Rupert Langer, Prof. Dr. med
Bern, October 2015
CURRICULUM VITAE
1. PERSONAL INFORMATION
Office Address:
Institute of Pathology
University of Bern
Murtenstrasse 31
CH-3010 Bern
Switzerland
Tel.: +41 31-632-3247
Fax.: +41 31-632-4995
E-mail: [email protected]
Date and place of birth:
Family Status:
Children:
Citizenship:
Position:
Home Address:
Junkerngasse 41
CH-3011 Bern
Switzerland
June, 28, 1973, Regensburg (Germany)
married
Marius (1996), Linus (2000)
German
Leitender Arzt, Institute of Pathology, University of Bern
2. PROFESSIONAL EXPERIENCE
Professional
20142012-2014
2009-2011
2001-2009
2000-2001
Degrees
2015
2010
2009
2001
2000
Leitender Arzt, Institute of Pathology, University of Bern
Oberarzt, Institute of Pathology, University of Bern
Oberarzt, head of the tumorbank of the Klinikum Rechts der Isar der Technischen Universität
München
Assistenzarzt (residency) Institut für Pathologie der Technischen Universität München
Arzt im Praktikum (residency) I. Medizinische Abteilung Städtisches Krankenhaus MünchenSchwabing (Hematology-Oncology)
Assoziierter Professor (Associate Professor)
Habilitation Pathologie (Umhabilitation to University of Bern, 2011)
Facharzt für Pathologie (board exam)
Promotion
Staatsexamen (graduation; medical school in Regensburg and Technische Universität
München)
Diagnostic focus
Gastrointestinal pathology
Soft tissue and bone pathology
Autopsy
Nephropathology
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Rupert Langer, Prof. Dr. med
Scientific focus
Pathology of the gastrointestinal tract, especially esophageal adenocarcinoma
-Histopathology and molecular genetics
-Morphology of tumor regression after chemotherapy
-Molecular response prediction
Biobanking (Tumorbanking)
Pathology in low resource settings
Medical Education
3. MISCELLANEOUS
Reviewer
Journals: Clinical Cancer Research, Annals of Surgical Oncology, Histopathology, Human Pathology,
Virchows Archiv, International Journal of Cancer, BMC Cancer, Medical Oncology, Pathology Research and
Practice, Frontiers of Oncology, Helicobacter, Cells
Foundations: African Health Sciences, Deutsche Forschungsgemeinschaft, Research Foundation Flanders,
Fondation contre le Cancer Belgie.
Associate Editor
BMC Cancer, Frontiers of Oncology
Honors
Die sechs besten Forschungsbeiträge 2004, 88. Jahrestagung der Deutschen Gesellschaft für Pathologie.
Grants
-Expression von Heat Shock Proteinen und Glucose regulierten Proteinen in Barrett-Carcinomen prädiktive
und prognostische Wertigkeit (2009-2011); DFG 163.360€
-Prädiktion des Ansprechens auf neoadjuvante Chemotherapie mittels microRNA Profiling beim lokal
fortgeschrittenen Adenocarcinom des Ösophagus (2010) Walter Schultz Stiftung 15.090€
-Chemotherapieresistenz beim neoadjuvant behandelten Magenkarzinom: Bedeutung des NotchSignalweges (2011-2013) Wilhelm Sander Stiftung (Co-applicant) 88.901€
-Die Bedeutung von microRNAs bei der Strahlenresistenz von humanen Plattenepithelkarzinomen des
oberen Gastrointestinal- und Respirationstraktes (2011-2012) Lütjen Drecoll Stiftung 55.000€
-Aufbau einer Tumorgewebebank in Malawi (2012) Monika Kutzner Stiftung (co-applicant) 21.900€
-The impact of autophagy on biology and chemo-resistance of esophageal adenocarcinomas (2013-2015).
Schweizerische Krebsliga CHF 236'000.
- The role of autophagy for resistance to Her2 directed therapy in adenocarcinomas of the upper
gastrointestinal tract (2015-2016). Bernische Krebsliga CHF 60.000 (co-applicant)
Memberships and Associations
European Society of Pathology
Deutsche Gesellschaft für Pathologie
International Academy of Pathology German Division
International Academy of Pathology British Division
OESO
Deutscher Hochschulverband
Schweizerische Gesellschaft für Pathologie
Robert Haggitt Society of Gastrointestinal Pathology (US)
International Gastric Cancer Association
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Rupert Langer, Prof. Dr. med
Publication List PD Dr Rupert Langer (October 2015)
Online access: http://www.ncbi.nlm.nih.gov/pubmed?term=Langer%20Rupert
Hirzel C, Nueesch S, Wendland T, Langer R. Necrotizing herpes-simplex virus tonsillitis mimicking peritonsillar abscess. Infection. 2015
Jul 21. [Epub ahead of print] PubMed PMID: 26194140.
Springfeld C, Wiecha C, Kunzmann R, Heger U, Weichert W, Langer R, Stange A, Blank S, Sisic L, Schmidt T, Lordick F, Jäger D,
Grenacher L, Bruckner T, Büchler MW, Ott K. Influence of Different Neoadjuvant Chemotherapy Regimens on Response, Prognosis,
and Complication Rate in Patients with Esophagogastric Adenocarcinoma. Ann Surg Oncol. 2015 May 22. [Epub ahead of print]
PubMed PMID: 26001861.
Schläfli AM, Berezowska S, Adams O, Langer R, Tschan M. Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin
embedded human tissue by immunohistochemistry. Eur J Histochem DOI: 10.4081/ejh.2015.2481
Buck A, Ly A, Balluff B, Sun N, Gorzolka K, Feuchtinger A, Janssen KP, Kuppen PJ, van de Velde CJ, Weirich G, Erlmeier F, Langer R,
Aubele M, Zitzelsberger H, Aichler M, Walch A. High-resolution MALDI-FT-ICR MS Imaging for the analysis of metabolites from
formalin-fixed paraffin-embedded clinical tissue samples. J Pathol. 2015 May 12. doi: 10.1002/path.4560. [Epub ahead of print] PubMed
PMID: 25965788.
Bauer L, Takacs A, Slotta-Huspenina J, Langer R, Becker K, Novotny A, Ott K, Walch A, Hapfelmeier A, Keller G. Clinical Significance
of NOTCH1 and NOTCH2 Expression in Gastric Carcinomas: An Immunohistochemical Study. Front Oncol. 2015 Apr 22;5:94. doi:
10.3389/fonc.2015.00094. eCollection 2015. PubMed PMID: 25954607; PubMed Central PMCID: PMC4406075.
Genitsch V, Novotny A, Seiler CA, Kröll D, Walch A, Langer R. Epstein-barr virus in gastro-esophageal adenocarcinomas - single center
experiences in the context of current literature. Front Oncol. 2015 Mar 26;5:73. doi: 10.3389/fonc.2015.00073. eCollection 2015.
PubMed PMID: 25859432; PubMed Central PMCID: PMC4374449.
