Neurodermine ® WELL-BEING FOR BEAUTIFUL SKIN BETA-ENDORPHINE LONG-LASTING SECRETION AS A GLOBAL SKIN PERFECTOR ACTIVITiES: HYDRATION / WELL- BEING / ANTI-AGEING / NATURAL PROTECTION PROVEN RESULTS: Increase in cutaneous hydration Improvement of the skin barrier function Stimulation of the Natural Defence System IN USE CONCENTRATION: 2 % Definition: Extract of Mediterranean algae and Padina pavonica in glycerine. CTFA name/INCI name: Glycerine-algae extract-Padina pavonica extract/ Glycerine - algae extract - Padina pavonica extract. CASE No.: glycerine: 56-81-5, algae extract: 921 28-82-0, Padina N.A. EINECS No.: glycerine: 200-289-5, algae extract: 295-780-4, Padina N.A. Customs code: 130 21 970 Regulatory status: OK Europe, USA, Japan, China p r o t e c ti o n Well-being Hydration Anti-ageing Neurodermine ® : a complete anti-ageing product providing intense hydration, elasticity, comfort, well-being and natural protection to the skin: Increased cutaneous hydration, improvement of the skin’s barrier function, stimulation of fibroblasts and stimulation of the immune protection system following exposure to the sun. facial redness reduction Volunteer 7 Volunteer 8 Day 0 maturation of the corneocytes Before treatment -5% After 28 days of treatment Day 28 Increase of cutaneous hydration Example of formulation +27% Neurodermine ® Cream ( R E F : A F 3 2 9 6 ) p e r 1 0 0 g PHASE 1: Emulgade 1000 NI 2.0 BASF 2.0 BASF 3.0 ADARA Cetearyl alcohol & ceteareth -20 Cutina CBS Glyceryl stearate & cetearyl alcohol & cetyl palmitate Tegoalkanol 1618 Cetearyl alcohol Cetiol C5 10.0 BASF Coco caprylate Copherol 1250 C 0.2 BASF Tocopheryl acetate PHASE 2: Demineralised water QSF 100.0 g Aqua / water Carbopol Ultrez 10 0.15 GATTEFOSSE Carbomer PHASE 3: Sepicide LD 3.0 SAFIC ALCAN 2.0 MATRISCIENCE 0.3 EXPRESSIONS PARF. Pentylene glycol Neurodermine® Algae extract & padina pavonica extract & glycerine Skin care perfume 1108946 Fragrance 20% NaOH solution 0.05 MERCK Sodium hydroxide dermocosmetic innovation Neurodermine ® can be formulated: - Emulsions (creams, milks, etc.), water/oil or oil/water - Aqueous or emulsion gels - Aqueous or hydroalcoholic lotions For use in: - Care for dry or very dry skin - Care for sensitive or reactive skin - Daily care for problem skin - Care for skin with an atopic tendency - Protective care for skin - Day/night care - Facial care - Body care - Hydrating care - Anti-ageing care 0.9 SEPPIC phenoxyethanol Hydrolite 5 Cosmetic applicatioNS Pépinière Paris Santé Cochin, 29 rue du Faubourg Saint Jacques, 75014 Paris Tel : +33 1 53 10 07 20 www.matriscience.com - [email protected] PROCEDURE: Prepare the phase 2 in the manufacturing tank and heat to 80°C. In a melting machine prepare the phase I, heat to 80°C. Introduce the phase 1 into the manufacturing tank. Emulsify for 15 mins. Cool in a vacuum. At 30°C introduce the phase 3 in a vacuum. Mix to homogenise. Measure the pH; it must be 6.0 + or – 0.5.