26
3. Murthy, KM, Savani RC, Lagatta JM, Wadhawan R, Truog W, Grover TR, Zhang H,
Zaniletti I, Asselin JM, Durand DJ, Short BL, Pallotto EK, Padula MA, Dykes FD, Reber KM, Evans JR: Predicting Death or Tracheostomy Placement in Infants with Severe
Bronchopulmonary Dysplasia; (J Perinatol accepted for publication January 2014).
4. Grover TR, Brozanski BS ; Evans JR, Barry J; Zaniletti I, Asselin JM; Durand DJ; Short
BL; Pallotto EK, Dykes FD , Reber KM, Padula MA, Murthy KM: High Surgical Burden
for Infants with Severe Chronic Lung Disease (sCLD) . (J Ped Surg accepted for publication Febuary 2014)
5. MA Padula, TR Grover, B Brozanski, I Zaniletti, LD Nelin, JM Asselin, DJ Durand, BL
Short, EK Pallotto, FD Dykes, KM Reber, JR Evans, K Murthy. Therapeutic interventions and short-term outcomes for infants born < 32 weeks’ gestation with severe bronchopulmonary dysplasia. J Perinatol. 2013 Jul 4.DOI: 10.1038/jp.2013.75
6. Padula MA, Grover TR, Brozanski B, Zaniletti I, Nelin LD, Asselin JA, Durand DJ,
Short BL, Pallotto EK, Dykes FD, Reber KM, Evans JR, and Murthy K. “Therapeutic
Interventions and Short-Term Outcomes for Infants with Severe Bronchopulmonary
Dysplasia Born at < 32 Weeks' Gestation.” Accepted for publication to J
Perinatology, June 3, 2013. 7. Natarajan, G, Farrow KN, Brozanski BR, Johnson YR, Zaniletti I, Pallotto EK, Padula
MA, Durand DJ, Short, BL, Reber KM, Dykes FD, Asselin JM, Evans JR, Murthy K.,
“Postnatal Weight Gain in Preterm Infants with Severe Bronchopulmonary Dysplasia.” EUCSF Division of Neonatology•www.neonatology.ucsf.edu
"30
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Published in Am J Perinatol, May 20, 2013.
Art D’Harlingue
1. Levy J, D’Harlingue A. Chapter 4: Recognition, Stabilization, and Transport of the
High-Risk Newborn. In Care of the High-Risk Neonate, 6th Edition, Elsevier/Saunders,
Philadelphia PA, 2012.
!
Golde Dudell
1. Cristofalo EA, Cristofalo EA, Schanler RJ, Blanco CL, Sullivan S, Trawoeger R, KiechlKohlendorfer, Dudell G, Rechtman DJ, Lee ML, Lucas A, Abrams S. Randomized trial
of exclusive human milk versus preterm formula diets in extremely premature infants. J
Pediatr 2013; 163:1592-1595
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David Durand
1. EK Pallotto, PG Hunt, FD Dykes, DJ Durand, K Murthy. Topics in neonatal informatics: infants and data in the electronic health record era. NeoReviews 2013; 14:e57. DOI:
10.1542/neo.14-2-e57.
2. Murthy KM, Evans JR, Bhatia A, Rothstein D, Wadhawan R, Zaniletti I, Rao R, Thurm
C, Mathur A, Piazza A, Stein JE, Reber KM, Short BL, Padula MA, Durand DJ, Asselin
JA, Pallotto EK, Dykes FD: The association of type of surgical closure on length of stay
among infants with gastroschisis born ≥ 34 weeks’ gestation. J Ped Surg accepted for publication Dec 2013 (10.1016/j.jpedsurg.2013.12.020)
3. Murthy KM, Dykes FD, Padula MA, Pallotto, EK, Reber KM, Durand DJ, Short BL,
Asselin JM, Zaniletti I; Evans JR: The Children's Hospitals Neonatal Database: An Overview of Patient Complexity, Outcomes and Variation in Care (J Perinatol, accepted for
publication January 2014 epub ahead of print: http://www.nature.com/doifinder/10.1038/
jp.2014.26
4. Murthy, KM, Savani RC, Lagatta JM, Wadhawan R, Truog W, Grover TR, Zhang H,
Zaniletti I, Asselin JM, Durand DJ, Short BL, Pallotto EK, Padula MA, Dykes FD, Reber KM, Evans JR: Predicting Death or Tracheostomy Placement in Infants with Severe
Bronchopulmonary Dysplasia; (J Perinatol accepted for publication January 2014).
