大阪大学大学院薬学研究科研究業績集
(2011)
高分子化学 (Biophysical Chemistry)
Assembly states of the nucleosome assembly protein 1 (NAP-1) revealed by sedimentation
velocity and non-denaturing MS
Noda M, Uchiyama S, McKay AR, Morimoto A, Misawa S, Yoshida A, Shimahara H, Takinowaki H,
Nakamura S, Kobayashi Y, Matsunaga S, Ohkubo T, Robinson CV, Fukui K
Biochem. J. 436, 101-112 (2011)
Increasing the hydrolysis constant of the reactive site upon introduction of an engineered
Cys14-Cys39 bond into the ovomucoid third domain from silver pheasant
Hemmi H, Kumazaki T, Kojima S, Yoshida T, Ohkubo T, Yokosawa H, Miura K, Kobayashi Y
J. Pept. Sci., 17, 595-600 (2011)
Ligand recognition mechanism of lipocalin-type prostaglandin D synthase
Shimamoto S, Yoshida T, Ohkubo T
Yakugaku Zasshi, 131, 1575-1581 (2011)
薬品製造化学 (Synthetic Medicinal Chemistry)
Asymmetric total synthesis of (+)-Danicalipin A
Yoshimitsu T, Nakatani R, Kobayashi A, Tanaka T
Org. Lett., 13, 908-911 (2011)
A novel samarium(II)-mediated tandem spirocyclization onto an aromatic ring
Iwasaki H, Tsutsui N, Eguchi T, Ohno H, Yamashita M, Tanaka T
Tetrahedron Lett., 52, 1770-1772 (2011)
Palladium-catalyzed construction of polycyclic heterocycles by an alkyne insertion and direct
arylation cascade
Ohno H, Yamamoto M, Iuchi M, Fujii N, Tanaka T
Synthesis, 2567-2578 (2011)
Total synthesis of (±)-Kainic acid: A photochemical C–H carbamoylation approach
Kamon T, Irifune Y, Tanaka T, Yoshimitsu T
Org. Lett., 13, 2674-2677 (2011)
Asymmetric alkynylation of aldehydes with propiolates without high reagent loading and any
additives
1
Kojima N, Nishijima S, Tsuge K, Tanaka T
Org. Biomol. Chem., 9, 4425-4428 (2011)
Total synthesis of (±)-Platencin
Yoshimitsu T, Nojima S, Hashimoto M, Tanaka T
Org. Lett., 13, 3698-3701 (2011)
Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against
human cancer cell lines
Kojima N, Suga Y, Hayashi H, Yamori T, Yoshimitsu T, Tanaka T
Bioorg. Med. Chem. Lett., 21, 5745-5749 (2011)
生体機能分子化学 (Bio-Functional Molecular Chemistry)
A novel screening system for claudin binder using baculoviral display
Kakutani H, Takahashi A, Kondoh M, Saito Y, Yamaura T, Sakihama T, Hamakubo T, Yagi K
PLoS One, 6, e16611 (2011)
Mutated C-terminal fragments of Clostridium perfringens enterotoxin have increased affinity to
claudin-4 and reversibly modulate tight junctions in vitro
Takahashi A, Kondoh M, Uchida H, Kakamu Y, Hamakubo T, Yagi K
Biochem. Biophys. Res. Commun., 410, 466-470 (2011)
A toxicological evaluation of a claudin modulator, the C-terminal fragment of Clostridium
perfringens enterotoxin, in mice
Suzuki H, Kondoh M, Li X, Takahashi A, Matsuhisa K, Matsushita K, Kakamu Y, Yamane S, Kodaka
M, Isoda K, Yagi K
Pharmazie, 66, 543-546 (2011)
Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for
hepatocytes in hepatitis C virus infection
Yoshida T, Takayama K, Kondoh M, Sakurai F, Tani H, Sakamoto N, Matsuura Y, Mizuguchi H, Yagi
K
Biochem. Biophys. Res. Commun., 416, 119-124 (2011)
