XXXIIIrd Winter School on Proteinases and Their Inhibitors Tiers am Rosengarten February 24 – 28, 2016 Cover Hans Fritz, together with Vito Turk, founded the “Winter School on Proteinases and Their Inhibitors” in the year 1981. Driven by the passion of the Munich and Ljubljana groups, this nucleus continuously developed into today’s premium meeting of protease research for young, and established, scientists in Europe and beyond. Till today Hans’ inspiring passion for science contributes to shaping the next generation of well-trained and enthusiastic protease researchers. We all wish to thank and celebrate Hans on the occasion of his 80th birthday! 33rd Winter School on Proteinases and Their Inhibitors in Tiers (Italy) February 24 – 28, 2016 Organizing Committee Klaudia Brix (Bremen) Thomas Reinheckel (Freiburg) Christian Sommerhoff (Munich) Boris Turk (Ljubljana) Hans Brandstetter (Salzburg) Editors Michaela Lassacher, Claudine Wernsperger & Hans Brandstetter Dept. Molecular Biology University of Salzburg Supported by GENERAL INSTRUCTIONS Accommodation All Winterschool participants are accommodated in one of the three hotels Rose, Paradies or Vajolet, all of which are in five minutes walking distance. If you are unsure, please ask at the registration of Hotel Paradies. They have a list of all participants and are happy to help you. While accommodation and meals including mineral water are covered, any extras are not: • • • Please pay all drinks (except mineral water) directly after the meal. Please do not forget to pay your good night-drinks before you leave for sleeping. Please do not forget to pay all your extras (personal orders, …) at your hotel before departure. If you want to rent ski equipment, please ask at the Hotel Paradies. Scientific sessions All lectures will take place at the Haus der Dorfgemeinde (City Hall). Social events • • • • Thursday evening, Paradies: Friday evening, City Hall: Saturday afternoon Saturday evening, Castle Prösels Meet and Make Friends in Proteolysis Research Night session with the InhibiTiers Allstar Band Several hiking tours, excursions Gala Dinner & Farewell Disclaimer To enable and foster the unrestrained presentation and discussion of new results and ongoing research, every Winter School attendee must respect that all contents presented and discussed at the Winter School are private communications, not allowed for public use. Consequently, recording of lectures or photographing/copying of slides or presentations is prohibited. 4 PROGRAM Regular talks are 8 min lecture plus 4 min discussion. WEDNESDAY, FEBRUARY 24 18:00 Dinner 20:00 – 21:45 Wednesday evening session: Extracellular Matrix & Metalloproteases 20:00 – 20:05 Opening 20:05 – 20:15 Chairs: Yoshi ITOH, Christoph BECKER-PAULY & Xavier GOMIS-RÜTH: Press releasetype introduction into the session: Background, important questions, challenges, solution strategies 20:15 – 20:27 Philipp ARNOLD (University of Kiel) Purification and sequential maturation of procollagen I using meprin metalloproteases 20:27 – 20:39 Pernille SØGAARD (University of Oxford) Signalling through the collagen receptor, DDR1, is required for epithelial polarisation and morphological remodelling in 3D matrix 20:39 – 20:51 Florian PETERS (University of Kiel) Role of astacin proteases in TGFβ and wnt signaling during extracellular matrix remodeling 20:51 – 21:03 Frederike SCHMIDT (University of Kiel) Meprins are regulators of muscle growth 21:03 – 21:15 Rielana WICHERT (University of Kiel) A unique molecular switch regulates shedding of meprin β by ADAM proteases in the small intestine important for mucus barrier function 21:15 – 21:27 Till BEDAU (University of Kiel) Biochemical and functional characterization of two CD99 cancer mutations with regard to proteolysis by metalloprotease meprin β 21:27 – 21:45 Margarete HECK (University of Edinburgh) The odyssey that is Invadolysin 22:00 SOME THINGS NEVER CHANGE: REFRESHING MEMORIES IN THE PARADIES BAR 5 THURSDAY, FEBRUARY 25 09:00 – 10:34 Thursday morning session I: Protein & Substrate Recognition 09:00 – 09:10 Chairs: Ulrich AUF DEM KELLER & Marcin DRAG: Press release-type introduction into the session: Background, important questions, challenges, solution strategies 09:10 – 09:22 Fabian EGLI (ETH Zurich) ProteasePredictor: linking cleavage sites to proteases 09:22 – 09:34 Amir RAZAI (Sanford Burnham Prebys Medical Discovery Institute, La Jolla) Protease Traps 09:34 – 09:46 Tobias KOCKMANN (ETH Zurich) Next-generation positional proteomics 09:46 – 09:58 Fabio SABINO (ETH Zurich) Degradomics analysis of wound exudates: identification of pivotal proteolytic events in acute wound healing by iTRAQ-TAILS 09:58 – 10:10 Wioletta RUT (Wroclaw University of Technology) HyCoSuL approach as a tool in the search of new, selective substrates for Human 20S Proteasome 10:10 – 10:22 Katherine FALKOWSKI (Jagiellonian University, Krakow) Analysis of kallikrein 7, 8, 13 and 14 on EGF-receptor family ligands, growth factors, and other biological systems using CleavEx libraries 10:22 – 10:34 Philipp SCHULZ (University of Münster) Heparan sulfate and Scube2 regulate proteolytic processing of Sonic Hedgehog morphogens from the surface of producing cells 10:34 – 11:00 COFFEE BREAK 11:00 – 12:15 Thursday morning session II: Protein modification in physiology & technology 11:00 – 11:10 Chairs: Kay GROBE & Peter GÖTTIG: Press release-type introduction into the session: Background, important questions, challenges, solution strategies 11:10 – 11:22 Lise BOON (KU Leuven, Rega Institute for Medical Research) Glycosylation of matrix metalloproteinases: present state, challenges and opportunities 11:22 – 11:34 Jennifer VANDOOREN (KU Leuven, Rega Institute for Medical Research) Novel insights in matrix metalloproteinase-9 trimerization and its functional implications 11:34 – 11:46 Mohanan MAHARAJ (Technische Universität München) SUMOylation regulates the stability of the receptor tyrosine kinase, EphB4 11:46 – 11:58 Julia FEGG (University of Salzburg) Enzymatic protein modifications and biotechnological applications 11:58 – 12:15 Edith HUMMLER (University of Lausanne) Serine protease in health and disease 12:30 LUNCH (Paradies, Rose) 6 THURSDAY AFTERNOON SESSIONS: PROTEASES IN HEALTH & DISEASE 14:30 – 16:24 Thursday afternoon session I: Proteases in health & disease 14:30 – 14:40 Chairs: Wolfram BODE, Judith CLEMENTS & Manfred SCHMITT: Press release-type introduction into the session: Background, important questions, challenges, solution strategies 14:40 – 14:55 Augusta MODESTINO & Elaine SKOWRONSKI (University of California, San Diego) An Electrophoretic Method for the Detection of Protease Activity in a Drop of Whole Blood; and its Potential for Diagnostics and Monitoring of Diseases 14:55 – 15:07 Han FANG (University of Salzburg) Human blood coagulation Factor IX and Factor VIII A2 domain peptides interaction studies 15:07 – 15:19 Anna KEPPNER (University of Lausanne) Role of the serine protease prostasin (CAP1/Prss8) in DSS-induced chronic colitis 15:19 – 15:31 Elisabeth NYSTRÖM (University of Gothenburg) The role of endogenous proteases in colonic mucus dynamics 15:31 – 15:43 Laura SASIADEK (Jagiellonian University, Krakow) Effects of kallikreins 8,13 and 14 on human skin fibroblast migration and morphology 15:43 – 15:55 Maria Luiza Vilela OLIVA (Federal University of São Paulo) In vitro and in vivo effect of CrataBL: the new pro-angiogenic protein extracted from Bark of Crataeva tapia 15:55 – 16:07 Michael KUSKE (University of Mainz) The metalloprotease ovastacin is the main ligand for the lectin Lens culinaris agglutinin in cortical granules of the mammalian oocyte 16:07 – 16:19 Hagen WESTPHAL (University of Mainz) Fertile or not? How ovastacin regulates fertility 16:19 – 16:31 Marcel NAUMANN (Fraunhofer Institute for Cell Therapy and Immunology, Halle/Saale) Proteolytic truncations of amyloid-beta peptides and their identification by mass spectrometry 16:31 – 17:00 COFFEE BREAK 17:00 – 18:10 Thursday afternoon session II: Immunity Chairs: Dieter JENNE & James BURROWS 17:00 – 17:12 Denise BIRK (Ludwig-Maximilians-University, Munich) Effect of elastase inhibitors on neutrophil granulocytes 17:12 – 17:30 Olga VASILJEVA (CytomX Therapeutics Inc., South San Francisco) Probody Therapeutics: Disease Tissue Targeting with Fully Recombinant Antibody Prodrugs 17:30 – 17:50 Stefan ROSE-JOHN (University of Kiel) Proteases in Interleukin-6 Biology – Strategies for Inhibition 17:50 – 18:10 