Karamitopoulou E, Zlobec I, Koelzer VH, Langer R, Dawson H, Lugli A. Tumour Border Configuration in Colorectal Cancer: Proposal for
an Alternative Scoring System based on the Percentage of Infiltrating Margin. Histopathology. 2015 Feb 4. doi: 10.1111/his.12665.
[Epub ahead of print] PubMed PMID: 25648412.
Liebl F, Demir IE, Mayer K, Schuster T, DʼHaese JG, Becker K, Langer R, Bergmann F, Wang K, Rosenberg R, Novotny AR, Feith M,
Reim D, Friess H, Ceyhan GO. The impact of neural invasion severity in gastrointestinal malignancies: a clinicopathological study. Ann
Surg. 2014 Nov;260(5):900-7; discussion 907-8. doi: 10.1097/SLA.0000000000000968. PubMed PMID: 25379860.
Allum WH, Bonavina L, Cassivi SD, Cuesta MA, Dong ZM, Felix VN, Figueredo E, Gatenby PA, Haverkamp L, Ibraev MA, Krasna MJ,
Lambert R, Langer R, Lewis MP, Nason KS, Parry K, Preston SR, Ruurda JP, Schaheen LW, Tatum RP, Turkin IN, van
der Horst S, van der Peet DL, van der Sluis PC, van Hillegersberg R, Wormald JC, Wu PC, Zonderhuis BM. Surgical treatments for
esophageal cancers. Ann N Y Acad Sci. 2014 Sep;1325(1):242-68. doi: 10.1111/nyas.12533. PubMed PMID: 25266029.
Al-Haddad S, Chang AC, De Hertogh G, Grin A, Langer R, Sagaert X, Salemme M, Streutker CJ, Soucy G, Tripathi M, Upton MP, Vieth
M, Villanacci V. Adenocarcinoma at the gastroesophageal junction. Ann N Y Acad Sci. 2014 Sep;1325(1):211-25. doi:
10.1111/nyas.12535. PubMed PMID: 25266027.
Cotton RG, Langer R, Leong T, Martinek J, Sewram V, Smithers M, Swanson PE, Qiao YL, Udagawa H, Ueno M, Wang M, Wei WQ,
White RE. Coping with esophageal cancer approaches worldwide. Ann N Y Acad Sci. 2014 Sep;1325(1):138-58. doi:
10.1111/nyas.12522. PubMed PMID: 25266022.
Aichler M, Motschmann M, Jütting U, Luber B, Becker K, Ott K, Lordick F, Langer R, Feith M, Siewert JR, Walch A. Epidermal growth
factor receptor (EGFR) is an independent adverse prognostic factor in esophageal adenocarcinoma patients treated with cisplatin-based
neoadjuvant chemotherapy. Oncotarget. 2014 Aug 30;5(16):6620-32. PubMed PMID: 25216514; PubMed Central PMCID:
PMC4196151.
Kaemmerer D, Posorski N, von Eggeling F, Ernst G, Hörsch D, Baum RP, Prasad V, Langer R, Esposito I, Klöppel G, Sehner S, Knösel
T, Hommann M. The search for the primary tumor in metastasized gastroenteropancreatic neuroendocrine neoplasm. Clin Exp
Metastasis. 2014 Oct;31(7):817-27. doi: 10.1007/s10585-014-9672-3. Epub 2014 Aug 7. PubMed PMID: 25098566.
Koelzer VH, Langer R, Zlobec I, Lugli A. Tumor budding in upper gastrointestinal carcinomas. Front Oncol. 2014 Aug 14;4:216. doi:
10.3389/fonc.2014.00216. eCollection 2014. Review. PubMed PMID: 25177546; PubMed Central PMCID: PMC4132482.
Feuchtinger A, Stiehler T, Jütting U, Marjanovic G, Luber B, Langer R, Walch A. Image analysis of immunohistochemistry is superior to
visual scoring as shown for patient outcome of esophageal adenocarcinoma. Histochem Cell Biol. 2014 Aug 26. [Epub ahead of print]
PubMed PMID: 25156293.
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Rupert Langer, Prof. Dr. med
Karamitopoulou E, Thies S, Zlobec I, Ott K, Feith M, Slotta-Huspenina J, Lordick F, Becker K, Langer R. Assessment of tumor
regression of esophageal adenocarcinomas after neoadjuvant chemotherapy: comparison of 2 commonly used scoring approaches. Am
J Surg Pathol. 2014 Nov;38(11):1551-6. doi: 10.1097/PAS.0000000000000255. PubMed PMID: 25140894.
Gündisch S, Slotta-Huspenina J, Verderio P, Ciniselli CM, Pizzamiglio S,Schott C, Drecoll E, Viertler C, Zatloukal K, Kap M, Riegman P,
Esposito I, Specht K, Babaryka G, Asslaber M, Bodó K, den Bakker M, den Hollander J, Fend F, Neumann J, Reu S, Perren A, Langer
R, Lugli A, Becker I, Richter T, Kayser G, May AM, Carneiro F, Lopes JM, Sobin L, Höfler H, Becker KF. Evaluation of colon cancer
histomorphology: a comparison between formalin and PAXgene tissue fixation by an international ring trial. Virchows Arch. 2014
Nov;465(5):509-19. doi: 10.1007/s00428-014-1624-4. Epub 2014 Aug 2. PubMed PMID: 25085759.
Helbling M, Lukesch A, Haimovici A, Karamitopoulou E, Berger MD, Hädrich M, Mallaev M, Schnüriger B, Koelzer VH, Dawson H,
Borner M, Langer R, Rosenberg R, Nitsche U, Inderbitzin D, Lugli A, Tschan M, Zlobec I. Investigation of IL-23 (p19, p40) and IL-23R
identifies nuclear expression of IL-23 p19 as a favorable prognostic factor in colorectal cancer: a retrospective multicenter study of 675
patients. Oncotarget. 2014 Jul 15;5(13):4671-82. PubMed PMID: 25015728; PubMed
Central PMCID: PMC4148090.
Slotta-Huspenina J, Becker KF, Feith M, Walch A, Langer R. Heat Shock Protein 90 (HSP90) and Her2 in Adenocarcinomas of the
Esophagus. Cancers (Basel). 2014 Jun 27;6(3):1382-93. doi: 10.3390/cancers6031382. PMID: 24978439 [PubMed]
Blank S, Lordick F, Bader F, Burian M, Dobritz M, Grenacher L, Becker K, Weichert W, Langer R, Sisic L, Stange A, Jäger D, Büchler
M, Bruckner T, Siewert J, Ott K. Post-therapeutic response evaluation by a combination of endoscopy and CT scan in esophagogastric
adenocarcinoma after chemotherapy: better than its reputation. Gastric Cancer. 2014 Apr 11. [Epub ahead of print] PubMed PMID:
24722800.
