Program - 高血圧関連疾患モデル学会

Program
WELCOME MESSAGE
Dear Friends and Colleagues,
It is a great pleasure for us to invite you to the Cardiovascular Genetic Symposium, to
be held September 22 – 23, 2016 at UDX Gallery, Akihabara, Tokyo. This symposium
is an official satellite symposium of ISH Seoul 2016, and is jointly held with the
17th International SHR symposium and the 52nd Annual Meeting of the Society for
Hypertension Related Disease Model Research.
While much encouragement and progress is going on these days in the cardiovascular
genetic field, both with humans as well as experimental animals. This symposium will
focus on the basic research and the human genetics for hypertension and related diseases.
Our program has the very best agenda, which covers the hottest topics from cardiovascular
genetics and hypertension fields, and it provides a variety of high-quality educational,
and networking opportunities for all participants.
Akihabara is located at near the center of Tokyo and has unique culture, otaku and
electric town. We hope you will take a little extra time to enjoy the fascinating town.
We are very much looking forward to meeting you at Akihabara in Tokyo.
With best wishes.
Masayoshi Soma
The Chair of the Local Organizing Committee
The 17th International SHR Symposium
Cardiovascular Genetics Satellite
2
ACCESS
ACCESS
Venue:
UDX Gallery (4th floor), Akihabara, Japan
(4-14-1, Soto-Kanda, Chiyoda-ku, Tokyo, 101-0021, Japan)
<< Access at a Glance >>
*Please note that traveling time may vary depending on traffic conditions
1.
From Narita International Airport (NRT)
Airport
Narita International Airport
(NRT)
2.
Transfer
Destination
JR Narita Express Line
Tokyo Station
JR Yamanote Line
About 56 min.
(Transfer: Express→Yamanote)
5 min.
Keisei Skyliner Line
Nippori Station
JR Yamanote Line
About 40 min.
(Transfer: Keisei→JR)
10 min.
Airport Limousine Bus
Tokyo Station
JR Yamanote Line
About 75-125 min.
(Transfer: Bus→Yamanote)
5 min.
Akihabara
Station
Symposium Venue
On foot
2 min.
UDX Gallery
Akihabara
(2nd floor)
*electric town
exit
From Haneda International Airport (HND)
Tokyo Monorail Line
18 min.
Haneda International
Airport (HND)
Hamamatsu-Cho
Station
(Transfer: Monorail→JR)
JR Yamanote Line or
JR Keihin-Tohoku Line
4 min.
JR Yamanote Line or
Keikyu Line
Shinagawa Station
JR Keihin-Tohoku Line
16 min.
(Transfer: Keikyu→JR)
8 min.
Akihabara
Station
*electric town
exit
Airport Limousine Bus
About 25-45 min.
3
On foot
2 min.
UDX Gallery
Akihabara
(2nd floor)
3.
From Akihabara Station
4.
UDX Gallery
Symposium
4F
ＧＡＬＬＥＲＹ
2F
オフィスロビー
EV
EV
EV
escalator 2F→4F
1F
elevator to 1st floor
Social Gathering (Thursday 22 Sept.)
“chiocciol@pizzeria”
4
Akihabara
Station
GENERAL INFORMATION
1.Venue
UDX Gallery (4th floor), Akihabara, Japan (4-14-1, Soto-Kanda, Chiyoda-ku, Tokyo, 101-0021, Japan)
2. Registration
1) Registration Desk
Registration desk is located on the 4th floor, UDX Gallery.
Opening Hours:
Thursday 22 September
8:00 - 17:00
Friday 23 September
8:30 - 15:00
2) Registration Fee (valid for 2 days)
Regular Delegate
15,000 JPY
Student
10,000 JPY
Social Gathering (22 September)
5,000 JPY
- Please complete your payment at the Registration Desk onsite.
-Payment must be made in Japanese yen. Cash payment is recommended. Credit cards (VISA, MasterCard,
Diners Club, AMEX or JCB) are acceptable, however, it will take approximately 5-10 minutes to process
payment.
- Pick up a name card at the registration desk and fill in your name by yourself.
- Make sure to wear your meeting badge at all times during the meeting.
- Student rate is applicable only to those who have student status at the time of symposium.
- Student is required to present his/her student ID or student certificate.
- Please be advised that student rate will not be applied to adult student with full time job.
4. Japan Vascular Disease Research Foundation Awards Ceremony:
International Okamoto Award / Young Investigator Okamoto Award
Date & Time: Thursday 22 September 13:10-14:00
5.
