Specialty: Trauma Institute Mailing Address: J.N.Medical College, D.M.I.M.S (DU) Wardha, India 442001 E-mail: [email protected] Title: Complex Wound Management ? Role of Autologus Platelet Rich Plasma (PRP) Author : Dr. Sandeep Shrivastava Co-Authors (for indexing): Pradeep Singh, Shounak Tayde, Nitin Samal, Roshan Bhaisare Text (250 words): Back Ground: Management of complex wounds is a big challenge and delay in healing leads to larger morbidity. An effective simple solution still remains a challenge under such conditions. Objective: To evaluate the efficacy of autologous PRP in complex wound management. Methods: Prospective interventional study conducted at territory teaching hospital between Jan.2013 to June 2014. Inclusion criteria: Patients with complex wounds - non progressive healing and associated with infections such as post traumatic with exposed bone/tendons ,Pressure sores, Diabetic sores , trophical ulcers etc Intervention: Sequential Local Infiltration of 4-6ml of PRP (5-7 times of blood platelet values). The observations were recorded on graph papers and sequential photographs were also evaluated. Results: The results enhanced wound healing including infection control. There were no major complications. None of them required the full thickness skin grafts/ flaps, preventing lots of resource burden and morbidity to the Patients Discussion: The PRP has immense biological potentials towards healing through different growth factors, and lysozymes. It has been used for tendon, bone & cartilage healing .But its use in open infected wound management is not yet established.. Prior to using in clinical settings we conducted a rabbit model experiment to understand the PRP role in healing. Conclusion: The Platelet Rich Plasma usage in the management of resistant wounds is very encouraging and is an effective solution to a complicated problem Type of Presentation: Oral Presentation