CURRICULUM VITAE
Name: Dr. Mark Steven Miller
Phone: 240-276-5004
E-mail Address: [email protected]
Date and Place of Birth: May 28, 1956, Bronx, New York
Marital Status: Married, two children
Education
1977
1978
1980
1983
B.S. - Fordham University, Biological Sciences (cum laude)
M.A. - Columbia University, Pharmacology
M.Phil. - Columbia University, Pharmacology
Ph.D. - Columbia University, Pharmacology
Positions Held
1983-1986 Postdoctoral Fellow, Laboratory of Toxicology, Department of Applied Biological Sciences,
Massachusetts Institute of Technology, Cambridge, MA.
1986-1990 Senior Staff Fellow, Perinatal Carcinogenesis Section, Laboratory of Comparative
Carcinogenesis, Division of Cancer Etiology, National Cancer Institute, Frederick Cancer
Research and Development Center, Frederick, MD.
1990-1995 Department of Pathology, University of Tennessee College of Veterinary Medicine, Knoxville,
TN. Research Assistant Professor, 1990-1993; Assistant Professor, 1993-1995.
1996-2014 Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC. Assistant
Professor, 1996-1998; Associate Professor, 1998-2004; tenured, 2002; Professor, 2004-2014.
2010-Pres. President and Founder, CancerTox Consulting, LLC.
2012-2013 Associate Director of Graduate Studies, Department of Cancer Biology, Wake Forest School of
Medicine, Winston-Salem, NC.
2013-2014 Director of Graduate Studies, Department of Cancer Biology, Wake Forest School of Medicine,
Winston-Salem, NC.
2014-Pres. Program Director, Chemopreventive Agent Development Research Group, Division of Cancer
Prevention, National Cancer Institute, Bethesda, MD.
Joint/Adjunct Appointments
1980-1983 Visiting Student Scientist, Department of Biochemistry and Drug Metabolism, HoffmannLaRoche Inc., Nutley, NJ.
1989-1990 Adjunct Faculty, Sciences and Technologies Division, Frederick Community College, Frederick,
MD.
1995
Assistant Professor, Department of Pathology, University of Tennessee Medical Center,
Knoxville, TN.
1996-2014 Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem,
NC. Associate Assistant Professor, 1996-1998; Associate Associate Professor, 1998-2004;
Associate Professor, 2004-Pres.
1996-2014 Member, DNA Damage and Cellular Defense Program, Basic Science Division of the
Comprehensive Cancer Center of Wake Forest University.
1997-2004 Member, Breast Cancer Center of Excellence, Clinical Science Division of the Comprehensive
Cancer Center of Wake Forest University.
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1997-2002 Member, Lung Cancer Affinity Group, Clinical Science Division of the Comprehensive Cancer
Center of Wake Forest University.
2012-2014 Affiliate Faculty Member, Center for Biomolecular Imaging.
Professional Development
1. Mentor and Mentee Myers-Briggs Type Indicator (MBTI) Training, Dr. Cathie Siders, sponsored by the
Women’s Health Center of Excellence Research, Leadership, Education and Mentoring Program, June 11,
2007.
2. LEADERTREK - Introduction to Leadership Developmental Classes, Organizational Development, April
16, 2010.
3. LEADERTREK 200 Core Curriculum, 2010-2011. Classes in best management practices, team building
and facilitation, and presentation skills.
4. BioReliance 27th Annual Genotoxicity and Carcinogenicity Workshop, May 8-9, 2013.
Research Interests
Development of mechanism-based novel cancer chemopreventive agents; lung carcinogenesis; transplacental
carcinogenesis; interaction of environmental and genetic factors in tumor pathogenesis; effects of low dose
computed tomography radiation exposure on carcinogenesis; molecular mechanisms of transformation of
normal cells to malignant cells; effects of chemical and physical carcinogens on the regulation of gene
expression; oncogenes and tumor suppressor genes; role of the cytochrome P-450 monooxygenase system as
a determinant of tumor susceptibility; breast cancer.
Society Memberships and Professional Affiliations
American Association for the Advancement of Science (1994-2013)
American Association for Cancer Research (since 1987)
American College of Toxicology (since 2014)
American Association of University Professors (2009-2012)
Genetics and Environmental Mutagenesis Society (since 1998)
1. 1999-2001
Outreach Subcommittee
2. 1999-2002
Councilor on the Board of Directors
3. 2000-2001
Travel Award Subcommittee
4. 2001-2002
Nominating Committee
5. 2002-2004
Two year term as President-elect and President
6. 2005
Career lunch speaker at the annual Spring meeting
7. 2012-2014
Councilor on the Board of Directors
Roundtable of Toxicology Consultants (since 2010)
Society of Toxicology (since 1994)
1. 2001-2004
Continuing Education Committee
Coordinator of student volunteers (2002-2003)
Chair (2003-2004)
2. 2001-Pres.
Participant in the Meet-the-Expert program for graduate students at the annual meeting
3. 2005
Participant in the Information & Recruitment session for minority students at the annual
meeting
Molecular Biology Specialty Section
1. 1994-1997
Program Committee
2. 1996-1998
Secretary/Treasurer
3. 1997-1999
Student Awards Committee
4. 2000-2003
Three year term as Vice President-Elect, Vice President, and President
5. 2000-2001
Chair, Program Committee
6. 2001-2002
Chair, Nominating Committee
7. 2003-2004
Past-President and Councilor
Carcinogenesis Specialty Section
1. 2005-2008
Three year term as Vice President-Elect, Vice President, and President
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2. 2006-2007
Chair, Nominating Committee
2. 2008-2009
Past-President and Councilor
Southeastern Regional Chapter (1994-1996)
1. 1994-1995
Nominating Committee
North Carolina Regional Chapter (1997-2014)
Lung Cancer Initiative of North Carolina (since 2010, formerly the NC Lung Cancer Partnership)
1. 2010-2014
Planning Committee, annual LCI 5K & 1 Mile Rally
Research Funding
Past
1. NIH Grant R01 CA42829
Transplacental carcinogenicity of NNK
Co-Investigator (PI: Dr. Hildegard M. Schuller, University of Tennessee)
January 1, 1990 to December 30, 1993, $397,366.
renewed as:
Transplacental pancreatic carcinogenesis by NNK
September 30, 1996 to July 31, 2000, $818,521.
2. NIH Grant R01 CA48014
Characterization of induced neuroendocrine lung cancer
Co-Investigator (PI: Dr. Hildegard M. Schuller, University of Tennessee)
February 7, 1992 to January 31, 1996, $386,224.
3. University of Tennessee Center of Excellence Grant
Analysis of lung tumors for activation of oncogenes in paraffin-embedded tissues
Principal Investigator
July 1, 1992 to June 30, 1993, $10,000.
4. USDA Grant CSRS92-37204-8111
Molecular basis of endothelial cell sensitivity to lipopolysaccharide
Co-Principal Investigator (PI: Dr. Philip N. Bochsler, University of Tennessee)
September 15, 1992 to September 30, 1994, $95,000.
5. University of Tennessee Center of Excellence Grant
Genetic differences in drug metabolic enzymes as determinants of individual susceptibility to
transplacental lung carcinogenesis
Principal Investigator
July 1, 1993 to June 30, 1994, $15,000.
6. NIH Grant R01 ES06501
Role of oncogenes in transplacental carcinogenesis
Principal Investigator
May 1, 1994 to April 30, 1998, $299,000.
7. University of Tennessee Center of Excellence Grant
Acute transplacental effects of dietary carcinogens
Principal Investigator
July 1, 1995 to December 31, 1995, $3,000.
8. NIH Grant R01 ES08252
Transplacental carcinogenesis of heterocyclic amines
Principal Investigator
May 1, 1996 to April 30, 1999, $321,946.
9. Comprehensive Cancer Center Pilot Project Grant (WFU)
Genetic polymorphisms in drug metabolic enzymes as risk factors for p53 gene mutations
Principal Investigator
December 20, 1996 to January 31, 1997, $5,300.
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10. Intramural Research Support Grant (WFU)
Acute effects of dietary exposure to perillyl alcohol
Principal Investigator
March 13, 1997 to March 12, 1998, $2,000.
11. Intramural Cross Campus Collaborative Research Grant (WFU)
Characterization of mutagenic metabolites of ochratoxin A
Co-Investigator (PI: Dr. Richard Manderville, WFU)
July 1, 1998 to June 30, 1999, $6,000.
12. Friends...you can count on
Genetic polymorphisms in drug metabolic enzymes as risk factors for p53 gene mutations
Principal Investigator
January 15, 1999 to December 31, 2000, $40,000.
13. Vaughn-Jordon Foundation, Inc.
Mechanisms of the anti-tumor effects of perillyl alcohol
Principal Investigator
May 28, 1999 to May 31, 2003, $120,000.
14. NIH Grant R01 CA81330
Metabolic genotypes and oncogenic damage in breast cancer
Principal Investigator
July 1, 2000 to June 30, 2006, $1,048,410.
15. Aventis Pharmaceuticals
Effect of specific types of genetic lesions on patient response to taxotere and gemcitabine in non-small
cell lung cancer
Principal Investigator
May 10, 2000 to December 31, 2006, $60,000.
16. Kulynych Interdisciplinary Cancer Research Funds (WFU)
Development of transgenic mice with mutant human Ki-ras alleles: Determination of the role of different
ras alleles in lung tumor initiation and progression
Principal Investigator
October 10, 2000 to June 30, 2002, $12,500.
17. The Susan G. Komen Breast Cancer Foundation
Metabolic genotypes and damage to p53
Principal Investigator
This 2 year grant for $250,000 was turned down due to overlap with NIH grant R01 CA81330.
18. EPA STAR Grant R829428-01-0
Activation of Ki-ras during transplacental carcinogenesis
Principal Investigator
September 24, 2001 to September 23, 2005, $636,959.
19. NIH Grant R01 CA91909
Role of Ki-ras in the pathogenesis of lung cancer
Principal Investigator
April 1, 2002 to March 30, 2007, $850,000.
Minority supplement awarded to Stephanie Dance effective April 25, 2003, $66,150.
20. NIH Grant R21 DK60480
GRHPR knockout mouse as a model of hyperoxaluria
Co-Investigator (P.I. Dr. Scott Cramer, WFUSM) - converted status to unpaid consultant, 10/02
June 1, 2002 to May 31, 2004, $200,000.
21. NIH Grant R01 CA86846
Targeting protein synthesis in AML
Co-Investigator (P.I. Dr. Art Frankel, WFUSM)
April 1, 2002 to March 30, 2007, $1,000,000.
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22. NIH Grant R01 CA96310
Chemoprevention of experimental tobacco tumorigenesis
Co-Investigator (P.I. Dr. Ramesh Gupta, University of Kentucky)
April 1, 2002 to March 30, 2006, $134,228 (subcontract to WFUSM).
23. Intramural Cross Campus Collaborative Research Grant (WFU)
Fetal exposure to ochratoxin A: a murine model for testicular cancer
Co-Investigator (PI: Dr. Gary Schwartz, WFUSM)
January 1, 2003 to December 31, 2004, $15,500.
24. Lance Armstrong Foundation
Fetal exposure to ochratoxin A: a murine model for testicular cancer
Co-Principal Investigator (P.I. Dr. Gary Schwartz, WFUSM)
January 1, 2003 to December 31, 2004, $50,000.
25. Susan G. Komen Breast Cancer Foundation
Dissertation Research Award for Beth Van Emburgh
Metabolic genotypes and tumor suppressor gene damage in breast cancer
Principal Investigator
May 1, 2004 to April 30, 2006, $30,000.
26. Comprehensive Cancer Center PUSH Pilot Grant
Microarray analysis of the effects of the mutant human Ki-ras gene on pulmonary gene expression in a
bitransgenic murine model of lung tumorigenesis
Principal Investigator
May 1, 2004 to April 30, 2005, $10,000.
27. Comprehensive Cancer Center CAM Pilot Grant
Chemopreventive Efficacy of Curcumin or Celecoxib in a Transgenic Lung Cancer Model
Co-Investigator (PI: Dr. Alan Townsend, WFUSM)
July 1, 2005 to January 31, 2007, $12,000.
28. Comprehensive Cancer Center PULL Pilot Grant
Angiotensin-(1-7) Reduces the Growth of Human Lung Tumors
Co-Investigator (PI: Dr. Patricia Gallagher, WFUSM)
July 1, 2005 to January 31, 2007, $12,000.
29. Comprehensive Cancer Center PUSH Pilot Grant
Interaction between the mutant human Ki-rasG12C allele and the mutant p53 gene on lung tumorigenesis in
transgenic murine models of lung cancer.
Principal Investigator
March 1, 2006 to March 31, 2007, $10,000.
30. Golfers Against Cancer
Inflammation Mediated Recruitment of Pulmonary Stem Cells
Principal Investigator
May 1, 2008 to June 30, 2009, $20,000.
31. Comprehensive Cancer Center Development Grant
Effects of Low Dose CT Radiation on Lung Tumorigenesis
Co-Investigator (PI: Dr. Michael Munley, WFUSM)
April 1, 2008 to June 30, 2009, $30,000.
32. Comprehensive Cancer Center Grant
Effects of Low Dose CT Radiation on Blood Biomarkers of Oxidative Damage
Co-Investigator (PI: Dr. James Winslow, WFUSM)
November 1, 2010 to August 31, 2012, $20,000.
33. NIH Grant R01 CA136910-01A1
Effects of Low Dose CT Radiation on Lung Tumorigenesis
Co-Investigator (PI: Dr. Michael Munley, WFUSM)
May 5, 2009 to February 28, 2013, $884,646.
One of three grants awarded a joint NCI/NASA supplement; Sept. 23, 2010.
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34. Comprehensive Cancer Center PUSH Grant
Low Dose CT Radiation-Induced Lung Tumorigenesis: Mechanisms and Chemoprevention
Principal Investigator
January 15, 2012 to January 14, 2013, $40,000.