The 2016 International Okamoto Award Lecture
“Interpretation and misinterpretation of the evidence on the effects of statin therapy”
Rory Collins (Head of Nuffield Department of Population Health, University of Oxford)
Date & Time: Thursday 22 September 14:00-14:40
6. Awards Ceremony: SHR Award, Ogihara Award, Yamori Award and Nagai Award
Date & Time: Thursday 22 September 18:00-18:30
7.
Special Presentation
“Genetics of hypertension and precision medicine”
Anna Dominiczak (Regius Professor of Medicine, University of Glasgow)
Date & Time: Thursday 22 September 10:40-11:10
8. Luncheon Seminar
Luncheon seminars are scheduled on 22 and 23 September. No tickets needed. A lunch box will be served on a
first come, first served basis.
9.
Social Gathering
Date & Time: Thursday 22 September 19:00-21:00
Place: Italian restaurant “chiocciol@pizzeria”, 1st floor, UDX Akihabara
Fee: 5,000 JPY
*Tickets are sold on a first come, first served basis. Purchase your ticket at the Registration Desk.
10.Cloak
Cloak is located on the 4th floor, UDX Gallery. Valuables and umbrellas cannot be accepted.
Opening hours:
Thursday 22 September 8:00 - 19:00
Friday 23 September
8:30 - 16:30
5
INSTRUCTIONS FOR PRESENTERS & CHAIRMAN
Instructions for Presenters
Presentation type will be “oral” or “ poster”.
Instructions for Oral Presentation
1.
Presentation Time
For presenters with 20 minutes time slot →Presentation: 15 min. Q&A: 5 min.
For presenters with 30 minutes time slot →Presentation: 25 min. Q&A: 5 min.
Please help your session chairman by keeping to the time limit.
2. Presentation Data Check-in
Please come to Data Check-in Desk no later than 20 min. before your presentation. Your presentation data will be
copied to a PC prepared by the Secretariat. Presentation data will be deleted completely after the symposium and not
be provided to participants.
3. Audio Visual Equipment
1) All presentations should be made by computer.
You can operate a PC by yourself to forward your slides. There is a mouse, a keyboard, and a monitor, on the podium.
① Presentation Data
·Bring your presentation data by USB flash drive.
·A PC prepared by the Secretariat is as follows:
OS: Windows 7 / Microsoft Powerpoint 2007·2010·2013·2016
·To avoid character garbling, please do not use any special characters depending on a particular OS.
·Please make sure if your presentation data can be read by a PC other than yours.
② Presentation with movie / Presentation by Macintosh
·If your presentation includes movie files, please bring your own computer.
·Macintosh computer is not prepared by the Secretariat. If you wish to make a presentation with Macintosh, please
bring your own computer.
·Please note that projectors are connected to computers via a D-sub 15-pin plug. If your computer does not use a D-sub
15-pin plug (e.g. Macintosh, HDMI etc.), please bring a necessary adaptor with you.
·If you wish to use your own computer, be sure to bring an AC adaptor.
·Bring back up presentation data by USB flash drive even if you bring your own computer.
2) Q&A
When you wish to ask a question, please move to a microphone in a session room. According to the chair’s directions,
please say your name and affiliation, and then ask your questions or make comments briefly.
1.
70cm
20cm
Instructions for Poster Presentation
Size of Poster Panel / Guidelines for Poster Display
·Poster panels with a presentation number (e.g. P1-1) will be prepared.
·Poster panel size: height 210cm x width 90cm
·A poster must be prepared within height 190cm x width 90cm.
Please leave the upper corner space for a presentation number (height 20cm x
width 20cm) and a title of poster presentation (height 20cm x width 70cm).
·Presentation number will be prepared by the Secretariat
·Pushpins will be provided by the Secretariat.
2. Poster Presentation
Posters will be displayed for two days during the Symposium.
Poster set up: Thursday 22 September
9:00-11:00
Poster removal: Friday 23 September
16:00-16:30
Posters still on display after the removal time will not be kept nor returned.
The Organizer and Secretariat will have no responsibility for any loss or damage
of posters.
Title of Presentation
20cm
Presentation No.
*Prepared by the Secretariat
190cm
3. Poster Discussion
Date & Time: Thursday 22 September
11:10-12:10
Presenters are kindly requested to stand by their posters for possible questions by the delegates.
Instructions for Chairman
·Please come to the Registration Desk to complete registration procedure and be seated at “Next Chairman Seat” in the
front row at least 10 min. prior to your session.
·Chairs are responsible for smooth progress of the session and to promote vigorous discussions.