Adenovirus vector-mediated assay system for hepatitis C virus replication
Yoshida T, Kondoh M, Ojima M, Mizuguchi H, Yamagishi Y, Sakamoto N, Yagi K
Nucleic Acids Res., 39, e64 (2011)
Effect of surface charge on nano-sized silica particles-induced liver injury
Isoda K, Hasezaki T, Kondoh M, Tsutsumi Y, Yagi K
2
Pharmazie, 66, 278-281 (2011)
Effect of 70-nm silica particles on the toxicity of acetaminophen, tetracycline, trazodone, and
5-aminosalicylic acid in mice
Li X, Kondoh M, Watari A, Hasezaki T, Isoda K, Tsutsumi Y, Yagi K
Pharmazie, 66, 282-286 (2011)
Hepatotoxicity of silica nanoparticles with a diameter of 100nm
Hasezaki T, Isoda K, Kondoh M, Tsutsumi Y, Yagi K
Pharmazie, 66, 698-703 (2011)
Development of a recombinant adenovirus vector production system free of
replication-competent adenovirus by utilizing a packaging size limit of the viral genome
Suzuki T, Sasaki T, Yano K, Sakurai F, Kawabata K, Kondoh M, Hayakawa T, Yagi K, Mizuguchi H
Virus Res., 158, 154-160 (2011)
Peptides as tight junction modulators (Review)
Takahashi A, Kondoh M, Kodaka M, Yagi K
Curr. Pharm. Design, 17, 2699-2703 (2011)
Claudin as a target for drug development (Review)
Takahashi A, Kondoh M, Suzuki H, Yagi K
Curr. Med. Chem., 18, 1861-1865 (2011)
Promising targets for anti-hepatitis C virus agents (Review)
Yosida T, Kondoh M, Yagi K
Curr. Med. Chem., 18, 1239-1244 (2011)
A non-invasive drug delivery system using claudin binder (Review)
Takahashi A, Kondoh M, Yagi K
YAKUGAKU ZASSHI, 131, 1583-1587 (2011)
分子生物学 (Biochemistry and Molecular Biology)
Efficient generation of hepatoblasts from human ES cells and iPS cells by transient
overexpression of homeobox gene HEX
Inamura M, Kawabata K, Takayama K, Tashiro K, Sakurai F, Katayama K, Toyoda M, Akutsu H,
Miyagawa Y, Okita H, Kiyokawa N, Umezawa A, Hayakawa T, Furue MK, Mizuguchi H
Mol. Ther., 19, 400-407 (2011)
Efficient and directive generation of two distinct endoderm lineages from human ESCs and
3
iPSCs by differentiation stage-specific SOX17 transduction
Takayama K, Inamura M, Kawabata K, Tashiro K, Katayama K, Sakurai F, Hayakawa T, Furue MK,
Mizuguchi H
PLoS One, 6, e21780 (2011)
Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by
incorporation of normal cell-specific microRNA-targeted sequences
Sugio K, Sakurai F, Katayama K, Tashiro K, Matsui H, Kawabata K, Kawase A, Iwaki M, Hayakawa T,
Fujiwara T, Mizuguchi H
Clin. Cancer Res., 17, 2807-2818 (2011)
Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction
Suzuki-Kouyama E, Katayama K, Sakurai F, Yamaguchi T, Kurachi S, Kawabata K, Nakagawa S,
Mizuguchi H
Biomaterials, 32, 1724-1730 (2011)
Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of
RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob
Matsui H, Sakurai F, Katayama K, Kurachi S, Tashiro K, Sugio K, Kawabata K, Mizuguchi H
Virus Res., 155, 48-54 (2011)
Development of a recombinant adenovirus vector production system free of
replication-competent adenovirus by utilizing a packaging size limit of the viral genome
