g¤L°³QĈš,X°³QŢ %,) ĈĈĈĈ Centrosome Biology Laboratory, Center for Frontier Research, National Institute of Genetics zwĈ,XE E-mail: [email protected] Tel: 055-981-5828 °³Q C C317 _°³Qī2011]ĩ?´ñL°³q|!ö&ìŇşʼnŠĩ åěĠè®|ěď°³QĥĝĊVĉ°³ÇĹ¯vĝELü¤Ĺ)þěĤďĮĝĊ Í8ĪĎĶ}īĒçĩęí¿ĖġĚď (projectĩúĝĶÞıÑďĮĝŢĊ °³S -10]ĩĸĠĵî+KĚķĠ¼ÊW;NĥĎĶ gĔħĪijĐĩÌ[ÕÔĝĶĪēŤ -ÎĪÕÔĦ¨ĨĵĉĘĪÕÿĨ¼ÊìĔħ ĪijĐĩZGĩÕÔĚķĶĪēŤ ğĪ!JŖĽŎņŕĹ¼Ê¤Lĉ¤+LĉñLĉ ¤¢Lĉì¤LĨħDaĨrĹ¥ďĤÙ ěĤďĶĊgÕÔĪ:ăī¡¤LĩĚķĠ EĪâĪģĥĎĵĉĘĪ°³ĹëĜĤ|ěďłşŇ Kitagawa D. et al (2011) Cell őōĪ& Ĺ¯věĤďĮĝĊ (°³SĪܼīÓœŠŅĩĎĵĮĝŢ m®ĨELü¤ĹéěĮĝ ĈA®ĩīĉďĕďĕĦ9nĹuĢĤµĪ°³Ĺ~ċěĺĥıĴđĶijĐĨ£Cĉ zÈĹxěĠďĦÆđĤďĮĝĊ°³īĪŗŊŒŠńřşĪÀuĔ§E"ĥĝĊ ğĪĠİĩīĉÌ!ĪĂĥÆđĤĻļŌĻĹ& ěĉğĪÞĹÛĝĶĠİĪ®Ĩ PĆĹŌŃļşěĉð"ĨőŞōłŠŜĉ ÚOĩdĢĤ¾ĹeĉğķĹÆTĝĶĦďĐ íĪĹÌĴPÑĝĶË'Ĕ2ġĦÆđĮĝĊĮĠĉ ĵijĔĵĥīĨĖĉÌ!Ī Ĺ᢮ĩ7>ĩőŝňşŋŠńřşěĉÇĦĪłŔŘŎŀŠńřşĪēĴ|ěď} 5jĹ&ìĝĶË'ıhÖĥĝšÏÝĹ¥ěĤŢĊĪijĐĨI*Ĺ_°³Qĥīæĩ ģėĤıĴďĠďĦÆđĤďĮĝĊ êĪá{šs¹Ţ 1. Kitagawa D. et al (2011) Cell, 144, 364-375 2. Kitagawa D. et al (2011) Developmental Cell, 20, 550-562 3. Kitagawa D. et al (2011) J. Cell Sci., 124, 3884-3893 4. Kitagawa D. et al (2009) Developmental Cell, 17, 900-907 5. Kitagawa D. et al (2006) EMBO J, 25, 3286-3297. 1 #+('!" °³S What Wh haatt we we are no now ow working wooork w rrk kin kin ing on on 1 W g Nigg EA and Raff JW (2009) Cell : ë\ĪgÕÔ : gï$ÕÔĩijĶŁŏŕĪMO+ 0ĭ¼ÊĔĺ+ 2 #(' 2 3 #('$- *& SAS-6 ¤9ĪĝĶıA®ĨjĪģīČÌ[ÕÔčĥĝĊ Ęķī.¼Ê¤ĨħŝŒŜĥÆđĶıĥĕĮĝěĉ ÎÕÔĨħñlBŝŒŜĥÆđĶıĥĕĮĝĊ 4ĩî+KĚķĠ¼ÊW;NĪģĥĎĶgı ¼Ê7ęĦĩ^ġėÕÔĚķĮĝĊgī!Ò» ÷Ī`pĩõÖĨb%ĹtĢĤĒĵĉ\ĨÎ!óĉ ¼Ê!ÒĩhāĥĎĶĬēĵĥĨĖĉğĪ¾ĦěĤŁŏŕ MOjÀuĩıĖúěĤďĮĝĊPýĉ¬Ī#ï²ĩ ĒĘĶgĪï$ÕÔī¬Īkj+ĩÄĔĶĔvyĚ ķĤďĮĝĊ gīğĪĦěĤËĝĶgW0ĭ ğķĹ1ĵ>įPCM(pericentriolar material)ēĴpĚķ ĤďĮĝĊĮĠĉgWīºJĀIJÃĪ`pĹà· ěĤĒĵgWĔ\ĩËěĨďĦĀIJÃĔ`p ĚķĞĉċĨ©ªĹäĘĝĘĦĔB6ĚķĤďĮĝ šciliopathyĉ¦jF«ĨħŢĊgWīţ<U±jĹ ěĠ¶Īf®ĨìĥĉğĪiãĨÌ[ÕÔ īÙĨò!ĔDĖĉ¼Ê¤LĪEĪâĪģĦ ĚķĤďĮĝĊ _°³Qĥī¼Ê¤Lĉ¤+LĉñLĉ¤¢Lĉ ì¤L®ÙĹąěĠÕ3®ĻőŞŠŊĩijĵg ĔħĪijĐĩ¸ĚķĶĪēĹ!JŝŒŜĥ¢ÙĝĶĘĦ Ĺ¯®ĩ°³ěĤďĮĝĊôĪÕÔšÎÕÔŢĦ¨Ĩĵĉ ĘĪÕÿĨìĔħĪijĐĩZGĩÕÔĚķĶēĹ°³ĝ ĶĘĦĥ|ĠĨłşŇőōĹ× ĝĹcěĤďĮĝĊ ĩÂÐ0ĭŐō@Ą¼ÊĹ¥ďĤĪ°³ßăĩ1ĵ ½ĺĥďĮĝĊ 1. |ØgWp=JĪ4O 2. gp=JùĪļşʼnŚľōŠŕÙ 3. In vitropĩijĶgW¸ĪŗŌśşĿ 4. ¤ï²ĩĒėĶg(o0ĭğĪ¤¢®mÅĪÙ 5. ºJĀAò`pĹ/=ĦĝĶ¦jF«Ī !JŖĽŎņŕĪÙ A. ÂÐ#ÉĩĒďĤgīGFP-TAC-1ĩijĵŚŒŜĚķĤďĶĊ ĈĈĈ SAS-6(RNAi)ĩijĵgÕÔĔûRĚķĶĊ B. Őō@Ą¼ÊĩĒďĤgWīCentrinĩijĵŚŒŜĚķĤďĶĊ ĈĈĈ SAS-6(RNAi)ĩijĵgWÕÔĔûRĚķĶĊ úíĝĶ~ÝÁÞćććć 1. ,XE (2013) gW¸ĦÕÔĪ!JŖĽŎņŕĈ¼ ¼ÊYL, vol. 32, No.2, 285-90 2. ,XEć(2011) gWÕÔøHĪ!JŖĽŎņŕĈP PĆ-L, vol. 29, No.11, 1777-1780
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