6
ORGANIZING COMMITTEE
Chair
Masayoshi Soma
Nihon University, School of Medicine
Representative of International
SHR Society
Theodore W. Kurtz
The University of California
Toru Nabika
Shimane University
Secretary General
Akira Haketa
Nihon University, School of Medicine
Treasurer
Noboru Fukuda
Nihon University, School of Medicine
Timothy J Aitman
University of Edinburgh
Giuseppe Bianchi
Milan University
Mark Caulfield
WHRI/Centre Lead for Clinical Pharmacology
Fadi Charchar
Federation University Australia
Christian Delles
The University of Glasgow
Alan Y. Deng
University of Montreal
Anna Dominiczak
University of Glasgow
Noboru Fukuda
Nihon University
Aron Geurts
Medical College of Wisconsin (MCW)
Pavel Hamet
Montreal Diabetes Research Center
Stephen Harrap
University of Melbourne
Yoshitaka Hirooka
Kyushu University
Norbert Hubner
Max-Delbrück-Center for Molecular Medicine
(MDC)
Howard J. Jacob
HudsonAlpha Institute for Biotechnology
Bina Joe
The University of Toledo
Norihiro Kato
National Center for Global Health and Medicine
Anne E. Kwitek
The University of Iowa
Tomoji Mashimo
The University of Osaka
Dominik Müller
Max-Delbrück-Center for Molecular Medicine
(MDC)
International Committee Members
of the International SHR
Symposium
Sandosh Padmanabhan The University of Glasgow
Honorary Members of the
International SHR Symposium
Board members of Society for
Hypertension Related Disease
Model Research
Tatsuya Sawamura
Shinshu University
Yoram Yagil
Laboratory for Molecular Medicine and Israeli
Rat Genome Center
Josef Zicha
Institute of Physiology AS CR
Detlev Ganten
Charité – Universitätsmedizin Berlin
Yukio Yamori
Mukogawa Women's University
Takuzo Hano, Yoshitaka Hirooka, Katsumi Ikeda, Hiroshi Itoh,
Norihiro Kato, Hiroshi Kawamura, Toru Nabika, Yasuo Nara,
Masami Niwa, Hiromi Rakugi, Hakuo Takahashi, Yukio Yamori and
Mitsuhiro Yoshioka
7
SCIENTIFIC PROGRAM
Thursday 22 September
8:00-
Registration
9:00-9:10
Welcome & Opening
9:10-11:10
Symposium 1
Epigenetics and beyond GWAS of hypertension
Masayoshi Soma
Chairman: Anna Dominiczak, Norihiro Kato
9:10-9:40
Keynote Presentation
S1-1
DNA methylation and hypertension
Norihiro Kato
9:40-10:00
S1-2
The role non-coding RNA in human hypertension
Fadi Charchar
10:00-10:20
S1-3
International collaborative efforts on genetics of hypertension
10:20-10:40
Coffee Break
10:40-11:10
Special Presentation
Genetics of hypertension and precision medicine
11:10-12:10
Poster Discussion
12:10-13:10
Luncheon Seminar sponsored by Daiichisankyo Co.Ltd
Hypertension and the kidney: recent advances
Patricia Munroe
Chairman: Yukio Yamori
Anna Dominiczak
Chairman: Noboru Fukuda
Shigeru Shibata
13:10-14:00
Awards Ceremony
14:00-14:40
The 2016 International Okamoto Award Lecture
Interpretation and misinterpretation of the evidence on the effects of statin therapy
14:40-18:20
Symposium 2
Cardiovascular genetics of hypertension
Rory Collins
Chairman: Toru Nabika
Tim Aitman
15:10-15:40
Keynote Presentation 1
S2-1
Exploring the function of the SHR genome
15:40-16:00
S2-3
Integrating genomic strategies in the dissection of complex diseases
Yoram Yagil
16:00-16:20
S2-4
Early genetic origins of cardiovascular disease
16:20-16:40
S2-5
Genes of hypertension – insights from the transcriptome profiling of the human kidney
Maciej Tomaszewski
16:40-17:00
Coffee Break
14:40-15:10
Keynote Presentation 2
S2-2
Dissecting the genetic basis of translational regulation in spontaneously hypertensive rats
Norbert Hubner
Stephen Harrap
Chairman: Norbert Hubner
17:00-17:20
S2-6
Mechanisms of monogenic and polygenic forms of salt-sensitivity
Theodore W. Kurtz
17:20-17:40
S2-7
Stim1; a candidate gene for sympathetic stress response in SHRSP
Toru Nabika
8
17:40-18:00
S2-8
DAPIT, an accessory subunit of mitochondrial ATP synthase, plays a role in regulation of
glucose homeostasis
Michal Pravenec
18:00-18:30
Awards Ceremony: SHR Award, Ogihara Award, Yamori Award and Nagai Award
Move to social gathering venue
19:00-21:00
Social Gathering in Akihabara UDX
Friday 23 September
9:00-12:30
Symposium 3
New insight into hypertension
Chairman: Josef Zicha
9:00-9:30
Keynote Presentation
S3-1
From animal models to personalized medicine
9:30-9:50
S3-2
Contribution of MHS rats with genetic hypertension to the personalized medicine
Giuseppe Bianchi
9:50-10:10
S3-3
Immunity and sympathetic nervous system in hypertension
Yoshitaka Hirooka
10:10-10:30
S3-4
Role of HCaRG in kidney function and injury
Johanne Tremblay
10:30-10:50
Coffee Break
Pavel Hamet
Chairman: Johanne Tremblay
Josef Zicha
10:50-11:10
S3-5
Calcium sensitization in genetic hypertension of the rat
11:10-11:30
S3-6