Suzuki T, Sasaki T, Yano K, Sakurai F, Kawabata K, Kondoh M, Hayakawa T, Yagi K, Mizuguchi H
Virus Res., 158, 154-160 (2011)
Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for
hepatocytes in hepatitis C virus infection
Yoshida T, Takayama K, Kondoh M, Sakurai F, Tani H, Sakamoto N, Matsuura Y, Mizuguchi H , Yagi
K
Biochem. Biophys. Res. Commun., 416, 119-124 (2011)
An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors
Motegi Y, Katayama K, Sakurai F, Kato T, Yamaguchi T, Matsui H, Takahashi M, Kawabata K,
Mizuguchi H
J. Cont. Rel., 153, 149-153 (2011)
Quantitative analysis of the leaky expression of adenovirus genes in cells transduced with a
replication-incompetent adenovirus vector
Shimizu K, Sakurai F, Machitani M, Katayama K, Mizuguchi H
Mol. Pharmaceutics, 8, 1430-1435 (2011)
4
Development of an adenovirus vector lacking the expression of virus-associated RNAs
Machitani M, Katayama K, Sakurai F, Matsui H, Yamaguchi T, Suzuki T, Miyoshi H, Kawabata K,
Mizuguchi H
J. Cont. Rel., 154, 285-289 (2011)
Enhanced in vivo gene transfer into the placenta using RGD fiber-mutant adenovirus vector
Katayama K, Furuki R, Yokoyama H, Kaneko M, Tachibana M, Yoshida I, Nagase H, Tanaka K,
Sakurai F, Mizuguchi H, Nakagawa S, Nakanishi T
Biomaterials, 32, 4185-4193 (2011)
Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural
mesothelioma
Iwahori K, Serada S, Fujimoto M, Nomura S, Osaki T, Lee CM, Mizuguchi H, Takahashi T, Ripley B,
Okumura M, Kawase I, Kishimoto T, Naka T
Int. J. Cancer, 129, 1005-1017 (2011)
Adenovirus vector-mediated assay system for hepatitis C virus replication
Yoshida T, Kondoh M, Ojima M, Mizuguchi H, Yamagishi Y, Sakamoto N, Yagi K
Nucleic Acids Res., 39, e64 (2011)
Optimization of a microRNA expression vector for function analysis of microRNA
Furukawa N, Sakurai F, Katayama K, Seki N, Kawabata K, Mizuguchi H
J. Cont. Rel., 150, 94-101 (2011)
EpCAM- and EGFR-targeted selective gene therapy for biliary cancers using Z33-fiber-modified
adenovirus
Kawashima R, Abei M, Fukuda K, Nakamura K, Murata T, Wakayama M, Seo E, Hasegawa N,
Mizuguchi H, Obata Y, Hyodo I, Hamada H, Yokoyama KK
Int. J. Cancer, 129, 1244-1253 (2011)
Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing
ability and resistance to cancer cell-derived inhibitory factors
Iwata-Kajihara T, Sumimoto H, Kawamura N, Ueda R, Takahashi T, Mizuguchi H, Miyagishi M,
Takeda K, Kawakami Y
J. Immunol., 187, 27-36 (2011)
Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene
therapy
Yao X, Yoshioka Y, Morishige T, Eto Y, Narimatsu S, Kawai Y, Mizuguchi H, Gao JQ, Mukai Y,
Okada N, Nakagawa S
Mol. Ther., 19, 1619-1625 (2011)
5
Adenovirus vector-derived VA-RNA-mediated innate immune responses (Review)
Machitani M, Yamaguchi T, Shimizu K, Sakurai F, Katayama K, Kawabata K, Mizuguchi H
Pharmaceutics, 3, 338-353 (2011)
MicroRNA-regulated transgene expression systems for gene therapy and virotherapy (Review)
Sakurai F, Katayama K, Mizuguchi H
Frontiers in Bioscience, 17, 2389-2401 (2011)
