Molecular Interactions in Malaria April 11-12, 2016 SYMPOSIUM Monday 1 Festsaal Humboldt Graduate School Luisenstraße 56, 10117 Berlin 9:00 am Welcome by Prof. Dr. Alexander Maier and Prof. Dr Kai Matuschewski 9:10 am Greeting by Dr. Lauren Bain Deputy Ambassador of Australia in Germany 9:20 am Greeting by Prof. Dr. Dr. h.c. Günter Stock Chair of the Executive Board, Einstein Foundation 9:30 am Greeting by Prof. Dr. Peter Hegemann Director of the Department of Biology, Humboldt-Universität zu Berlin 9:40 am Greeting by Prof. Dr. Kiaran Kirk Dean of the College of Medicine, Biology & Environment, The Australian National University, Canberra 9:50 am Coffee Break 10:05 am Session I: Malaria Metabolism Assoc. Prof. Dr. Alexander Maier (The Australian National University, Canberra) The Lipids of Plasmodium falciparum: Maintaining a well-greased transmission machinery 10:35 am Dr. Nishith Gupta (Humboldt-Universität zu Berlin) Make it or take it - Membrane biogenesis in Toxoplasma gondii 11:05 am Dr. Christina Spry (The Australian National University, Canberra) Understanding and targeting the utilisation of pantothenate by Plasmodium falciparum 11:35 am Coffee Break 11:50 am Prof. Dr. Kevin Saliba (The Australian National University, Canberra) Riboflavin and the intraerythrocytic stage of the human malaria parasite Plasmodium falciparum 12:20 pm Prof. Dr. Frank Seeber (Robert Koch-Institute, Berlin) Metabolic pathways in the apicoplast dependent on the ferredoxin redox system 12:50 pm Lunch Break www.iri-lifesciences.de www.iri-lifesciences.de Molecular Interactions in Malaria April 11-12, 2016 SYMPOSIUM Monday 2 2:00 pm Festsaal Humboldt Graduate School Luisenstraße 56, 10117 Berlin Session II: Transport and Trafficking Dr. Melanie Rug (The Australian National University, Canberra) Sticky Business: Proteins involved in Malaria Pathogenesis 2:30 pm Prof. Dr. Edda Klipp (Humboldt-Universität zu Berlin) Thermodynamic modeling of cellular ion transport 3:00 pm Poster Session & Coffee Break 4:00 pm Session III: Parasite Genetics Prof. Dr. Christian Schmitz-Linneweber (Humboldt-Universität zu Berlin) Plasmodium organellar gene expression 4:30 pm Dr. Giel van Dooren (The Australian National University, Canberra) Proteomic mapping of mitochondrion of Toxoplasma gondii. 5:00 pm Dr. Benedikt Beckmann (Humboldt-Universität zu Berlin) Cross-species RNA-protein interactions in the Malaria-infected cell www.iri-lifesciences.de www.iri-lifesciences.de Molecular Interactions in Malaria April 11-12, 2016 SYMPOSIUM Tuesday1 9:00 am Festsaal Humboldt Graduate School Luisenstraße 56, 10117 Berlin Session IV: Host Genetics and Responses Assoc. Prof. Dr. Ian Cockburn ( The Australian National University, Canberra ) CD8+ T cells require LFA-1 to patrol the liver and protect against malaria 9:30 am Dr. Alyssa Ingmundson (Humboldt-Universität zu Berlin) Acquisition of cholesterol from the host late endocytic pathway is important for efficient liverstage Plasmodium development 10:00 am Prof. Dr. Kai Matuschewski (Humboldt-Universität zu Berlin) Breaking the silence of Plasmodium liver stage development 10:30 am Coffee Break 10:50 am Prof. Dr. Emanuel Heitlinger (Humboldt-Universität zu Berlin) Dual RNASeq transcriptomics of Eimeria falciformis development in its natural host, the mouse 11:20 am Assoc. Prof. Dr. Brendan McMorran (The Australian National University, Canberra) Platelets in Malaria 11:50 am Prof. Dr. Frank Mockenhaupt (Charité – Universitätsmedizin Berlin) Polymorphisms of iron regulation in susceptibility and manifestation of malaria 12:20 pm Lunch Break www.iri-lifesciences.de www.iri-lifesciences.de Molecular Interactions in Malaria April 11-12, 2016 SYMPOSIUM Tuesday 2 1:30 pm Festsaal Humboldt Graduate School Luisenstraße 56, 10117 Berlin Session V: New approaches in antimalarial therapy Prof. Dr. Simon Foote (The Australian National University, Canberra) Developing new drugs using host-directed therapy 2:00 pm Dr. Leif