Mitochondrial dysfunction as a contributory mechanism to increased stroke susceptibility in
high salt fed SHRSP
Speranza Rubattu
11:30-11:50
S3-7
LOX-1 in cardiovascular disease
11:50-12:10
S3-8
Role of complement 3 in development of hypertension
12:10-12:30
S3-9
Complement-mediated inhibition of perivascular adiponectin contributes to vascular injury
in deoxycorticosterone acetate-salt hypertensive mice
Pingjin Gao
12:40-13:40
Luncheon Seminar sponsored by MSD K.K.
Clinical management of diabetic kidney disease with hypertension
13:40
International Session Closing
14:00-16:00
The 52th Annual Meeting of the Society for Hypertension Related Disease Model Research
Tatsuya Sawamura
Noboru Fukuda
Chairman: Masayoshi Soma
Masanori Abe
Toru Nabika
Poster Presentation (Poster in English, Discussion in Japanese with Modulators)
16:00
Closing
Masayoshi Soma
9
Poster Presentation (Thursday 22 September *Poster Discussion 11:10-12:10)
1: Genome
P1-1
The altered circadian clock inducing glucocorticoid reactivation in SHR.
Sho Tanaka, Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon
University School of Medicine
P1-2
Identification of clock controlled blood pressure regulating genes in the kidney of SHR/Izm
Yusuke Murata, Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine,
Nihon University School of Medicine
P1-3
A comparative analysis of the transcriptome and heart function between clock mutant animals
Tomomi Nakao, Departments of Physiology and Pathology, and Radioisotope Laboratory Center, Wakayama
Medical University
P1-4
Further reduction of stroke QTLs on chromosomes 1 and 18 in SHRSP using double subcongenic rats
Kaoru Niiya, Department of Functional Pathology, Shimane University School of Medicine
P1-5
Epigenetic changes in the brain with high-salt intervention in SHR
Hana Shimizu-Furusawa, Department of Gene Diagnostics and Therapeutics, Research Institute, National
Center for Global Health and Medicine
P1-6
Epigenetic changes in the liver with high-fat-diet intervention in SHR
Hana Shimizu-Furusawa, Department of Gene Diagnostics and Therapeutics, Research Institute, National
Center for Global Health and Medicine, Tokyo, Japan
P1-7
Epigenetic changes in the liver with dexamethasone administration in SHR
Hana Shimizu-Furusawa, Department of Gene Diagnostics and Therapeutics, Research Institute, National
Center for Global Health and Medicine, Tokyo, Japan
P1-8
Comparison of epigenetic changes in the liver between Tg-CETP rat and SHR
Hana Shimizu-Furusawa, Department of Gene Diagnostics and Therapeutics, Research Institute, National
Center for Global Health and Medicine, Tokyo, Japan
P1-9
Comparison of epigenetic changes in the liver between RNO4-derived congenic rat and progenitor
strains
Hana Shimizu-Furusawa, Department of Gene Diagnostics and Therapeutics, Research Institute, National
Center for Global Health and Medicine, Tokyo, Japan
2: Pathogenesis of Hypertension
P2-1
The precedence role of metabotropic glutamate receptors in the regulation of baseline blood pressure in
SHRSP
Md Zahid Hasan, Department of Functional Pathology, Shimane University Faculty of Medicine, Shimane,
Japan
P2-2
Oxidative stress and HDAC in the spontaneously hypertensive rats (SHRs)
Mamiko Aoki, Kindai University Graduate School of Systems Engineering, *Kindai University Life Science
Research Institute, Hiroshima
P2-3
Complement 3 induces the salt-sensitive hypertension by induction of dedifferentiation of mesenchymal
tissues with activation of renal RA system in SHR
Eriko Negishi, Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon
University School of Medicine
10
P2-4
The role of C3 on renin expression during the process of mesenchymal stem cell differentiating into
vascular smooth muscle cell
Lan Chen, Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon
University School of Medicine
P2-5
Role of TWIST-1 on the increased expression of complement 3 in mesenchymal tissues from SHR
Tomoyasu Otsuki, Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon
University School of Medicine
P2-6
The anti-inflammatory effects of hydrogen sulfide in 3T3-L1 adipocytes
Sachiko Juman, School of Pharmacy and Pharmaceutical sciences, Mukogawa Women’s university
P2-7
Difference of taste sensitivity between SHR and WKY
Mohammad Farhadur Reza, Department of Functional Pathology, Shimane University School of Medicine
P2-8
The combination of hypertension and high-fat and -cholesterol diet induces severe hepatic inflammation
in rats via NF-kB and Nrf2 signalings
Yuan Yuan, College of Life and Health Sciences, CHUBU University
P2-9
Novel pathophysiological functions of α-synuclein, causative molecule of Parkinson disease, in vascular
aging and endothelial dysfunction.