Scientific Reviews
A. Member, Editorial Board
1. Journal of Cancer Research & Therapy (2013-2014)
B. Ad hoc reviewer
1. Biochemical Pharmacology
2. Cancer Detection and Prevention
3. Cancer Letters
4. Cancer Prevention Research
5. Cancer Research
6. Carcinogenesis
7. Chemical Research in Toxicology
8. Experimental Lung Research
9. International Journal of Cancer
10. Journal of Pharmacology and Experimental Therapeutics
11. Journal of Radiation Research
12. Journal of Toxicology and Environmental Health
13. Life Sciences
14. Molecular Pharmacology
15. Toxicology and Applied Pharmacology
C. Granting Agencies
1. Ad Hoc Reviewer, USDA National Research Initiative Competitive Grants Program, Mechanisms of Animal
Disease Program, 1992-1993.
2. Member, Alcohol and Toxicology 2 study section (ALTX-2), Clinical Sciences Special Emphasis Panel, NIH,
1996-1997.
3. Ad Hoc Reviewer, Peer Review Panel, Louisiana Cancer and Lung Trust Fund Board, 1996, 2001.
4. Member, Alcohol and Toxicology 1 study section (ALTX-1), NIH, 1997-2000.
5. Served on Clinical Sciences Special Emphasis Panel for Alcohol and Toxicology 4 (ALTX-4) study section to
review grants with member conflicts, NIH, July, 1999.
6. Ad Hoc Reviewer, U.S. Army Medical Research and Materiel Command, The BESCT (Biology, Education,
Screening, Chemoprevention, and Treatment) Lung Cancer Program, review conducted by the American
Institute of Biological Sciences, October, 2000.
7. Peer Reviewer, Children’s Vulnerability to Toxic Substances in the Environment (2-D1), U.S. Environmental
Protection Agency, June, 2002.
8. Ad hoc Reviewer, Special Emphasis Panel in Prevention Research and Epidemiology, Small Grants Program
for Cancer Epidemiology, NIH, March, 2003.
9. Ad hoc Reviewer, Subcommittee C, Research Programs and Review Branch (D6), review of supplement for
an existing PO1 grant, NCI, January, 2004.
10. Member, AIBS Panel A: Molecular Basis of Cancers Associated with Second Hand Smoke, Flight Attendant
Medical Research Institute, review conducted by the American Institute of Biological Sciences, November
17-19, 2004.
11. Ad hoc Reviewer, Special Emphasis Panel, Oncology Fellowship and Area Grants, NIH, July, 2005.
12. Served on Special Emphasis Panel to review a grant for a member conflict, Genetic Modifiers of Lung
Cancer, NIH, August, 2005.
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13. Member, AIBS Panel A: Molecular Basis of Cancers Associated with Second Hand Smoke, Flight Attendant
Medical Research Institute, review conducted by the American Institute of Biological Sciences, November 30
to December 2, 2005.
14. Member, FAMRI Progress Reports Review Panel, Flight Attendant Medical Research Institute, review
conducted by the American Institute of Biological Sciences, May, 2007.
15. Member, FAMRI Progress Reports Review Panel, Flight Attendant Medical Research Institute, review
conducted by the American Institute of Biological Sciences, April, 2009.
16. Ad hoc Reviewer, Challenge Grants Panel 6, Special Topics in Biological Sciences special emphasis panel
(OBT-A), NIH, June, 2009.
17. Member, Oncological Sciences Fellowship Panel (F09-A), NIH: 10/09, 10/10, 3/11.
18. Member, CDMRP Lung Cancer Research Program CTRA peer review panel, review conducted by SRA
International for the DOD, January, 2010.
19. Pennsylvania Performance review panel for the Pennsylvania Department of Health, reviewed conducted by
Oak Ridge Associated Universities (ORAU), 2/10; 3/11.
20. Pennsylvania Department of Health panel review on Commercialization of Cancer Diagnostics/Therapeutics,
January 10-13, 2012.
D. Outside Academic Reviews
1. Ad hoc reviewer, NIEHS Promotion and Tenure Committee, February, 2001.
2. Reviewer for EPA draft manuscript, Assessing Susceptibility to Early-Life Exposure to Carcinogens, review
conducted by Versar Inc. for the EPA, 2/14/05 to 3/15/05.
3. Consultant for the Environmental Carcinogenesis Division, National Health and Environmental Effects
Research Laboratory, U.S. Environmental Protection Agency, 2005 to 2006.
4. Career Development Mentoring Committee for Dr. Minnie Holmes-McNary, NCA&T, 2006 to 2008.
5. Chair, Review Panel for EPA IRIS Assessment of Nitrobenzene, review conducted by Oak Ridge Associated
Universities/Oak Ridge Institute for Science and Education for the EPA, 5/14/07 to 5/15/07.
6. Member, External Advisory Board, North Carolina A&T University MARC grant, 2008 to 2010.
7. Member, External Advisory Board, North Carolina A&T University RISE grant, 2009 to 2010.
8. Reviewer, National Toxicology Program Technical Reports Peer Review Panel, 2/11; 4/11.
9. Member, Mouse Lung Tumor Workshop – Organizing Committee (MLTW-OC), National Center for
Environmental Assessment (NCEA), EPA, 5/13 to 10/13; assist in determining scientific content of the
workshop.
Education Related Committees
At the Wake Forest School of Medicine
1996-2014 Associate Faculty, Graduate Program in Molecular Genetics and Genomics, Wake Forest
University.
1996-1998 Committee on Undergraduate Medical Education
Professional Attitudes and Behavior Subcommittee (1996)
1996-2002 Graduate Studies Committee, Department of Physiology & Pharmacology
Recruitment and Admissions Subcommittee (1996-2002)
Curriculum and Examinations Subcommittee (1998-2001)
1997
Curriculum for 2002 Phase III Committee
Systems Integration and Pathophysiology II Subcommittee
1997-2014 Graduate Program Committee, Department of Cancer Biology
Graduate and MD/PhD Student Recruitment (1997-2010), Chair (2011-Pres.)
Chair, Curriculum Subcommittee (1999-Pres.)
Faculty Retreat Mentoring Committee (2004)
Strategic Planning Committee (2005)
1998-2014 Graduate Program in Molecular Medicine and Translational Science, Wake Forest University.
Associate Faculty, 1998-2000; Full Faculty, 2000-Pres.
Curriculum Development Subcommittee (2007-2008)
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1998-2008
1999-2000
2000-2002
2001-2007
2001-2003
2002-2014
2003-2009
2004-2008
2004-2009
2004-2006
2006-2010
2006-2014
2008
2009-2010
2011
2011-2013
2012
Medical Student Applicant Interviewer
Judge of posters for Surgical Research Day
Mentoring Program for Women Jr. Faculty, Women’s Health Center of Excellence
Member, Executive Committee, Toxicology Training Program, NRSA Training Grant T32
ES07331, Multidisciplinary Training in Molecular Toxicology. Associate Director, 2003-2007.
Marketing and Recruitment Committee, Molecular Medicine Graduate Program
Office of Women in Medicine and Science
Research, Leadership, and Education Committee
Subcommittees
Mentoring Program Committee (2002-2003)
Chair, Liaison Subcommitee (2006-2010)
Mentoring Award Subcommittee (2009-Pres.)
Research Committee (2009-Pres.)
Mentees
Dr. April Ronca (2004-2007)
Dr. Suzanne Danhauer (2008-2009)
Dr. Cynthia Horn (2008-2010)
Dr. Rebecca Slager (2011-Pres.)
Elected to two consecutive 3 year terms on the Graduate Council of Wake Forest University
Curriculum Committee (2003-2006; Chair, 2004-2006; 2008-2009)
Outstanding PhD Student Nomination Committee (2004)
Chair, Outstanding PhD Student Nomination Committee (2006)
Policy Committee (2006-2007)
Credentials Committee (2007-2008)
Outstanding Masters Student Nomination Committee (2008)
Outstanding Masters Student Nomination Committee (2009)
Member, Executive Committee, Department of Cancer Biology, NRSA Training Grant T32
CA79448,Training Program in Cancer Biology.
Member, Core Teaching Faculty, WFUSM.
Phase 1B Subcommittee (2004-2005)
Faculty Development Subcommittee (2005-2009)
Curriculum Development Subcommittee (2007-2009)
Career Development Mentoring Committee for Dr. John Wilkinson IV; NIDDK KO1 award
Career Development Mentoring Committee for Dr. W. Jeffrey Petty for American Cancer Society
grant.
Associate Faculty, Office of Women in Medicine and Science
Judge of posters for Graduate Research Day
Ad hoc Advisory Committee on Statistical Training
WFU Postdoctoral Scholarship Development Award committee
Molecular and Cellular Biosciences (Track 4) Recruitment Committee
Molecular Medicine and Translational Science Policies and Procedures Committee
Institutional Committees
At the Wake Forest School of Medicine
1996-1999 Library and Learning Resources Committee
1997
Comprehensive Cancer Center Pilot Grant Review Committee
1998-2004 Chemical Safety Committee
Chemical Regulation Subcommittee (2000)
1999
Was one of four faculty members invited to give a presentation to Dr. Ken Olden, Director of the
NIEHS, during his visit to Wake Forest University on April 27
1999
Interview Committee for Dr. Eva Szabo, Department of Medicine
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1999-2005 Faculty Team Leader for Environmental Health and Safety Office in the Department of Cancer
Biology
2000
Interview Committee for Dr. Michelle Bennett, Department of Dermatology
2000
Interview Committee for Dr. William Huang, Department of Radiation Oncology
2000
Interview Committee for Dr. David Leitenberg, Department of Microbiology and Immunology
2000
Interview Committee for Dr. David Horita, Department of Biochemistry
2000
Interview Committee for Dr. Jed Pitera, Department of Biochemistry
2000/2002 Pilot Projects Review Committee, Center for the Neurobehavioral Study of Alcohol
2000
Interview Committee for Dr. Patrick Furrer, Department of Biochemistry
2000
Interview Committee for Dr. Roy Kaplan, Department of Anesthesiology
2001
Interview Committee for Dr. Mohan Thakuri, Section on Hematology/Oncology
2001
Interview Committee for Dr. Edward Swords, Department of Microbiology and Immunology
2001
Chair, Ad hoc Barrier Facility Advisory Committee
2002
Interview Committee for Dr. Michael Brooks, Department of Radiology
2002
Chair, Interview Committee for Dr. Coty Ho, Section on Hematology/Oncology
2002
Interview Committee for Dr. Swarajya Vemuri, Section on Hematology/Oncology
2002
Chair, Interview Committee for Dr. Ignatius Ou, Section on Hematology/Oncology
2002
Interview Committee for Dr. Rajendar Deora, Department of Microbiology and Immunology
2002
Interview Committee for Dr. Mitchell Balish, Department of Microbiology and Immunology
2002
Interview Committee for Dr. Indranil Biswas, Department of Microbiology and Immunology
2002
Interview Committee for Dr. Fang-Ting Liang, Department of Microbiology and Immunology
2002
Interview Committee for Dr. Claudia Häse, Department of Microbiology and Immunology
2002
Interview Committee for Dr. Sean Reid, Department of Microbiology and Immunology
2002
Interview Committee for Dr. Matthew Wolfgang, Department of Microbiology and Immunology
2002
Interview Committee for Dr. Paul Fawcett, Department of Microbiology and Immunology
2003
Interview Committee for Dr. James Kimball, Department of Psychiatry and Behavioral Medicine
2003
Chair, Interview Committee for Dr. Denise Levitan, Section on Hematology/Oncology
2004
MRI Advisory Committee, Imaging Research Center
2004
Interview Committee for Dr. Wen Xuan Wu, Department of Obstetrics and Gynecology
2004
Search Committee for Assistant Dean for Research
2004
Interview Committee for Dr. Jung Hee Woo, Section on Hematology/Oncology
2004-2006 Animal Imaging Advisory Committee, Imaging Research Center
2004
Interview Committee for Dr. Susan Perkins, Section on Hematology/Oncology
2004
Interview Committee for Dr. Nomeli Nunez, Section on Hematology/Oncology
2005-2006 Chair, Ad hoc Barrier Facility Advisory Committee
2006-2009 CCC Grant Development Core
2006
Interview Committee for Dr. Mercedes Porosnicu, Section on Hematology/Oncology
2006
WFUSM Strategic Planning Committee, Infrastructure Working Group
Chair, Technology Transfer/Industry Relations subcommittee
2006-2009 Recruitment, Retention, Promotion, and Tenure Committee
2007
Break out Session Chair at New Faculty Orientation
Balancing Research and Teaching
2007-2011 Elected to a 4 year term on the Wake Forest University Senate
Fringe Benefits Subcommittee (2007-Pres.)
2008-2011 Institutional Animal Care and Use Committee
Chair (2008-2010)
Past Chair (2010-2011)
Adverse Effects subcommittee (2010-2011)
2009-2012 Faculty Development Advisory Committee
2009-2010 Tobacco Free Campus Committee for Reynolda Campus
2010-2011 Faculty Representative Council, ex-officio representative of the Faculty Senate.
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2011
2012
2013
PUSH Pilot Grant review committee, Cell Signaling and Survival Program, Wake Forest
University Comprehensive Cancer Center
Surgical Translational Research Team pilot grant review committee, Division of Surgical
Sciences, Wake Forest School of Medicine
Reviewer for Pilot Grants from the Wake Forest University Comprehensive Cancer Center
Departmental Committees
At the Wake Forest School of Medicine
1997-2002 Faculty Search Committee, Department of Cancer Biology
2000
Co-chair, Cancer Liaison Committee, Department of Phys./Pharm. retreat
2005
Department of Cancer Biology Strategic Planning Committee
2005-2014 Chair, Department of Cancer Biology Promotion and Tenure Committee
2006-2007 Department of Cancer Biology Junior Faculty Mentoring Committee
2005
Faculty Search Committee, Department of Cancer Biology
At the University of Tennessee
1991-1995 Graduate Program in Comparative and Experimental Medicine
1992-1995 Graduate Studies Committee, Department of Pathology
1993-1995 Institutional Animal Care and Use Committee
Spring 1993, Inspection Team
Spring 1994, Inspection Team Leader
Fall 1995, Inspection Team Leader
Spring 1995, Inspection Team
1994-1995 Graduate Program in Environmental Toxicology
Academic Honors/Awards:
2003 Research Excellence Award, WFUSM
2004 Research Excellence Award, WFUSM
Listed in:
1. American Men and Women of Science (1995 edition).
2. Who's Who in the South and Southwest (since 1995).
3. Dictionary of International Biography (1995 edition).
4. Who's Who in Science and Engineering (since 1996).
5. Who's Who in American Education (since 1996).
6. Who's Who in the World (1996 edition).
7. Who's Who in Medicine and Healthcare (since 1997).
8. International Who’s Who of Professionals (1998 edition).
9. America’s Registry of Outstanding Professionals (2001-2002 edition).
10. Strathmore’s Who’s Who (2002-2003 edition).
11. Who’s Who in Medical Sciences Education (since 2005).
International Training Experience
2000
Graduate Student Laboratory Rotations for two International German Exchange Students, Claudia
Grewe and Anne Grabner
2011
Dr. Fikriye Polat, Faculty of Education, Department of Primary Education, Kocaeli University,
Kocaeli, Republic of Turkey. Dr. Polat received a grant from her university to train in my
laboratory for 3 months to learn techniques in molecular biology.