Chris OVERALL (University of British Columbia) The paracaspase MALT1 puts the brake on NF-κB signaling by cleaving HOIL1 and terminating linear ubiquitination 18:30 DINNER (PARADIES, ROSE) 20:00 – 23:00 MEETING AND MAKING FRIENDS IN PROTEOLYSIS RESEARCH (PARADIES) 7 FRIDAY, FEBRUARY 26 09:00 – 10:10 Friday morning session I: Cancer imaging 09:00 – 09:10 Chairs: Rich WILLIAMS & Achim KRÜGER: Press release-type introduction into the session: Background, important questions, challenges, solution strategies 09:10 – 09:22 Yael BEN-NUN (The Hebrew University, Jerusalem) Photodynamic Quenched Cathepsin Activity Based Probes as Cancer Theranostics 09:22 – 09:34 Alejandro GOMEZ-AULI (University of Freiburg) Analysis of the interstitial fluid proteome from murine breast cancers with differential cathepsin B 09:34 – 09:46 Matej VIZOVIŠEK (Jožef Stefan Institute, Ljubljana) A selective macromolecular probe for in vivo imaging of cathepsin B activity in the tumor 09:46 – 09:58 Francesco COGO (Queen's University Belfast) Activity based probes loaded nanoparticles to selectively label and visualise active caspases in prostate cancer cells 09:58 – 10:10 Darya TSVIRKUN (The Hebrew University, Jerusalem) Cathepsin Targeted Computed Tomography X-Ray Contrast Agents for Molecular Imaging of Cancer 10:10 – 10:40 COFFEE BREAK 10:40 – 12:00 Friday morning session II: Cancer signaling 10:40 – 10:50 Chairs: Thomas REINHECKEL, Rama KHOKHA & Klaudia BRIX: Press release-type introduction into the session: Background, important questions, challenges, solution strategies 10:50 – 11:02 Johanna FELBER (Technische Universität München) Kallikrein-related peptidase 4 (KLK4) increases prostate cancer cell proliferation and migration by regulation of COL1A2 and SPARC expression 11:02 – 11:14 Estefania UGARTE-BERZAL (Rega Institute for Medical Research, Leuven) Role of MMP9 hemopexin domain in chronic lymphocytic leukemia and extracellular matrix degradation 11:14 – 11:26 Barbara GRÜNWALD (Technische Universität München) Suppression of the hepatic premetastatic niche in pancreatic cancer by interference with TIMP-1-induced hepatic stellate cell activation 11:26 – 11:38 Stephanie KETTERER (University of Freiburg) Cell type-specific deletion of cathepsin D in murine breast cancer 11:38 – 11:50 Larissa HILLEBRAND (University of Freiburg) Proteolysis - hallmark of tumor-initiating cells in poyoma-middle-T-oncogene induced murine mammary carcinomas 11:50 – 12:02 Barbara BREZNIK (Jožef Stefan Institute, Ljubljana) Direct cross-talk between glioblastoma and mesenchymal stem cells affected invasion and protease expression pattern in glioblastoma cells 12:30 LUNCH (Paradies, Rose) 8 FRIDAY AFTERNOON SESSIONS: PATHOGENS & INHIBTION 14:30 – 15:30 Friday afternoon session I: Pathogens 14:30 – 14:40 Chairs: Jan POTEMPA & Boris TURK: Press release-type introduction into the session: Background, important questions, challenges, solution strategies 14:40 – 14:52 Pavla FAJTOVÁ (Academy of Sciences of the Czech Republic, Praha) Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: from Functional Analysis to Anti-schistosomal Inhibitors 14:52 – 15:04 Christian PICHLO (University of Cologne) New Insights into the Mechanism and Specificity of Proline-Proline Endopeptidase-1 from Clostridium difficile 15:04 – 15:16 Magdalena KALINSKA (Jagiellonian University, Krakow) Gingipains of Porphyromonas gingivalis affect stability and function of SPINK6, a tissue inhibitor of human kallikreins. 15:16 – 15:28 Linda KRISCH (University of Salzburg) Processing of Helicobacter pylori CagA in B cells 15:30 – 16:00 COFFEE BREAK 16:00 – 17:20 Friday afternoon session II: Inhibition: structure, mechanism, delivery 16:00 – 16:10 Chairs: Christian SOMMERHOFF & Michael GROLL: Press release-type introduction into the session: Background, important questions, challenges, solution strategies 16:10 – 16:22 Miroslaw KSIAZEK (Jagiellonian University, Krakow) Miropin, a serpin from a major periodontopathogen Tannerella forsythia, inhibits both serine and cysteine proteases 16:22 – 16:34 Therese DAU (Helmholtz-Zentrum München) Interactions between α-1-antitrypsin and neutrophil elastase are influenced by plasma factors 16:34 – 16:46 Carla GUARINO (INSERM, Tours) Peptidyl