10.ࡅࠬ࠻ࡦ⣕ࠕ࠮࠴࡞ൻᛥ೙ߪᐜ⧯࡜࠶࠻ߩ༦ⷡህᖡቇ⠌ࠍଦㅴߔࠆ
₺ቝ᧱‫ޔ‬ᅏ⼱ᢥਫ‫ޔ‬ᬋ⑲ੱ
↢ℂቇ⻠ᐳ
⸥ᙘߩᒻᚑ߿ࠪ࠽ࡊࠬน႟ᕈߦߪࠛࡇࠫࠚࡀ࠹ࠖ࠶ࠢࡔࠞ࠾࠭ࡓ߇㊀ⷐߥᓎഀࠍᨐߚߔ‫ߦ․ޕ‬㐳ᦼ
⸥ᙘᚑ┙ߩೋᦼᲑ㓏ߦ߅޿ߡ‫ߦࡦ࠻ࠬࡅޔ‬㑐ㅪߒߚࡋ࠹ࡠࠢࡠࡑ࠴ࡦߩ᭴ㅧ߇ᄌൻߔࠆߎߣ߇⍮ࠄࠇ
ߡ޿ࠆ‫ᧂޕ‬㐿⍘ߩᐜ⧯࡜࠶࠻ߪ↢ሽᚢ⇛ߣߒߡ૕ᕈᗵⷡߣ༦ⷡߦଐሽߒߡ߅ࠅ‫ⷡⷞޔ‬ᖱႎߥߒߦᲣ࡜
࠶࠻ߩ൬޿ࠍቇ⠌ߔࠆ‫ߩߎޕ‬༦ⷡቇ⠌ߩᚑ┙ߦߪ༦ⷡೝỗߣ૕ᕈᗵⷡೝỗߩኻឭ␜߇ਇนᰳߢ޽ࠆ‫ޕ‬
ࠊࠇࠊࠇߪᣢߦ༦⃿ߦ߅ߌࠆࠪ࠽ࡊࠬน႟ᕈ߇༦ⷡህᖡቇ⠌ߩ␹⚻ၮ⋚ߢ޽ࠆߎߣࠍ᣿ࠄ߆ߦߒߡ߈
ߚ‫ޕ‬
ⴕേ⮎ℂቇ⊛ᚻᴺߦࠃࠅ㐳ᦼߩ༦ⷡቇ⠌ߪォ౮⺞▵࿃ሶ CREB ߩᵴᕈൻ߇ᔅⷐߢ޽ࠆߎߣࠍ␜ߒ‫ޔ‬
߹ߚ࠙ࠚࠬ࠲ࡦࡉࡠ࠶࠻ߦࠃࠅ൬޿ߣ㔚᠄ߩኻឭ␜ᓟ㧝ᤨ㑆ߢ࡝ࡦ㉄ൻ MAPK ߩ⊒⃻߇Ⴧടߒ‫ߠߟޔ‬
޿ߡ࡝ࡦ㉄ൻ CREB ߩ⊒⃻Ⴧട߇㧢ᤨ㑆⛯ߊߎߣ߽␜ߐࠇߚ‫⚦ߩࠄࠇߎߦࠄߐޔߡߒߘޕ‬⢩ౝࠪࠣ࠽
࡞વ㆐ߣㆮવሶ⊒⃻ߣߩㅪ⚿ߦߪࠛࡇࠫࠚࡀ࠹ࠖ࠶ࠢߥ⺞▵߇㑐ਈߔࠆߣ⠨߃ࠄࠇߡ޿ࠆ‫ޔߢߎߘޕ‬
ࠊࠇࠊࠇߪࡅࠬ࠻ࡦ⣕ࠕ࠮࠴࡞ൻ㉂⚛㒖ኂ೷ߢ޽ࠆ࠻࡝ࠦࠬ࠲࠴ࡦ A(TSA)ߩ༦⃿ౝᵈ౉ߦࠃࠆቇ⠌
ଦㅴലᨐߦߟ޿ߡᬌ⸛ߒߚ‫ޕ‬TSA ࠍ൬޿ߣ㔚᠄ߩኻឭ␜࠻࡟࡯࠾ࡦࠣਛߦᵈ౉ߔࠆߣỚᐲଐሽᕈߦህ
ᖡቇ⠌ᚑ┙߇ଦㅴߐࠇߚ‫ߦࠄߐޕ‬൬޿ߣ㔚᠄ߩኻឭ␜࠻࡟࡯࠾ࡦࠣߦࠃࠆ༦⃿ౝߩࡅࠬ࠻ࡦࠕ࠮࠴࡞
ൻ෻ᔕߩ⺃ዉߦߟ޿ߡ⚻ᤨ⊛ߦᬌ⚝ࠍߒߚߣߎࠈ‫ޔ‬൬޿ߩߺ޽ࠆ޿ߪೝỗߥߒߩ᧦ઙߦኻߒ‫ޔ‬൬޿ߣ
㔚᠄ߩኻឭ␜ߢߪ࠻࡟࡯࠾ࡦࠣᓟ㧝ᤨ㑆ߢ H3 ߩࠕ࠮࠴࡞ൻߪ᦭ᗧߦჇടߒߚ‫࡞࠴࠮ࠕޕ‬ൻ H㧠ߩჇ
ടߪ 4 ᤨ㑆ᜬ⛯ߒߚߩߦኻߒ‫ ✚ޔ‬H3 ߅ࠃ߮ H4 ߩ⊒⃻㊂ߪ޿ߕࠇߩ᧦ઙߢ߽Ꮕ߇ߥ߆ߞߚ‫ޔߚ߹ޕ‬TSA
ᵈ౉ߪ᦭ᗧߦࠕ࠮࠴࡞ൻࡅࠬ࠻ࡦߩ⊒⃻ࠍჇടߐߖߚ‫ޕ‬એ਄ࠃࠅ‫ޔ‬ᐜ⧯࡜࠶࠻ߩ༦ⷡህᖡቇ⠌ᚑ┙ߪ
ࡅࠬ࠻ࡦࠕ࠮࠴࡞ൻ෻ᔕࠍ઻߁ߎߣ߇᣿ࠄ߆ߣߥߞߚ‫ޕ‬
㧙 㧙