NCCN結直腸癌化療指引

NCCN Guideline
Colon Cancer
Version 3. 2013
健保藥品給付限制註記說明：
(！) ：健保有條件給付該藥品，詳參閱最新之健保給付規定
(＄) ：健保尚未給付該藥品用於此癌症化療，詳參閱最新之健保給付規定
(資料彙整日期 2013.06.01)
(一)Adjuvant therapy of Colon cancer:
mFOLFOX6

Oxaliplatin 85 mg/m2 IV over 2 hours, day 1


2
(！)
Leucoverin 400 mg/m IV over 2 hours, day 1
5-FU 400 mg/m2 IV bolus on day 1

5-FU 1200 mg/m2/day X 2days IV continuous infusion
Repeat every 2 weeks
FLOX



5-FU 500 mg/m2 IV bolus weekly X 6
Leucoverin 500 mg/m2 IV weekly X 6
Oxaliplatin 85 mg/m2 IV on weeks 1,3,5 of each 8-week cycle
Each 8-week cycle X 3
Capecitabine

Capecitabine 1250 mg/m2 BID day 1-14
(！)
Every 3 weeks X 24 wks
CapeOx


Oxaliplatin 130 mg/m2 IV over 2 hours, day 1 (！)
Capecitabine 1000 mg/m2 BID day 1-14 (！)
Every 3 weeks X 24 wks
5-FU+LV

Leucoverin 500 mg/m2 IV 2 hours weekly X 6
(！)

5-FU 500 mg/m2 IV bolus 1 hours weekly X 6
Every 8 weeks for 4 cycles
sLV5FU2

Leucoverin 400 mg/m2 IV over 2 hours, day 1

5-FU 400 mg/m2 IV bolus X 2days

5-FU 1200 mg/m2/day IV continuous infusion X 2days
Repeat every 2 weeks
LV5FU: (HDFL)

Leucoverin 200 mg/m2 IV over 2 hours, day 1

5-FU 2000 mg/m2/day IV continuous infusion 30hours, day 1
Repeat every 2 weeks
NCCN Guideline
Rectal Cancer
Version 4. 2013
健保藥品給付限制註記說明：
(！) ：健保有條件給付該藥品，詳參閱最新之健保給付規定
(＄) ：健保尚未給付該藥品用於此癌症化療，詳參閱最新之健保給付規定
(資料彙整日期 2013.06.01)
(二)Adjuvant therapy of Rectal cancer:
A. Chemotherapy
mFOLFOX6
 Oxaliplatin 85 mg/m2 IV over 2 hours, day 1


(！)
2
Leucoverin 400 mg/m IV over 2 hours, day 1
5-FU 400 mg/m2 IV bolus on day 1
 5-FU 1200 mg/m2/day X 2 days IV continuous infusion
Repeat every 2 weeks to total of 6 mo perioperative therapy.
sLV5FU2
 Leucoverin 400 mg/m2 IV over 2 hours, day1
 5-FU 400 mg/m2 IV bolus on day 1
 5-FU 1200 mg/m2/day X 2 days IV continuous infusion
Repeat every 2 weeks to total of 6 mo perioperative therapy
Capecitabine

Capecitabine 1250 mg/m2 BID day 1-14
(！)
Every 3 weeks to total of 6 mo perioperative therapy
CapeOx


Oxaliplatin 130 mg/m2 IV over 2 hours, day1 (！)
Capecitabine 1000 mg/m2 BID day1-14 (！)
Every 3 weeks to total of 6 mo perioperative therapy
5-FU+LV

5-FU 500 mg/m2 IV bolus weekly X 6
 Leucoverin 500 mg/m2 IV weekly X 6
Each 8-week cycle
Repeat every 8 weeks to total of 6 mo perioperative therapy
LV5FU: (HDFL)
 Leucoverin 200 mg/m2 IV over 2 hours, day 1
 5-FU 2000 mg/m2/day IV continuous infusion 30hours, day 1
Repeat every 2 weeks
B. Chemotherapy + RT
XRT + 5-FU

5-FU 225 mg/m2 over 24 hours 5-7days/week
XRT + mFOLFOX6：

Oxaliplatin 85 mg/m2 IV over 2 hours, day1
(！)
2

Leucoverin 400 mg/m IV over 2 hours, day1


5-FU 400 mg/m2 IV bolus on day1
5-FU 1200 mg/m2/day X 2days IV continuous infusion
XRT + 5-FU/LV

5-FU 400 mg/m2 IV bolus + Leucoverin 20 mg/m2 IV bolus for 4 days during week 1, 5
XRT + 5-FU/LV

5-FU 325 mg/m2 IV bolus + Leucoverin 20 mg/m2 IV bolus for 5 days during week 1, 5
XRT + Capecitabine
Capecitabine 825 mg/m2 BID 5-7days/week (！) + XRT X 5weeks

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