di(chlorophenyl)-phosphonate esters inhibitors with increased potency blocking selectively human neutrophil proteinase 3 16:46 – 16:56 Andreas KANY (Helmholtz Institute for Pharmaceutical Research Saarland) Development of novel inhibitors targeting elastase (LasB) from Pseudomonas aeruginosa 16:56 – 17:08 Haissi CUI (Technische Universität München) Targeted Delivery of Proteasome Inhibitors towards Somatostatin-Receptor Expressing Cancer Cells by Octreotide-Conjugation 17:08 – 17:20 Hartmut RAUCH (Technische Universität München) Affibody Mediated Delivery of Proteasome Inhibitors 18:00 DINNER (PARADIES, ROSE) 20:30 – 23:45 NIGHT SESSION WITH THE INHIBITIERS (CITY HALL) 9 SATURDAY, FEBRUARY 27 09:00 – 10:25 Saturday morning session I: Protease structure, dynamics & function 09:00 – 09:10 Chairs: Milton STUBBS & Guy SALVESEN: Press release-type introduction into the session: Background, important questions, challenges, solution strategies 09:10 – 09:22 Ursula KAHLER (University of Innsbruck) Mapping Conformational States of Thrombin by Comparison of X-Ray Structures 09:22 – 09:34 Anders Bundgård SORENSEN (Aalborg University & Novo Nordisk A/S) The crystal structure of the zymogen Factor VII:sTF complex: A highly disordered activation domain and its implication for FVIIa activity regulation 09:34 – 09:46 Florian ZAUNER (University of Salzburg) Structural insights into the auto-activation mechanism of plant legumain 09:46 – 09:58 Jaroslav SRP (Academy of Sciences of the Czech Republic, Praha) Plant protease inhibitors from Kunitz family: structural and functional diversity 09:58 – 10:10 Elfriede DALL (University of Salzburg) Oligomerization of cystatin E and its impact on legumain 10:10 – 10:22 Mathias W. HACKL (Technische Universität München) Phenyl Esters as Potent Inhibitors of Caseinolytic Protease P 10:25 – 10:45 COFFEE BREAK 10:45 – 11:45 Saturday morning session II: Protease structure, dynamics & function Chairs: Robert PIKE & Walter STÖCKER 10:45 – 10:57 Thomas ZÖGG (VUB Vrije Universiteit Brussel) Nanobodies as chaperones for structural biology of coagulation proteases 10:57 – 11:09 Raphaël DUTOIT (Université Libre de Bruxelles) The crystal structure of TmPep1050 from Thermotoga maritima sheds light on the oligomerization of M42 aminopeptidases 11:09 – 11:21 Marie-Theres VIELBERG (Technische Universität München) Anbu- a potential proteasomal ancestor? 11:21 – 11:33 Camille LeCHAPELAIN (Technische Universität München) Elucidation of the Binding Mode of a Selective, Non-covalent Immunoproteasome Inhibitor 11:33 – 11:45 Lakshmi WIJEYEWICKREMA (La Trobe University, Melbourne) The Structure of Compstasin from Haementaria (leech) species, in Complex with the Complement Protease, C1s, provides novel insights into the Inhibitory Mechanism 12:15 LUNCH 10 SATURDAY AFTERNOON: HIKING, EXCURSION, ROUND TABLE DISCUSSIONS 12:15 – 17:00 “Extreme” hiking tour, guided by Thomas REINHECKEL (lunch package will be provided) 13:30 – 17:00 Relaxed hiking tour, guided by Hans FRITZ 12:15 – 17:00 Locally organized skiing tours (ski equipment can be rent at the Hotel Paradies; lunch package will be provided) 13:30 – 17:00 Bus tour to Bozen (Visit Ötzi & more) 19:00 GALA DINNER AT CASTLE PRÖSELS SUNDAY, FEBRUARY 28 10:00 Bus departure 11 ABSTRACTS Available in the printed program only. The Winterschool Facebook Philipp ARNOLD University of Kiel Anatomical Institute Otto-Hahn-Platz 8 D-24118 Kiel Germany [email protected] +49 431 880 2558 Denise BIRK University Hospital Ludwig-Maximilians University Institute of Laboratory Medicine Nussbaumstrasse 20 D-80336 Munich Germany [email protected] +49 89 4400 52597 Ulrich AUF DEM KELLER ETH Zurich Institute of Molecular Health Sciences Otto-Stern-Weg 7 CH-8093 Zurich Switzerland [email protected] +41 44 633 3392 Wolfram BODE Max Planck Institute of Biochemistry Proteinase Research Group Am Klopferspitz 18 D-82152 Martinsried Germany [email protected] +49 89 8504807 Christoph BECKER-PAULY University of Kiel Institute of Biochemistry Otto-Hahn-Platz 9 D-24118 Kiel Germany [email protected] +49 431 880 7118 Lise BOON KU Leuven Rega Institute for Medical Research Dept. Microbiology and Immunology Minderbroedersstraat 10 B-3000 Leuven Belgium [email protected] + 32 