Blank S, Rachakonda S, Keller G, Weichert W, Lordick F, Langer R, Springfeld C, Bruckner T, Becker K, Kumar R, Ott K. A
retrospective comparative exploratory study on two methylentetrahydrofolate reductase (MTHFR) polymorphisms in esophagogastric
cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer patients.
BMC Cancer. 2014 Feb 3;14:58. doi: 10.1186/1471-2407-14-58. PubMed PMID: 24490800; PubMed Central PMCID: PMC3922603.
Heger U, Blank S, Wiecha C, Langer R, Weichert W, Lordick F, Bruckner T, Dobritz M, Burian M, Springfeld C, Grenacher L, Siewert
JR, Büchler M, Ott K. Is preoperative chemotherapy followed by surgery the appropriate treatment for signet ring cell containing
adenocarcinomas of the esophagogastric junction and stomach? Ann Surg Oncol. 2014 May;21(5):1739-48.
Schmidt T, Sicic L, Blank S, Becker K, Weichert W, Bruckner T, Parakonthun T, Langer R, Büchler MW, Siewert JR, Lordick F, Ott K.
Prognostic value of histopathological regression in 850 neoadjuvantly treated oesophagogastric adenocarcinomas. Br J Cancer. 2014
Apr 1;110(7):1712-20. doi: 10.1038/bjc.2014.94. Epub 2014 Feb 25.
Drecoll E, Nitsche U, Bauer K, Berezowska S, Slotta-Huspenina J, Rosenberg R, Langer R. Expression analysis of heat shock protein
90 (HSP90) and Her2 in colon carcinoma. Int J Colorectal Dis. 2014 Apr 15. [Epub ahead of print] PubMed PMID: 24733427.
Geppert CI, Rümmele P, Sarbia M, Langer R, Feith M, Morrison L, Pestova E, Schneider-Stock R, Hartmann A, Rau TT. Multi-colour
FISH in oesophageal adenocarcinoma-predictors of prognosis independent of stage and grade. Br J Cancer. 2014 May 22. [Epub ahead
of print]
Florian Liebl, Ihsan Ekin Demir, Katharina Mayer, Jan G. D’Haese, Karen Becker, Rupert Langer, Frank Bergmann, Tibor Schuster, Kun
Wang, Robert Rosenberg, Alexander R. Novotny, Marcus Feith, Daniel Reim, Helmut Friess, Güralp O. Ceyhan. The genuine extent
and impact of neural invasion in gastrointestinal malignancies – a clinicopathological study. Ann Surg, accepted for publication
Pierre Hainaut, Elodie Caboux, Generoso Bevilacqua, Fref Bosman, Thibaut Dassesse, Heinz Hoefler, Anne Janin, Rupert Langer,
Denis Larsimont, Manuel Morente, Peter Riegman, Peter Schirmacher. Pathology as the Cornerstone of Human Tissue Banking:
European Consensus Expert Group Report Biopreservation and Biobanking . 01/2009; 7(3):157-160.
Langer R, Reim D, Höfler H, Becker K. Reply to Letter: "Tumor Regression After Neoadjuvant Chemotherapy in Gastric Carcinoma: Is
There Really So Few Responders?" Ann Surg. 2013 Nov 11. [Epub ahead of print] PubMed PMID: 24169167.
Langer R, Becker K, Zlobec I, Gertler R, Sisic L, Büchler M, Lordick F, Slotta-Huspenina J, Weichert W, Höfler H, Feit M, Ott K. A
multifactorial histopathologic score for the prediction of prognosis of resected esophageal adenocarcinomas after neoadjuvant
chemotherapy. Ann Surg Oncol. 2014 Mar;21(3):915-21. doi: 10.1245/s10434-013-3410-y. Epub 2013 Nov 27.
S Blank, F Lordick, M Dobritz, L Grenacher, M Burian, R Langer, W Roth, A Schaible, K Becker, H Bläker, L Sisic, A Stange, P
Compani, H Schulze-Bergkamen, D Jäger, M Büchler, J R Siewert, K Ott . A reliable risk score for stage IV esophagogastric cancer. Eur
J Surg Oncol. 2013 Aug;39(8):823-30. doi: 10.1016/j.ejso.2013.01.005. Epub 2013 Jan 31
Holzscheiter M, Layland LE, Loffredo-Verde E, Mair K, Vogelmann R, Langer R, Wagner H, Prazeres da Costa C. Lack of Host Gut
Microbiota Alters Immune Responses and Intestinal Granuloma Formation during Schistosomiasis. Clin Exp Immunol. 2013 Oct 30. doi:
10.1111/cei.12230. [Epub ahead of print] PubMed PMID:
24168057.
Thies S, Langer R. Tumor Regression Grading of Gastrointestinal Carcinomas after Neoadjuvant Treatment. Front Oncol. 2013 Oct
7;3:262. Review. PubMed PMID: 24109590.
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Rupert Langer, Prof. Dr. med
Heger U, Bader F, Lordick F, Burian M, Langer R, Dobritz M, Blank S, Bruckner T, Becker K, Herrmann K, Siewert JR, Ott K. Interim
endoscopy results during neoadjuvant therapy for gastric cancer correlate with histopathological response and prognosis. Gastric
Cancer. 2013 Sep 1. [Epub ahead of print] PubMed PMID: 23996162.
Slotta-Huspenina J, Wolff C, Drecoll E, Feith M, Bettstetter M, Malinowsky K, Bauer L, Becker K, Ott K, Höfler H, Becker KF, Langer R.
A specific expression profile of heat-shock proteins and glucose-regulated proteins is associated with response to neoadjuvant
chemotherapy in oesophageal adenocarcinomas. Br J Cancer. 2013 Jul 23;109(2):370-8. doi: 10.1038/bjc.2013.319. Epub 2013 Jul 9.
PubMed PMID: 23839491; PubMed Central PMCID: PMC3721390
Moghaddam N, Langer R, Ross S, Nielsen E, Lösch S. Multiple osteosclerotic lesions in an Iron Age skull from Switzerland (320-250
BC)--an unusual case. Swiss Med Wkly. 2013 Jul 29;143:w13819. doi: 10.4414/smw.2013.13819. PubMed PMID: 23897004.
Berezowska S, Novotny A, Bauer K, Feuchtinger A, Slotta-Huspenina J, Becker K, Langer R, Walch A. Association between HSP90 and
Her2 in gastric and gastroesophageal carcinomas. PLoS One. 2013 Jul 11;8(7):e69098. doi: 10.1371/journal.pone.0069098. Print 2013.
PubMed PMID: 23874879; PubMed Central PMCID: PMC3708885.
Aichler M, Elsner M, Ludyga N, Feuchtinger A, Zangen V, Maier SK, Balluff B, Schöne C, Hierber L, Braselmann H, Meding S, Rauser
S, Zischka H, Aubele M, Schmitt M, Feith M, Hauck SM, Ueffing M, Langer R, Kuster B, Zitzelsberger H, Höfler H, Walch AK. Clinical
response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria. J Pathol. 2013
Aug;230(4):410-9. doi: 10.1002/path.4199. PubMed PMID: 23592244.