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Teaching Experience:
At the Wake Forest University School of Medicine
Graduate Students
1996-1999, 2006-2007
Course: Principles and Methods of Toxicology
Topic: Carcinogenesis
1996
Course: Advanced Pharmacology
Topic: Oncogenes and Signal Transduction
Transcription Factors
1996
Course: Advanced Physiology
Topics: Transcription Factors
Oncogenes
1997-2008. Course: Advanced Physiology/Pharmacology
Topic: Oncogenes and Signal Transduction
Transcription Factors
Introduction to Carcinogenesis
1997-2014 Course: Carcinogens, DNA Damage and Repair
Course director
1999-2001 Course: Molecular Pathogenesis of Cancer
Topic: Genetic Alterations in Experimental Cancer Models
2000
Course: Molecular Biology Tutorial: DNA Mismatch Repair
Course Co-director (Director: Dr. Fred Perrino)
2000-2007 Course: Basis of Human Disease
Topic: Molecular Pathogenesis of Cancer
2000-2007 Course: Contemporary Issues in Molecular Medicine
Topic: Research Opportunities in Cancer Biology
Molecular Pathogenesis of Transplacentally-Induced Murine Lung Tumors
2003
Course: Special Topics in Biochemistry - Signaling Pathways in Toxicology
Topic: RAS-Mediated Signaling
2004
Course: Fundamentals of Scientific Integrity (small group discussions - 2 sessions)
2008
Course: Tutorial in Molecular Genetics
Topic: PTEN and Lung Morphogenesis
2010-2014 Course: Scientific Profession/Scientific Integrity (small group discussions)
2011
Course: Cancer Cell Biology
Served on student grant writing committee.
2011
Course: Engineering Approaches to Understanding, Diagnosing, and Treating Cancer
Topic: Interdisciplinary Research in Radiation Biology: Collaborations in Biology and Physics
2012-2014 Course: Cancer Biology Seminar Series
Course director
2013
Course: Topics in Cancer Biology
Multi-step Tumorigenesis
Medical and Physician Assistant (PA) Students
1996-2006 Course: Medicine as a Profession (small group discussions)
1997-1998 Course: Unit III Hematology-Oncology Core Lecture Series
Topic: Molecular Pathogenesis of Cancer
1998-1999 Phase IB Tutorials: Cellular Mechanisms
1999-2002 Course: Heme and Lymph System Core Lecture Series
Topic: Molecular Pathogenesis of Cancer
1999-2002 Phase IIA Tutorials: Systems Pathophysiology
2004-2007 Phase 1B Basic and Clinical Science Problem Course
2005-2007 Phase 1A Basic and Clinical Science Problem Course
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2006-2007
2006-2008
2007-2008
2007-2008
2007-2009
2007-2008
2007
2007-2009
2007-2009
2006-2008
Population-Epidemiology/Evidence Based Medicine
Standardized Patient Assessment (SPA), Part 2 - Unit III, PA Program
Standardized Patient Assessment (SPA), Part 2 - Unit IV, PA Program
Standardized Patient Assessment (SPA), Part 2 - Unit V, PA Program
Standardized Patient Assessment (SPA), Part 2, Medical Students
Standardized Patient Assessment (SPA), Part 3, Medical Students
Doctor-Patient Relationship
Case Centered Learning, Block 1, Human Structure and Development
Case Centered Learning, Block 2, Cell and Subcellular Processes
Standardized Patient Assessment (SPA), Part 2 - Unit I, PA Program
Medical Residents and Fellows
1998-2001 Oncology Core Curriculum
Topic: Carcinogenesis
NIH Grant Submissions and Review - Perspectives of a Study Section Member
Faculty Seminars
1996-2001 Breast Cancer Affinity Group Research Conference
Topics: Role of Oncogenes in Transplacental Carcinogenesis
Metabolic Genotypes, Gene Mutations, and Breast Cancer: Preliminary
Results from a WFUCCC Pilot Study
1996
Perinatal Research Conference
Topic: Molecular Pathogenesis of Transplacentally-Induced Lung Cancer
1996
DNA Damage and Cellular Defense Program Retreat
Topic: Role of Cytochrome P450 in Modulating Damage to Oncogenes During
Transplacental Carcinogenesis
1996-2007 Course: Physiology and Pharmacology Seminar Series
Topic: Molecular Pathogenesis of Transplacentally-Induced Lung Cancer
1996-2014 DNA Damage and Cellular Defense Program Seminar
Topics: The Discovery of Oncogenes: a Historical Perspective
Fantastic Voyage: A Trip from the Cell Surface to the Nucleus
Molecular Pathogenesis of Transplacentally-Induced Lung Cancer
Murine Models of Lung Cancer: From Pathogenesis to Chemoprevention
1996-2007 Course: Molecular Genetics Program Seminar
Topics: Molecular Pathogenesis of Transplacentally-Induced Lung Tumors
NIH Grant Submissions and Review - Perspectives of a Study Section Member
Doxycycline Regulated, Lung-Specific Expression of Mutant Human Ki-ras
Induces Lung Adenomas In Bitransgenic Mice
1997
Course: Chemistry Seminar Series
Topic: Everything You Ever Wanted to Know About Molecular Biology, but Didn’t
Know How to Ask.
1997
Cancer Epidemiology and Prevention Program Meeting
Topic: Application of Molecular Biology to Epidemiological Research
1998
Lung Cancer Affinity Group Meeting
Topic: Application of Molecular Biology to Clinical Research
2001
DNA Damage and Cellular Defense Program Retreat
Topic: Molecular Carcinogenesis
2002
DNA Damage and Cellular Defense Program Retreat
Topic: Molecular Carcinogenesis of Lung Cancer
2004-2008 Course: Molecular Medicine Program Seminar
Topic: Mouse Models of Lung Cancer
12
2012
Animal Resource Program seminar series
Topic: Effects of Low Dose CT Radiation on Lung Cancer in Mice
At the University of Tennessee
1991-1995 Course: Mechanisms of Disease
Topic: Oncogenes
1991-1993 Course: House Officers Seminar Series
Topics: Oncogenes
Basic Techniques in Molecular Biology
1993-1995 Course: Special Topics in Environmental Toxicology
Topics: Oncogenes
Basic Techniques in Molecular Biology
Signal Transduction
Fetal Susceptibility to Chemical Carcinogenesis
1993
Course: Veterinary Pharmacology and Therapeutics
Topic: Drug Metabolism
1995
Course: Advanced Topics in Medical Biology
Topic: Transcription Factors
1995
Course: Sources and Services in Science and Engineering
Topic: Search Strategies for the Biomedical Sciences
At Frederick Community College
1989-1990 Course: Genetics
Course director: Taught entire course (both lecture and laboratory)
At the Laboratory of Comparative Carcinogenesis, NCI
1987-1989 Served as Moderator of the Gene Expression Journal Club
At the Massachusetts Institute of Technology
1986
Course: Regulation of Cellular Metabolism
Topic: Steroid Hormones: The Action of Glucocorticoids
Undergraduate, Graduate, and Medical Student Advisor/Research Sponsor
At the Wake Forest University School of Medicine
Laboratory Rotations/Advising
1996
Physiology/Pharmacology Laboratory Rotation - Kiersten Gressani
1997-1998 1st Year Cancer Biology Graduate student advisor for Randy Strube
1998
Cancer Biology Laboratory Rotation - Tasha Smith
1999
Cancer Biology Laboratory Rotation- Debbie Sachs
2000
Medical Student Summer Research Program - Suzanne Lynch
2000
Cancer Biology Laboratory Rotation - Beth O’Brien
2000
Molecular Genetics Laboratory Rotation - Allison Bagwell
2001
Molecular Medicine Laboratory Rotation - Abbie Connoy
2001
Physiology/Pharmacology Laboratory Rotation - Stephanie Oldham
2001
Cancer Biology Laboratory Rotation - Heather Smith
2001
Cancer Biology Laboratory Rotation - Bimjhana Bishwokarma
2001
Molecular Medicine Laboratory Rotation - Patrick Rowe
2001-2003 Faculty advisor for JessicaWatkins, medical school class of 2005
2001-2002 Faculty advisor for Erik Condon, medical school class of 2005
2002
Medical Student Summer Research Program - Jessica Watkins
2002
Medical Student Summer Research Program - Melissa Mizesko
2002
Summer Research Undergraduate Opportunities Program - Joy Little
13
2002
2002
2002-2004
2003
2003
2003
2002-2005
2005
2008-2009
2008
2009
2009
2010
2010
2012-2013
Medical Student Research Rotation - Suzanne Lynch
Molecular Genetics Laboratory Rotation - Megan Overcast
Faculty advisor for Doris Brown, medical school class of 2006
Summer Research Undergraduate Opportunities Program - Amy Webb
Medical Student Research Rotation - Elisabeth Curtis
Undergraduate Work Study Student - JeffreyTomalka
Faculty advisor for Niklaus Eriksen, medical school class of 2007
Medical Student Research Rotation - Melissa Mizesko
John Gregory Zora, Summer undergrad student volunteer and Honors Program Internship, WFU
Summer Research Undergraduate Opportunities Program - Ashlynn Boler
Ivie Okundaye, Honors Program Internship, WFU
Aneesha Reddy, WHCoE Program Internship, WFU
Jennifer McBride, WHCoE summer Program Internship, UNCG
LaShanale Wallace, MARC summer research program, NCA&T
Katya Strage, WFU. Summer (2012) undergraduate student volunteer; Internship for course credit
(Fall 2012, Spring 2013)
2012-2013 Brooke Porter, WFU. Summer (2012) undergraduate student volunteer; Internship for course
credit (Fall 2012, Spring 2013).
2012
Cancer Biology Laboratory Rotation - Jessica Swanner
2013
Lisa Anderson, WFU. Summer (2013) undergraduate internship for course
Thesis Committees
1996-1999 Major advisor, Doctoral Thesis Committee for Kiersten Gressani (Physiology/Pharmacology)
Title: Transplacental Carcinogenesis of Dietary and Environmental Carcinogens
Degree Awarded: May, 1999.
1996-2001 Member, Doctoral Thesis Committee for Stephen Waters (Molecular Genetics)
Title: Investigation on the Repair of G:T and G:U Mispairs Arising from the Deamination of 5Methylcytosine and Cytosine
Degree Awarded: December, 2001.
1998-2002 Major advisor, Doctoral Thesis Committee for Tasha Smith (Cancer Biology)
Title: The Elucidation of DNA Damage/Repair and Breast Cancer Risk
Degree Awarded: December, 2002
2001-2006 Major advisor, Doctoral Thesis Committee for Beth Van Emburgh (Cancer Biology)
Title: Metabolic Genotypes and Tumor Suppressor Gene Damage in Breast Cancer
Degree Awarded: August, 2006.
2001-2005 Major advisor, Doctoral Thesis Committee for Heather Smith Floyd (Cancer Biology)
Title: The Effects of Mutant Human Ki-ras on Lung Tumor Development
Degree Awarded: May, 2005.
2002-2005 Member, Doctoral Thesis Committee for Mary Kushman (Cancer Biology)
Title: Investigating the Differential Toxicity of Polycyclic Aromatic Hydrocarbons in
Transgenic Cell Systems Engineered to Express Specific Human Cytochrome P450 and
Human Glutathione-S-transferase Isoforms
Degree Awarded: August, 2005.
2003-2004 Chair, Master’s Thesis Committee for Holly Weir (Biochemistry & Molecular Biology)
Title: Genetic Basis for Resistance to Murine Tumors
Degree Awarded: May, 2004.
2003-2007 Major advisor, Doctoral Thesis Committee for Stephanie Dance-Barnes (Cancer Biology)
Title: The Role of Inflammation in Tumor Promotion and as a Target of Chemoprevention of
Lung Cancer
Degree Awarded: December, 2007.
14
2004-2007 Member, Doctoral Thesis Committee for Anne Sanders (Molecular & Cellular Pathobiology)
Title: Characterization of the Inheritance, Effector Mechanisms, and Response Against
Endogenous Cancers in the SR/CR Mouse Model of Cancer Resistance
Degree Awarded: December, 2007.
2004-2009 Member, Doctoral Thesis Committee for Elizabeth Joy Akins (Molecular Medicine)
Title: Characterizing Changes in T Cell Composition and Function Within Prostate Tumors
Following Androgen Ablation and Non-invasive Imaging of Anti-Tumor Immune Responses
Degree Awarded: August, 2009.
2005-2008 Member, Doctoral Thesis Committee for Jyotsana Menon (Physiology/Pharmacology)
Title: Angiotensin-(1-7): A Novel Chemotherapuetic and Chemopreventive Agent for Lung
Cancer
Degree Awarded: May, 2008.
2006-2007 Member, Doctoral Thesis Committee for Gregory Redlinger (Cancer Biology)
Title: New Insights into How Resistance is Mediated by SR/CR Mice and the Critical Role of
Chemoattraction in the Spectrum of Resistance
Degree Awarded: August, 2007.
