2013-14 Department of Molecular and Cellular Biology DISTINGUISHED SPEAKER SEMINAR SERIES View 2014 schedule at www.uoguelph.ca/mcb Wednesday, February 26, 2014 at 1:30 p.m. in MACK 120 “Nod proteins in immunity and infection” Dr. Dana Philpott Dept. of Immunology, University of Toronto Faculty Host: Dr. Emma Allen-Vercoe Our group studies a family of innate immune receptors called the Nod-like receptors (NLRs). These proteins represent an intracellular surveillance system for detecting microbial and hostderived danger signals. In particular, we study Nod1 and Nod2, which detect peptidoglycan (PG) from the bacterial cell wall and trigger inflammation. Detection of these PG by Nod1 and Nod2 triggers a signal transduction cascade that culminates in the activation of NFκB and the production of pro-inflammatory mediators. Moreover, Nod triggering can regulate autophagy. Importantly, Nod1 and Nod2 have been implicated in inflammatory bowel disease (IBD), in particular Nod2 has been associated with Crohn’s disease, yet a clear understanding of how dysfunctional Nod activation leads to aberrant inflammation is still lacking. ATG16L1 is a protein involved in autophagy and has also been linked to Crohn’s disease. We showed previously that Nod1 and Nod2 interact with ATG16L1 and this association promotes autophagy of intracellular bacteria. Since Nod1 and Nod2 are important for triggering bacterial-induced autophagy, and autophagy can influence the immune response, our current work aims to examine how autophagy might regulate the cytokine response to infection and Nod1 or Nod2 stimulation. Coffee,Tea & Timbits A great opportunity to hear leading researchers in the scientific community discuss their work! All Welcome to Attend
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