4.4.4.
19
1
p. 4-5�
2
α
3
4
p. 4-5�
1969
1973
Chemistry of Marine Natural Products
4.4.5.
p. 4-6�
1
1-1
H3C
S
H3C
N
H3C
N
S
Lumbriconereis heteropoda
H3C
SCONH2
SCONH2
p. 4-6�
2
2-1
p. 4-6�
2-2
Estée Lauder
p. 4-6�
2-3
p. 4-6�
O
HN
N
O
O
HO
HO
OH
R = CH3�
R = H��
NH2
NH2
R
N
N
O
N
N
N
Ara
-C
Ara =
N
Ara
-A
p. 4-9�
1
Cys-Lys-Gly-Lys-Gly-Ala-Lys
S
S
8
Cys-Ser-Arg-Leu-Met-Tyr-Asp
S
Cys-Thr-Gly-Ser
16
S
Cys-Arg-Ser-Gly-Lys
20
S
15
Cys
S
Cys-NH2
25
MVII
ω-
p. 4-8�
OCH3
HO
OAc
H
N
Me
N
O
O
O
H3CO
HO
O S OH
743
NH
p. 4-7�
H
H
H
H
O
O
O
O
O
HO
H
O
O
O
H
H
H
O
H
O
H
O
H
O
B
H
O O
HO
O
O
HO
H3CO
OH
H
H2N
O
O
H
O
H
O
H
O
H
O O
O
O
p. 4-9�
4.4.6.
表4-2. 臨床試験に入った主な海洋天然物とその誘導体
!
!
!
!
!
!
!
!
!
!
KRN7000
!
!
F
!
!
!
!
A
p. 4-10�
!
!
!
p. 4-10�
800〜1,000
432,132
2〜3
225
3〜5
180
3〜7
77
2〜3
70
18
97〜01
p. 4-10�
18
97〜01
432,132
>30,000
0.042%
>0.17%
180
>50
38.9
%
70
<6.0%
3
p. 4-11�
KRN7000,
10, LU-103793,
B
, ω743
B (Lissodendoryx sp.)
(Bugula neritina)
743 (Ecteinascidia tubinata)
(cyanobacteria)
(bacteria)
(yeast)
(filamentous fungi)
p. 4-11�
2
 
 
Neopetrosia exigua
Neopetrosia exigua
2
 
 2

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