2006-2009 Chair, Masters Thesis Committee for Lisa Rudd (Biochemistry & Molecular Biology)
Title: Comparison of Redox-Active and Conjugative Enzymes With and Without Efflux
Transporters and Their Comparative Effectiveness in Protection Against Cellular Toxicity of 4Hydroxy-2-Nonenal (HNE), an Aldehyde Lipid Peroxidation Product
Degree Awarded: August, 2009.
2006-2008 Member, Doctoral Thesis Committee for Adrienne Smith (Cancer Biology)
Title: The Dual Role of Bcl-2 Protein BAD in Prostate Cancer
Degree Awarded: May, 2008.
2006-2010 Member, Doctoral Thesis Committee for Patricia Durant (Molecular Medicine)
Title: Understanding the Effects of Dietary Chemopreventive Agents on Metabolism and
Mutagenicity of Polycyclic Aromatic Hydrocarbons by Human Cytochrome P450 and Human
Glutathione S-Transferase Enzymes
Degree Awarded: August, 2010.
2008-2012 Member, Doctoral Thesis Committee for Karen Burger (Cancer Biology)
Title: Regulation of Cell Invasion by the Podosome/Invadopod Protein Tks5
Degree Awarded: May, 2013.
2011-Pres. Member, Doctoral Thesis Committee for Alison Arter (Physiology/Pharmacology)
Title: Molecular Mechanisms for the Angiotensin-(1-7)-Mediated Inhibition of Metastatic Triple
Negative Breast Cancer
Degree Awarded: May, 2014.
2012-Pres. Member, Doctoral Thesis Committee for Christine Lehman (Cancer Biology)
Postdoctoral Fellows
1996-1999 Dr. Liyan Zhang
2003-2006 Dr. Jamie Jennings-Gee
At the University of Tennessee
Laboratory Rotations
Fall 1991 Special Topics in Pathobiology, Student Laboratory Rotation - Wayne Moore
1991
Center of Excellence Summer Student Research Program - Steven Warner
1992
Center of Excellence Summer Student Research Program - Mark Faldzinski
1993
Center of Excellence Summer Student Research Program - Janet Lewis
Thesis Committees
1991-1992 Co-advisor, Doctoral Thesis Committee for James Baxter, DVM (student withdrew from program
in 1992)
1991-1995 Member, Master's Thesis Committee for Wayne Moore (left UT before student completed his
degree requirements)
15
1994-1996 Major advisor, Master's Thesis Committee for Lisa Wessner
Title: Molecular Mechanisms Governing Lung Tumor Pathogenesis in Mice with Differing
Susceptibility to Polycyclic Hydrocarbon-Mediated Tumorigenesis
Degree Awarded: August, 1996
1994-1995 Member, Master's Thesis Committee for Jill Morris
Title: Benchmarking of Two Human Health Risk Assessment Methods: Description, Evaluation,
and Comparison of the Streamlined Programmatic Environmental Impact Statement Risk
Assessment Method and the Conventional Risk Assessment Methods
Degree Awarded: May, 1995
At the Laboratory of Comparative Carcinogenesis, NCI
1987-1990 Summer Student Research Training Program - Amy McDowell
1988
Independent Study Student from Hood College - Karen Bova
1988-1989 Postdoctoral advisor for Dr. Gregory Buzard
At the Massachusetts Institute of Technology
1985-1986 Undergraduate Research Opportunities Program - Masahiro Kono
Sum 1986 Undergraduate Research Opportunities Program - Karen Wu
Awards to Students, Postdocs, and Technicians
1. Kiersten Gressani, 1st place for the Best Poster Award at the Fall meeting of the Genotoxicity and
Environmental Mutagen Society, 1998.
2. Tasha Smith, 1st place for the Best Presentation Award at the Fall meeting of the Genotoxicity and
Environmental Mutagen Society, 1999.
3. Debbie Sachs, 2nd place for the Best Poster Award at the Fall meeting of the Genotoxicity and Environmental
Mutagen Society, 1999.
4. Tasha Smith, 1st place for the Travel Award at the annual meeting of the Environmental Mutagen Society,
2000.
5. Tasha Smith, 3rd place for the Molecular Biology Specialty Section Graduate Student Award at the annual
meeting of the Society of Toxicology, 2000.
6. Tasha Smith, Poster Award from the Risk Assessment Specialty Section at the annual meeting of the Society
of Toxicology, 2000.
7. Melissa Mizesko, 1st place for the Best Poster Award at the Fall meeting of the Genotoxicity and
Environmental Mutagen Society, 2000.
8. Tasha Smith, 2nd place for the Carcinogenesis Specialty Section Graduate Student Award at the annual
meeting of the Society of Toxicology, 2001.
9. Tasha Smith, Graduate Student Travel Award for the annual meeting of the Society of Toxicology, 2001.
10. Tasha Smith, AACR-AFLAC, Inc. Scholar in Training Award for travel to the annual meeting of the
American Association for Cancer Research, 2001.
11. Tasha Smith, Poster Award from the Risk Assessment Specialty Section at the annual meeting of the Society
of Toxicology, 2001.
12. Tasha Smith, Best Poster Award (1 of 6) for Graduate Student Research Day at Wake Forest University,
2001.
13. Heather Smith, Best Presentation Award at the Fall meeting of the Genotoxicity and Environmental Mutagen
Society, 2001.
14. Tasha Smith, 2nd place for the Best Poster Award at the Fall meeting of the Genotoxicity and Environmental
Mutagen Society, 2001.
15. Jessica Watkins, Fellowship, NIH Medical Student Summer Research Program, WFUSM, 2002 .
16. Heather Smith Floyd, 1st place for the Best Poster Award at the Fall meeting of the Genotoxicity and
Environmental Mutagen Society, 2002.
17. Main Xu, 2nd place for the Best Poster Award at the Fall meeting of the Genotoxicity and Environmental
Mutagen Society, 2002.
16
18. Heather Smith Floyd, 1st place for the Molecular Biology Specialty Section Graduate Student Award at the
annual meeting of the Society of Toxicology, 2003.
19. Stephanie Dance, Awarded NCI Minority Supplement grant, CA91909-S1, April 25, 2003 to March 31, 2006,
$66,150, 2003.
20. Heather Smith Floyd, Graduate Student Travel Award for the annual meeting of the Society of Toxicology,
2004.
21. Beth Van Emburgh, Dissertation Research Award from the Susan G. Komen Breast Cancer Foundation, May
1, 2004 to April 30, 2006, $30,000, 2004.
22. Beth Van Emburgh, 3rd place for Best Presentation Award, Dept. of Cancer Biology annual retreat, 2004.
23. Beth Van Emburgh, tied for 1st place for the Best Poster Award at the Fall meeting of the Genetics and
Environmental Mutagenesis Society, 2004.
24. Heather Smith Floyd, Merck Travel Award from the Carcinogenesis Specialty Section at the annual meeting
of the Society of Toxicology, 2005.
25. Stephanie Dance, AACR Minority Scholar Award for the AACR Frontiers in Cancer Prevention Research
conference, 2005.
26. Stephanie Dance, AACR Minority Scholar Award in Cancer Research for the 97th annual meeting, 2006.
27. Stephanie Dance, poster selected for presentation at a mini-symposium at the 97th annual meeting of the
AACR, 2006.
28. Stephanie Dance, received the American Foundation for Aging Research-GlaxoSmithKline Foundation
Award, $3,000 for the 2006-2007 academic year.
29. Stephanie Dance, selected to attend the NIH National Graduate Student Research Festival, 2006.
30. Stephanie Dance, WFUSM Lucy Robbins Fellowship Award, awarded annually to a 4th year graduate student
conducting cancer-related research in “recognition of outstanding academic and research expertise,
demonstrated leadership, outstanding interpersonal skills and a commitment to the ideals of excellence in
academic research”.
31. Stephanie Dance, Graduate Student Travel Award for the annual meeting of the Society of Toxicology, 2007.
32. Stephanie Dance, 1st place for the Carcinogenesis Specialty Section Graduate Student Award at the annual
meeting of the Society of Toxicology, 2007.
Educational Materials Developed
PowerPoint Tutorials for Faculty
1. Miller, M.S., Bodin, S.G., Gorney, B., and Clinch, C.R.: Student performance and curriculum enhancement:
how to grow life-long learners. 2007.
2. Bodin, S.G., Miller, M.S., and Clinch, C.R.: Providing feedback to students: concepts and considerations.
2007.
3. Stanton, C.A., Grant, E., and Miller, M.S.: Case writing guidelines. 2008.
Case Development
1. Demonte case on multiple myeloma. 2007.
2. Silverman case on breast cancer. 2007.
Community Service:
At the Wake Forest University School of Medicine
1996
Participated with two other scientists from WFUSM in discussions with Congressman Burr (RNC) regarding funding in the biomedical sciences.
1997
Interviewed by Stephanie Walker, a high school senior at the Salem Academy, for her Advanced
Placement biology project.
1997
Presented a talk on “Careers in the Biomedical Sciences” to the 6th grade class of Northwest
Middle School in Guilford County.
1998
Participated in the Society of Toxicology’s Minority Recruitment Program at the annual meeting
in Seattle, WA.
17
1998
Spoke at the Guilford County Board of Commissioners meeting on May 7th to protest plans for
airport expansion near residential housing.
1998
Arranged an open public forum on May 19th in Guilford County for State Assembly
Representative Steven Wood to give area residents a chance to voice concerns regarding a
proposed airport expansion. Was quoted in several newspaper articles and was featured on the
local TV and radio news programs.
1998
Spoke at an open public hearing of the House Finance Committee of the North Carolina State
General Assembly on June 25th regarding funding of a proposed airport expansion.
1998
Spoke at an open public Federal Aviation Administration Scoping Hearing on August 17th
regarding the environmental impact of a proposed airport expansion on the surrounding
communities. Was quoted in several newspaper articles and was featured on the local TV and
radio news programs.
1998
Invited to write a Guest Editorial for the Winston-Salem Journal on the health effects of a
proposed cargo hub expansion at the airport. Article appeared Aug. 29th.
1998
Provided background information for the Winston-Salem Journal on laureth sulfate after they
received an E-mail suggesting this compound, which is used in a large number of shampoos and
soaps, was a carcinogen. Quoted in the paper on Sept. 3rd.
1998
Sponsored a Surry High School student, Angie Leonard, for visit to my laboratory and discussion
of careers in science.
1998-2000 Scientific Consultant for Environmental Issues for the Piedmont Quality of Life Coalition.
1998
Invited to speak by a local civics group, the Piedmont Quality of Life Coalition, on
Environmental Chemicals and Effects on Human Health, Nov. 19th.
1999
Invited to write a Guest Editorial for the Greensboro News & Record on the health effects of a
proposed cargo hub expansion at the airport. Article appeared Jan.31st.
1999
Organized scientists from WFUSM, UNCG, and Greensboro A&T University (in conjunction
with the North Carolina Congressional Liaison Committee of the Joint Steering Committee for
Public Policy) to discuss issues relating to funding in the biomedical sciences with Congressman
Howard Coble (R-NC), March 30th.
1999
Gave a short talk and tour of my laboratory on careers in cancer research to a group of high
school seniors from Thomasville Senior High School for the TARGET HEALTH program, April
20th.
1999
Interviewed by and gave a tour of my laboratory to Martha Wolf and her son as part of his 3rd
grade assignment on careers from Jamestown Elementary School.
1999
Invited to give a talk at the High Point Rotary Club on Effects of Environmental Chemicals on
Human Health, May 6th.
1999
Invited to give a talk to the Guilford County Sierra Club on Effects of Environmental Chemicals
on Human Health, May 11th.
1999
Invited to give a talk to the Forsyth County Sierra Club on Effects of Environmental Chemicals on
Human Health, June 10th.
1999-2001 Faculty Representative for the WFUSM United Way Campaign in the Department of Cancer
Biology.
1999
Attended Friends...you can count on charity luncheon as one of the representatives from the
Comprehensive Cancer Center, September 29th.
2000
Provided mentorship experience for Glenn Martin from Philo Middle School by allowing student
to “shadow” me for half a day for Target Health & Screening Services, May 3rd.
2000
Interviewed by Southern Living magazine for an article about the Friends...you can count on
Foundation, April 28th; article appeared in March 2001 issue.
2000
Interviewed for article on the Friends...you can count on foundation; quoted in the Greensboro
News and Record, Sept. 12th edition of the paper.
2000
Invited to speak at the Friends...you can count on charity luncheon and dinner, Sept. 20th.
2000
Filmed a video on breast cancer research for the fund raising efforts of the Friends...you can
count on foundation that was distributed nationally to local news programs.
18
2001-2002 Treasurer, Co-founder, and Member of the Board of Directors for the Alliance for Legal Action, a
citizens group formed to raise funds to mount a legal challenge against airport expansion at the
Piedmont Triad International Airport.
2001
Interviewed by Sam Stokes, a high school sophomore at Northwest High School in Guilford
County, for his Honors biology project.
2001
Interviewed by Matthew Miller, a high school sophomore at Northwest High School in Guilford
County, for his Honors biology project.
2001
Attended Friends...you can count on charity dinner as one of the representatives from the
Comprehensive Cancer Center, October 4th.
2001
Invited to speak at a Hadassah meeting (a national Jewish women’s charity) on Breast Cancer
Research, October 29th.
2002
Attended Friends...you can count on charity dinner as one of the representatives from the
Comprehensive Cancer Center, October 17th.
2003
Participated in a discussion of the ethics of gene cloning and stem cell research at Beth David
Synagogue, Greensboro, NC, February 11th.
2003
Presented a talk on “Smoking Cessation: Smoking and Genetic Damage” to the 7th grade classes
of Kernodle Middle School in Guilford County, February 14th.
2003
Attended Friends...you can count on charity dinner as one of the representatives from the
Comprehensive Cancer Center, October 16th.
2004-2005 Member of the Board of Directors for the Alliance for Legal Action.
2004
Attended Friends...you can count on charity luncheon as one of the representatives from the
Comprehensive Cancer Center, October 20th.
2005
Attended Friends...you can count on charity dinner as one of the representatives from the
Comprehensive Cancer Center, October 11th.
2005
Provided mentorship experience for Laura Hollar, a senior from Ledford High School in
Davidson county, by allowing student to observe laboratory techniques and discuss careers in
science for 2 half days as part of her biology program, December 13th and 21st.