改良型アデノウイルスベクターの開発と神経系細胞への遺伝子導入 (Review)
松井勇人, 櫻井文教, 形山和史, 水口裕之
日本薬理学雑誌, 137, 70-74 (2011)
ウイルスベクターと遺伝子治療 (Review)
水口裕之, 櫻井文教
化学療法の領域, 27, 867-873 (2011)
ヒト ES/iPS 細胞から肝細胞への高効率分化誘導と毒性評価系への応用 (Review)
稲村充, 高山和雄, 川端健二, 水口裕之
生産と技術, 63, 67-69 (2011)
iPS 細胞分化誘導による HCV 培養モデル (Review)
水口裕之, 近藤昌夫, 八木清仁
肝胆膵, 63, 919-924 (2011)
スーパー特区研究『ヒト iPS 細胞を用いた新規 in vitro 毒性評価系の構築』の概要 (Review)
水口裕之
動物実験代替法学会News Letter, 40, 21-22 (2011)
分子合成化学 (Synthetic Organic Chemistry)
Intramolecular iodoetherification of ene or diene ketals: facile synthesis of spiroketals
Fujioka H, Nakahara K, Hirose H, Hirano K, Oki T, Kita Y
Chem. Commun., 47, 1060-1062 (2011)
C 3 -symmetric chiral trisimidazoline: the role of a third imidazoline and its application to the
nitro Michael reaction and the α-amination of β-ketoesters
Murai K, Fukushima S, Nakamura A, Shimura M, Fujioka H
Tetrahedron, 67, 4862-4868 (2011)
Phenyliodine diacetate-mediated oxidative cleavage of cyclobutanols leading to γ-hydroxy
ketones
6
Fujioka H, Komatsu H, Miyoshi A, Murai K, Kita Y
Tetrahedron Lett., 52, 973-975 (2011)
The synthetic and biological studies of discorhabdins and related compounds
Wada Y, Harayama Y, Kamimura D, Yoshida M, Shibata T, Fujiwara K, Morimoto K, Fujioka H, Kita
Y
Org. Biomol. Chem., 9, 4959-4976 (2011)
The reaction of acetal-type protective groups in combination with TMSOTf and 2,2’-bipyridyl;
mild and chemoselective deprotection and direct conversion to other protective groups
Fujioka H, Minamitsuji Y, Kubo O, Senami K, Maegawa T
Tetrahedron, 67, 2949-2960 (2011)
Asymmetric total synthesis of clavolonine
Nakahara K, Hirano K, Maehata R, Kita Y, Fujioka H
Org. Lett., 13, 2015-2017 (2011)
Reversing the reactivity of carbonyl functions with phosphonium salts: enantioselective total
synthesis of (+)-centrolobine
Fujioka H, Yahata K, Kubo O, Sawama Y, Hamada T, Maegawa T
Angew. Chem. Int. Ed., 50, 12232-12235 (2011)
Efficient phenolic oxidations to construct ortho-spirolactone structures using oxo-bridged
hypervalent iodine(III) compound
Takenaga N, Uchiyama T, Kato D, Fujioka H, Dohi T, Kita Y
Heterocycles, 82, 1327-1336 (2011)
Direct conversion of acetals to esters with high regioselectivity via O,P-acetals
Maegawa T, Otake K, Goto A, Fujioka H
Org. Biomol. Chem., 9, 5648-5651 (2011)
2,5-cis-2,3,5-Trisubstituted tetrahydrofurans from the diastereomixture of 2,4-disubstituted
1,3-dioxepins via stereomutation
Kubo O, Yahata K, Maegawa T, Fujioka H
Chem. Commun., 47, 9197-9199 (2011)
An unusual reaction of α-alkoxyphosphonium salts with Grignard reagents under an O 2
atmosphere
Fujioka H, Goto A, Otake K, Kubo O, Sawama Y, Maegawa T
Chem. Commun., 47, 9894-9896 (2011)
Metal-free C-H cross-coupling toward oxygenated naphthalene-benzene linked biaryls
7
Dohi T, Ito M, Itani I, Yamaoka N, Morimoto K, Fujioka H, Kita Y
Org. Lett., 13, 6208-6211 (2011)
Palladium on carbon-catalyzed solvent-free and solid-phase hydrogenation and Suzuki-Miyaura
reaction