Lawlor RT, Sluss PM, Langer R, Sughayer MA, Igbe MA, Siddiqui K, De Blasio P, Duma B, Mendy M, Chabannon C, Ibrahim M.
European, Middle Eastern, and African Society for Biopreservation and Biobanking (ESBB). 2012 Conference Session on Biobanking in
Emerging Countries Biopreservation and Biobanking. June 2013, 11(3): 176-181.
Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, Lechel A, Rudolph KL, Langer R, Slotta-Huspenina J, Bader
FG, Prazeres da Costa O, Neurath MF, Meining A, Kirchner T, Greten FR. Loss of p53 in Enterocytes Generates an Inflammatory
Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors. Cancer Cell. 2013 Jan
14;23(1):93-106. doi: 10.1016/j.ccr.2012.11.014. Epub 2012 Dec 27. PubMed PMID: 23273920.
Ott K, Blank S, Becker K, Langer R, Weichert W, Roth W, Sisic L, Stange A, Jäger D, Büchler M, Siewert JR, Lordick F. Factors
predicting prognosis and recurrence in patients with esophago-gastric adenocarcinoma and histopathological response with less than
10 % residual tumor. Langenbecks Arch Surg. 2012 Dec 27. [Epub ahead of print] PubMed PMID: 23269519.
Reim D, Loos M, Vogl F, Novotny A, Schuster T, Langer R, Becker K, Höfler H, Siveke J, Bassermann F, Friess H, Schuhmacher C.
Prognostic implications of the seventh edition of the international union against cancer classification for patients with gastric cancer: the
Western experience of patients treated in a single-center European institution. J Clin Oncol. 2013 Jan 10;31(2):263-71. doi:
10.1200/JCO.2012.44.4315. Epub 2012 Dec 3. PubMed PMID: 23213098.
Bettstetter M, Berezowska S, Keller G, Walch A, Feuchtinger A, Slotta-Huspenina J, Feith M, Drecoll E, Höfler H, Langer R. Epidermal
growth factor receptor, phosphatidylinositol-3-kinase catalytic subunit/PTEN, and KRAS/NRAS/BRAF in primary resected esophageal
adenocarcinomas: loss of PTEN is associated with worse clinical outcome. Hum Pathol. 2012 Nov 14. doi:pii: S0046-8177(12)00289-4.
10.1016/j.humpath.2012.08.005. [Epub ahead of print] PubMed PMID: 23158210.
Liebl F, Demir IE, Rosenberg R, Boldis A, Yildiz E, Kujundzic K, Kehl T, Dischl D, Schuster T, Maak M, Becker K, Langer R, Laschinger
M, Friess H, Ceyhan GO. The severity of neural invasion is associated with shortened survival in colon cancer. Clin Cancer Res. 2013
Jan 1;19(1):50-61. doi: 10.1158/1078-0432.CCR-12-2392. Epub 2012 Nov 12. PubMed PMID: 23147996.
Gollwitzer H, Gloeck T, Roessner M, Langer R, Horn C, Gerdesmeyer L, Diehl P. Radial extracorporeal shock wave therapy (rESWT)
induces new bone formation in vivo: results of an animal study in rabbits. Ultrasound Med Biol. 2013
Jan;39(1):126-33. doi: 10.1016/j.ultrasmedbio.2012.08.026. Epub 2012 Nov 2. PubMed PMID: 23122639.
Wulfkuhle JD, Berg D, Wolff C, Langer R, Tran K, Illi J, Espina V, Pierobon M, Deng J, DeMichele A, Walch A, Bronger H, Becker I,
Waldhör C, Höfler H, Esserman L; I-SPY 1 TRIAL Investigators, Liotta LA, Becker KF, Petricoin EF 3rd. Molecular analysis of HER2
signaling in human breast cancer by functional protein pathway activation mapping. Clin Cancer Res. 2012 Dec 1;18(23):6426-35. doi:
10.1158/1078-0432.CCR-12-0452. Epub 2012 Oct 8. PubMed PMID: 23045247.
Bauer L, Langer R, Becker K, Hapfelmeier A, Ott K, Novotny A, Höfler H, Keller G. Expression profiling of stem cell-related genes in
neoadjuvant-treated gastric cancer: a NOTCH2, GSK3B and β-catenin gene signature predicts survival. PLoS One. 2012;7(9):e44566.
doi: 10.1371/journal.pone.0044566. Epub 2012 Sep 10. PubMed PMID: 22970250; PubMed Central PMCID: PMC3438181.
Becker K, Reim D, Novotny A, Zum Büschenfelde CM, Engel J, Friess H, Höfler H, Langer R. Proposal for a multifactorial prognostic
score that accurately classifies 3 groups of gastric carcinoma patients with different outcomes after neoadjuvant chemotherapy and
surgery. Ann Surg. 2012 Dec;256(6):1002-7. doi: 10.1097/SLA.0b013e318262a591. PubMed PMID: 22968067.
Slotta-Huspenina J, Berg D, Bauer K, Wolff C, Malinowsky K, Bauer L, Drecoll E, Bettstetter M, Feith M, Walch A, Höfler H, Becker KF,
Langer R. Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal
adenocarcinomas. PLoS One. 2012;7(7):e41420. doi: 10.1371/journal.pone.0041420. Epub 2012 Jul 24. PubMed PMID: 22911792;
PubMed Central PMCID: PMC3404067.
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Rupert Langer, Prof. Dr. med
Bauer K, Nitsche U, Slotta-Huspenina J, Drecoll E, von Weyhern CH, Rosenberg R, Höfler H, Langer R. High HSP27 and HSP70
expression levels are independent adverse prognostic factors in primary resected colon cancer. Cell Oncol (Dordr). 2012
Jun;35(3):197-205. doi: 10.1007/s13402-012-0079-3. Epub 2012 Apr 26. PubMed PMID: 22535481.
Seiz L, Dorn J, Kotzsch M, Walch A, Grebenchtchikov NI, Gkazepis A, Schmalfeldt B, Kiechle M, Bayani J, Diamandis EP, Langer R,
Sweep FC, Schmitt M, Magdolen V. Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor
prognosis of ovarian cancer patients. Biol Chem. 2012 Apr 1;393(5):391-401. doi: 10.1515/hsz-2011-0264. PubMed PMID: 22505521.
Regel I, Merkl L, Friedrich T, Burgermeister E, Zimmermann W, Einwächter H, Herrmann K, Langer R, Röcken C, Hofheinz R, Schmid
R, Ebert MP. Pan-histone deacetylase inhibitor panobinostat sensitizes gastric cancer cells to anthracyclines via induction of CITED2.
Gastroenterology. 2012 Jul;143(1):99-109.e10. doi: 10.1053/j.gastro.2012.03.035. Epub 2012 Mar 27. PubMed PMID: 22465428.