2009-2012 Executive Committee of the Men’s Club, Beth David Synagogue.
2009-2014 Assistant Organizer, Greensboro Tennis Meet-up Group.
2010-2014 Planning Committee, Annual Lung Cancer Initiative of NC 5K & 1 Mile Rally.
2010
Wrote a Guest Editorial for the Greensboro News and Record: “Lung Cancer is not Just for
Smokers”. Article appeared Aug. 28th.
2010
Interviewed on Nov. 4th by WXII television for a short piece on lung cancer funding. Interview
aired on Nov. 12th
2010
Live on air interview by WQMG radio station on lung cancer funding and the Free to
Breathe®Lung Cancer 5K & Rally on Nov. 6th. Interview ran throughout the week leading up to
the rally on Nov. 13th.
2010
Participated in the Community Outreach program for high school students, Nov. 10th.
2010
Key Note speaker and volunteer worker at the Free to Breathe®Lung Cancer 5K & Rally, Nov.
13th.
2011-2012 Treasurer of the Men’s Club, Beth David Synagogue.
2011
Live TV interview by WFMY TV station on lung cancer, Nov. 11th.
2012
Provided background information for Blake Bomier, Wake Forest University undergraduate, for
her Journalism class on health issues and lung cancer screening, Feb. 13th.
At the University of Tennessee
1990-1991 Sponsored tour of the College of Veterinary Medicine for pre-schoolers from the La Petite
Academy.
1991
Sponsored tours of the College of Veterinary Medicine for Kindergarten students from Blue
Grass elementary school.
1993-1994 Participated in the Science-by-Mail program sponsored by the National Science Center.
19
1994-1995 Presented demonstrations to the third grade class at Blue Grass elementary school on the "Parts of
the Human Body" and "Smoking Cessation".
1995
Sponsored tours of the College of Veterinary Medicine for Kindergarten students from Blue
Grass elementary school.
Bibliography
1.
Miller, M.S., Huang, M-T., Jeffrey, A.M., and Conney, A.H.: Betamethasone-mediated activation of
biphenyl 2-hydroxylation in rat liver microsomes: studies on possible mechanisms. Molec. Pharmacol.
24: 137-145, 1983.
2.
Miller, M.S., Huang, M-T., Williams, G.M., Jeffrey, A.M., and Conney, A.H.: Effects of betamethasone
on the in vitro and in vivo 2-hydroxylation of biphenyl in the rat. Drug Metab. Disp. 11: 556-561, 1983.
3.
Miller, M.S. and Wogan, G.N.: Inhibition of steroid-inducible tyrosine aminotransferase gene expression
by N-methyl-N'-nitro-N-nitrosoguanidine in a rat hepatoma cell line. Carcinogenesis 7: 1273-1278, 1986.
4.
Miller, M.S., Kono, M., and Wogan, G.N.: Inhibitory effects of N-methyl-N'-nitro-N-nitrosoguanidine
and benzo[a]pyrene-7,8-diol-9,10-epoxide on glucocorticoid-inducible polyoma virus middle-T gene
expression in rat mT-1 cells. Carcinogenesis 8: 1159-1163, 1987.
5.
Waalkes, M.P., Miller, M.S., Wilson, M.J., Bare, R.M., and McDowell, A.E.: Increased metallothionein
gene expression in 5-aza-2'-deoxycytidine-induced resistance to cadmium cytotoxicity. Chem.-Biol.
Interact. 66: 189-204, 1988.
6.
Miller, M.S., Jones, A.B., Chauhan, D.P., Park, S.S., and Anderson, L.M.: Differential induction of fetal
mouse liver and lung cytochromes P-450 by β-naphthoflavone and 3-methylcholanthrene. Carcinogenesis
10: 875-883, 1989.
7.
Anderson, L.M., Jones, A.B., Miller, M.S., and Chauhan, D.P.: Metabolism of transplacental
carcinogens. In: Transplacental and Multigeneration Carcinogenesis (Napalkov, N.P., Rice, J.M.,
Tomatis, L., and Yamasaki, H., Eds.) IARC Scientific Publications No. 96, Lyon, pp. 155-188, 1989.
8.
Miller, M.S.: Differential effects of N-methyl-N'-nitro-N-nitrosoguanidine on constitutive and hormoneinducible gene expression in rat hepatoma cells. Chem.-Biol. Interact. 73: 207-219, 1990.
9.
Miller, M.S., Jones, A.B., Park, S.S., and Anderson, L.M.: The formation of 3-methylcholanthreneinitiated lung tumors correlates with induction of cytochrome P-450IA1 by the carcinogen in fetal but not
adult mice. Toxicol. Appl. Pharmacol. 104: 235-245, 1990.
10.
Miller, M.S., Jones, A.B., Chauhan, D.P., and Anderson, L.M.: Role of the maternal environment in
determining susceptibility to transplacentally-induced chemical carcinogenesis in mouse fetuses.
Carcinogenesis 11: 1979-1984, 1990.
11.
Chauhan, D.P., Miller, M.S., Owens, I.S., and Anderson, L.M.: Perinatal development of UDPglucuronosyl transferase activity and gene expression in mouse fetal liver and transplacental induction by
β-naphthoflavone. Develop. Pharmacol. Therap. 16: 139-149, 1991.
12.
Miller, M.S., Jones, A.B., Chauhan, D.P., Park, S.S., and Anderson, L.M.: Induction of cytochrome P450IA1 in fetal rat liver by a single dose of 3-methylcholanthrene. Biochem. Biophys. Res. Commun. 176:
280-287, 1991.
13.
Lubet, R.A., Dragnev, K.H., Chauhan, D.P., Nims, R.W., Diwan, B.A., Ward, J.M., Jones, C.R., Rice,
J.M., and Miller, M.S.: A pleiotropic response to phenobarbital-type enzyme inducers in the F344/NCr
rat: effects of chemicals of varied structure. Biochem. Pharmacol. 43: 1067-1078, 1992.
14.
Lubet, R.A., Nims, R.W., Dragnev, K.H., Jones, C.R., Diwan, B.A., Devor, D.E., Ward, J.M., Miller,
M.S., and Rice, J.M.: A markedly diminished pleiotropic response to phenobarbital and structurallyrelated xenobiotics in Zucker rats in comparison with F344/NCr or DA rats. Biochem. Pharmacol. 43:
1079-1087, 1992.
15.
Miller, M.S., Warner, S.P., Jorquera, R., Castonguay, A., and Schuller, H.M.: Expression of the
cytochrome P-4502E and 2B gene families in the lungs and livers of nonpregnant, pregnant, and fetal
hamsters. Biochem. Pharmacol. 44: 797-803, 1992.
16.
Miller, M.S., Buzard, G.S., and McDowell, A.E.: In vivo inhibition of glucocorticoid-inducible gene
expression by dimethylnitrosamine in rat liver. Biochem. Pharmacol. 45: 1465-1470, 1993.
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Wahba, Z.Z., Miller, M.S., and Waalkes, M.P.: Absence of changes in metallothionein RNA in the rat
testes made refractory to cadmium toxicity by zinc pretreatment. Human Exp. Toxicol. 13: 65-67, 1994.
Miller, M.S., Baxter, J.L., Moore, J.W., Lewis, J.D., and Schuller, H.M.: Molecular characterization of
neuroendocrine lung tumors induced in hamsters by treatment with nitrosamines and hyperoxia. Intl. J.
Oncol. 4: 5-12, 1994.
Miller, M.S.: Transplacental lung carcinogenesis: a pharmacogenetic mouse model for the modulatory
role of cytochrome P450 1A1 on lung cancer initiation. Chem. Res. Toxicol. 7: 471-481, 1994.
Yang, Z., Carter, C.D., Miller, M.S., and Bochsler, P.N.: CD14 and tissue factor expression by bacterial
lipopolysaccharide-stimulated bovine alveolar macrophages in vitro. Infect. Immun. 63: 51-56, 1995.
Jian, Z.J., Yang, Z.G., Miller, M.S., Carter, C.D., Slauson, D.O., and Bochsler, P.N.: Interleukin-6
secretion by bacterial lipopolysaccharide-stimulated bovine alveolar macrophages in vitro. Vet. Immunol.
Immunopath. 49: 1-10, 1995.
Miller, M.S., Fan, M., and Schuller, H.M.: Induction of c-fos expression following stimulation of
pulmonary neuroendocrine cell proliferation by alterations in CO2/O2 concentration. Intl. J. Oncol. 8:
423-429, 1996.
Schuller, H.M., Miller, M.S., Park, P.G., and Orloff, M.: Promoting mechanisms of CO2 on
neuroendocrine cell proliferation mediated by nicotinic receptor stimulation: significance for the lung
cancer risk in individuals with chronic lung disease. Chest (Supplement) 109: 20S-21S, 1996.
Yang, Z., Breider, M.A., Carroll, R.C., Miller, M.S., and Bochsler, P.N.: Soluble CD14 and
lipopolysaccharide-binding protein from bovine serum enable bacterial lipopolysaccharide-mediated
cytotoxicity and activation of bovine vascular endothelial cells in vitro. J. Leukoc. Biol. 59: 241-247,
1996.
Wessner, L.L., Fan, M., Schaeffer, D.O., McEntee, M.F., and Miller, M.S.: Mouse lung tumors exhibit
specific Ki-ras mutations following transplacental exposure to 3-methylcholanthrene. Carcinogenesis 17:
1519-1526, 1996.
Miller, M.S., Juchau, M.R., Guengerich, F.P., Nebert, D.W., and Raucy, J.L.: Drug metabolic enzymes in
developmental toxicology. Fund. Appl. Toxicol. 34: 165-175, 1996.
Leone-Kabler, S., Wessner, L.L., McEntee, M.F., D’Agostino, Jr., R.B., and Miller, M.S.: Ki-ras
mutations are an early event and correlate with tumor stage in transplacentally-induced murine lung
tumors. Carcinogenesis 18: 1163-1168, 1997.
Miller, M.S., McCarver, D.G., Bell, D.A., Eaton, D.L., and Goldstein, J.A.: Genetic polymorphisms in
human drug metabolic enzymes. Fund. Appl. Toxicol. 40: 1-14, 1997.
Rollins, L.A., Kabler-Leone, S., O’Sullivan, M.G., and Miller, M.S.: Role of tumor suppressor genes in
transplacental lung carcinogenesis. Molec. Carcinogenesis 21: 177-184, 1998.
Gressani, K.M., Rollins, L.A., Leone-Kabler, S., Cline, J.M., and Miller, M.S.: Induction of mutations in
Ki-ras and INK4a in liver tumors of mice exposed in utero to 3-methylcholanthrene. Carcinogenesis 19:
1045-1052, 1998.
Miller, M.S., Leone-Kabler, S., Rollins, L.A., Wessner, L.L., Fan, M., Schaeffer, D.O., McEntee, M.F.,
and O’Sullivan, M.G.: Molecular pathogenesis of transplacentally-induced mouse lung tumors. Exp. Lung
Research 24: 557-577, 1998.
Hulla, J.E., Miller, M.S., Taylor, J.A., Hein, D.W., Furlong, C.E., Omiecinski, C.J., and Kunkel, T.A.:
The role of genetic polymorphisms and repair deficiencies in environmental disease. Toxicol. Sci. 47:
135-143, 1999.
Miller, M.S.: Tumor suppressor genes in rodent lung carcinogenesis - mutation of p53 does not appear to
be an early lesion in lung tumor pathogenesis. Toxicol. Appl. Pharmacol. 156: 70-77, 1999.
Gressani, K.M., Leone-Kabler, S., O’Sullivan, M.G., Case, L.D., Malkinson, A.M. and Miller, M.S.:
Strain-dependent lung tumor formation in mice transplacentally exposed to 3-methylcholanthrene and
postnatally exposed to butylated hydroxytoluene. Carcinogenesis 20: 2159-2165, 1999.
Frankel, A.E., McCubrey, J., Miller, M.S., Delatte, S., Ramage, J., Kiser, M., Kucera, G.L., Alexander,
R.L., Beran, M., Tagge, E.P., Hall, P.D., Kreitman, R.J., and Hogge, D.: Diphtheria toxin fused to human
interleukin-3 is toxic to blasts from patients with myeloid leukemias. Leukemia 14: 576-585, 2000.
21
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Gressani, K.M., Leone-Kabler, S., O’Sullivan, M.G., Townsend, A.J., and Miller, M.S.: Prenatal toxicity
and lack of carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) following transplacental
exposure. Toxicol. Sci. 55: 407-414, 2000.
Mattes, W.B. and Miller, M.S.: PCR: methods and limitations. In: Genetic Polymorphisms and
Susceptibility to Disease (Miller, M.S. and Cronin, M.T., Eds.) Taylor and Francis, London, pp.17-39,
2000.
Zhang. L., Weddle, D.L., Thomas, P.E., Zheng, B., Castonguay, A., Schuller, H.M., and Miller, M.S.:
Low levels of expression of cytochromes P-450 in normal and cancerous fetal pancreatic tissues of
hamsters treated with NNK and/or ethanol. Toxicol. Sci. 56: 313-323, 2000.
Frankel, A.E., Ramage, J., Gannaway, S., Kiser, M., Alexander, R., Kucera, G., and Miller, M.S.:
Characterization of diphtheria fusion toxins targeted to the interleukin-3 receptor. Protein Engineering
13: 575-581, 2000.
Miller, M.S., Gressani, K.M, Leone-Kabler, S., Townsend, A.J., Malkinson, A.M., and O’Sullivan, M.G.:
Differential sensitivity to lung tumorigenesis following transplacental exposure of mice to polycyclic
hydrocarbons, heterocyclic amines, and lung tumor promoters. Exp. Lung Research 26: 709-730, 2000.
Kiser, M., McCubrey, J.A., Steelman, L.S., Shelton, J.G., Ramage, J., Alexander, R.L., Kucera, G.L.,
Pettenati, M., Willingham, M.C., Miller, M.S., and Frankel, A.E.: Oncogene-dependent engraftment of
human myeloid leukemia cells in immunosuppressed mice. Leukemia 15: 814-818, 2001.