5. Grover TR, Brozanski BS ; Evans JR, Barry J; Zaniletti I, Asselin JM; Durand DJ; Short
BL; Pallotto EK, Dykes FD , Reber KM, Padula MA, Murthy KM: High Surgical Burden
for Infants with Severe Chronic Lung Disease (sCLD) . (J Ped Surg accepted for publication Febuary 2014)
6. MA Padula, TR Grover, B Brozanski, I Zaniletti, LD Nelin, JM Asselin, DJ Durand, BL
Short, EK Pallotto, FD Dykes, KM Reber, JR Evans, K Murthy. Therapeutic interventions and short-term outcomes for infants born < 32 weeks’ gestation with severe bronchopulmonary dysplasia. J Perinatol. 2013 Jul 4.DOI: 10.1038/jp.2013.75
7. Padula MA, Grover TR, Brozanski B, Zaniletti I, Nelin LD, Asselin JA, Durand DJ,
Short BL, Pallotto EK, Dykes FD, Reber KM, Evans JR, and Murthy K. “Therapeutic
Interventions and Short-Term Outcomes for Infants with Severe Bronchopulmonary
Dysplasia Born at < 32 Weeks' Gestation.” Accepted for publication to J
Perinatology, June 3, 2013. UCSF Division of Neonatology•www.neonatology.ucsf.edu
"31
8. Natarajan, G, Farrow KN, Brozanski BR, Johnson YR, Zaniletti I, Pallotto EK, Padula
MA, Durand DJ, Short, BL, Reber KM, Dykes FD, Asselin JM, Evans JR, Murthy K.,
“Postnatal Weight Gain in Preterm Infants with Severe Bronchopulmonary Dysplasia.” EPublished in Am J Perinatol, May 20, 2013.
!
Joanna Halkias
1. Halkias J, Melichar HJ, Taylor KT, Ross JO, Yen B, Cooper SB, Winoto A, Robey EA:
Opposing chemokine gradients control human thymocyte migration in situ. J Clin Invest. 2013 May 1;123(5):2131-42. DOI:10.1172/JC167175. Epub 2013 Apr 15 PMID:
23585474 [PubMed – indexed for MEDLINE]
2. Halkias J, Melichar HJ, Taylor KT, Robey EA: Tracking migration during human T cell
development. Cell Mol Life Sci. 2014 Aug; 71 (16):3101-17. DOI: 10.1007/s00017-0141607-2. Epub 2014 Mar 30. PMID: 24682469 (PubMed – in process)
3. Coombes JL, Charsar BA, Han SJ, Halkias J, Chan SW, Koshy AA, Striepen B, Robey,
EA: Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice
reveal a potential mechanism for parasite spread. Proc Natl Acad Sci U S A. 2013 May
21;110(21):E1913-22. DOI 10.1073/pnas.1220272110. Epub 2013 May
!
Priscilla Joe
1. A randomized clinical trial of therapeutic hypothermia during transport for hypoxic ischemic encephalopathy (HIE): Device-regulated cooling versus standard practice: California Transport Cooling Trial (CTCT). Vishnu Priya Akula, M.D., Priscilla Joe, M.D.,
!
Kajori Thusu, M. D., Alexis S. Davis, M.D., M.S., John S. Tamaresis, Ph.D. M.S., Sunhwa Kim, M.D., Thomas K. Shimotake, M. D., Stephen Butler, M.D., Jose Honold,
M.D., Michael Kuzniewicz, M.D., Glenn DeSandre, M.D., Mihoko Bennett, Ph.D.,1
Kathi Randall, N.N.P. C.N.S., Jeﬀery Gould, M.D., M.P.H. Krisa Van Meurs, M.D.
Submitted for publication, JAMA.
Jennifer Levy
1. Levy J, D’Harlingue A. Chapter 4: Recognition, Stabilization, and Transport of the
High-Risk Newborn. In Care of the High-Risk Neonate, 6th Edition, Elsevier/Saunders,
Philadelphia PA, 2012.
Carolyn Lund
1. Lund CH, Kuller JM (2014): Integumentary System (chapter 12) in Comprehensive
Neonatal Care (5th Ed), Kenner, C. and Lott, JW (editors). St. Louis MO: Saunders Elsevier, pp 299-333
2. McNichol L, Lund, C, Rosen T, Gray M (2013): Medical Adhesives and Patient Safety:
State of the Science. Journal of Wound,Ostomy Continence Nursing, 40: 1-15.
UCSF Division of Neonatology•www.neonatology.ucsf.edu
"32
3. Lund CH (clinical practice guideline team leader) J Kuller, D Branden, A Holden, C
Hill, “Neonatal skin care: evidence-based clinical practice guideline.” 3rd edition Washington DC: The Association of Women’s Health, Obstetric and Neonatal Nurses. (awarded American Journal of Nursing, AJN Award Book of the Year Award in Maternal-Child
Nursing; 3rd place) AWHONN (2013)
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UCSF Division of Neonatology•www.neonatology.ucsf.edu
"33

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