b-Oxidation: Abbau von Stearinsäure C18 : 0
Ort: Mitochondrien-Matrix
w
CH3
(CH2)11
g
b
a
CH2
CH2
CH2
O
C
S-CoA
Acyl-CoA
Irmelin Probst, Walter Storch Vorlesungspräsentation Biochemie Teil 1, SS 2007
FAD
b
Acyl-CoA
Dehydrogenase
Flavin-Enzym
a
OO
H
FADH
C2 C
CH
CH
CH
(CH
CH
2 2 CC
3 3 (CH
2)11
2 2 CH
2)11 CH
H
S-CoA
S-CoA
Trans-Enoyl-CoA
Acyl-CoA
H20
Enoyl-CoA
Hydratase
CH3
(CH2)11
CH2
H
C
HO
H
C
H
L-3-Hydroxyacyl-CoA
Trans-Enoyl-CoA
O
C
S-CoA
+
NAD
ß-C Atom wird oxidiert
L-3-Hydroxyacyl-CoA
Dehydrogenase
CH3
H
H
C
C
NADH+H+HO
H
(CH2)11
CH2
L-3-Hydroxyacyl-CoA
3-Ketoacyl-CoA
O
C
S-CoA
CoA-SH
wird abgespalten
O
b-Ketothiolase
CH3
(CH2)11
CH2
H
S-CoA
C HC
C
H
S-CoA
O
3-Ketoacyl-CoA
Palmityl-CoA
Citratcyclus
Ketogenese
Acetyl-CoA

Urine Sample Report

UNIT 6B Introduction to biochemistry of mitochondria