氏名大野修司所属薬剤師教育研究部門職位准教授

Hoshi University
氏
名
大野修司
所
属
薬剤師教育研究部門
学
位
薬学博士
最終学歴
教育活動
（担当授業科目）
研究活動
（研究テーマ）
星薬科大学大学院
職
位
薬学研究科
准教授
博士課程
生理活性分子とシグナル伝達、基礎薬学演習、薬学特別演習Ⅱ /Ⅲ、総合薬学演習Ⅰ /Ⅱ
ホルモンによる生体調節機構に関する研究
所属学会
日本薬学会、日本生化学会、Endocrine Society
学内活動
放射線取扱主任者
（役職・委員等）
学外活動
（委員会委員等）
研究業績等
（主な著書・論文）
1. OHNO, S., NAKAGAWARA, S., HONDA, Y. AND NAKAJIN S. : Evidence for expression of
11-hydroxysteroid dehydrogenase type3 (HSD11B1L) in neonatal pig testis. Mol. Cell.
Biochem., 381, 145-156 (2013)
2. WATANABE, M., OHNO, S. AND NAKAJIN, S.: Effects of Bisphenol A on the expression of
cytochrome P450 aromatase (CYP19) in human fetal osteoblastic and granulose cell -like cell
lines. Toxcol. Lett. , 210(1), 95-99 (2012)
3. OHNO, S. AND NAKAJIN, S.: Quantitative analysis of UGT2B28 mRNA expression by
real-time RT-PCR and application to human tissue distribution study. Drug. Metab. Lett.,
5, 202-208 (2011)
4. OHNO, S., OHTA, M. AND NAKAJIN, S.: Quantitative determination and tissue
distribution
of
human
11-hydroxysteroid
dehydrogenase,
hexose-6-phosphate
dehydrogenase,
glucose-6-phosphate
transporter,
glucocorticoid
receptor
and
mineralocorticoid receptor mRNAs. Horm. Mol. Biol. Clin. Invest ., 2(1), 219-226 (2010)
5. OHNO, S., OHTA, M., HONDA, Y. AND NAKAJIN, S.: Sequence and expression of
11-hydroxysteroid dehydrogenase type 1 cDNA cloned from pig testis . Mol. Cell. Biochem .,
338(1-2), 149-156 (2010)
6. OHNO, S., YUKINAWA, F., NODA, M. AND NAKAJIN, S.: Mono-(2-ethylhexyl) phthalate
induces NR4A subfamily and GIOT-1 gene expression, and suppresses CYP19 expression in
human granulosa-like tumor cell line KGN. Toxcol. Lett. , 191(2-3), 353-359 (2009)
7. OHNO, S. AND NAKAJIN, S.: Determination of mRNA Expression of Human UDPGlucuronosyltransferases and Application for Localization in Various Human Tissues by
Real- Time Reverse Transcriptase-Polymerase Chain Reaction. Drug Metab. Dispos., 37,
32-40 (2009)
8. OHNO, S., KAWANA, K. AND NAKAJIN, S.: Contribution of UDP-glucuronosyltransferase
1A1 and 1A8 to morphine 6-glucuronidation and its kinetic properties. Drug Metab. Dispos. ,
36 (4), 688-694 (2008)
9. OHNO, S., NISHIKAWA, K., HONDA, Y. AND NAKAJIN, S.: Expression in E. coli and
tissue distribution of the human homologue of the mouse Ke 6 gene, 17-hydroxysteroido
dehydrogenase type 8. Mol. Cell. Biochem., 309, 209-215 (2008)
10. HONDA, Y., OHNO, S. AND NAKAJIN, S.: Leydig cells from neonatal pig testis
abundantly express 11-Hydroxysteroid dehydrogenase (11-HSD) type2 and effectively
inactivate cortisol to cortisone. J. Steroid Biochem. Molec. Biol., 108 (1-2), 91-101 (2008)
11. NODA, M., OHNO, S. AND NAKAJIN, S.: Mono-(2-ethylhexyl) phthalate (MEHP) induces
nuclear receptor 4A subfamily in NCI-H295R cells: A possible mechanism of aromatase
suppression by MEHP. Molec. Cell. Endocrinol., 274, 8–18 (2007)
12. OHNO, S., HONDA, Y., NAKAJIMA, Y. AND NAKAJIN, S.: Sequence of pig
17-hydroxysteroid dehydrogenase Type3 cDNA and its expression in mammalian cells . J.
Steroid Biochem. Molec. Biol ., 101, 145-150 (2006)
13. LEWIS, J.G., NAKAJIN, S., OHNO, S., WARNOCK, A., FLORKOWSKI, C.M. AND
ELDER, P.A.: Circulating levels of isoflavones and markers of 5alpha-reductase activityare
higher in Japanese compared with New Zealand males: What is the role of circulating
steroids in prostate disease? Steroids, 70, 974-979 (2005)
14. OHSHIMA, M., OHNO, S. AND NAKAJIN, S.: Inhibitory Effects of Some Endocrine
Disrupting Chemicals on the Isozymes of Human 11-Hydroxysteroid Dehydrogenase and
Their Distributions in Gonads and Adrenal. Environ. Sci. , 12 (4), 219-230 (2005)
15. OHNO, S., NAKAJIMA, Y. AND NAKAJIN, S.: Triphenyltin and tributyltin inhibit pig
testicular 17-hydroxysteroid dehydrogenase activity and suppress testicular testosterone
biosynthesis. Steroids , 70, 645-651 (2005)
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