1633 7306 Till BEDAU University of Kiel Institute of Biochemistry Otto-Hahn-Platz 9 D-24118 Kiel Germany [email protected] +49 431 880 2513 Hans BRANDSTETTER University of Salzburg Dept. Molecular Biology Billrothstraße 11 A-5020 Salzburg Austria [email protected] +43 662 8044 7270 Yael BEN-NUN The Hebrew University Institute for Drug Research The School of Pharmacy Jerusalem 9112001 Israel [email protected] +972 2 675 8778 Andreja BRATOVŠ Jožef Stefan Institute Biochemistry and Molecular Biology Jamova cesta 39 SI-1000 Ljubljana Slovenia [email protected] +386 1477 3410 I Barbara BREZNIK National Institute of Biology Dept. Genetic Toxicology and Cancer Biology Večna pot 111 SI-1000 Ljubljana Slovenia [email protected] +386 592 32 870 Haissi CUI Technische Universität München Dept. Biochemistry Lichtenbergstraße 4 D-85748 Garching/Munich Germany [email protected] +49 89 289 12891 Klaudia BRIX Jacobs University Bremen Department of Life Sciences and Chemistry Campus Ring 1 D-28759 Bremen Germany [email protected] +49 421 200 3246 Elfriede DALL University of Salzburg Dept. Molecular Biology Billrothstraße 11 A-5020 Salzburg Austria [email protected] +43 662 8044 7278 Therese DAU Helmholtz-Zentrum München Comprehensive Pneumology Center Max-Lebsche-Platz 31 D-81377 Munich Germany [email protected] +49 89 31871653 James BURROWS Queen's University Belfast School of Pharmacy 97 Lisburn Road Belfast, BT9 7BL Northern Ireland, UK [email protected] +44 28 9097 2703 Judith CLEMENTS Australian Prostate Cancer Research Centre-Queensland Institute of Health and Biomedical Innovation Queensland University of Technology at the Translational Research Institute 37 Kent Street Woolloongabba QLD, Australia 4102 [email protected] +61 7 3443 7241 Marcin DRAG Wroclaw University of Technology Dept. Bioorganic Chemistry Wyb. Wyspianskiego 27 PL-50-370 Wroclaw Poland [email protected] +48 71 320 4526 Raphaël DUTOIT Université Libre de Bruxelles Dept. Molecular Biology Rue des Professeurs Jeener & Brachet 12 BE-6041 Gosselies Belgium [email protected] +32 25267279 Francesco COGO Queen's University Belfast School of Pharmacy 97 Lisburn Road Belfast, BT9 7BL Northern Ireland, UK [email protected] +44 28 9097 2086 II Fabian EGLI ETH Zurich Institute of Molecular Health Sciences Otto-Stern-Weg 7 CH-8093 Zurich Switzerland [email protected] +41 44 633 3392 Johanna FELBER Technische Universität München Klinische Forschergruppe der Frauenklinik Ismaningerstrasse 22 D-81675 Munich Germany [email protected] +49 1516 4516 3410 Pavla FAJTOVÁ Academy of Sciences of the Czech Republic Institute of Organic Chemistry and Biochemistry Flemingovo nam. 542/2 CZ-166 10 Praha 6 Czech Republic [email protected] +420 220 183 287 Hans FRITZ Ludwig-MaximiliansUniversity Munich Dept. Clinical Chemistry and Clinical Biochemistry Nußbaumstraße 20 D-80336 Munich Germany [email protected] +49 8178 1534 Katherine FALKOWSKI Jagiellonian University Faculty of Biochemistry Dept. Microbiology ul. Gronostajowa 7 PL-30-387 Krakow Poland [email protected] +48 12 6646098 Alejandro GOMEZ-AULI University of Freiburg Institute of Molecular Medicine and Cell Research Stefan-Meier-Straße 17 D-79104 Freiburg Germany [email protected] +49 761 203 9603 Han FANG University of Salzburg Dept. Molecular Biology Billrothstraße 11 A-5020 Salzburg Austria [email protected] +43 662 8044 7278 F. Xavier GOMIS-RÜTH Molecular Biology Institute of Barcelona, CSIC Dept. Structural Biology c/ Baldiri Reixac, 4-6 ESP-08028 Barcelona Spain [email protected] +34 934020186 Julia FEGG University of Salzburg Dept. Molecular Biology Billrothstraße 11 A-5020 Salzburg Austria [email protected] +43 662 8044 7278 Peter GÖTTIG University of Salzburg Dept. Molecular Biology Structural Biology Group Billrothstraße 11 A-5020 Salzburg Austria [email protected] +43 662 8044 7283 III Jessica GÖTZFRIED Helmholtz-Zentrum München Comprehensive Pneumology Center Max-Lebsche-Platz 31 D-81377 Munich Germany [email protected] +49 89 3187 1686 Carla GUARINO Centre d'Etude des Pathologies Respiratoires INSERM U1100/EA6305 Faculté de médecine de Tours 10 Bd Tonnellé F-37032 Tours France [email protected] +33 67 8579343 Kay GROBE Westfälische WilhelmsUniversität Münster Institute of Physiological Chemistry and Pathobiochemistry Waldeyerstrasse 15 D-48149 Münster Germany [email protected] +49 251 83 52289 Mathias W. HACKL Technische Universität München Dept. Chemistry Lichtenbergstrasse 4 D-85748 Garching/Munich Germany [email protected] +49 89 2891 3678 Michael GROLL Technische Universität München Dept. Biochemistry Lichtenbergstrasse 4 D-85748 Garching/Munich Germany [email protected] +49 89 289 13361 Margarete HECK University of Edinburgh Queen's Medical Research Insitute 47 Little France Crescent Edinburgh EH16 4TJ United Kingdom [email protected] +44 131 242 6694 Maresa GRUNDHUBER Ludwig-Maximilians-University of Munich Institute of Laboratory Medicine Nussbaumstrasse 20 D-80336 Munich Germany [email protected] +49 89 4400 52597 Annelie HELLVARD Jagiellonian University Malopolska Centre of Biotechnology Gronostajowa 7A PL-30-387 Krakow Poland [email protected] +48 795761 409 Barbara GRÜNWALD Technische Universität München Klinikum rechts der Isar Institut für Experimentelle Onkologie und Therapieforschung Ismaningerstrasse 22 D-81675 Munich Germany [email protected] +49 89 4140 4459 Larissa HILLEBRAND University of Freiburg Institute of Molecular Medicine and Cell Research Stefan-Meier-Strasse 17 D-79104 Freiburg Germany [email protected] +43 761 203 9605 IV Katarina HOCEVAR Jožef Stefan Institute Department of Biochemistry, Molecular and Structural Biology Jamova cesta 39 SI-1000 Ljubljana Slovenia [email protected] +386 41 887827 Magdalena KALINSKA Jagiellonian University Faculty of Biochemistry Dept. Microbiology Gronostajowa 7 PL-30-387 Krakow Poland [email protected] +48 60749064 Andreas KANY Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Dept. Drug Design and Optimization (DDOP) Campus E8 1 D-66123 Saarbrücken Germany [email protected] +49 681 98806 2042 Edith HUMMLER University of Lausanne Dept. Pharmacology & Toxicology Rue du Bugnon 27 CH-1011 Lausanne Switzerland [email protected] +41 21 692 5357 Yoshifumi ITOH University of Oxford Kennedy Institute of Rheumatology Roosevelt Drive, Headington Oxford OX3 7FY United Kingdom [email protected] +44 1865 612647 Anna KEPPNER University of Lausanne Dept. Pharmacology and Toxicology Rue du Bugnon 27 CH-1011 Lausanne Switzerland [email protected] + 41 21 692 54 26 Dieter JENNE Helmholtz Center Munich & Max-Planck-Institute of Neurobiology Max-Lebsche-Platz 31 D-81377 Munich Germany [email protected] +49 89 3187 4664 Stephanie KETTERER University of Freiburg Institute of Molecular Medicine and Cell Research Stefan-Meier-Straße 17 79104 Freiburg [email protected] +49 761 203 9604 Ursula KAHLER University of Innsbruck Institute of General, Inorganic und Theoretical Chemistry Innrain 80/82 6020 Innsbruck Austria [email protected] .at +43 512 507 57121 Rama KHOKHA University Health Network Princess Margaret Cancer Centre Research Tower 101 College Street Toronto, Ontario M5G-1L4 Canada [email protected] +1 416 634 8773 V Tobias KOCKMANN ETH Zurich Institute of Molecular Health Sciences Otto-Stern-Weg 7 CH-8093 Zurich Switzerland [email protected] +41 44 633 3392 Miroslaw KSIAZEK Jagiellonian University Faculty of Biochemistry Dept. Microbiology ul. Gronostajowa 7 PL-30-387 Krakow Poland [email protected] +48 12 664 6098 Brice KORKMAZ Centre d'Etude des Pathologies Respiratoires INSERM U1100/EA6305 Faculté de médecine de Tours 10 Bd Tonnellé F-37032 Tours France [email protected] +33 2 47 36 62 53 Michael KUSKE University of Mainz Dept. Cell and Matrix Biology Johann-Joachim-Becher-Weg 9-11 D-55128 Mainz Germany [email protected] +49 6131 39 24271 Michaela LASSACHER University of Salzburg Dept. Molecular Biology Billrothstraße 11 A-5020 Salzburg Austria [email protected] +43 662 8044 7200 Ludwig KORNREITER Omnibusunternehmen Habermayr Schleifmühlweg 14 D-86633 Neuburg/Donau Germany [email protected] +49 171 651941 Camille LeCHAPELAIN Technische Universität München Dept. Biochemistry Lichtenbergstraße 4 D-85748 Garching/Munich Germany [email protected] +49 89 289 12891 Linda KRISCH University of Salzburg Dept. Molecular Biology Billrothstraße 11 A-5020 Salzburg Austria [email protected] +43 662 8044 7212 Mohanan MAHARAJ Technische Universität München Klinische Forschergruppe der Frauenklinik Ismaningerstrasse 22 D-81675 