Yoichi Takami, Department of Geriatric and General Medicine, Osaka University Graduate School of
Medicine
P2-10
Increased renal AcylCoA Oxidase2 (ACOX2) expression in SHR/Izm
Masahiro Okamura, Division of Nephrology, Hypertension and Endocrinology, Department of Internal
Medicine, Nihon University School of Medicine
P2-11
Gabapentin-Induced Cardiovascular Changes in Spontaneously Hypertensive Rats: The Role of
Sympathetic Nervous System
Michal Behuliak , Institute of Physiology Czech Academy of Sciences, Prague, Czech Republic
P2-12
Expression of Catecholaminergic System Genes in Adrenal Medulla of Spontaneously Hypertensive Rat
Anna Vavřínová, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
3: Kidney // Cardiovascular System // Nervous System
P3-1
Systematic implantation of dediffarentiated fat cells ameliorated immuno-induced glomerulonephritis
with stimulation of TSG-6
Takashi Maruyama, Division of Nephrology Hypertension and Endocrinology, Department of Medicine,
Nihon University School of Medicine
P3-2
HCaRG is a inhibitor of ErbB receptor-driven tumorigenesis and prognostic for survival in renal cell
carcinoma
Jin Ikeda, Division of General Medicine, Department of Internal Medicine, Nihon University School of
Medicine
P3-3
The role of serine proteases in the regulation of osmotic free water homeostasis.
Yutaka Kakizoe, Department of Nephrology, Kumamoto University Graduate School of Medical Sciences
P3-4
Renoprotective effect of LCZ696 in type 2 diabetic rats with overt proteinuria
Akira Nishiyama, Kagawa University Medical School
P3-5
Establishment of a mouse model of renal anemia
Akira Nishiyama, Kagawa University Medical School
11
P3-6
Dipping pattern of blood pressure in Dahl salt-sensitive hypertensive rats during the progression of
renal injury
Akira Nishiyama, Kagawa University Medical School
P3-7
Effect of Angelica acutiloba Kitagawa extract on blood flow regulation in stroke-prone spontaneously
hypertensive rats
Ayaka Kawakami, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University
P3-8
Apelin-induced blood pressure elevation in mice overexpressing APJ on vascular smooth muscle cells
Chulwon Kwon, Graduate School of Life and Environmental Sciences, Tsukuba Advanced Research Alliance,
University of Tsukuba
P3-9
Disruptive arterial pressure stability is improved by sodium-glucose co-transporter 2 inhibitor in
streptozotocin-induced diabetic rats
Tomoko Yoshikawa, Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical
Sciences
P3-10
Switching of two HIF- isoforms regulates inflammatory processes and cardiac remodeling
Norihiko Takeda, Department of Cardiovascular Medicine, Graduate School of Medicine, The University of
Tokyo
P3-11
N-type Ca Channel in sympathetic nerve terminals and α1A linked Ca channel are contributed to
increased vascular tone but mobilization size from ER is reduced in SHR
Takuzo Hano, Medical Education and Population-based Medicine, Wakayama Medical University
P3-12
Effects of a dopamine re-uptake inhibitor on cortical and accambal dopaminergic system in SHRSP/Ezo
Sachiko Hiraide, Department of Pharmacology, Faculty of Pharmaceutical Science, Health Science University
of Hokkaido
P3-13
Hypertension is a system disruption of dynamic circulatory homeostasis mediated by brain
Takuya Kishi, Collaborative Research Institute of Innovation for Cardiovascular Diseases, Kyushu University
Center for Disruptive Cardiovascular Medicine
4: Therapy/Intervention // Experimental Model
P4-1
Intranasal administration of cationic nanogel-based vaccine targeting angiotensin II type 1 receptor
attenuates the development of hypertension in SHR
Tatsuhiko Azegami, Department of Internal Medicine, School of Medicine, Keio University
P4-2
Inhibition of an increase in the blood pressure by food produced by processing residues after fruit juice
extraction in spontaneously hypertensive rats (SHR)
Kohei Kawakami, Department of Experimental Animals, Center for Integrated Research in Science, Shimane
University
P4-3
Drug discovery of a novel gene silencer pyrrole-imidazole polyamide targeting human TGF-β1 for
progressive renal dysfunction
Masari Moriuchi, Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon
University School of Medicine
P4-4
Contribution of TGF-β1 and effects of novel gene silencer PI polyamides to TGF-β1 in diabetic
nephropathy
Shu Horikoshi, Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon
University School of Medicine
12
P4-5
Different effect of NEP inhibition with LCZ696 on developing and developed cardiac hypertrophy and
diastolic dysfunction in salt-loaded hypertensive rats.
