RESEARCH DAY
st
1
Edition
Department of Pharmacy - Drug Sciences
Friday, February
th
28 ,
2014
In azzurro le presentazioni disponibili
9.00 - Opening
1. Camerino Giulia Maria, Mele Antonietta, Calzolaro Sara,
Cannone Maria and Tricarico Domenico. Staurosporine
causes a muscle phenotype dependent atrophy in skeletal
muscle of mice via caspase-9 gene induction and
downregulation of SUR2A gene
Magnifico Rettore Prof. Antonio Felice Uricchio, Prof. Angelo Carotti, Prof. Roberto Perrone
9.15 - Oral Communications, I Section
Chairpersons: Prof. Annamaria De Luca, Prof. Cosimo Damiano Altomare
Orazio Nicolotti
Dirty simulations: gambling on protein promiscuity, polypharmacology and exploratory toxicology
2. Tricarico D., Mele A., Calzolaro S., Cannone G., Camerino
G.M., Dinardo M.M., Latorre R., Conte Camerino D.
Pharmacological modulation of BK channel improves cell
viability under hyperkalemia condition
Laura Carroccia
Development of sustainable and stereoselective synthetic processes by using flow microreactors
Annalisa Cutrignelli
Characterization and release studies of liposomal gels containing glutathione/cyclodextrins complexes
potentially useful for cutaneous administration
Maria Grazia Perrone
COX-1 inhibitors in the inflammatory syndrome: oncology and neurodegeneration
Marilena Dinardo
Pharmacogenetic studies of kidney ClC-K channels: new molecular targets for the treatment of
hypertension
Giuseppe Fracchiolla
Towards high-affinity ligands for CLC-K channel: optimal pharmacophoric requirements of new ligands
bearing 2-benzofuran carboxylic acid scaffold
Antonio Rosato
Antimicrobial activity of natural extracts and interactions with synthetic antibiotics: synergistic relationships
11.00 - Coffee Break
11.30 – Oral Communications, II Section
Chairpersons: Prof. Pinarosa Avato, Prof. Carlo Franchini
Roberta Capogrosso
Pre-clinical research of muscular dystrophies and idiopathic inflammatory myopathies: cross talk between
inflammation and altered metabolism and identification of novel drug targets
Ivana Defrenza
Design, synthesis and antimicrobial activity evaluation of 1,3-benzothiazole derivatives
Angelina Boccarelli
Screening tests for selecting anticancer metal compounds
Concetta Altamura
Functional and pharmacological studies of skeletal muscle hClC-1 channel mutations identified in Myotonia
Congenita patients
13.00 - Lunch
14.00 – Poster Section
Chairpersons: Prof. Diana Conte Camerino, Prof. Francesco Berardi
Sabina Sblano
New Peroxisome Proliferator-Activated Peceptor (PPAR) ligands as potential drugs for treatment of type 2
diabetes and dyslipidemias
Angela Stefanachi
Is the inhibition of Tubuline Polymerization the only mechanism explaining the antiproliferative activity of
our nicotinoyl anilides?
Maria Cannone
Study of the molecular mechanisms involved in statin-induced myopathy: implications and perspectives
butyrylcholinesteras
inhibitors
with
potential
for
Marialessandra Contino
Biomarkers for the early diagnosis of neurodegenerative disorders and tumor diseases
Ruggiero Rizzi
Direct functionalization of aryltetrahydrofurans as a new synthetic tool for the preparation of valuable
compounds of pharmaceutical interest
Carmen Abate
2 Receptors ligands for PET diagnosis and potential treatment of tumors.
17.30 – Conclusion
4. Conte E, Liantonio A, Camerino GM, Scaramuzzi A,
Pierno S, De Bellis M, Cannone M and Conte D. Calcium
homeostasis is altered in skeletal muscle of
spontaneously hypertensive rats: identification of
biomarkers and pharmacological targets
5. Cozzoli Anna, Capogrosso Roberta F, Massari Ada,
Mantuano Paola, Cannone Maria, Giustino Arcangela,
Camerino Giulia M and De Luca Annamaria.
Pharmacological evaluation of the NADPH Oxidase
involvement in pathophysiology of mdx mouse, an animal
model of muscular dystrophy
6. Camerino GM, Cannone M, Musaraj K, Fonzino A,
Desaphy JF, Pierno S, Musarò A and Conte Camerino D.
Gene expression analysis in skeletal muscle of
MLC/mlGF-1 transgenic mice during hindlimb unloading
8. Marina Zenzola, Laura Carroccia, Leonardo Degennaro,
Vanna Parisi, Mara Anelli, Sara Pellicano and Renzo
Luisi. Preparation of new molecular scaffolds by direct
functionalization of 4-membered ring heterocycles
9. Marilena Tauro, Fulvio Loiodice, Gemma Shay, Conor C
Lynch, Paolo Tortorella and Antonio Laghezza. Boneseeking MMP inhibitors for the treatment of Multiple
Myeloma
15.30 – Oral Communications, III Section
selective
3. Imbrici P, Liantonio A, Giannoccaro A, Gradogna A,
Zifarelli G, Laghezza A, Fracchiolla G, Carbonara G,
Loiodice F, Pusch M and Conte D. The pharmacological
profile of kidney CLC-K channels depends on the
expression system: comparison of CLC-K chloride
currents in a mammalian cell line and Xenopus oocytes
7. Carbonara R, Costanza T, Desaphy J.-F and Conte
Camerino D. Preclinical in vivo and in vitro evaluation of
antimyotonic activity of sodium channel blockers
Maria Pia Argentieri
Chemistry and bioactivity of secondary metabolites from plants
Modesto De Candia
Azepino[4,3-b]indole derivatives,as
neurodegenerative diseases
Poster Communications
10. Leonardo Pisani, Marco Catto, Francesco Campagna,
Orazio Nicolotti, Angela Stefanachi, Francesco Leonetti,
Roberta
Farina
and
Angelo
Carotti.
New
multidisciplinary and multitarget strategies to address
neurodegenerative diseases
11. Nunzio Denora, Valentino Laquintana, Annalisa Cutrignelli,
Antonio Lopalco, Rosa Maria Iacobazzi, Mara Perrone,
Angela Lopedota, and Massimo Franco. Targeting and
Imaging the Translocator Protein TSPO through a
Dendritic Nano-Platform
12. Delia Mandracchia, Giuseppe Tripodo, Adriana Trapani,
Andrea Latrofa and Giuseppe Trapani. In vitro release
studies from curcumin-loaded Insulin-graft-Vitamin E
(INVITE) mucoadhesive micelles
13. Maria Pia Argentieri, Pinarosa Avato.
Bioactive
compounds from Capparis spinosa subsp. Spinosa
14. Maria Maddalena Cavalluzzi. Lubeluzole: from antiischemic to chemosensitizing agent

Photopharmacology: Optical Control of Activity