Hu, J.J., Smith, T.R., Miller, M.S., Mohrenweiser, H.W., Golden, A. and Case, L.D.: Amino acid
substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity.
Carcinogenesis 22: 917-922, 2001.
Mizesko, M.C., Grewe, C., Grabner, A., and Miller, M.S.: Alterations at the Ink4a locus in
transplacentally induced murine lung tumors. Cancer Lett. 172: 59-66, 2001.
Hu, J.J., Smith, T.R., Miller, M.S., Lohman, K., and Case, L.D.: Genetic regulation of ionizing radiation
sensitivity and breast cancer risk. Environ. Molec. Mutagenesis 39: 208-215, 2002.
Govindarajan, B., Klafter, R., Miller, M.S., Mansur, C., Mizesko, M., Bai, X., LaMontagne, Jr., K., and
Arbiser, J.L.: Reactive oxygen-induced carcinogenesis causes hypermethylation of p16Ink4a and activation
of MAP kinases. Molecular Med. 8: 1-8, 2002.
Witschi, H., Espiritu, I., Dance, S.T., and Miller, M.S.: A mouse lung tumor model of tobacco smoke
carcinogenesis. Toxicol. Sci. 68: 322-330, 2002.
Schuller, H.M., Zhang, L., Weddle, D.L, Castonguay, A., Walker, K., and Miller, M.S.: The
cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis
induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK. J. Cancer
Res. Clin. Oncology 128: 525-532, 2002.
Hu, J.J., Mohrenweiser, H.W. Bell, D.A., Leadon, S.A., and Miller, M.S.: Genetic polymorphisms in
DNA repair and cancer risk. Toxicol. Appl. Pharmacol. 185: 64-73, 2002.
Smith, T.R., Miller, M.S., Lohman, K., Lange, E.M., Case, L.D., Mohrenweiser, H.W., and Hu, J.J.:
Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer. Cancer Lett. 190: 183190, 2003.
Smith, T.R., Miller, M.S., Lohman, K., Case, L.D., and Hu, J.J.: DNA damage and breast cancer risk.
Carcinogenesis 24: 883-889, 2003.
Cui, Z., Willingham, M.C., Hicks, A.M., Alexander-Miller, M.A., Howard, T.D., Hawkins, G.A., Miller,
M.S., Weir, H.M., Du, W., and DeLong, C.J.: Spontaneous regression of advanced cancer: identification
of a unique genetically determined, age-dependent trait in mice. Proc. Natl. Acad. Sci., USA 100: 66826687, 2003.
Govindarajan, B., Mizesko, M.C., Miller, M.S., Onda, H., Nunnelly, M., Casper, K., Brat, D., Cohen, C.,
and Arbiser, J.L.: Tuberous sclerosis-associated neoplasms express activated p42/44 mitogen-activated
protein (MAP) kinase, and inhibition of MAP kinase signaling results in decreased in vivo tumor growth.
Clin. Cancer Res. 9: 3469-3475, 2003.
22
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Smith, T.R., Levine, E.A., Perrier, N.D., Miller, M.S., Freimanis, R.I., Lohman, K., Case, L.D., Xu, J.,
Mohrenweiser, H.W., and Hu, J.J.: DNA-repair genetic polymorphisms and breast cancer risk. Cancer
Epidem. Biomarkers, and Prev. 12: 1200-1204, 2003.
Xu, M., Floyd, H.S., Greth, S.M., Chang, W.-C.L., Lohman, K., Stoyanova, R., Kucera, G.L., Kute, T.E.,
Willingham, M.C., and Miller, M.S.: Perillyl alcohol-mediated inhibition of lung cancer cell line
proliferation: potential mechanisms for its chemotherapeutic effects. Toxicol. Appl. Pharmacol. 195: 232246, 2004.
Liu, T.E., Urieto, J.O.,Moore, J.E., Miller, M.S., Lowe, A.C., Thorburn, A., and Frankel, A.E.:
Diphtheria toxin fused to variant interleukin-3 provides enhanced binding to the interleukin-3 receptor
and more potent leukemia cell cytotoxicity. Exp. Hematol. 32: 277-281, 2004.
Miller, M.S.: Transplacental lung carcinogenesis: molecular mechanisms and pathogenesis. Toxicol.
Appl. Pharmacol. 198: 95-110, 2004.
Arbiser, J.L., Fan, C.-H., Su, X., Van Emburgh, B.O., Cerimele, F., Miller, M.S., Harvell, J., and
Marinkovich, P.: Involvement of p53 and p16 tumor suppressor genes in recessive dystrophic
epidermolysis bullosa-associated squamous cell carcinoma. J. Invest. Dermatol. 123: 788-790, 2004.
Xu, M. and Miller, M.S.: Determination of murine fetal Cyp1a1and 1b1 expression by real-time
fluorescence reverse transcription-polymerase chain reaction. Toxicol. Appl. Pharmacol. 201: 295-302,
2004.
Xu, M., Nelson, G.B., Moore, J.E., McCoy, T.P., Dai, J., Manderville, R.A., Ross, J.A., and Miller, M.S.:
Induction of Cyp1a1 and Cyp1b1 and formation of DNA adducts in C57BL/6, Balb/c, and F1 mice
following in utero exposure to 3-methylcholanthrene. Toxicol. Appl. Pharmacol. 209: 28-38, 2005.
Floyd, H.S., Farnsworth, C.L., Kock, N.D., Mizesko, M.C., Little, J.L., Dance, S.T., Everitt, J., Tichelaar,
J., Whitsett, J.A., and Miller, M.S.: Conditional expression of the mutant Ki-rasG12C allele results in
formation of benign lung adenomas: development of a novel mouse lung tumor model. Carcinogenesis
26: 2196-2206, 2005.
Yu, Z., Loehr, C.V., Fischer, K.A., Louderback, M.A., Krueger, S.K., Dashwood, R.H., Kerkvliet, N.I.,
Pereira, C.B., Jennings-Gee, J.E., Dance, S.T., Miller, M.S., Bailey, G.S., and Williams, D.E.: In utero
exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon
receptor. Cancer Res. 66: 755-762, 2006.
Floyd, H.S., Jennings-Gee, J., Kock, N.D., and Miller, M.S.: Genetic and epigenetic alterations in lung
tumors from bitransgenic Ki-rasG12C expressing mice. Molec. Carcinogenesis 45: 506-517, 2006.
Xu, M., Moore, J.E., Leone-Kabler, S., McCoy, T.P., Swank, A., Ross, J.A., Townsend, A.J., and Miller,
M.S.: Expression of glutathione S-transferases in fetal lung and liver tissue from C57BL/6, Balb/c, and
F1 mice following in utero exposure to 3-methylcholanthrene. Biochem. Pharmacol. 72: 115-123, 2006.
Jennings-Gee, J.E., Moore, J.E., Xu, M., Dance, S.T., Kock, N.D., McCoy, T.P., Carr, J.J., and Miller,
M.S.: Strain specific induction of murine lung tumors following in utero exposure to 3methylcholanthrene. Molec. Carcinogenesis 9: 676-684, 2006.
Petty, W.J., Knight, S.N., Mosley, L., Lovato, J., Capellari, J., Tucker, R., Blackstock, W., Miller, M.S.,
and Miller, A.A.: A pharmacogenomic study of docetaxel and gemcitabine for the initial treatment of
advanced non-small cell lung cancer. J. Thoracic Oncol. 2: 197-202, 2007.
Van Emburgh, B.O., Hu, J.J., Levine, E.A., Mosley, L.J., Case, D.L., Lin, H.-Y., Knight, S.N., Perrier,
N.D., Rubin, P., Sherrill, G.B., Shaw, C.S., Carey, L.A., Sawyer, L.R., Allen, G.O., Willingham, M.C.,
and Miller, M.S.: Polymorphisms in drug metabolism genes, smoking, and p53 mutations in breast
cancer. Molec. Carcinogenesis 47: 89-99, 2008.
Van Emburgh, B.O., Allen, G.O., Hu, J.J., Levine, E.A., Mosley, L.J., Perrier, N.D., Freimanis, R.I., Lin,
H.-Y., Rubin, P., Sherrill, G.B., Shaw, C.S., Carey, L.A., Sawyer, L.R., and Miller, M.S.:
Polymorphisms in CYP1B1, GSTM1, GSTT1, and GSTP1 and susceptibility to breast cancer. Oncology
Reports 19: 1311-1321, 2008.
Dance-Barnes, S.T., Kock, N.D., Floyd, H.S., Moore, J.E., Mosley, L.J., D’Agostino, Jr., R.B., Pettenati,
M.J., and Miller, M.S.: Effects of mutant human Ki-rasG12C gene dosage on murine lung tumorigenesis
and signaling to its downstream effectors. Toxicol. Appl. Pharmacol. 231: 77-84, 2008.
23
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Dance-Barnes, S.T., Kock, N.D., Moore, J.E., Lin, E.Y., Mosley, L.J., D’Agostinto, Jr., R.B., McCoy,
T.P., Townsend, A.J., and Miller, M.S.: Lung tumor promotion by curcumin. Carcinogenesis, 30: 10161023, 2009.
Jennings-Gee, J.E., Tozlovanu, M., Manderville, R., Miller, M.S., Pfohl-Leszkowicz, A., and Schwartz,
G.G.: Ochratoxin A: In utero exposure in mice induces adducts in testicular DNA. Toxins, 2: 1428-1444,
2010.
Chen, L., Moore, J., Samathanam, C., Shao, C., Cobos, E., Miller, M.S., and Gao, W.: CRM-dependent
p53 nuclear accumulation in lung lesions of a bitransgenic mouse lung tumor model. Oncology
Reports,26: 223-228, 2011.
Smith, T.R., Liu-Mares, W., Van Emburgh, B.O., Levine, E.A., Allen,G.O., Hill, J.W., Miller, M.S., Hu,
J.J.: Genetic polymorphisms of multiple DNA repair pathways impact age of diagnosis and TP53
mutations in breast cancer. Carcinogenesis, 1354-1360, 2011.
Munley, M.T., Moore, J.E., Walb, M.C., Isom, S.P., Olson, J.D., Zora, J.G., Kock, N.D., Wheeler, K.T.,
and Miller, M.S.: Cancer-prone mice expressing the Ki-rasG12Cgene show increased lung carcinogenesis
after CT screening exposures. Radiation Research, 176: 842-848, 2011.
A news release of this research was reported by 12 online media outlets: Health Imaging, The Medical
news, News Blaze, e!science news, Health News, Healthnewsdigest.com, Bioportfolio, Business Leader,
Health Imaging Hub, auntminnie.com, moledularimaging.net, and news-line.com.
Miller, M.S. and Miller, L.D.: RAS mutations and oncogenesis: not all RAS mutations are created
equally. Frontiers in Genetics, 2: doi: 10.3389/fgene.2011.00100, Epub 2012. Invited review.
Miller, M.S.: Transplacental Carcinogenesis. In: Encyclopedia of Cancer (Schwab, M., Ed.) Springer
Reference
(www.springerreference.com).
Springer-Verlag
Berlin
Heidelberg,
2012.
DOI:10.1007/Springer Reference_303446 2012-02-01 14:59:05 UTC. Invited Review.
Walb, M.C., Moore, J.E., Attia, A., Wheeler, K.T., Miller, M.S., and Munley, M.T.: A technique for
murine irradiation in a controlled gas environment. Biomed. Sci. Instrum., 48: 470-477, 2012.
Olson, J.D., Walb, M.C., Moore, J.E., Attia, A., Sawyer, H.L., Wheeler, K.T., Miller, M.S., and Munley,
M.T.: A gated-7T MRI technique for tracking lung tumor development and progression in mice after
exposure to low doses of ionizing radiation. Radiation Research, 178: 321-327, 2012.
Miller, M.S., Moore, J.E., Walb, M.C., Kock, N.D., Attia, A., Isom, S., McBride, J.E.,Wheeler, K., and
Munley, M.T.: Chemoprevention by N-acetylcysteine of low dose CT-induced increases murine lung
tumorigenesis. Carcinogenesis, 34: 319-324, 2013.
Books Edited
1.
Genetic Polymorphisms and Susceptibility to Disease (Miller, M.S. and Cronin, M.T., Eds.) Taylor and
Francis, London, 2000.
Submissions to Genetic Databases
1.
GenBank U70769: Mus musculus p53 gene, intron 4, partial sequence showing polymorphism. Rollins,
L.A., Fan, M., Gressani, K.M., Schaeffer, D.O., and Miller, M.S. (1996).
2.
GenBank AF004588: Mus musculus p16INK4a (Cdkn2a) gene, exon 1, and partial cds. Gressani, K.M.,
Rollins, L.A., and Miller, M.S. (1997).
3.
GenBank AF063903: Mesocricetus auratus Ki-ras protein (Ki-ras) gene, exon 2 and partial cds. Zhang,
L., Schuller, H.M., and Miller, M.S. (1998).
4.
GenBank AF097940: Mesocricetus auratus N-ras gene, exon 1, partial sequence. Zhang, L., Schuller,
H.M., and Miller, M.S. (1998).
5.
GenBank AF097941: Mesocricetus auratus N-ras gene, exon 2, partial sequence; and partial cds. Zhang,
L., Schuller, H.M., and Miller, M.S. (1998).
6.
GenBank AF140035: Mesocricetus auratus tumor suppressor p53 gene, partial cds. Zhang, L., Schuller,
H.M., and Miller, M.S. (1999).
24
Transgenic Mouse Model Developed
1.
FVB-Tg(tetO/CMV-KRAS*G12C)9.1Msmi/J (Deposited in The Jackson Laboratory repository, stock
number 006439)
Abstracts
1.
Miller, M.S., Huang, M-T., Jeffrey, A.M., and Conney, A.H.: Studies on the mechanism of activation of
biphenyl 2-hydroxylation by betamethasone in rat liver microsomes. Pharmacologist 24: 608, 1982.
2.
Miller, M.S. and Wogan, G.N.: Inhibitory effects of MNNG on steroid-inducible tyrosine
aminotransferase gene expression in a rat hepatoma cell line. Pharmacologist 27: 896, 1985.
3.
Miller, M.S.: Effects of N-methyl-N'-nitro-N-nitrosoguanidine on steroid-inducible gene expression.
