ポスターはこちら - 独立行政法人医薬基盤研究所

基盤研セミナー
Role of Innate Lymphoid Cells
for Mucosal Homeostasis
日時：
2014年11月28日（金） 14:00-15:00
場所：
医薬基盤研究所大会議室
演者：
東京大学医科学研究所
所長
炎症免疫学分野教授
清野宏先生
The mucosal immune system (MIS) creates a homeostatic condition to
an enormous number and volume of innocuous and/or instructive antigens
(e.g., commensal microorganisms and foods) which need to be
appropriately ‘ignored’. Mounting an immunologically harmonized response
therefore represents a key decision-making process of active and/or
quiescent immune responses by the MIS. To this end, the MIS has been
shown to be enriched with the variety of innate and acquired immunityassociated cells. Our studies have provided new evidence for the intratissue habitation of commensal flora (e.g., Alcaligenes) in the organized
lymphoid structure associated with gut mucosa (e.g., Peyer’s patch:PP)
which involves in the development of IgA immune system and creation of
homeostatic condition. Recent evidences have suggested that intestinal
innate lymphoid cells (ILCs) play a critical role in the containment of
Alcaligenes in PP. Intestinal epithelial cells(ECs) possess unique α(1,2)fucose- moiety and these cells are thus refereed as fucosylated ECs
(F-ECs) which are contributing in the formation of co-habitation platform for
commensal bacteria. These F-ECs are induced and regulated by mucosal
ILCs. Our data provide a new perspective of the surface connections with
innate immunity associated cells, epithelial cells and microbiota for the
mucosal mutualisums.
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