US 20140170155Al
(19) United States
(12) Patent Application Publication (10) Pub. No.: US 2014/0170155 A1
(43) Pub. Date:
Loibner et al.
(54)
2012, Which is a continuation-in-part of application
METHOD FOR TREATINGA GD2 POSITIVE
CANCER
(71) Applicant: APEIRON BIOLOGICS AG, Vienna
(ZYT)
No. PCT/EP2012/061618, ?led on Jun. 18, 2012.
Publication Classi?cation
(51)
Int. Cl.
C07K 16/28
A61K 45/06
A61K 31/485
A61K 39/395
(72) Inventors: Hans Loibner, Vienna (AT); Oliver
Mutschlechner, Wiener Neudorf (AT);
Ruth Ladenstein, Vienna (AT); Isabel
Klier, Vienna (AT)
(52)
U.S. Cl.
(2013.01); A61K 45/06 (2013.01); A61K
31/485 (2013.01)
USPC
(22)
Filed:
Feb. 18, 2014
Related US. Application Data
(63)
Continuation of application No. 14/086,696, ?led on
Nov. 21, 2013, Which is a continuation-in-part of ap
plication No. PCT/EP2012/064970, ?led on Jul. 31,
(2006.01)
(2006.01)
(2006.01)
(2006.01)
CPC ......... .. C07K 16/28 (2013.01); A61K 39/39533
(73) Assignee: APEIRON BIOLOGICS AG, Vienna
(ZYT)
(21) App1.No.: 14/182,776
Jun. 19, 2014
..................................................... ..
(57)
424/1391
ABSTRACT
Preparations and methods for treating a GD2 positive cancer
by administering a preparation comprising an anti-GD2 anti
body to a patient, Wherein the patient is not concomitantly
treated With Interleukin-2 (IL-2), and Wherein one or more
treatment periods With the antibody may be preceded, accom
panied, and/or followed by one or more treatment periods
With a retinoid.
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