Proc. Am. Assoc. Cancer Res. 29: 551, 1988.
4.
Miller, M.S., Jones, A.B., Park, S.S., and Anderson, L.M.: Differential induction of cytochrome(s) P-450
in fetal mouse liver and lung by ß-naphthoflavone and 3-methylcholanthrene. Proc. Am. Assoc. Cancer
Res. 29: 493, 1988.
5.
Miller, M.S., Jones, A.B., and Anderson, L.M.: 3-Methylcholanthrene-initiated lung tumors correlate
with cytochrome P-450IA1 induction in fetal but not adult mice. Toxicologist 9: 512, 1989.
6.
Miller, M.S., Jones, A.B., and Anderson, L.M.: Maternal phenotype for the Ah locus has no influence on
the induction of aryl hydrocarbon hydroxylase activity in D2B6F1 mouse fetuses. Proc. Am. Assoc.
Cancer Res. 30: 630, 1989.
7.
Chauhan, D.P., Miller, M.S., Owens, I.S., and Anderson, L.M.: Perinatal development of UDPglucuronosyl transferase activity and gene expression in mouse fetal liver and transplacental induction by
β-naphthoflavone. Proc. Am. Assoc. Cancer Res. 30: 647, 1989.
8.
Miller, M.S. and Chauhan, D.P.: Expression of the polyoma virus middle-T gene in rat fibroblasts
increases the steady-state levels of α-tubulin RNA accumulation. Proc. Am. Assoc. Cancer Res. 30: 1807,
1989.
9.
Miller, M.S., Jones, A.B., Chauhan, D.P., and Anderson, L.M.: A single dose of 3-methylcholanthrene
(MC) induces cytochrome P-450s in fetal rat tissues. Toxicologist 10: 1293, 1990.
10.
Buzard, G.S., McDowell, A.E., and Miller, M.S.: Dimethylnitrosamine-mediated inhibition of steroidinducible gene expression in vivo. Proc. Am. Assoc. Cancer Res. 31: 812, 1990.
11.
Lubet, R.A., Nims, R.W., Chauhan, D.P., Jones, C.R., Miller, M.S., and Rice, J.M.: Induction of a
pleiotropic response by phenobarbital (PB) type inducers in rat liver. Proc. Am. Assoc. Cancer Res. 31:
933, 1990.
12.
Jones, C.R., Lubet, R.A., Nims, R.W., Diwan, B.A., Devor, D.E., Ward, J.M., Miller, M.S., and Rice,
J.M.: A "pleiotropic" response to phenobarbital (PB), barbital (BB), and ethylphenylhydantoin (EPH) in
DA and F344 rats and a relative absence of this response in Zucker rats. FASEB J. 4: 1623, 1990.
13.
Wahba, Z.Z., Miller, M.S., and Waalkes, M.P.: Absence of changes in metallothionein RNA levels in rat
testes made refractory to cadmium toxicity by metal pretreatment. Toxicologist 11: 1259, 1991.
14.
Miller, M.S., Jorquera, R., Warner, S.P., Castonguay, A., and Schuller, H.M.: Expression of CYPIIE1
and CYPIIB1/B2 in nonpregnant, pregnant, and fetal hamsters. Proc. Am. Assoc. Cancer Res. 33: 914,
1992.
15.
Miller, M.S., Moore, J.W., and Schuller, H.M.: Oncogene RNA expression in hamster neuroendocrine
lung tumors induced by treatment with nitrosamines and hyperoxia. Proc. Am. Assoc. Cancer Res. 33:
638, 1992.
16.
Schuller, H.M., Miller, M.S., and Reznik, G.K.: Antiproliferative effects of dihydropyridines on human
lung cancer cell lines. Proc. Am. Assoc. Cancer Res. 34: 2069, 1993.
17.
Miller, M.S. and Schuller, H.M.: The mitogenic effect of nicotine on fetal pulmonary neuroendocrine
cells. Toxicologist 14: 427, 1994.
18.
Miller, M.S. and Schuller, H.M.: Nicotine stimulates the proliferation of fetal hamster neuroendocrine
lung cells. Proc. Am. Assoc. Cancer Res. 35: 746, 1994.
25
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20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
Yang, Z., Miller, M.S., Slauson, D.O., and Bochsler, P.N.: Tissue factor expression and Northern blot
analysis of LPS-stimulated bovine alveolar macrophages: relationship to the CD14 receptor. FASEB J. 8:
3940, 1994.
Bochsler, P.N., Yang, Z., Miller, M.S., and Breider, M.A.: Anti-CD14 monoclonal antibody inhibits
bovine serum dependent tissue factor expression and cytotoxicity in bovine vascular endothelial cells.
FASEB J. 8: 1825, 1994.
Jian, Z., Yang, Z., Miller, M.S., Carter, C.D., Slauson, D.O., and Bochsler, P.N.: Interleukin-6 secretion
by bacterial lipopolysaccharide-stimulated bovine alveolar macrophages in vitro. J. Leukoc. Biol. Suppl.
56: 90, 1994.
Mason, G.L., Yang, Z., Jian, Z-J., Olchowy, T.W.J., Miller, M.S., and Bochsler, P.N.: Induction of nitric
oxide synthase (iNOS) in bovine alveolar macrophages: effects of bacterial lipopolysaccharide, serum,
and cytokines. FASEB J. 9: 6023, 1995.
Miller, M.S.: Drug metabolic enzymes in developmental toxicology: introduction. Fund. Appl.
Toxicology, Supplement (Toxicologist) 30: 213, 1996.
Miller, M.S., Wessner, L.L., Fan, M., McEntee, M.F., and Schaeffer, D.O.: Frequent mutations in Ki-ras
in mouse lung tumors following transplacental exposure to 3-methylcholanthrene. Fund. Appl.
Toxicology, Supplement (Toxicologist) 30: 218, 1996.
Wessner, L.L., Fan, M., Schaeffer, D.O., McEntee, M.F., and Miller, M.S.: Role of oncogenes in
transplacental carcinogenesis. Proc. Am. Assoc. Cancer Res. 37: 887, 1996.
Miller, M.S. and Eaton, D.L.: Genetic polymorphisms in human drug metabolic enzymes: introduction.
Fund. Appl. Toxicology, Supplement (Toxicologist) 36: 1694, 1997.
Kabler, S.L., Wessner, L.L., McEntee, M.F., and Miller, M.S.: Specific Ki-ras mutations correlate with
tumor stage in transplacentally-induced murine lung tumors. Fund. Appl. Toxicology, Supplement
(Toxicologist) 36: 894, 1997.
Rollins, L.A., Fan, M., Gressani, K.M., Schaeffer, D.O., and Miller, M.S.: Analysis of transplacentallyinduced murine lung tumors for p53 mutations - identification of a genetic polymorphism. Fund. Appl.
Toxicology, Supplement (Toxicologist) 36: 599, 1997.
Gressani, K.M., Kabler, S.L., Cline, M.J., and Miller, M.S.: Induction of Ki-ras mutations in liver
neoplasms following in utero exposure to environmental toxicants. Proc. Am. Assoc. Cancer Res. 38:
250, 1997.
Fan, M., Miller, M.S., and Schuller, H.M.: Progression of phenotypic and genetic markers of NNKinduced neuroendocrine lung tumors into adenocarcinomas. Proc. Am. Assoc. Cancer Res. 38: 3920,
1997.
Hulla, J.E. and Miller, M.S.: The role of genetic polymorphisms and repair deficiencies in environmental
disease. Toxicological Sciences, Supplement (Toxicologist) 42(1-S): 563, 1998.
Gressani, K., Leone-Kabler, S., Malkinson, A., and Miller, M.S.: Transplacental effects of dietary and
environmental carcinogens. Proc. Am. Assoc. Cancer Res. 40: 997, 1999.
Zhang, L., Schuller, H.M., and Miller, M.S.: Absence of mutations in Ki-, Ha- and N-ras and p53 genes
in transplacentally induced hamster pancreatic adenocarcinomas. Proc. Am. Assoc. Cancer Res. 40: 2305,
1999.
Smith, T.R., Miller, M.S., Lohman, K., and Hu, J.J.: DNA repair genes - potential cancer susceptibility
genes. Toxicological Sciences, Supplement (Toxicologist) 54(1-S): 880, 2000.
Smith, T.R., Miller, M.S., Lohman, K., Mohrenweiser, H.W., and Hu, J.J.: DNA repair gene-gene
interaction and breast cancer risk. Environ. Molec. Mutagenesis (Supplement 31) 35: 194, 2000.
Smith, T.R., Miller, M.S., Lohman, K., Mohrenweiser, H.W., and Hu, J.J.: Polymorphisms of DNA
repair genes in breast cancer. Proc. Am. Assoc. Cancer Res. 41: 817, 2000.
Miller, M.S., Kucera, G.L., Hogge, D., McCubrey, J., Ramage, J., Kiser, M., Alexander, R.L., Kreitman,
R., and Frankel, A.: Diphtheria toxin/interleukin-3 (DT/IL-3) fusion protein is toxic to blasts from
patients with acute phase chronic myeloid leukemia and acute myeloid leukemia. Proc. Am. Assoc.
Cancer Res. 41: 1816, 2000.
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Klafter,R., Miller, M.S., Mansur, C., Mizesko, M., Bai, X., LaMontagne, K., and Arbiser, J.L.: Genetic
and signal transduction analysis of a nickel sulfide-induced sarcoma. Proc. Am. Assoc. Cancer Res. 41:
2760, 2000.
Sachs, D., Fleming, R.A., and Miller, M.S.: Biochemical modulation of mitomycin C by induction of
NAP(P)H:quinone reductase. Proc. Am. Assoc. Cancer Res. 41: 2816, 2000.
Hu, J.J. and Miller, M.S.: Genetic polymorphisms in DNA repair and cancer risk. Toxicological Sciences,
Supplement (Toxicologist) 60(1-S): 1556, 2001.
Hu, J.J., Smith, T.R., Miller, M.S., Anderson, J., Mohrenweiser, H.W., and Sandler, R.S.: Functional
significance of DNA repair variants in human cancer risk. Toxicological Sciences, Supplement
(Toxicologist) 60(1-S): 1558, 2001.
Miller, M.S., Mizesko, M.C., Grewe, C., and Grabner, A.: Different mutant Ki-ras alleles determine
subsequent damage at the Ink4a locus in transplacentally induced murine lung tumors. Toxicological
Sciences, Supplement (Toxicologist) 60(1-S): 736, 2001.
Smith, T.R., Golden, A., Miller, M.S., Mohrenweiser, H.W., and Hu, J.J.: Amino acid substitution
variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity. Toxicological Sciences,
Supplement (Toxicologist) 60(1-S): 1204, 2001.
Kucera, G.L., Kiser, M., Alexander, R.L., Ramage, J., Miller, M.S., McCubrey, J.A., Willingham, M.C.,
and Frankel, A.E.: Development of an animal model for human acute myeloid leukemia (AML). Proc.
Am. Assoc. Cancer Res. 42: 2698, 2001.
Smith, T.R., Golden, A., Miller, M.S., Mohrenweiser, H.W., and Hu, J.J.: Association between DNA
repair genetic variants APE1 and XRCC1 and hypersensitivity to ionizing radiation. Proc. Am. Assoc.
Cancer Res. 42: 188, 2001.
Govindarajan, B., Miller, M.S., Kwiatkowski, D., Onda, H., Nunnelly, M., Brown, L.F., and Arbiser,
J.L.: Collaboration between MAP kinase activation and p16 deletion in a tuberous sclerosis-related
sarcoma. J. Invest. Dermatol. 116: 608, 2001.
Frankel, A.E., Black, J.H., Ramage, J.G, Miller, M.S., Hogge, D.E., McCubrey, J., and Willingham,
M.C.: Diphtheria toxin-interleukin 3 fusion protein (DT388IL3) prolongs survival of leukemic SCID mice.
Blood 98:1386, 2001.
Miller, M.S. and Anderson, L.M.: Transplacental carcinogenesis of environmental toxicants.
Toxicological Sciences, Supplement (Toxicologist) 66(1-S): 537, 2002.
Miller, M.S. and Mizesko, M.C.: Alterations in oncogenes and tumor suppressor genes in
transplacentally–induced tumors. Toxicological Sciences, Supplement (Toxicologist) 66(1-S): 539, 2002.
Smith, H.M., Tichelaar, J.W., Mizesko, M.C., Dance, S.T., Everitt, J., Whitsett, J.A. and Miller, M.S.:
Doxycycline (DOX)-regulated, lung-specific expression of mutant human Ki-ras in bitransgenic mice:
alterations in lung morphology. Toxicological Sciences, Supplement (Toxicologist) 66(1-S): 1519, 2002.
Smith, T.R., Miller, M.S., Lohman, K., and Hu, J.J.: DNA strand breaks and breast cancer risk.
Toxicological Sciences, Supplement (Toxicologist) 66(1-S): 757, 2002.
Schuller, H.M., Weddle, D.L., Zhang, L.,Walker, K., Miller, M.S., and Castonguay, A.: Inhibition of
pancreatic carcinogenesis in hamsters by inhibitors of the AA-cascade or a beta-blocker. Proc. Am. Assoc.
Cancer Res. 43: 3201, 2002.
Floyd, H.S., Tichelaar, J.W., Dance, S.T., Everitt, J., Whitsett, J.A. and Miller, M.S.: Expression of
mutant human Ki-ras induces lung tumors in bitransgenic mice. Toxicological Sciences, Supplement
(Toxicologist) 72(1-S): 413, 2003.
Xu, M., Floyd, H.S., Greth, S.M., Chang, W.-C., Vaughn, J.P., Lohman, K., Stoyanova, R., Kucera, G.L.,
Willingham, M.C., and Miller, M.S.: Chemotherapeutic effects of perillyl alcohol (POH) on lung cancer
cell lines. Toxicological Sciences, Supplement (Toxicologist) 72(1-S): 1027, 2003.
Floyd, H.S., Farnsworth, C.L., Kock, N.D., Little, J.L., Dance, S.T., and Miller, M.S.: Activation of
downstream RAS effectors in lung lesions following doxycycline (DOX) regulated expression of mutant
human Ki-ras in a bitransgenic mouse model. Toxicological Sciences, Supplement (Toxicologist) 78(1S): 1643, 2004.