Meding S, Balluff B, Elsner M, Schöne C, Rauser S, Nitsche U, Maak M, Schäfer A, Hauck SM, Ueffing M, Langer R, Höfler H, Friess H,
Rosenberg R, Walch A. Tissue-based proteomics reveals FXYD3, S100A11 and GSTM3 as novel markers for regional lymph node
metastasis in colon cancer. J Pathol. 2012 Mar 19. doi:
10.1002/path.4021. [Epub ahead of print] PubMed PMID: 22430872.
Berezowska S, Tomoka T, Kamiza S, Milner DA Jr, Langer R. Surgical pathology in sub-Saharan Africa--volunteering in Malawi.
Virchows Arch. 2012 Apr;460(4):363-70. doi: 10.1007/s00428-012-1217-z. Epub 2012 Mar 10. PubMed PMID:
22407448.
Elsner M, Rauser S, Maier S, Schöne C, Balluff B, Meding S, Jung G, Nipp M, Sarioglu H, Maccarrone G, Aichler M, Feuchtinger A,
Langer R, Jütting U, Feith M, Küster B, Ueffing M, Zitzelsberger H, Höfler H, Walch A. MALDI imaging mass spectrometry reveals
COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma. J Proteomics. 2012 Aug 3;75(15):4693704. doi: 10.1016/j.jprot.2012.02.012. Epub 2012 Feb 17. PubMed PMID: 22365974.
Troeltzsch M, Stimmer H, Langer R, Troeltzsch M, Steiner T, Wolff KD. High-grade supraclavicular soft tissue sarcoma as secondary
malignancy after successful treatment of acute myeloid leukemia: case report and literature
review. J Oral Maxillofac Surg. 2012 Sep;70(9):2211-7. doi: 10.1016/j.joms.2011.10.008. Epub 2012 Jan 26. Review. PubMed PMID:
22281128.
Meding S, Nitsche U, Balluff B, Elsner M, Rauser S, Schöne C, Nipp M, Maak M, Feith M, Ebert MP, Friess H, Langer R, Höfler H,
Zitzelsberger H, Rosenberg R, Walch A. Tumor classification of six common cancer types based on proteomic profiling by MALDI
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Ebert MP, Tänzer M, Balluff B, Burgermeister E, Kretzschmar AK, Hughes DJ, Tetzner R, Lofton-Day C, Rosenberg R, ReinacherSchick AC, Schulmann K, Tannapfel A, Hofheinz R, Röcken C, Keller G, Langer R, Specht K, Porschen R, Stöhlmacher-Williams J,
Schuster T, Ströbel P, Schmid RM. TFAP2E-DKK4 and chemoresistance in colorectal cancer. N Engl J Med. 2012 Jan 5;366(1):44-53.
doi: 10.1056/NEJMoa1009473. PubMed PMID: 22216841.
Luber B, Deplazes J, Keller G, Walch A, Rauser S, Eichmann M, Langer R, Höfler H, Hegewisch-Becker S, Folprecht G, Wöll E, Decker
T, Endlicher E, Lorenzen S, Fend F, Peschel C, Lordick F. Biomarker analysis of cetuximab plus
oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of
the Arbeitsgemeinschaft Internistische Onkologie (AIO). BMC Cancer. 2011 Dec 7;11:509. doi: 10.1186/1471-2407-11-509. PubMed
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Reim D, Gertler R, Novotny A, Becker K, zum Büschenfelde CM, Ebert M, Dobritz M, Langer R, Hoefler H, Friess H, Schumacher C.
Adenocarcinomas of the esophagogastric junction are more likely to respond to preoperative chemotherapy than distal gastric cancer.
Ann Surg Oncol. 2012 Jul;19(7):2108-18. doi: 10.1245/s10434-011-2147-8. Epub 2011 Dec 1. PubMed PMID: 22130620.
Kap M, Smedts F, Oosterhuis W, Winther R, Christensen N, Reischauer B, Viertler C, Groelz D, Becker KF, Zatloukal K, Langer R,
Slotta-Huspenina J, Bodo K, de Jong B, Oelmuller U, Riegman P. Histological assessment of PAXgene tissue fixation and stabilization
reagents. PLoS One. 2011;6(11):e27704. doi: 10.1371/journal.pone.0027704. Epub 2011 Nov 16. PubMed PMID: 22110732; PubMed
Central PMCID: PMC3218013.
Nitsche U, Maak M, Schuster T, Künzli B, Langer R, Slotta-Huspenina J, Janssen KP, Friess H, Rosenberg R. Prediction of prognosis is
not improved by the seventh and latest edition of the TNM classification for colorectal cancer in a single-center collective. Ann Surg.
2011 Nov;254(5):793-800; discussion 800-1. doi: 10.1097/SLA.0b013e3182369101. PubMed PMID: 22042471.
Berg D, Wolff C, Langer R, Schuster T, Feith M, Slotta-Huspenina J, Malinowsky K, Becker KF. Discovery of new molecular subtypes in
oesophageal adenocarcinoma. PLoS One. 2011;6(9):e23985. doi: 10.1371/journal.pone.0023985. Epub 2011 Sep 23. PubMed PMID:
21966358; PubMed Central PMCID: PMC3179464.
Gertler R, Stein HJ, Loos M, Langer R, Friess H, Feith M. How to classify adenocarcinomas of the esophagogastric junction: as
esophageal or gastric cancer? Am J Surg Pathol. 2011 Oct;35(10):1512-22. doi: 10.1097/PAS.0b013e3182294764. PubMed PMID:
21934477.
Maak M, Nitsche U, Keller L, Wolf P, Sarr M, Thiebaud M, Rosenberg R, Langer R, Kleeff J, Friess H, Johannes L, Janssen KP. Tumorspecific targeting of pancreatic cancer with Shiga toxin B-subunit. Mol Cancer Ther. 2011 Oct;10(10):1918-28. doi: 10.1158/15357163.MCT-11-0006. Epub 2011 Jul 25. PubMed PMID: 21788400.
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Rupert Langer, Prof. Dr. med
zum Büschenfelde CM, Herrmann K, Schuster T, Geinitz H, Langer R, Becker K, Ott K, Ebert M, Zimmermann F, Friess H, Schwaiger
M, Peschel C, Lordick F, Krause BJ. (18)F-FDG PET-guided salvage neoadjuvant radiochemotherapy of adenocarcinoma of the
esophagogastric junction: the MUNICON II trial. J Nucl Med. 2011 Aug;52(8):1189-96. doi: 10.2967/jnumed.110.085803. Epub 2011 Jul
15. PubMed PMID: 21764790.
Eichner R, Schwendy S, Liebl F, Huber A, Langer R. Two cases of primary pulmonary angiosarcoma as a rare cause of lung
haemorrhage. Pathology. 2011 Jun;43(4):386-9. doi: 10.1097/PAT.0b013e3283468789. PubMed PMID: 21566500.