Erik Sander ( Charité – Universitätsmedizin Berlin) Sensing microbial threats: mechanisms & consequences for disease and vaccination 2:30 pm Dr. Florian Kurth (Charité – Universitätsmedizin Berlin) Drug safety in artemisinin-based therapy 3:00 pm Poster Session & Coffee Break 4:00 pm Prof. Dr. Kiaran Kirk (The Australian National University, Canberra) Membrane transport proteins as antimalarial drug targets 4:30 pm Dr. Simone Reber (Humboldt-Universität zu Berlin ) Purification & characterization of Plasmodium tubulin – a novel lead to anti-malarial drug discovery 5:00 pm Dr. Gaetan Burgio (The Australian National University, Canberra) A new way to find anti-malarial drug targets using a large-scale ENU mutagenesis screen in mice 5:30 pm Reception www.iri-lifesciences.de www.iri-lifesciences.de Molecular Interactions in Malaria Poster Josefine Dunst (Freie Universität Berlin, Institute of Chemistry and Biochemistry) Plasmodium GPI - moesin interaction does not affect immune response to Plasmodium berghei ANKA and infection outcome Prabhanjan Gai (Charité – Universitätsmedizin Berlin, Tropical Medicine and International Health) Malaria in Mangalore, India: a case-control study Özlem Günay-Esiyok (Humboldt-Universität zu Berlin, Molecular Parasitology) Cyclic GMP-mediated signaling in the apicomplexan parasite Toxoplasma gondii Arne Hillebrand (Humboldt-Universität zu Berlin, Molecular Genetics) Discovery of novel putative RNA binding proteins in Plasmodium organelles William Hirst (Humboldt-Universität zu Berlin, Quantitative Biology) Investigating Tubulin as a Drug Target for Novel Antimalarial Therapies Totta Kasemo (Humboldt-Universität zu Berlin, Molecular Parasitology) RNAseq Transcriptome Reflects Eimeria falciformis Development in its Natural Host, the Mouse Pengfei Kong (Humboldt-Universität zu Berlin, Molecular Parasitology) Two phylogenetically distinct CDP-diacylglycerol synthases in endoplasmic reticulum and apicoplast cooperate to ensure lipid biogenesis in Toxoplasma gondii Oriana Kreutzfeld ( Max Planck Institute for Infection Biology ) Plasmodium berghei HSP101 is the limiting factor for protein export during liver stage development Arunakar Kuchipudi (Humboldt-Universität zu Berlin, Molecular Parasitology) Optogenetic monitoring identifies phosphatidylthreonine-regulated calcium homeostasis in Toxoplasma gondii Joachim Michael Matz (Max Planck Institute for Infection Biology, Parasitology) Got milk? A dietary approach to assess folate synthesis and salvage by the malaria parasite Dr. Katja Müller (Humboldt-Universität zu Berlin, Molecular Parasitology) A preclinical malaria vaccine model: Immunizations with single-dose co-administrations of Plasmodium sporozoites and antimalarial drugs Matthias Noll (Humboldt-Universität zu Berlin, Molecular Parasitology ) Illumination of cyclic AMP signaling in Toxoplasma gondii Prof. Dr. Jude Przyborski (Philipps University Marburg, Parasitology) Proteomic analysis of exported chaperone/co-chaperone complexes of P. falciparum reveals an array of complex protein-protein interactions Laura Radtke (Humboldt-Universität zu Berlin, Molecular Parasitology ) Optogenetic dissection of stage-specific metabolism in Toxoplasma gondii Bingjian Ren (Humboldt-Universität zu Berlin, Molecular Parasitology ) Apicomplexan parasites, Toxoplasma gondii and Eimeria falciformis, induce and co-opt a master transcription factor cFos in the mammalian host cell Zaira Rizopoulos (Max Planck Institute for Infection Biology ) Heme biosynthesis in the Plasmodium life cycle Constanza Tacoli ( Charité – Universitätsmedizin Berlin, Tropical Medicine and International Health ) Analysis of polymorphisms in K13 gene in African isolates Erika Urdaneta ( Humboldt-Universität zu Berlin, Molecular Infection Biology) PTex: a rapid method for purification of crosslinked RNA-protein complexes www.iri-lifesciences.de www.iri-lifesciences.de
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