氏名金田利夫所属生薬学教室職位准教授学位博士（学術）最終

Hoshi University
氏
名
金田
利夫
所
属
生薬学教室
学
位
博士（学術）
職
位
准教授
最終学歴
北海道大学大学院薬学研究科修士課程修了
教育活動
（担当授業科目）
生薬学、天然物化学（薬になる天然資源 II, III）
研究活動
（研究テーマ）
所属学会
学内活動
（役職・委員等）
学外活動
（委員会委員等）
天然物の薬理作用、特に骨代謝、脂質代謝、免疫に作用する天然物成分の研究
日本薬学会、日本生薬学会、日本骨代謝学会
研究業績等
（主な著書・論文）
1. Wong CP, Kaneda T, Morita H. Plant natural products as an anti -lipid droplets accumulation agent.
J Nat Med., 68: 253-266 (2014)
2. Wong CP, Deguchi J, Nugroho AE, Kaneda T, Hadi AH, Morita H. Ceramicines from Chisocheton
ceramicus as lipid-droplets accumulation inhibitors. Bioorg Med Chem Lett., 23: 1786-1788 (2013)
3. Okayasu M, Nakayachi M, Hayashida C, Ito J, Kaneda T, Masuhara M, Suda N, Sato T, Hakeda Y.
Low-density lipoprotein receptor deficiency causes impaired osteoclas togenesis and increased bone mass in
mice because of defect in osteoclastic cell-cell fusion. J Biol Chem., 287: 19229-19241 (2012)
4. Hada N, Okayasu M, Ito J, Nakayachi M, Hayashida C, Kaneda T, Uchida N, Muramatsu T, Koike C,
Masuhara M, Sato T, Hakeda Y. Receptor activator of NF-κB ligand-dependent expression of caveolin-1 in
osteoclast precursors, and high dependency of osteoclastogenesis on exogenous lipoprotein. Bone, 50:
226-236 (2012)
5. Wong CP, Shimada M, Nagakura Y, Nugroho AE, Hirasawa Y, Kaneda T, Awang K, Hadi AH, Mohamad K,
Shiro M, Morita H. Ceramicines E-I, new limonoids from Chisocheton ceramicus. Chem Pharm Bull., 59:
407-411 (2011)
6. Takeshi Ono, Toshio Kaneda, Akihiro Μuto and Tadashi Yoshida
Positive transcriptional regulation of the human μ opioid receptor gene by poly (ADP -ribose) polymerase-1
(PARP-1) and increasing of its DNA binding affinity based on base substitution of -172G/T
J. Biol. Chem., 284: 20175-20183 (2009)
7. Muto A, Hori M, Sasaki Y, Saitoh A, Yasuda I, Ma ekawa T, Uchida T, Asakura K, Nakazato T, Kaneda T,
Kizaki M, Ikeda Y, Yoshida T. Emodin has a cytotoxic activity against human multiple myeloma as a
Janus-activated kinase 2 inhibitor. Mol. Cancer Ther., 6: 987-994 (2007)
8. Kaneda T, Honda A, Hakozaki A, Fuse T, Muto A, Yoshida T.
An improved Graves' disease model established by using in vivo electroporation exhibited long-term immunity
to hyperthyroidism in BALB/c mice. Endocrinology, 148: 2335-2244 (2007)
9. Kobayashi Y, Ueyama S, Arai Y, Yoshida Y, Kaneda T, Sato T, Shin K, Kumegawa M, Hakeda Y.
The active metabolite of leflunomide, A771726, inhibits both the generation of and the bone -resorbing activity
of osteoclasts by acting directly on cells of the osteoclast lineage.
J. Bone Miner. Metab., 22: 318-328 (2004)
10. Takuma A, Kaneda T, Sato T, Ninomiya S, Kumegawa M, Hakeda Y.
Dexamethasone enhances
osteoclast formation synergistically with transforming growth factor - by stimulating the priming of osteoclast
progenitors for differentiation into osteoclasts. J. Biol. Chem., 278: 44667-44674 (2003)
11. Hayashi T, Kaneda T, Toyama Y, Kumegawa M, Hakeda Y. Regulation of receptor activator of NF -B
ligand-induced osteoclastogenesis by endogenous interferon-beta (INF-) and suppressors of cytokine
signaling (SOCS). The possible counteracting role of SOCSs - in IFN--inhibited osteoclast formation.
J. Biol. Chem., 277: 27880-27786 (2002)
12. Ogasawara A, Arakawa T, Kaneda T, Takuma T, Sato T, Kaneko H, Kumegawa M, Hakeda Y. Fluid
shear stress-induced cyclooxygenase-2 expression is mediated by C/EBP, cAMP-response element-binding
protein, and AP-1 in osteoblastic MC3T3-E1 cells. J. Biol. Chem., 276: 7048-7054 (2001)
13. Kaneda T, Nojima T, Nakagawa M, Ogasawara A, Kaneko H, Sato T, Mano H, Kumegawa M, Hakeda
Endogenous production of TGF- is essential for osteoclastogenesis induced by a combination of receptor
activator of NF-B ligand and macrophage-colony-stimulating factor.
J. Immunol., 165: 4254-4263 (2000)
14. Mano H, Kimura C, Fujisawa Y, Kameda T, Watanabe -Mano M, Kaneko H, Kaneda T, Hakeda Y,
Kumegawa M. Cloning and function of rabbit peroxisome proliferator -activated receptor delta/beta in mature
osteoclasts. J. Biol. Chem., 275: 8126-8132 (2000)
15. Kaneda T, Kitamura Y, Nomura Y. Presence of m3 subtype muscarinic acetylcholine receptors and
receptor-mediated increases in the cytoplasmic concentration of Ca 2+ in Jurkat, a human leukemic helper T
lymphocyte line. Mol. Pharmacol., 43: 356-364 (1993)
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