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Miller, M.S., Moore, J.E., Xu, M., Nelson, G.B., Dance, S.T., Kock, N.D., and Ross, J.A.: Straindependent susceptibility to transplacentally-induced murine lung tumors. Toxicological Sciences,
Supplement (Toxicologist) 78(1-S): 556, 2004.
Nelson, G.B., Ross, J.A., Moore, J.E., Xu, M., Kock, N.D., and Miller, M.S.: Strain-dependent
susceptibility to transplacentally-induced murine lung tumors and DNA adducts of 3-methylcholanthrene.
Proc. Am. Assoc. Cancer Res. 45: 3185, 2004.
Van Emburgh, B.O., Levine, E.A., Hu, J.J., Perrier, N.D., Freimanis, R.I., Watkins, J., Curtis, E.,
Lohman, K., and Miller, M.S.: Polymorphisms in CYP1B1 and breast cancer risk. Proc. Am. Assoc.
Cancer Res. 45: 4488, 2004.
Floyd, H.S., Jennings-Gee, J., Kock, N.D., and Miller, M.S.: Secondary genetic alterations in lung
tumors possessing a primary Ki-ras mutation. Toxicological Sciences, Supplement (Toxicologist) 84(1-S):
1792, 2005.
Dance, S.T., Moore, J.E., Kock, N.D., Townsend, A.J., and Miller, M.S.: Tumor promotion as a target
for chemoprevention of lung cancer. Cancer Epidmiol. Biomarkers Prev. 14(11 Pt. 2): 2715S, 2005.
Van Emburgh, B.O., Hu, J.J., Levine, E.A., Mosley, L.J., Knight, S.N., Perrier, N.D., Watkins, J., Curtis,
E., Rubin, P., Sherrill, G.B., Willingham, M.C., Peters, E.S., and Miller, M.S.: Polymorphisms in phase
I and phase II enzymes and mutations in p53. Proc. Am. Assoc. Cancer Res. 46: 4924, 2005.
Zhu, J.-M., Robbins, M., and Miller, M.S.: Tumor detection in mice lung using fast imaging with steadystate precession (FISP). Proc. Intl. Soc. Magnetic Resonance Med. 13: 1803, 2005.
Dance, S.T., Moore, J.E., Townsend, A.J., Kock, N.D., and Miller, M.S.: Tumor promotion as a target
for chemoprevention of lung cancer. Proc. Am. Assoc. Cancer Res. 47: 1469, 2006.
Jennings-Gee, J.E., Moore, J.E., Xu, M., Dance, S.T., Leone-Kabler, S., Kock, N.D., McCoy, T.P., Carr,
J.J., Townsend, A.J., and Miller, M.S.: Strain specific induction of murine lung tumors following in utero
exposure to 3-methylcholanthrene (MC). Proc. Am. Assoc. Cancer Res. 47: 2848, 2006.
Van Emburgh, B.O., Hu, J.J., Levine, E.A., Mosley, L.J., Case, D.L., Knight, S.N., Perrier, N.D., Rubin,
P., Sherrill, G.B., Shaw, C.S., Carey, L.A., Sawyer, L., Willingham, M.C., and Miller, M.S.: Phase I and
phase II enzyme polymorphisms and p53 mutations in breast cancer. Proc. Am. Assoc. Cancer Res. 47:
5397, 2006.
Dance, S.T., Floyd, H.S., Moore, J.E., Mosley, L.J., Kock, N.D., and Miller, M.S.: Dose response effects
of mutant Ki-rasG12C in mouse lung. Toxicological Sciences, Supplement (Toxicologist) 96(1-S): 1941,
2007.
Dance, S.T., Kock, N.D., Moore, J.E., D’Agostino, Jr., R.B., Mosley, L.J., and Miller, M.S.:
Chemoprevention of murine lung tumor progression by sulindac. Toxicological Sciences, Supplement
(Toxicologist) 102(1-S): 876, 2008.
Miller, M.S., .Dance, S.T., Kock, N.D., Moore, J.E., D’Agostino, Jr., R.B., Mosley, L.J., and Townsend,
A.J.: Lung tumor promotion by curcumin. Toxicological Sciences, Supplement (Toxicologist) 102(1-S):
116, 2008.
Menon, J., Miller, M.S., Soto-Pantoja, D.R., Callahan, M.F., Tallant, E.A., and Gallagher, P.E.:
Angiotensin-(1-7) reduces lung tumor incidence in a novel bitransgenic Ki-rasG12C mouse model of lung
tumorigenesis through a reduction in cyclooxygenase-2. Proc. Am. Assoc. Cancer Res. 49: 4654, 2008.
Chen, L., Moore, J., Shao, C., Cobos, E., Miller, M.S., Gao, W.: p53 nuclear accumulation and CRM1
down-regulation in lung lesions of a bitransgenic mouse lung tumor model. Proc. Am. Assoc. Cancer Res.
50: 2356, 2009.
Munley, M.T., Wheeler, K., Moore, J.E., Olson, J., and Miller, M.S.: Carcinogenic potential of low dose
CT radiation. 55th Annual Meeting of the Rad. Res. Society Abstracts Rad. Res. Society MS1006, 2009.
Munley, M.T., Moore, J.E., Olson, J., Isom, S., Walb, M., Zora, J.G., Kock, N.D., Wheeler, K., and
Miller, M.S.. Increased lung tumorigenesis following low dose CT radiation. 56th Annual Meeting of the
Rad. Res. Society, PS5.09, p. 137, 2010.
Miller, M.S., Moore, J.E., Olson, J., Kock, N.D.,. Zora, J.G., Wheeler, K., and Munley, M.T.: Low dose
CT irradiation increases lung tumorigenesis in a Ki-ras driven mouse model: results from a pilot study. J.
Thorac. Oncol., 5 (supp. 3): S230 (abst. A14), 2010.
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Miller, M.S., Moore, J.E., Walb, M.C., Kock, N.D., Attia, A., Isom, S., McBride, J.E., Cecil, W.T., Polat,
F., Zhao, W., Miller, L.D., Townsend, A.J., Wheeler, K., and Munley, M.T.: N-Acetylcysteine inhibits
low dose CT-induced increases in murine lung tumorigenesis. Toxicological Sciences, Supplement
(Toxicologist) 126(1-S): 78, 2012.
Munley, M.T., Moore, J.E., Walb, M.C., McBride, J.E., Isom, S., Wheeler, K.T., and Miller, M.S.:
Excess tumor formation after a single CT exposure appears to be independent of dose between 1.25 – 80
mGy. 98th Annual Meeting of the Rad. Society of North American, SSK16-06, 2012.
Wang, H., Moore, J.E., Walb, M.C., Winslow, J., Munley, M.T., Miller, L.D., Zhou, X., Miller, M.S.:
Toxicogenomic analysis of low dose CT exposure in neonatal mouse lungs. Toxicological Sciences,
Supplement (Toxicologist) 138(1-S): 842, 2014.
Conference Presentations
1.
BRI-Basic Research Program, 4th Annual Conference, Gene Regulation and Carcinogenesis, “Effects
of chemical carcinogens on steroid-inducible gene expression.” October 27-30, 1987, Luray, VA.
2.
Foundation for Advanced Cancer Studies' 5th Annual Meeting on Oncogenes, “Expresssion of the
polyoma virus middle-T gene in rat fibroblasts increases α-tubulin gene expression.” June 27-July 1,
1989, Frederick, MD.
3.
AACR Special Conference in Cancer Research, Genetics of Cancer, “A hamster model for
neuroendocrine lung tumors induced by treatment with nitrosamines and hyperoxia exhibits the same
molecular lesions as human small cell lung cancer.” November 4-8, 1992, Hilton Head, SC.
4.
Society of Toxicology 33rd Annual Meeting, Poster Session Co-Chair, “Proliferative events in
toxicology.” March 13-17 1994, Dallas, TX.
5.
Society of Toxicology 35th Annual Meeting, Symposium Chairman, “Drug metabolic enzymes in
developmental toxicology.” March 10-14, 1996, Anaheim, CA.
6.
Society of Toxicology 36th Annual Meeting, Symposium Chairman, “Genetic polymorphisms in human
drug metabolic enzymes.” March 9-13, 1997, Cinncinnati, OH.
7.
Society of Toxicology 36th Annual Meeting, Continuing Education Course Co-Chairman,
“Techniques for determining genetic polymorphisms.” March 9-13, 1997, Cinncinnati, OH.
8.
Center in Molecular Toxicology, Vanderbilt University, Enzymatic Transformation of Xenobiotic
Chemicals, “Role of Cyp1a1 in the molecular pathogenesis of transplacentally-induced murine lung
tumors.” April 18-19, 1997, Nashville, TN. 11.Society of Toxicology 37th Annual Meeting, Symposium
Co-Chairman, “The role of genetic polymorphisms and repair deficiencies in environmental disease.”
March 1-5, 1998, Seattle, WA.
9.
Society of Toxicology 40th Annual Meeting, Symposium Co-Chairman, “Genetic polymorphisms in
DNA repair and cancer risk” March 25-29, 2001, San Francisco, CA.
10.
Society of Toxicology 41st Annual Meeting, Symposium Chairman, “Transplacental carcinogenesis of
environmental toxicants.” March 17-21, 2002, Nashville, TN.
12.
Society of Toxicology 42nd Annual Meeting, Poster Session Co-Chair, “Inhibition of carcinogenesis.”
March 9-13, 2003, Salt Lake City, UT.
13.
Society of Toxicology 43rd Annual Meeting, Poster Session Co-Chair, “Carcinogenesis 1.” March 2125, 2004, Baltimore, MD.
14.
EPA Science Forum 2004: Healthy Communities and Ecosystems,“Strain-dependent susceptibility to
transplacentally-induced murine lung tumors.” June 1-3, 2004, Washington, D.C.
15.
Society of Toxicology 44th Annual Meeting, Poster Session Co-Chair, “Mechanisms of
Carcinogenesis.” March 6-10, 2005, New Orleans, LA.
16.
Society of Toxicology 46th Annual Meeting, Symposium Co-Chairman, “Chemoprevention by
Xenobiotics” March 25-29, 2007, Charlotte, NC.
17.
AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Prospects for Personalized
Prevention and Therapy, “Low Dose CT Irradiation Increases Lung Tumorigenesis in a Ki-ras Driven
Mouse Model: Results from a Pilot Study.” January 11-14, 2010, Coronado, CA.
29
18.
19.
20.
Society of Toxicology 49th annual meeting, poster presentation, abstract number 2222 “Increased lung
tumorigenesis following low dose CT exposure.” March 7-11, 2010, Salt Lake City, UT.
Society of Toxicology 51st Annual Meeting, Symposium Co-Chairman, “Mechanisms of
Carcinogenesis” March 11-15, 2012, San Francisco, CA.
Society of Toxicology 53rd Annual Meeting, Education-Career Development Session Co-Chairman,
The Role of Consultants in the Science and Practice of Safety Assessment (Abst. 381), Consulting in
an academic environment.” March 23-27, 2014, Phoenix, AZ.
Invited Conference Presentations
1.
Southeastern Regional Chapter of the Society of Toxicology annual meeting: Symposium on
Genotoxicity, “Molecular analysis of experimentally-induced neuroendocrine lung tumors.” October 2021, 1994, Knoxville, TN.
2.
2nd International Mouse Lung Tumorigenesis Symposium, “Molecular pathogenesis of
transplacentally-induced mouse lung tumors.” Ohio State University, June 18-20, 1997, Columbus, OH.
3.
3rd International Mouse Lung Tumorigenesis Symposium, “Differential sensitivity to lung
tumorigenesis following transplacental exposure of mice to polycyclic hydrocarbons, heterocyclic
amines, and lung tumor promoters.” Ohio State University, June 16-17, 2000, Toledo, OH.
4.
Modeling Human Lung Cancer in Mice: 4th International Mouse Lung Tumorigenesis Symposium,
“Doxycycline-regulated, lung-specific expression of mutant human Ki-ras induces lung adenomas in
bitransgenic mice.” The Jackson Laboratory, October 23-26, 2003, Bar Harbor, ME.
5.
EPA STAR Human Heath Symposium, “Strain-dependent susceptibility to transplacentally-induced
murine lung tumors.” October 28-29, 2004, Philadelphia, P.A.
6.
Brazilian Society of Environmental Mutagenesis, Carcinogenesis and Teratogenesis (SBMCTA) IX
Congress, “Cancer chemoprevention vs. chemopromotion: promotion of lung tumorigenesis by
curcumin.” November 11-14, 2009, Ouro Preto, Brazil.
7.
North Carolina Association for Biomedical Research, IACUC Fundamentals Symposium, IACUC
Review of Noncompliance and Animal Welfare Concerns: A Case Study:“The IACUC non-compliance
tightrope: maintaining balance in the force.” May 2nd, 2012, Research Triangle Park, NC.
8.
Genetic and Environmental Mutagenesis Society Spring meeting: Mechanisms of Environmental
Carcinogenesis, “Low dose CT-induced lung tumorigenesis and chemoprotection by N-acetylcysteine.”
May 21, 2013, Research Triangle Park, NC.
Workshops
1.
NCI Workshop, Invited attendee, “Gene-environment interactions in the etiology of childhood cancer.”
March 25-26, 2002, Bethesda, MD.
2.
Bio-Rad Real Time User Forum: Analysis of Gene Expression, Invited speaker, “Real time PCR
applications in cancer toxicology research.” April 13, 2004, Research Triangle Park, NC.
3.
Bio-Rad Real Time User Forum: Analysis of Gene Expression: Making Sense out of Sequences,
Invited speaker, “Real time PCR applications in cancer toxicology research.” June 7, 2005, Raleigh, NC.
4.
EPA Mouse Lung Tumor Workshop: State-of-the-Science Workshop on Chemically-induced Mouse
Lung Tumors: Application to Human Health Risk Assessment, Co-chair and speaker, “Low dose CTinduced lung tumorigenesis and chemoprotection by N-acetylcysteine.” October 24-25, 2013.
30

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