NATTOKINASE NSK-SD® Brochure

Normal
*
Blood Pressure
Promotes
*
Arterial Health
NATTOKINASE NSK-SD®
With Rutin For Healthy Blood Circulation
Superiority
Other products claim to be Nattokinase, but only NSK-SD:
• Has the highest potency available > 20,000 F.U./gram
• Contains less than 1 ppm Vitamin K2
• Is the most clean, white, uniform and deodorized powder available
• Is non-GMO, vegetarian and non-irradiated
• Has the highest proven potency of any Vitamin K2 free Nattokinase on the market
• Is recognized by the JHFA (Japan Health and Nutrition Food Authorization) and the JNKA (Japan Nattokinase
Association) as authentic Nattokinase
Health Benefits
The potential health benefits of NSK-SD are numerous. More than 25 years of research and scientific testing suggest
the following benefits:
• Strong thrombolytic activity – promotes arterial health*
• May promote normal blood pressure*
• Promotes proper whole blood viscosity*
• May increase in blood circulation*
• Promotes normal platelet aggregation*
• Enhances the production of Tissue Plasminogen Activator (t-PA)*
• Reduction of Plasminogen Activator Inhibitor Type 1 (PAI-1)*
• May activate Pro-Urokinase*
• Promotes normal clotting (degrades Fibrin directly)*
• Promotes overall cardiovascular health*
What is NATTOKINASE NSK-SD®?
Nattokinase is a fibrinolytic enzyme derived from a Japanese food called natto. Natto is boiled soybeans fermented
with the bacteria Bacillus natto. Nattokinase is thought to be produced through this specific fermentation process.
Therefore, Nattokinase isn't a component of other soy foods.
How does NATTOKINASE NSK-SD® Work?
Nattokinase works by inactivating plasminogen activator inhibitor 1 (PAI-1) (12070,12091). Nattokinase has
fibrinolytic activity that is 4-times more potent than plasmin (12074). Its average activity is about 40 CU (plasmin
units) /gram (12072).
Nattokinase is thought to help for atherosclerosis due to its fibrinolytic activity at the blood vessel wall. There is
preliminary evidence that taking a natto extract containing nattokinase can reduce vessel wall thickening following
endothelial injury. Nattokinase also seems to cause lysis of thrombi that form at the vessel wall (12070, 12071).
What is Rutin?
Rutin (quercetin rutinoside), is a glycoside of the flavonoid quercetin. Rutin is used in many countries as medications
for blood vessel protection, and are ingredients of numerous multivitamin preparations and herbal remedies.
How does Rutin Work?
Rutin inhibits platelet aggregation, as well as decreases capillary permeability, making the blood thinner and
improving circulation (12098). Recent studies show rutin could help prevent blood clots, so could be used to treat
patients at risk of heart attacks and strokes (12099).
NATTOKINASE NSK-SD® Product Details
Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 30
Amount Per Serving
%DV
†
Nattokinase (NSK-SD®) 20,000 FU/gram
75mg
†
Rutin
100 mg
Other Ingredients: Rice flour, vegetable capsule, silicon
dioxide.
No wheat, milk, egg, sugar, starch, artificial flavors, colors
or preservatives.
NON-GMO - VEGETARIAN
†Daily Value has not been established.
References
12070 - Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and
modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.
12071 - Suzuki Y, Kondo K, Ichise, H, et al. Dietary supplementation with fermented soybeans suppresses intimal thickening. Nutrition
2003;19:261–4.
12072 - Sumi H, Hamada H, Tsushima H, et al. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and
popular soybean food in the Japanese diet. Experientia 1987;43:1110-1.
12074 - Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in a rat. Biol Pharm
Bull 1995;18:1387-91.
12091 - Urano T, Ihara H, Umemura K, et al. The Profibrinolytic Enzyme Subtilisin NAT Purified from Bacillus subtilis Cleaves and
Inactivates Plasminogen Activator InhibitorType 1. J Biol Chem 2001;276:24690-6.
12098 - Navarro-Núñez; et al.; Palomo, M.; Martínez, C.; Vicente, V.; Castillo, J.; Benavente-García, O.; Diaz-Ricart, M. et al. (2008).
"Apigenin Inhibits Platelet Adhesion and Thrombus Formation and Synergizes with Aspirin in the Suppression of the Arachidonic Acid
Pathway". J. Agric. Food Chem. 56 (9): 2970–6. doi:10.1021/jf0723209. PMID 18410117.
12099 - Reporter, Daily Mail. "Chemical found in apples, onions and green tea can help beat blood clots". Mail Online. Retrieved 11 May
2012.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat,
cure, or prevent any disease.

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