03-30生体磁気-学会誌-抄録集.qxp_レイアウト 1 2015/05/22 18:06 ページ 128 脳・感覚、音楽 日本生体磁気学会誌 特別号 P2-7 Vol.28 No.1 2015 第 30 回日本生体磁気学会大会論文集 ⯉ࡢⅬ㆑ูぬ㸸⬻☢ᅗᑐᛂゐぬ่⃭⨨ࡢ㛤Ⓨ ࣑ࢫ࣐ࢵࢳᛂࡢ ᐃ Two-point discrimination on the tongue: Development of an MEG-ready tactile stimulator and measurements of mismatch responses to tongue stimulation ᒾ⏣㤶⧊(1)㸪᰿ᮏဴஓ(2)㸪ఀ⸨࿃(1)㸪୰ᮧ⠊(1) (1) ᅜ❧㛗ᑑ་⒪◊✲ࢭࣥࢱ࣮ ⬻ᶵ⬟⏬ീデ᩿㛤Ⓨ㒊 (2) ྠ ᗣ㛗ᑑᨭࣟ࣎ࢵࢺࢭࣥࢱ࣮ Kaori Iwata (1), Tetsuya Nemoto (2), Kengo Ito (1), Akinori Nakamura (1) (1) Department of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology (NCGG) (2) Center for Assistive Robotics and Rehabilitation for Geriatrics and Health, NCGG Abstract Cutaneous two-point discrimination is useful in evaluating central sensory disturbance, however, its assessment becomes difficult if a subject has comorbid peripheral neuropathy like Minamata disease. It is considered that evaluation of the two-point discrimination on the tongue should solve this problem because the oral area is generally spared in case of peripheral neuropathy. Therefore, we newly developed a