Ott K, Herrmann K, Schuster T, Langer R, Becker K, Wieder HA, Wester HJ, Siewert JR, zum Büschenfelde CM, Buck AK, Wilhelm D,
Ebert MP, Peschel C, Schwaiger M, Lordick F, Krause BJ. Molecular imaging of proliferation and glucose utilization: utility for monitoring
response and prognosis after neoadjuvant therapy in locally advanced gastric cancer. Ann Surg Oncol. 2011 Nov;18(12):3316-23. doi:
10.1245/s10434-011-1743-y. Epub 2011 May 3. PubMed PMID: 21537865.
Langer R, Rauser S, Feith M, Nährig JM, Feuchtinger A, Friess H, Höfler H, Walch A. Assessment of ErbB2 (Her2) in oesophageal
adenocarcinomas: summary of a revised immunohistochemical evaluation system, bright field double in situ hybridisation and
fluorescence in situ hybridisation. Mod Pathol. 2011 Jul;24(7):908-16. doi: 10.1038/modpathol.2011.52. Epub 2011 Apr 22. PubMed
PMID: 21516080.
Becker K, Langer R, Reim D, Novotny A, Meyer zum Buschenfelde C, Engel J, Friess H, Hofler H. Significance of histopathological
tumor regression after neoadjuvant chemotherapy in gastric adenocarcinomas: a summary of 480 cases. Ann Surg. 2011
May;253(5):934-9. doi: 10.1097/SLA.0b013e318216f449. PubMed PMID:21490451.
Gertler R, Stein HJ, Langer R, Nettelmann M, Schuster T, Hoefler H, SiewertJR, Feith M. Long-term outcome of 2920 patients with
cancers of the esophagus and esophagogastric junction: evaluation of the New Union Internationale Contre le Cancer/American Joint
Cancer Committee staging system. Ann Surg. 2011 Apr;253(4):689-98. doi: 10.1097/SLA.0b013e31821111b5. PubMed PMID:
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Mutze K, Langer R, Schumacher F, Becker K, Ott K, Novotny A, Hapfelmeier A, Höfler H, Keller G. DNA methyltransferase 1 as a
predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer. Eur J Cancer. 2011 Aug;47(12):1817-25. doi:
10.1016/j.ejca.2011.02.024. Epub 2011 Mar 31. PubMed PMID: 21458988.
Loos M, Langer R, Schuster T, Gertler R, Walch A, Rauser S, Friess H, Feith M. Clinical significance of the costimulatory molecule B7H1 in Barrett carcinoma. Ann Thorac Surg. 2011 Apr;91(4):1025-31. doi: 10.1016/j.athoracsur.2010.12.041. PubMed PMID: 21440117.
Ott K, Rachakonda PS, Panzram B, Keller G, Lordick F, Becker K, Langer R, Buechler M, Hemminki K, Kumar R. DNA repair gene and
MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the esophagus or stomach treated with
cisplatin and 5-fluorouracil-based neoadjuvant chemotherapy. Ann Surg Oncol. 2011 Sep;18(9):2688-98. doi: 10.1245/s10434-0111601-y. Epub 2011 Feb24. PubMed PMID: 21347786.
Berg D, Langer R, Tran K, Walch A, Schuster T, Bronger H, Becker KF. Protein microarray-based comparison of HER2, estrogen
receptor, and progesterone receptor status in core biopsies and surgical specimens from FFPE breast cancer tissues. Appl
Immunohistochem Mol Morphol. 2011 Jul;19(4):300-5. doi:10.1097/PAI.0b013e3182054f9f. PubMed PMID: 21293257.
Langer R, Becker K, Feith M, Friess H, Höfler H, Keller G. Genetic aberrations in primary esophageal melanomas: molecular analysis of
c-KIT, PDGFR, KRAS, NRAS and BRAF in a series of 10 cases. Mod Pathol. 2011 Apr;24(4):495-501. doi:
10.1038/modpathol.2010.220. Epub 2010 Dec 3. PubMed PMID: 21131919.
Lorenzen S, Panzram B, Keller G, Lordick F, Herrmann K, Becker K, Langer R, Schwaiger M, Siewert JR, Ott K. Association of the
VEGF 936C>T polymorphism with FDG uptake, clinical, histopathological, and metabolic response in patients with adenocarcinomas of
the esophagogastric junction. Mol Imaging Biol. 2011 Feb;13(1):178-86. doi: 10.1007/s11307-010-0330-0. PubMed PMID: 20449668.
Rauser S, Langer R, Tschernitz S, Gais P, Jütting U, Feith M, Höfler H, Walch A. High number of CD45RO+ tumor infiltrating
lymphocytes is an independent prognostic factor in non-metastasized (stage I-IIA) esophageal adenocarcinoma. BMC Cancer. 2010
Nov 5;10:608. doi: 10.1186/1471-2407-10-608. PubMed PMID: 21054833; PubMed Central PMCID: PMC2988756.
Ceyhan GO, Liebl F, Maak M, Schuster T, Becker K, Langer R, Demir IE, Hartel M, Friess H, Rosenberg R. The severity of neural
invasion is a crucial prognostic factor in rectal cancer independent of neoadjuvant radiochemotherapy. Ann Surg. 2010 Nov;252(5):797804. doi: 10.1097/SLA.0b013e3181fcab8d. PubMed PMID: 21037435.
Langer R, Mutze K, Becker K, Feith M, Ott K, Höfler H, Keller G. Expression of class I histone deacetylases (HDAC1 and HDAC2) in
oesophageal adenocarcinomas: an immunohistochemical study. J Clin Pathol. 2010 Nov;63(11):994-8. doi: 10.1136/jcp.2010.080952.
Epub 2010 Oct 5. PubMed PMID: 20924032.
Ergin B, Meding S, Langer R, Kap M, Viertler C, Schott C, Ferch U, Riegman P, Zatloukal K, Walch A, Becker KF. Proteomic analysis of
PAXgene-fixed tissues. J Proteome Res. 2010 Oct 1;9(10):5188-96. doi: 10.1021/pr100664e. PubMed PMID: 20812734.
Langer R, Geissinger E, Rüdiger T, von Schilling C, Ott G, Mandl-Weber S, Quintanilla-Martinez L, Fend F. Peripheral T-cell lymphoma
with progression to a clonally related, Epstein Barr virus+, cytotoxic aggressive T-cell lymphoma:evidence for secondary EBV infection
of an established malignant T-cell clone. Am J Surg Pathol. 2010 Sep;34(9):1382-7. doi: 10.1097/PAS.0b013e3181ec577a. PubMed
PMID: 20739840.
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Rupert Langer, Prof. Dr. med
Langer R, Ott K, Feith M, Lordick F, Specht K, Becker K, Hofler H. High pretherapeutic thymidylate synthetase and MRP-1 protein levels
are associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patients. J Surg Oncol. 2010 Oct
1;102(5):503-8. doi: 10.1002/jso.21641. PubMed PMID: 20589706.