Go Hamano, Department of Geriatric and General Medicine, Osaka University
P4-6
Dietary fibre intake, through a connection between gut and kidney, prevents hypertension and improves
renal function in a mineralocorticoid-excess model
Francine Marques, Baker IDI Heart and Diabetes Institute, Australia
P4-7
Increased locomotor activity in congenic SHRSPwch1.0 rats is derived from the increase in systolic
arterial pressure but not the systolic arterial pressure level itself
Hiroshi Kawamura, MGJ Cardiovascular Institute
P4-8
Development of a new rat model for combined hypertension and atherosclerosis; Apoprotein Eknockout SHR
Hiroyuki Matsuo, Department of Functional Pathology, School of Medicine, Shimane University
P4-9
Excitatory synapse dysfunction in the prefrontal cortex of SHRSP/Ezo as an attention deficit/
hyperactivity disorder animal model
Takayuki Senriuchi, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences
University of Hokkaido
P4-10
Cardio-metabolic characterisation of a Complement factor b knockout rat
Philip Coan, University of Edinburgh, UK
P4-11
Effects of CAMK2N1 gene knock-out in a Spontaneously Hypertensive Rat
Neza Alfazema, Institute of Genetics and Molecular Medicine & Centre for Cardiovascular Science,
University of Edinburgh, UK
P4-12
Chronic blood pressure effects of systemic or intracerebroventricular administration of losartan and
aliskiren are mediated by sympathoinhibition in Ren-2 transgenic rats
Ivana Vaneckova, Institute of Physiology, Czech Republic
13
第52回
高血圧関連疾患モデル学会学術総会
第52回高血圧関連疾患モデル学会学術総会のご案内
ポスターミニシンポのご案内
第52回高血圧関連疾患モデル学会では、第17回国際SHRシンポジウムで掲示された国内からのポスタ
ーを、9月23日㈮の午後にポスターミニシンポとして発表者、モデュレーター、コメンテーターでデ
ィスカッションを行います。
1．発表日時
日付
9月23日㈮
時間
セッション名
P１－１～９
14:00-16:00各セッション、 P２－１～10
同時スタートとなります。 P３－１～３、７～９、11～13
P４－１～５、７～９
2．発表時間：発表7分、質疑3分
3．会場：秋葉原UDX　4F　UDXギャラリー　ポスター会場
4．モデュレーターの皆様へ：発表の進行、討論の盛り上げ役をお願い致します。研究内容に関する
質疑応答や相互討論の他、研究手法、結果の解釈、将来展開など様々な角度からディスカッショ
ンしていただき、研究テーマを掘り下げるなどして下さい。
5．コメンテーターの皆様へ：各演題発表後に、ご専門の立場から質問やコメントをいだだきますよ
うお願い致します。
6．ポスターサイズ・掲示方法は第17回国際SHRシンポジウムと同じで英文のポスター
7．ポスター掲示日時
掲示：2016年9月22日㈭ 9:00−11:00
撤去：2016年9月23日㈮ 16:00−16:30
※撤去時間以降の保管･返却は致しかねますのでご了承下さい。
日本高血圧学会専門医資格更新のための単位取得について
高血圧専門医を取得されている方は、本会の参加で、資格更新のための単位を2単位取得出来ます。
資格更新時に参加証を提出して頂きますので、大切に保管して下さい。
16
ポスターミニシンポ
Poster Presentation (Friday 23 September 14:00-16:00)
1: Genome
P1-1～P1-9
モデュレーター：竹内史比古（国立国際医療研究センター研究所）
コメンテーター：中尾友美（和歌山県立医科大学第二生理学講座）
P1-1
The altered circadian clock inducing glucocorticoid reactivation in SHR.