tactile two-point stimulator which is compatible for MEG measurements. Then we measured brain magnetic responses to tactile Oddball paradigm (standard: 80% one-point stimuli, deviant: 20% two-point stimuli) in 5 healthy volunteers. We could successfully measured mismatch responses (MMR) related to two-point discrimination. It was suggested that the MMR waveforms were changed as a function of the two-point distances and therefore considered to be useful for the objective assessments of two-point discrimination ability. ࡿࡓࡵࠊ⯉࡛Ⅼ㆑ูぬࢆ ᐃࡋᐈほⓗホ౯ࡍ ࡿࡇࡣព⩏῝࠸ࠋࡇࢀࡲ࡛ Akatsuka ࡽ[1]ࡣࠊ 㟁Ẽ่⃭ᑐࡍࡿⅬ㆑ูぬࢆ⬻☢ᅗ᳨࡛ウࡋࠊ యᛶឤぬࡢ Mismatch Response (MMR)ࡼࡗ࡚ Ⅼ㆑ูぬࢆᐈほⓗホ౯࡛ࡁࡿྍ⬟ᛶࢆ♧ࡋ࡚࠸ ࡿࡀࠊ‵ᛶࡢ⯉࠾࠸࡚㟁Ẽ่⃭࡛ࡇࢀࢆᐇ⌧ࡍ ࡿࡇࡣࡰྍ⬟࡛࠶ࡿࠋࡑࡇ࡛ࠊ⯉ࡢゐぬ่ ⃭ࡀྍ⬟࡞⬻☢ᅗᑐᛂࡢ่⃭⨨ࢆ᪂ࡓ㛤Ⓨࡋࠊ ⯉ࡢⅬ㆑ู㛵㐃ࡋࡓ MMR ࡢ ᐃࢆヨࡳࡓࠋ 2. ᪉ἲ 1) ⬻☢ᅗᑐᛂࡢ⯉ゐぬ่⃭⨨ࡢ㛤Ⓨ ࢱ࣑ࣥࢢࢆṇ☜ࢥࣥࢺ࣮ࣟࣝࡋ࡞ࡀࡽ㏻ᖖ ࡢⅬ㆑ูぬ᳨ᰝྠ➼ࡢゐぬ่⃭ࢆ⯉࠼ࡿ ࡇࡀ࡛ࡁࠊࢭࣥࢧ࣮ࡢ┤㏆࡛✌ືࡋ࡚ࡶ☢ሙࢆ ୍ษࡉ࡞࠸่⃭⨨ࡢタィ࣭సᡂࢆ⾜ࡗࡓࠋ㒊 ရ⏝࠸ࡿ⣲ᮦࡣࠊᐇ㝿ࡢ⬻☢ィ㸦Neuromag㸧ࢆ ⏝࠸࡚☢ሙࣀࢬࣞ࣋ࣝࢆ ᐃࡋࡓୖ࡛㑅ᐃࡋࡓࠋ 2) ⬻☢ᅗ ᐃཬࡧࢹ࣮ࢱゎᯒ సᡂࡋࡓ่⃭⨨ࢆ⏝࠸࡚ࠊᖖᗣᡂே 5 ྡࢆ ᑐ㇟⬻☢ᅗ ᐃࢆ⾜ࡗࡓࠋゐぬ่⃭ࡣ⿕㦂⪅ࡢ ⯉ඛ➃ 1 Ⅼ่⃭㸦standard㸸80%, 400㹼480 ᅇ㸧 2 Ⅼ่⃭㸦deviant㸸20%, 100㹼120 ᅇ㸧ࢆࣛࣥ ࢲ࣒࠼ࡿ Oddball ㄢ㢟࡛(่⃭㛫㝸ࡣ 