Munich Germany [email protected] +49 152 3705 3792 Achim KRÜGER Technische Universität München Klinikum rechts der Isar Institut für Molekulare Immunologie und Experimentelle Onkologie Ismaningerstrasse 22 D-81675 Munich Germany [email protected] +49 89 4140 4463 VI Viktor MAGDOLEN Technische Universität München Klinische Forschergruppe der Frauenklinik Ismaningerstrasse 22 D-81675 Munich Germany [email protected] +49 89 4140 2493 Christopher OVERALL University of British Columbia Centre for Blood Research 4401-2350 Health Sciences Mall Vancouver, BC V6T 1Z3 Canada [email protected] +1 604 822 2958 Augusta MODESTINO University of California, San Diego Bioengineering Department 9500 Gilman Drive La Jolla, CA 92093 USA [email protected] +1 858 257 8982 Florian PETERS University of Kiel Institute of Biochemistry Otto-Hahn-Platz 9 D-24118 Kiel Germany [email protected] +49 431 880 2513 Christoph PETERS University of Freiburg Institute for Molecular Medicine and Cell Research Stefan-Meier-Straße 17 D-79104 Freiburg Germany [email protected] +49 761 203 9600 Marcel NAUMANN Fraunhofer Institute for Cell Therapy and Immunology IZI-MWT Dept. Drug Design and Analytical Chemistry Weinbergweg 22 D-06120 Halle (Saale) Germany [email protected] +49 345 1314 2817 Christian PICHLO University of Cologne Institute of Biochemistry Otto-Fischer-Strasse 14 D-50674 Cologne Germany [email protected] +49 221 470 3211 Elisabeth NYSTRÖM University of Gothenburg Dept. Medical Biochemistry and Cell Biology Medicinaregatan 9A SE-413 90 Gothenburg Sweden [email protected] +46 31 786 3046 Robert PIKE La Trobe University Institute for Molecular Sciences Dept. Biochemistry and Genetics Science Drive Bundoora VIC 3086 Melbourne Australia [email protected] +61 394792196 Maria Luiza Vilela OLIVA Federal University of São Paulo Dept. Biochemistry Rua Três de Maio 100 Vila Clementino 04044-020 São Paulo Brazil [email protected] +55 11 5576 4848 VII Jan POTEMPA Jagiellonian University Dept. Microbiology ul. Gronostajowa 7 PL-30-387 Krakow, Poland & University of Louisville School of Dentistry Dept. Oral Immunology & Infect. Diseases 501 South Preston Street Louisville, Kentucky 40202 USA [email protected] +1 502 852 1319 Thomas REINHECKEL Albert-Ludwigs-University Freiburg Institute of Molecular Medicine and Cell Research Stefan-Meier-Straße 17 D-79194 Freiburg Germany thomas.reinheckel@uniklinik -freiburg.de +49 761 203 9606 Stefan ROSE-JOHN University of Kiel Department of Biochemistry Olshausenstrasse 40 D-24098 Kiel Germany [email protected] +49 431 880 3336 Daniel RAMSBECK Fraunhofer Institute for Cell Therapy and Immunology IZI-MWT Dept. Drug Design and Analytical Chemistry Weinbergweg 22 D-06120 Halle (Saale) Germany [email protected] +49 345 1314 2826 Wioletta RUT Wroclaw University of Technology Dept. Bioorganic Chemistry Wyb. Wyspianskiego 27 PL-50-370 Wroclaw Poland [email protected] +48 71 320 24 55 Hartmut RAUCH Technische Universität München Dept. Biochemistry Lichtenbergstraße 4 D-85748 Garching/Munich Germany [email protected] +49 89 289 13354 Fabio SABINO ETH Zurich Institute of Molecular Health Sciences Otto-Stern-Weg 7 CH-8093 Zurich Switzerland [email protected] +41 44 633 3392 Amir RAZAI Sanford Burnham Prebys Medical Discovery Institute 10901 North Torrey Pines Road La Jolla, CA 92037 USA [email protected] +1 661 312 3290 Guy SALVESEN Sanford Burnham Prebys Medical Discovery Institute 10901 North Torrey Pines Road La Jolla, CA 92037 USA [email protected] +1 858 646 3114 VIII Laura SASIADEK Jagiellonian University Faculty of Biochemistry Dept. Microbiology ul. Gronostajowa 7 PL-30-387 Krakow Poland [email protected] +48 60749064 Øyvind L. SCHÖNBERGER Munich, Germany [email protected] +43 152 0643 4404 Philipp SCHULZ University of Münster Institute for Physiological Chemistry and Pathobiochemistry Waldeyerstrasse 15 D-48149 Münster Germany [email protected] +49 251 83 55570 Simonas SAVICKAS ETH Zurich Institute of Molecular Health Sciences Otto-Stern-Weg 7 CH-8093 Zurich Switzerland [email protected] +41 44 633 3392 Christopher SCOTT Queen’s University Belfast School of Pharmacy 97 Lisburn Road Belfast, BT9 7BL Northern Ireland, UK [email protected] +44 28 9097 2350 Frederike SCHMIDT University of Kiel