Mutze K, Langer R, Becker K, Ott K, Novotny A, Luber B, Hapfelmeier A, Göttlicher M, Höfler H, Keller G. Histone deacetylase (HDAC)
1 and 2 expression and chemotherapy in gastric cancer. Ann Surg Oncol. 2010 Dec;17(12):3336-43. doi: 10.1245/s10434-010-1182-1.
Epub 2010 Jun 29. PubMed PMID: 20585871.
Ludwig L, Büchler P, Kleeff J, Gaa J, Stangl M, Prinz C, Langer R, Friess H, Schmid RM, Algül H. Multidisciplinary treatment of
aggressive and rapidly progressing biliary papillomatosis. Dig Dis Sci. 2010 Dec;55(12):3627-9. doi:
10.1007/s10620-010-1205-6. Epub 2010 Apr 22. PubMed PMID: 20411427.
Raggi M, Langer R, Feith M, Friess H, Schauer M, Theisen J. Successful evaluation of a new animal model using mice for esophageal
adenocarcinoma. Langenbecks Arch Surg. 2010 Apr;395(4):347-50. doi: 10.1007/s00423-010-0607-4. Epub 2010 Mar 19. PubMed
PMID: 20300770.
Bevilacqua G, Bosman F, Dassesse T, Höfler H, Janin A, Langer R, Larsimont D, Morente MM, Riegman P, Schirmacher P, Stanta G,
Zatloukal K, Caboux E, Hainaut P. The role of the pathologist in tissue banking: European Consensus Expert Group Report. Virchows
Arch. 2010 Apr;456(4):449-54. doi: 10.1007/s00428-010-0887-7. Epub 2010 Feb 16. Review. PubMed PMID: 20157825; PubMed
Central PMCID: PMC2852521.
Langer R, Ott K, Feith M, Lordick F, Siewert JR, Becker K. Prognostic significance of histopathological tumor regression after
neoadjuvant chemotherapy in esophageal adenocarcinomas. Mod Pathol. 2009 Dec;22(12):1555-63. doi: 10.1038/modpathol.2009.123.
Epub 2009 Oct 2. PubMed PMID: 19801967.
Schemann M, Hafsi N, Michel K, Kober OI, Wollmann J, Li Q, Zeller F, Langer R, Lee K, Cellek S. The beta3 adrenoceptor agonist
GW427353 (Solabegron) decreases excitability of human enteric neurons via release of somatostatin. Gastroenterology. 2010
Jan;138(1):266-74. doi: 10.1053/j.gastro.2009.09.046. Epub 2009 Sep 25. PubMed PMID: 19786030.
Eckel F, Herrmann K, Schmidt S, Hillerer C, Wieder HA, Krause BJ, Schuster T, Langer R, Wester HJ, Schmid RM, Schwaiger M, Buck
AK. Imaging of proliferation in hepatocellular carcinoma with the in vivo marker 18F-fluorothymidine. J Nucl Med. 2009 Sep;50(9):14417. doi: 10.2967/jnumed.109.065896. Epub 2009 Aug 18. PubMed PMID: 19690030.
Buhner S, Li Q, Vignali S, Barbara G, De Giorgio R, Stanghellini V, Cremon C, Zeller F, Langer R, Daniel H, Michel K, Schemann M.
Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome.
Gastroenterology. 2009 Oct;137(4):1425-34. doi: 10.1053/j.gastro.2009.07.005. Epub 2009 Jul 28. PubMed PMID: 19596012.
Keller G, Geist B, Slotta-Huspenina J, Langer R, Nagl F, Fend F, Höfler H, Perren A. Novel multiple, monoallelic KRAS mutations at
codon 12 and 13. Int J Cancer. 2009 Dec 1;125(11):2744-5. doi: 10.1002/ijc.24635. PubMed PMID: 19521964.
Gillen S, Feith M, Gertler R, Langer R, Massmann J, Sarbia M, Friess H. Testicular metastasis from adenocarcinoma of the esophagus.
Ann Thorac Surg. 2009 Mar;87(3):957-9. doi: 10.1016/j.athoracsur.2008.07.115. PubMed PMID: 19231438.
Langer R, Dinges J, Dobritz M, Brauer RB, Perren A, Becker K, Kremer M. Sclerosing angiomatoid nodular transformation of the spleen
presenting as a rapidly growing tumour in a patient with rectal cancer. BMJ Case Rep. 2009;2009. doi:pii: bcr11.2008.1191.
10.1136/bcr.11.2008.1191. Epub 2009 Sep 15. PubMed PMID: 21918654; PubMed Central PMCID: PMC3030094.
Gollwitzer H, Roessner M, Langer R, Gloeck T, Diehl P, Horn C, Stemberger A, von Eiff C, Gerdesmeyer L. Safety and effectiveness of
extracorporeal shockwave therapy: results of a rabbit model of chronic osteomyelitis. Ultrasound Med Biol. 2009 Apr;35(4):595-602. doi:
10.1016/j.ultrasmedbio.2008.10.004. Epub 2008 Dec 24. PubMed PMID: 19110371.
Langer R, Ott K, Specht K, Becker K, Lordick F, Burian M, Herrmann K, Schrattenholz A, Cahill MA, Schwaiger M, Hofler H, Wester HJ.
Protein expression profiling in esophageal adenocarcinoma patients indicates association of heat-shock protein 27 expression and
chemotherapy response. Clin Cancer Res. 2008 Dec 15;14(24):8279-87. doi: 10.1158/1078-0432.CCR-08-0679. PubMed PMID:
19088045.
Specht K, Harbeck N, Smida J, Annecke K, Reich U, Naehrig J, Langer R, Mages J, Busch R, Kruse E, Klein-Hitpass L, Schmitt M,
Kiechle M, Hoefler H. Expression profiling identifies genes that predict recurrence of breast cancer after adjuvant CMF-based
chemotherapy. Breast Cancer Res Treat. 2009 Nov;118(1):45-56. doi: 10.1007/s10549-008-0207-y. Epub 2008 Oct 17. PubMed PMID:
18925433.
Voland P, Besig S, Rad R, Braun T, Baur DM, Perren A, Langer R, Höfler H, Prinz C. Correlation of matrix metalloproteinases and
tissue inhibitors of matrix metalloproteinase expression in ileal carcinoids, lymph nodes and liver metastasis with prognosis and survival.
Neuroendocrinology. 2009;89(1):66-78. doi: 10.1159/000151482. Epub 2008 Aug 18. PubMed PMID: 18708724.
Bajbouj M, Phillip V, Langer R, Schmid RM, Ludwig L. Electronic clinical challenges and images in GI. Colonic tuberculosis.
Gastroenterology. 2008 Aug;135(2):e6-7. doi: 10.1053/j.gastro.2008.06.058. Epub 2008 Jul 9. PubMed PMID:
18619443.
Wiech T, Nikolopoulos E, Weis R, Langer R, Bartholomé K, Timmer J, Walch AK, Höfler H, Werner M. Genome-wide analysis of
genetic alterations in Barrett's adenocarcinoma using single nucleotide polymorphism arrays. Lab Invest. 2009 Apr;89(4):385-97. doi:
10.1038/labinvest.2008.67. Epub 2008 Jul 28. PubMed PMID: 18663352.
