「2型糖尿病感受性遺伝子による膵β細胞量調節機構の解明」を開催します。

新学術創成研究機構
革新的統合バイオ研究コア栄養・代謝研究ユニットセミナー
「2 型糖尿病感受性遺伝子による膵β細胞量調節機構の解明」
淺原俊一郎先生
神戸大学大学院医学研究科糖尿病・内分泌内科
日時：平成 28 年 3 月 4 日（金） 17:00～18:00
場所：金沢大学宝町医学部 B 棟１階小会議室
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Asahara S, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, Kawada Y, Bartolome A, Hashimoto N, Matsuda T,
Koyanagi-Kimura M, Kanno A, Hirota Y, Hosooka T, Nagashima K, Nishimura W, Inoue H, Matumoto M, Higgins MJ,
Yasuda K, Inagaki N, Seino S, Kasuga M, Kido Y. Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β cell
mass via epigenetic modification of Cdkn1c. Proc Natl Acad Sci USA. 112: 8332-8337
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Kanno A, Asahara S, Masuda K, Matsuda T, Kimura-Koyanagi M, Seino S, Ogawa W, Kido Y. Compensatory
hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translation in islets. Biochem.
Biophys. Res. Commun. 458: 681-686
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Asahara S, Matsuda T, Kido Y, Kasuga M. Increased ribosomal biogenesis induces pancreatic β cell failure in mice
model of type 2 diabetes. Biochem. Biophys. Res. Commun. 381: 367-371
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Koyanagi M, Asahara S, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani Y, Kanno A, Fuchita M, Mikami T, Hosooka
T, Inoue H, Matsumoto M, Koike M, Uchiyama Y, Noda T, Seino S, Kasuga M, Kido Y. Ablation of TSC2 enhances
insulin secretion by increasing the number of mitochondria through activation of mTORC1. PLoS ONE 6: e23238
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Shigeyama Y, Kobayashi T, Kido Y, Hashimoto N, Asahara S, Matsuda T, Takeda A, Inoue T, Shibutani Y, Koyanagi M,
Uchida T, Inoue M, Hino O, Kasuga M, Noda T Biphasic response of pancreatic β cell mass to ablation of TSC2 in mice.
Mol Cell Biol 28:2971-2979
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Hashimoto N, Kido Y, Uchida T, Asahara S, Shigeyama Y, Matsuda T, Takeda A, Tsuchihashi D, Nishizawa A, Ogawa W,
Fujimoto Y, Okamura H, Arden KC, Herrera PL, Noda T, Kasuga M. Ablation of PDK1 in pancreatic β cells induces
diabetes as a result of loss of β-cell mass. Nat. Genet. 38:589-593
連絡先：金沢大学新学術創成研究機構
革新的統合バイオ研究コア栄養・代謝研究ユニット井上啓
TEL：076-265-2840 E-Mail：[email protected]

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