Prof. Dr. Nisar Peter Malek

Deputy-Director of
the Cancer Center
Prof. Dr. Nisar Peter Malek
Chair, Dept. of Internal Medicine 1
Gastroenterology, Hepatology, Infectious
Disease
University Hospital and Medical Faculty
Eberhard Karls University Tübingen
Otfried Müller Str. 1, 72076 Tübingen, Germany
Phone +49 7071 2982721, Fax: +49 7071 2982721
[email protected]
Scientific and Professional Career
1989-95
Student of Medicine, Hannover Medical School (MHH)
1996
Doctor of Medicine
1997-99
Resident, Dept. of Gastroenterology, Hepatology, Endocrinology, MHH
1999-2001
Research Fellow, Fred Hutchinson Cancer Research Center, Seattle,
USA
2002-2007
2006
2006
2007
2008
2009
09/2011
since 2012
since 2013
Societies
Clinical Fellow Dept. of Gastroenterology, Hepatology, Endocrinology,
MHH
Group Leader funded by the Max Eder program of the German Cancer
Society, Inst. for Molecular Biology, MHH
Board Certified Internal Medicine
Consultant Internal Medicine
Habilitation Internal Medicine, MHH
University Professorship (W2) in Molecular Biology and Cell
Proliferation Control, MHH
Board Certified Gastroenterology
Full Professor and Director, Dept. of Internal Medicine,
Gastroenterology, Hepatology, Infectious Disease, University Tübingen
Deputy Director Dept. Internal Medicine University Hospital Tübingen
Deputy-Director CCC Tübingen
German Society for Internal Medicine (DGIM) German Society for
German Society for Gastroenterology DGVS)
Head of phase 1/drug development group German Oncology Study
group (AIO)
Awards
Science Award German Oncology Study Group
Johann Georg Zimmermann Award for Cancer Research
Funding
>6 Million € extrabudgetary funding (German Research Council (DFG),
German Federal Ministry of Education and Research (BMBF), German
Cancer Society) as individual grants for own research group or as
member of of collaborative research projects (only own contribution
indicated)
Publications
62 publications in scientific journals and book chapters
Research focus
Development of new treatments in hepatobiliary cancers
Ten most important publications
1.
Zender, S., Nickeleit, I., Wuestefeld, T., Sorensen, I., Dauch, D., Bozko, P., El-Khatib, M., Geffers, R.,
Bektas, H., Manns, M. P., Gossler, A., Wilkens, L., Plentz, R., Zender, L., and Malek, N. P. (2013) A critical
role for notch signaling in the formation of cholangiocellular carcinomas. Cancer Cell 23, 784-795
2.
Wuestefeld, T. Pesic, M., Rudalska, R., Dauch, D., Longerich, T., Kang, T. W., Yevsa, T., Heinzmann, F.,
Hoenicke, L., Hohmeyer, A., Potapova, A., Rittelmeier, I., Jarek, M., Geffers, R., Scharfe, M., Klawonn, F.,
Schirmacher, P., Malek, N. P., Ott, M., Nordheim, A., Vogel, A., Manns, M. P., and Zender, L. (2013) Direct
in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration. Cell 153, 389-401
3.
Serres, M. P., Kossatz, U., Chi, Y., Roberts, J. M., Malek, N. P. and Besson, A. (2012) p27(Kip1) controls
cytokinesis via the regulation of citron kinase activation. J Clin Invest 122, 844-858
4.
Puklowski, A., Homsi, Y., Keller, D., May, M., Chauhan, S., Kossatz, U., Grunwald, V., Kubicka, S., Pich, A.,
Manns, M. P., Hoffmann, I., Gonczy, P., and Malek, N. P. (2011) The SCF-FBXW5 E3-ubiquitin ligase is
regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. Nat Cell Biol 13, 1004-1009
5.
Kossatz, U., Breuhahn, K., Wolf, B., Hardtke-Wolenski, M., Wilkens, L., Steinemann, D., Singer, S., Brass,
F., Kubicka, S., Schlegelberger, B., Schirmacher, P., Manns, M. P., Singer, J. D., and Malek, N. P. (2010)
The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells.
J Clin Invest 120, 3820-3833
6.
Nickeleit, I., Zender, S., Sasse, F., Geffers, R., Brandes, G., Sorensen, I., Steinmetz, H., Kubicka, S.,
Carlomagno, T., Menche, D., Gutgemann, I., Buer, J., Gossler, A., Manns, M. P., Kalesse, M., Frank, R.,
and Malek, N. P. (2008) Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in
mediating antitumor activities in response to proteasome inhibition. Cancer Cell 14, 23-35
7.
EMBO Kossatz, U., Vervoorts, J., Nickeleit, I., Sundberg, H. A., Arthur, J. S., Manns, M. P., and Malek, N.
P. (2006) C-terminal phosphorylation controls the stability and function of p27kip1. EMBO J 25, 5159-5170
8.
Timmerbeul, I., Garrett-Engele, C. M., Kossatz, U., Chen, X., Firpo, E., Grunwald, V., Kamino, K., Wilkens,
L., Lehmann, U., Buer, J., Geffers, R., Kubicka, S., Manns, M. P., Porter, P. L., Roberts, J. M., and Malek,
N. P. (2006) Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung
and colon cancer. Proc Natl Acad Sci U S A 103, 14009-14014
9.
Kossatz, U., Dietrich, N., Zender, L., Buer, J., Manns, M. P., and Malek, N. P. (2004) Skp2-dependent
degradation of p27kip1 is essential for cell cycle progression. Genes Dev 18, 2602-2607
10. Malek, N. P., Sundberg, H., McGrew, S., Nakayama, K., Kyriakides, T. R., and Roberts, J. M. (2001) A
mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase.
Nature 413, 323-327

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