Sho Tanaka, Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon
University School of Medicine
P1-2
Identification of clock controlled blood pressure regulating genes in the kidney of SHR/Izm
Yusuke Murata, Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine,
Nihon University School of Medicine
P1-3
A comparative analysis of the transcriptome and heart function between clock mutant animals
Tomomi Nakao, Departments of Physiology and Pathology, and Radioisotope Laboratory Center, Wakayama
Medical University
P1-4
Further reduction of stroke QTLs on chromosomes 1 and 18 in SHRSP using double subcongenic rats
Kaoru Niiya, Department of Functional Pathology, Shimane University School of Medicine
P1-5
Epigenetic changes in the brain with high-salt intervention in SHR
Hana Shimizu-Furusawa, Department of Gene Diagnostics and Therapeutics, Research Institute, National
Center for Global Health and Medicine
P1-6
Epigenetic changes in the liver with high-fat-diet intervention in SHR
Hana Shimizu-Furusawa, Department of Gene Diagnostics and Therapeutics, Research Institute, National
Center for Global Health and Medicine, Tokyo, Japan
P1-7
Epigenetic changes in the liver with dexamethasone administration in SHR
Hana Shimizu-Furusawa, Department of Gene Diagnostics and Therapeutics, Research Institute, National
Center for Global Health and Medicine, Tokyo, Japan
P1-8
Comparison of epigenetic changes in the liver between Tg-CETP rat and SHR
Hana Shimizu-Furusawa, Department of Gene Diagnostics and Therapeutics, Research Institute, National
Center for Global Health and Medicine, Tokyo, Japan
P1-9
Comparison of epigenetic changes in the liver between RNO4-derived congenic rat and progenitor
strains
Hana Shimizu-Furusawa, Department of Gene Diagnostics and Therapeutics, Research Institute, National
Center for Global Health and Medicine, Tokyo, Japan
17
2: Pathogenesis of Hypertension
P2-1～P2-5
モデュレーター：根岸裕子（武庫川女子大学薬学部）
コメンテーター：青木真美子（近畿大学工学部大学院）
P2-6～P2-10
モデュレーター：大原浩貴（島根大学医学部病理学講座）
コメンテーター：十万佐知子（武庫川女子大学薬学部）
P2-1
The precedence role of metabotropic glutamate receptors in the regulation of baseline blood pressure in
SHRSP
Md Zahid Hasan, Department of Functional Pathology, Shimane University Faculty of Medicine, Shimane,
Japan
P2-2
Oxidative stress and HDAC in the spontaneously hypertensive rats (SHRs)
Mamiko Aoki, Kindai University Graduate School of Systems Engineering, *Kindai University Life Science
Research Institute, Hiroshima
P2-3
Complement 3 induces the salt-sensitive hypertension by induction of dedifferentiation of mesenchymal
tissues with activation of renal RA system in SHR
Eriko Negishi, Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon
University School of Medicine
P2-4
The role of C3 on renin expression during the process of mesenchymal stem cell differentiating into
vascular smooth muscle cell
Lan Chen, Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon
University School of Medicine
P2-5
Role of TWIST-1 on the increased expression of complement 3 in mesenchymal tissues from SHR
Tomoyasu Otsuki, Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon
University School of Medicine
P2-6
The anti-inflammatory effects of hydrogen sulfide in 3T3-L1 adipocytes
Sachiko Juman, School of Pharmacy and Pharmaceutical sciences, Mukogawa Women’s university
P2-7
Difference of taste sensitivity between SHR and WKY
Mohammad Farhadur Reza, Department of Functional Pathology, Shimane University School of Medicine
P2-8
The combination of hypertension and high-fat and -cholesterol diet induces severe hepatic inflammation
in rats via NF-kB and Nrf2 signalings
Yuan Yuan, College of Life and Health Sciences, CHUBU University
P2-9
Novel pathophysiological functions of α-synuclein, causative molecule of Parkinson disease, in vascular
aging and endothelial dysfunction.
