MAb polishing on your mind.
Our Capto™ S ImpAct.
We developed Capto S ImpAct for efficient MAb aggregate removal
to improve your productivity and cost-efficiency. With an extendedsurface ligand, Capto S ImpAct offers high binding capacity and
excellent resolution, even at high sample loads. When MAb polishing
is on your mind, we are a partner like no other.
upstream
downstream
GE works.
www.gelifesciences.com/CaptoSImpAct
single-use
services
• High resolution for efficient
aggregate removal
• Large operational window of flow
rates and bed heights for easy
optimization and scaling
• High productivity, enabling costefficient manufacturing
MAb polishing using Capto S ImpAct medium.
Medium: Column: Sample: Sample load: Start buffer: Elution buffer: Flow at loading: Flow at elution: Gradient: System: Cleaning-in-place (CIP): Capto S ImpAct
Tricorn™ 5/50, 1 mL column volume (CV)
MAb purified on MabSelect SuRe™ medium
80 mg MAb/mL medium
50 mM sodium acetate, pH 5.0 + 50 mM NaCl
50 mM sodium acetate, pH 5.0 + 500 mM NaCl
0.25 mL/min, 4 min residence time
0.125 mL/min, 8 min residence time
Linear, 20 CV
ÄKTA™ pure 25
1 M NaOH
3000
• Security of supply and comprehensive
regulatory support
2500
1750
mAU
75
70
65
60
55
50
45
40
35
30
25
20
15
10
5
0
% aggregate in fraction
UV 280 nm
Conductivity
Pool with 90% monomer yield
and 0.7% aggregate content
2750
1500
1250
1000
To learn more about Capto S ImpAct, visit
www.gelifesciences.com/CaptoSImpAct
750
500
CIP
250
0
0
5
10
15
GE and GE monogram are trademarks of General Electric Company.
ÄKTA, Capto, HiScreen, MabSelect SuRe, and Tricorn are trademarks of General Electric Company or one of its subsidiaries.
© 2014 General Electric Company – All rights reserved. First published Sep. 2014.
GE Healthcare Bio-Sciences AB, Björkgatan 30, 751 84 Uppsala, Sweden
29-1084-78 AB 09/2014
20
25
30
35
40
ml
175
150
125
100
75
50
25
0
Conductivity (mS/cm)
• High binding capacity, more than
100 mg MAb/mL medium
High resolution enables efficient removal of MAb
aggregates from the MAb monomer fraction.
Aggregate (%)
Capto S ImpAct delivers high binding
capacity and resolution to your MAb
purification platform.
Key benefits of Capto S ImpAct include:

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[PDF] pGEXベクター選択ガイド（比較表）