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Rupert Langer, Prof. Dr. med
Langer R, Feith M, Siewert JR, Wester HJ, Hoefler H. Expression and clinical significance of glucose regulated proteins GRP78 (BiP)
and GRP94 (GP96) in human adenocarcinomas of the esophagus. BMC Cancer. 2008 Mar 10;8:70. doi: 10.1186/1471-2407-8-70.
PubMed PMID: 18331622; PubMed Central PMCID: PMC2270853.
Walch A, Seidl S, Hermannstädter C, Rauser S, Deplazes J, Langer R, von Weyhern CH, Sarbia M, Busch R, Feith M, Gillen S, Höfler
H, Luber B. Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer. Mod Pathol. 2008
May;21(5):544-52. doi: 10.1038/modpathol.2008.3. Epub 2008 Feb 1. PubMed PMID: 18246045.
Bremm A, Walch A, Fuchs M, Mages J, Duyster J, Keller G, Hermannstädter C, Becker KF, Rauser S, Langer R, von Weyhern CH,
Höfler H, Luber B. Enhanced activation of epidermal growth factor receptor caused by tumor-derived E-cadherin mutations. Cancer Res.
2008 Feb 1;68(3):707-14. doi:10.1158/0008-5472.CAN-07-1588. PubMed PMID: 18245470.
Wagner S, Gollwitzer H, Wernicke D, Langer R, Siebenrock KA, Hofstetter W. Interface membrane fibroblasts around aseptically
loosened endoprostheses express MMP-13. J Orthop Res. 2008 Feb;26(2):143-52. PubMed PMID: 17853491.
Rauser S, Weis R, Braselmann H, Feith M, Stein HJ, Langer R, Hutzler P, Hausmann M, Lassmann S, Siewert JR, Höfler H, Werner M,
Walch A. Significance of HER2 low-level copy gain in Barrett's cancer: implications for fluorescence in situ hybridization testing in
tissues. Clin Cancer Res. 2007 Sep 1;13(17):5115-23. PubMed PMID: 17785566.
Langer R, Specht K, Becker K, Ewald P, Ott K, Lordick F, Siewert JR, Höfler H. Comparison of pretherapeutic and posttherapeutic
expression levels of chemotherapy-associated genes in adenocarcinomas of the esophagus treated by 5-fluorouracil- and cisplatinbased neoadjuvant chemotherapy. Am J Clin Pathol. 2007 Aug;128(2):191-7. PubMed PMID: 17638652.
Höfler H, Langer R, Ott K, Keller G. Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal
tract. Recent Results Cancer Res. 2007;176:33-6. PubMed PMID: 17607914.
Höfler H, Langer R, Ott K, Keller G. Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal
tract. Adv Exp Med Biol. 2006;587:115-20. Review. PubMed PMID: 17163161.
Langer R, Von Rahden BH, Nahrig J, Von Weyhern C, Reiter R, Feith M, Stein HJ, Siewert JR, Höfler H, Sarbia M. Prognostic
significance of expression patterns of c-erbB-2, p53, p16INK4A, p27KIP1, cyclin D1 and epidermal growth factor receptor in
oesophageal adenocarcinoma: a tissue microarray study. J Clin Pathol. 2006 Jun;59(6):631-4. PubMed PMID: 16731604; PubMed
Central PMCID: PMC1860401.
Baumann S, Keller G, Pühringer F, Napieralski R, Feith M, Langer R, Höfler H, Stein HJ, Sarbia M. The prognostic impact of O6Methylguanine-DNA Methyltransferase (MGMT) promotor hypermethylation in esophageal adenocarcinoma. Int J Cancer. 2006 Jul
15;119(2):264-8. PubMed PMID: 16477636.
Langer R, Specht K, Becker K, Ewald P, Bekesch M, Sarbia M, Busch R, Feith M, Stein HJ, Siewert JR, Höfler H. Association of
pretherapeutic expression of chemotherapy-related genes with response to neoadjuvant chemotherapy in Barrett carcinoma. Clin
Cancer Res. 2005 Oct 15;11(20):7462-9. PubMed PMID: 16243820.
von Rahden BH, Stein HJ, Pühringer F, Koch I, Langer R, Piontek G, Siewert JR, Höfler H, Sarbia M. Coexpression of cyclooxygenases
(COX-1, COX-2) and vascular endothelial growth factors (VEGF-A, VEGF-C) in esophageal adenocarcinoma. Cancer Res. 2005 Jun
15;65(12):5038-44. PubMed PMID: 15958546.
Sarbia M, zur Hausen A, Feith M, Geddert H, von Rahden BH, Langer R, von Weyhern C, Siewert JR, Höfler H, Stein HJ. Esophageal
(Barrett's) adenocarcinoma is not associated with Epstein-Barr virus infection: an analysis of 162 cases. Int J Cancer. 2005 Nov
20;117(4):698-700. PubMed PMID: 15929074.
Michel K, Zeller F, Langer R, Nekarda H, Kruger D, Dover TJ, Brady CA, Barnes NM, Schemann M. Serotonin excites neurons in the
human submucous plexus via 5-HT3 receptors. Gastroenterology. 2005 May;128(5):1317-26. PubMed PMID: 15887114.
von Rahden BH, Stein HJ, Langer R, von Weyhern CW, Schenk E, Döring C, Siewert JR, Höfler H, Sarbia M. C609T polymorphism of
the NAD(P)H:quinone oxidoreductase I gene does not significantly affect susceptibility for esophageal adenocarcinoma. Int J Cancer.
2005 Jan 20;113(3):506-8. PubMed PMID: 15455349.
Albrecht B, Hausmann M, Zitzelsberger H, Stein H, Siewert JR, Hopt U, Langer R, Höfler H, Werner M, Walch A. Array-based
comparative genomic hybridization for the detection of DNA sequence copy number changes in Barrett's adenocarcinoma. J Pathol.
2004 Jul;203(3):780-8. PubMed PMID: 15221937.
Gollwitzer H, Langer R, Diehl P, Mittelmeier W. Chronic osteomyelitis due to Mycobacterium chelonae diagnosed by polymerase chain
reaction homology matching. A case report. J Bone Joint Surg Am. 2004 Jun;86-A(6):1296-301. PubMed PMID: 15173306.
Langer R, Burzler C, Bechtner G, Gärtner R. Influence of iodide and iodolactones on thyroid apoptosis. Evidence that apoptosis induced
by iodide is mediated by iodolactones in intact porcine thyroid follicles. Exp Clin Endocrinol Diabetes. 2003 Sep;111(6):325-9. PubMed
PMID: 14520597.
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Rupert Langer, Prof. Dr. med
Bern, 3.4.15
Rupert Langer
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1 PRIV.-DOZ. MAG.PHARM. DR.RER.NAT. OLIVER LANGER