Yoichi Takami, Department of Geriatric and General Medicine, Osaka University Graduate School of
Medicine
P2-10
Increased renal AcylCoA Oxidase2 (ACOX2) expression in SHR/Izm
Masahiro Okamura, Division of Nephrology, Hypertension and Endocrinology, Department of Internal
Medicine, Nihon University School of Medicine
18
3: Kidney // Cardiovascular System // Nervous System
P3-1～P3-3
モデュレーター：鷹見洋一（大阪大学大学院医学系研究科老年・腎臓内科学）
コメンテーター：柿添豊（熊本大学大学院生命科学研究部腎臓内科学分野）
P3-7～P3-9
モデュレーター：岸拓弥（九州大学循環器病未来医療研究センター）
コメンテーター：吉川智子（九州大学循環器内科）
P3-11～P3-13
モデュレーター：岸拓弥（九州大学循環器病未来医療研究センター）
コメンテーター：平出幸子（北海道医療大学薬学部）
P3-1
Systematic implantation of dediffarentiated fat cells ameliorated immuno-induced glomerulonephritis
with stimulation of TSG-6
Takashi Maruyama, Division of Nephrology Hypertension and Endocrinology, Department of Medicine,
Nihon University School of Medicine
P3-2
HCaRG is a inhibitor of ErbB receptor-driven tumorigenesis and prognostic for survival in renal cell
carcinoma
Jin Ikeda, Division of General Medicine, Department of Internal Medicine, Nihon University School of
Medicine
P3-3
The role of serine proteases in the regulation of osmotic free water homeostasis.
Yutaka Kakizoe, Department of Nephrology, Kumamoto University Graduate School of Medical Sciences
P3-7
Effect of Angelica acutiloba Kitagawa extract on blood flow regulation in stroke-prone spontaneously
hypertensive rats
Ayaka Kawakami, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University
P3-8
Apelin-induced blood pressure elevation in mice overexpressing APJ on vascular smooth muscle cells
Chulwon Kwon, Graduate School of Life and Environmental Sciences, Tsukuba Advanced Research Alliance,
University of Tsukuba
P3-9
Disruptive arterial pressure stability is improved by sodium-glucose co-transporter 2 inhibitor in
streptozotocin-induced diabetic rats
Tomoko Yoshikawa, Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical
Sciences
P3-11
N-type Ca Channel in sympathetic nerve terminals and α1A linked Ca channel are contributed to
increased vascular tone but mobilization size from ER is reduced in SHR
Takuzo Hano, Medical Education and Population-based Medicine, Wakayama Medical University
P3-12
Effects of a dopamine re-uptake inhibitor on cortical and accambal dopaminergic system in SHRSP/Ezo
Sachiko Hiraide, Department of Pharmacology, Faculty of Pharmaceutical Science, Health Science University
of Hokkaido
P3-13
Hypertension is a system disruption of dynamic circulatory homeostasis mediated by brain
Takuya Kishi, Collaborative Research Institute of Innovation for Cardiovascular Diseases, Kyushu University
Center for Disruptive Cardiovascular Medicine
19
4: Therapy/Intervention // Experimental Model
P4-1～P4-5
モデュレーター：松田裕之（日本大学医学部総合内科）
コメンテーター：畔上達彦（慶應義塾大学腎臓内分泌代謝内科）
P4-7～P4-9
モデュレーター：北森一哉（金城学院大学生活環境学部）
コメンテーター：松尾裕之（島根大学医学部病態病理学）
P4-1
Intranasal administration of cationic nanogel-based vaccine targeting angiotensin II type 1 receptor
attenuates the development of hypertension in SHR
Tatsuhiko Azegami, Department of Internal Medicine, School of Medicine, Keio University
P4-2
Inhibition of an increase in the blood pressure by food produced by processing residues after fruit juice
extraction in spontaneously hypertensive rats (SHR)
Kohei Kawakami, Department of Experimental Animals, Center for Integrated Research in Science, Shimane
University
P4-3
Drug discovery of a novel gene silencer pyrrole-imidazole polyamide targeting human TGF-β1 for
progressive renal dysfunction
Masari Moriuchi, Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon
University School of Medicine
P4-4
Contribution of TGF-β1 and effects of novel gene silencer PI polyamides to TGF-β1 in diabetic
nephropathy
Shu Horikoshi, Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon
University School of Medicine
P4-5
Different effect of NEP inhibition with LCZ696 on developing and developed cardiac hypertrophy and
diastolic dysfunction in salt-loaded hypertensive rats.
Go Hamano, Department of Geriatric and General Medicine, Osaka University
P4-7
Increased locomotor activity in congenic SHRSPwch1.0 rats is derived from the increase in systolic
arterial pressure but not the systolic arterial pressure level itself
Hiroshi Kawamura, MGJ Cardiovascular Institute
P4-8
Development of a new rat model for combined hypertension and atherosclerosis; Apoprotein Eknockout SHR
Hiroyuki Matsuo, Department of Functional Pathology, School of Medicine, Shimane University
P4-9
Excitatory synapse dysfunction in the prefrontal cortex of SHRSP/Ezo as an attention deficit/
hyperactivity disorder animal model
Takayuki Senriuchi, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences
University of Hokkaido
20

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