650㹼 850ms, ࣉ࣮ࣟࣈࡢᢲฟ㛫 200ms)ࠊⅬ㛫㊥㞳 ࢆ 5mm ཬࡧ 2mm タᐃࡋࡓሙྜࡢㄏⓎᛂࢆಶ ูグ㘓ࡋࡓࠋࢹ࣮ࢱゎᯒࡣࠊSPM8 (Wellcome Trust Centre for Neuroimaging, University College, UK)ࢆ⏝࠸ࠊstandard ่⃭ deviant ่⃭ࡑࢀࡒࢀ 1. ⥴ゝ Ⅼ㆑ูぬࡣ⤫ྜ⓶ឤぬࡢ✵㛫ศゎ⬟ࡢᣦᶆ ࡞ࡿᇶᮏⓗ࡞ㄆ▱⬟ຊࡢࡦࡘ࡛࠶ࡾࠊ୰ᯡᛶ ឤぬ㞀ᐖࡢホ౯ࡋࡤࡋࡤ⏝࠸ࡽࢀࡿࠋࡋࡋࠊ ࠼ࡤỈಛࡢࡼ࠺ᮎᲈ⚄⤒㞀ᐖࡶྜేࡍࡿሙ ྜࡣホ౯ࡀᅔ㞴࡛࠶ࡿࠋᮎᲈ⚄⤒㞀ᐖࡣ୍⯡ⓗ ᡭ⿄㠐ୗᆺࡢศᕸࢆ࿊ࡋࠊ⯉ࡣ㏻ᖖ㞀ᐖࢆචࢀ 128 03-30生体磁気-学会誌-抄録集.qxp_レイアウト 1 2015/05/22 18:06 ページ 129 日本生体磁気学会誌 特別号 Vol.28 No.1 2015 第 30 回日本生体磁気学会大会論文集 ᑐࡍࡿᛂࡢᕪࢆ⤫ィᏛⓗ᳨ᐃࡋࠊ᭷ព࡞ MMR ࡀฟ⌧ࡋ࡚࠸ࡿ࠺ࡢุᐃ⏝࠸ࡓࠋ ᑦࠊᮏ◊✲ࡣᙜヱタࡢ⌮࣭┈┦ጤဨ ᢎㄆࡢඖࠊ⿕᳨⪅ࡽ᭩㠃࡛ࣥࣇ࢛࣮࣒ࢻࢥ ࣥࢭࣥࢺࢆᚓࡓୖ࡛⾜ࢃࢀࡓࠋࡲࡓࠊཱྀࡢ᥋ゐ 㠃ࢆ་⒪⏝ࡢയ⿕そಖㆤᮦ࡛࢝ࣂ࣮ࡋࠊ⿕᳨⪅ ẖࡍࡿࡇࡼࡾΎ₩ᛶࡶᢸಖࡋࡓࠋ 3. ⤖ᯝཬࡧ⪃ᐹ 1) ⬻☢ᅗᑐᛂࡢ⯉ゐぬ่⃭⨨ࡢ㛤Ⓨ ่⃭ࣉ࣮ࣟࣈࡣ✵Ẽᅽ࡛㥑ືࡉࢀࠊ1Ⅼ㸭2Ⅼ่ ⃭ࡢ✀㢮ࠊᢲࡋฟࡋࢱ࣑ࣥࢢࠊᣢ⥆㛫ࠊ่⃭ 㛫㝸➼ࢆ࣑ࣜ⛊௨ୗࡢ⢭ᗘ࡛⢭ᐦไᚚ࡛ࡁࡿ่ ⃭⨨ࢆ㛤Ⓨࡋࡓ㸦ᅗ1㸧 ࠋ㥑ື࣭ᵓ㐀యࡣ࣑ࣝ ྜ㔠A2017ࠊ࣎ࣝࢺ➼ࡣPOM㸦ࣉࣛࢫࢳࢵࢡ㸧 ࠊ࢚ 㥑ື⭷ࡣࢩࣜࢥࣥᶞ⬡ࢆ⏝࠸ࡿࡇࡼࡾࠊࢭ ࣥࢧ࣮┤㏆࡛㥑ືࡋ࡚ࡶ ᐃᙳ㡪ࢆ࠼ࡿࡼ࠺ ࡞☢ሙࣀࢬࡢⓎ⏕ࢆᢚ࠼ࡿࡇࡀ࡛ࡁࡓࠋ 2) ⬻☢ᅗ ᐃཬࡧࢹ࣮ࢱゎᯒ 2Ⅼ㛫㝸ࡀ5 mmࡢ่⃭ᑐࡍࡿ⬻☢ᅗ ᐃ⤖ᯝ ࡢ௦⾲ⓗἼᙧࢆᅗ2♧ࡍࠋ่⃭ᚋ₯⣙110-150 msࢆpeak᫂░࡞Ἴᙧࡀ୧ഃࡢ㢌㡬㒊ࢭࣥࢧ࣮ ࡽグ㘓ࡉࢀࠊ⯉ࡢᶵᲔⓗ่⃭ᑐࡍࡿయᛶឤぬ ㄏⓎᛂࡢグ㘓ᡂຌࡋࡓ⪃࠼ࡽࢀࡓࠋ₯115 ms ㏆㎶࡛ࡣࠊ1Ⅼ㸭2Ⅼ่⃭㛵ಀ࡞ࡃ୧ഃࡢ㢌 㡬ⴥࡑࢀࡒࢀ༢୍ࡢ㟁※άືࡀㄆࡵࡽࢀࡓ㸦ᅗ 2, ୖ㸧 ࠋ୍᪉ࠊ₯145 ms ㏆㎶࡛ࡣࠊ≉ᕥഃ࡛ 2Ⅼ่⃭ᑐࡍࡿᛂࡀ1Ⅼ่⃭ᑐࡍࡿᛂࡼࡾ ࡶࡁࡃࠊ1Ⅼ㸭2Ⅼ่⃭ࢆ⮬ືⓗᘚูࡍࡿMMR ࡀᤊ࠼ࡽࢀ࡚࠸ࡿࡇࡀ♧၀ࡉࢀࡓ㸦ᅗ2, ୗ㸧ࠋ SPM8ࢆ⏝࠸ࡓゎᯒࡢ⤖ᯝࠊ1Ⅼ่⃭2Ⅼ่⃭ࡑ ࢀࡒࢀᑐࡍࡿᛂࡢᕪࡣ᭷ព࡛࠶ࡾࠊᐈほⓗ ࡶ⯉ࡢⅬ㆑ูぬ㛵㐃ࡋࡓMMRࡀㄏⓎࡉࢀ࡚ ࠸ࡿࡇࡀ♧ࡉࢀࡓ㸦ᅗ3㸧 ࠋ᭦ಶேẖࡢ ᐃ⤖ ᯝࢆゎᯒࡋࡓࡇࢁࠊ2Ⅼ㛫㝸ࡀ5mmࡢOddball่ ⃭ࡢሙྜࡣဨ࡛᭷ព࡞MMRࡀほᐹࡉࢀࡓࡀࠊ㛫 㝸ࡀ2mmࡢሙྜࡣ1ྡࡢࡳ࡛࠶ࡾࠊ2Ⅼ㛫㊥㞳౫ Ꮡࡋ࡚MMRࡢฟ⌧㢖ᗘࡀኚࢃࡿࡇࡀ♧၀ࡉࢀ ࡓࠋ 4 ⤖ㄽ 1. ⬻☢ᅗ ᐃᑐᛂࡋࡓ⯉ࡢゐぬⅬ㆑ู่⃭ ⨨ࢆ᪂つ㛤Ⓨࡋࡓࠋ 2. ᮏ⨨ࢆ⏝࠸࡚ࠊ⯉ࡢⅬ㆑ูぬ㛵㐃ࡋࡓ MMR ࡢ ᐃࡀྍ⬟࡞ࡾࠊⅬ㆑ูぬࡢ㜈್ࢆ ᐈほⓗ᥎ᐃ࡛ࡁࡿྍ⬟ᛶࡀ♧ࡉࢀࡓࠋ ᅗ1㸸㛤Ⓨࡋࡓ่⃭⨨ࠋ ᕥ㸸⯉่⃭ࣉ࣮ࣟࣈ㒊ศࠋ ྑ㸸 ᐃ㢼ᬒࠋ่⃭㒊ࡣ࢝ࢭࢵࢺ࡛そ࠸ࠊࡑࢀࢆ ㍍ࡃཱྀࡃࢃ࠼࡚⯉ඛࢆᙜ࡚ࡿࠊࢫࣜࢵࢺࡽ ่⃭ࣉ࣮ࣟࣈࡀ✺ฟࡋ࡚⯉ࢆ่⃭ࡍࡿࠋ 2Ⅼ่⃭(dev) 1Ⅼ่⃭(std) 2Ⅼ่⃭(dev) 1Ⅼ่⃭(std) 115 ms x 10 -12 channel MEG0213 (MEGPLANAR) x 10 Trial 1 (average of 401 events): std Trial 2 (average of 100 events): dev 4 channel MEG1312 (MEGPLANAR) 2 0 field intensity field intensity 2 -2 -4 0 -2 -4 -6 -100 -12 4 -6 -50 0 50 100 150 200 250 time (in ms after time onset) 300 350 400 -100 -50 0 50 100 150 200 250 time (in ms after time onset) 300 350 400 145 ms 2Ⅼ่⃭(dev) 1Ⅼ่⃭(std) 2Ⅼ่⃭(dev) 1Ⅼ่⃭(std) ᅗ2㸸ᕥྑࡢ㢌㡬㒊ࢭࣥࢧ࣮ࡽグ㘓ࡉࢀࡓࠊ⯉ ࡢOddball่⃭ᑐࡍࡿㄏⓎᛂ㸦㉥㸸2Ⅼ่⃭ࠊ 㟷㸸1Ⅼ่⃭㸧ࠋ ᅗ3㸸ᅗ2♧ࡋࡓࢹ࣮ࢱࡢSPM8ࡼࡿゎᯒ⤖ᯝ(2 Ⅼ่⃭ vs 1Ⅼ่⃭) ཧ⪃ᩥ⊩ [1] Akatsuka K, Wasaka T, et al. Clin Neurophysiol. 2007; 118 (2): 403-11. 129
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