Institute of Biochemistry Otto-Hahn-Platz 9 D-24118 Kiel Germany [email protected] +49 431 880 2513 Elaine SKOWRONSKI University of California, San Diego Bioengineering Department 9500 Gilman Drive La Jolla, CA 92093 USA [email protected] +1 760 717 9237 Manfred SCHMITT Technische Universität München Klinische Forschergruppe der Frauenklinik Ismaningerstrasse 22 D-81675 München Germany [email protected] +49 89 4140 2420 Pernille SØGAARD University of Oxford Kennedy Institute of Rheumatology Roosevelt Drive, Headington OX3 7LF, Oxford United Kingdom [email protected] +44 01865 612600 Elisabeth SCHMITT Munich, Germany [email protected] IX Wai Tuck SOH University of Salzburg Dept. Molecular Biology Billrothstraße 11 A-5020 Salzburg Austria [email protected] +43 662 8044 7277 Milton T. STUBBS II Martin-Luther-Universität Halle-Wittenberg Institut für Biochemie und Biotechnologie Kurt-Mothes-Straße 3 D-06120 Halle Germany [email protected] +49 345 55 24901 Christian SOMMERHOFF Klinikum der Universität München Institute of Laboratory Medicine Nussbaumstrasse 20 D-80336 Munich Germany [email protected] +49 89 4400 55153 Darya TSVIRKUN The Hebrew University Institute for Drug Research The School of Pharmacy Jerusalem 9112001 Israel [email protected] +972 2 675 8778 Anders B. SORENSEN Aalborg University & Novo Nordisk A/S Dept. Chemistry & Bioscience - Hemophilia Biochemistry Novo Nordisk Park DK-2760 Måløv Denmark [email protected] +45 29 64 91 94 Boris TURK Jožef Stefan Institute Dept. Biochemistry and Molecular and Structural Biology Jamova cesta 39 SI-1000 Ljubljana Slovenia [email protected] +386 1 477 3772 Estefania UGARTE-BERZAL KU Leuven Rega Institute for Medical Research Minderbroedersstraat 10 BE-3000 Leuven Belgium [email protected] +32 16 33 73 67 Jaroslav SRP Academy of Sciences of the Czech Republic Institute of Organic Chemistry and Biochemistry Flemingovo nam. 542/2 CZ-166 10 Praha 6 Czech Republic [email protected] +420 220 183 470 Jennifer VANDOOREN KU Leuven Rega Institute for Medical Research Minderbroedersstraat 10 BE-3000 Leuven Belgium [email protected] +32 16 33 73 83 Walter STÖCKER University of Mainz Institute of Zoology, Cell and Matrix Biology Johannes-von-Müller-Weg 6 D-55128 Mainz Germany [email protected] +49 6221 3924273 X Olga VASILJEVA CytomX Therapeutics Inc. Dept. Protease Biology 343 Oyster Point Blvd. South San Francisco, CA 94080 USA [email protected] +1 650 515 3912 Rielana WICHERT University of Kiel Institute of Biochemistry Otto-Hahn-Platz 9 D-24118 Kiel Germany [email protected] +49 431 880 2513 Marie-Theres VIELBERG Technische Universität München Dept. Biochemistry Lichtenbergstraße 4 D-85748 Garching/Munich Germany [email protected] +49 89 289 13354 Lakshmi WIJEYEWICKREMA La Trobe University Institute for Molecular Sciences Dept. Biochemistry and Genetics Science Drive Bundoora VIC 3086 Melbourne Australia [email protected] +61 394792156 Matej VIZOVIŠEK Jožef Stefan Institute Department of Biochemistry, Molecular and Structural Biology Jamova cesta 39 SI-1000 Ljubljana Slovenija [email protected] +386 1 477 3854 Rich WILLIAMS Queen's University Belfast Centre for Cancer Research and Cell Biology 97 Lisburn Road Belfast, BT9 7BL Northern Ireland, UK [email protected] +44 28 9097 2791 Claudine WERNSPERGER University of Salzburg Dept. Molecular Biology Billrothstraße 11 A-5020 Salzburg Austria [email protected] .at +43 662 8044 7201 Florian ZAUNER University of Salzburg Dept. Molecular Biology Billrothstraße 11 A-5020 Salzburg Austria [email protected] +43 662 8044 7279 Hagen WESTPHAL University of Mainz Dept. Cell and Matrix Biology Johann-Joachim-Becher Weg 9-11 D-55128 Mainz Germany [email protected] +49 6131 39 24271 Shuo ZHAO Technische Universität München Klinische Forschergruppe der Frauenklinik Ismaningerstrasse 22 D-81675 Munich Germany [email protected] +49 1522 5715 679 XI Thomas ZÖGG VUB Vrije Universiteit Brussel VIB Dept. Molecular and Cellular Interactions Pleinlaan 2 B-1050 Brussels Belgium [email protected] +32 2 629 19 49 Friederike ZUNKE Northwestern University, Chicago Dept. Neurobiology Ward 12-140, 303 E Chicago Ave Chicago, IL 60611 USA [email protected] +1 312 503 5804 XII
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