Monguchi Y, Fujita Y, Hashimoto S, Ina M, Takahashi T, Ito R, Nozaki K, Maegawa T, Sajiki H
Tetrahedron, 67, 8628-8634 (2011)
Facile hydrogenation of ketones catalyzed by platinum on carbon under ordinary pressures and
temperatures
Fujiwara Y, Iwasaki Y, Maegawa T, Monguchi Y, Sajiki H
ChemCatChem, 3, 1624-1628 (2011)
(+)-Sorangicin A: evolution of a viable synthetic strategy
Smith AB, III, Dong S, Fox RJ, Brenneman JB, Vanecko JA, Maegawa T
Tetrahedron, 67, 9809-9828 (2011)
Marine pyrroloiminoquinone alkaloids
Kita Y, Fujioka H
Top. Curr. Chem. (Recent advances in alkaloid synthesis) (Springer), 1-32 (2011)
細胞生物学 (Cell Biology)
The multidrug efflux pump MdtEF protects against nitrosative damage during the anaerobic
respiration in Escherichia coli
Zhang Y, Xiao M, Horiyama T, Zhang Y, Li X, Nishino K, Yan A
J. Biol. Chem., 286, 26576-26584 (2011)
Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
Nakashima R, Sakurai K, Yamasaki S, Nishino K, Yamaguchi A
Nature, 480, 565-569 (2011)
AcrA dependency of the AcrD efflux pump in Salmonella enterica serovar Typhimurium
Yamasaki S, Nagasawa S, Hayashi-Nishino M, Yamaguchi A, Nishino K
J. Antibiot., 64, 433-437 (2011)
Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels
Matsumoto Y, Hayama K, Sakakihara S, Nishino K, Noji H, Iino R, Yamaguchi A
PLoS One, 6, e18547 (2011)
Regulation of the AcrAB multidrug efflux pump in Salmonella enterica serovar Typhimurium in
8
response to indole and paraquat
Nikaido E, Shirosaka I, Yamaguchi A, Nishino K
Microbiology, 157, 648-655 (2011)
Effect of overexpression of small non-coding DsrA RNA on multidrug efflux in Escherichia coli
Nishino K, Yamasaki S, Hayashi-Nishino M, Yamaguchi A
J. Antimicrob. Chemother., 66, 291-296 (2011)
Roles of Salmonella multidrug efflux pumps in tigecycline resistance
Horiyama T, Nikaido E, Yamaguchi A, Nishino K
J. Antimicrob. Chemother., 66, 105-110 (2011)
The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the
phosphorylated form of the immunomodulating agent FTY720
Hisano Y, Kobayashi N, Kawahara A, Yamaguchi A, Nishi T
J. Biol. Chem., 286, 1758-1766 (2011)
薬剤排出ポンプによる細菌多剤耐性化･病原性発現制御 (Review)
西野邦彦
化学療法の領域, 27, 1495-1503 (2011)
Small RNA による多剤耐性制御 (Review)
西野邦彦, 山﨑聖司, 西野-林美都子, 山口明人
日本化学療法学会雑誌, 59, 1-7 (2011)
生物有機化学 (Bioorganic Chemistry)
Cleavage of oligonucleotides containing a P3’→N5’ phosphoramidate linkage mediated by
single-stranded oligonucleotide templates
Ito KR, Kodama T, Makimura F, Hosoki N, Osaki T, Orita A, Imanishi T, Obika S
Molecules, 16, 10695-10708 (2011)
Design, synthesis, and properties of boat-shaped glucopyranosyl nucleic acid
Mori K, Kodama T, Obika S
Org. Lett., 13, 6050-6053 (2011)
Synthesis and properties of a bridged nucleic acid with a perhydro-1,2-oxazin-3-one ring
Shrestha AR, Hari Y, Yahara A, Osawa T, Obika S
J. Org. Chem., 76, 9891-9899 (2011)
Increased expression of periostin in vitreous and fibrovascular membranes obtained from
9
patients with proliferative diabetic retinopathy
Yoshida S, Ishikawa K, Asato R, Arima M, Sassa Y, Yoshida A, Yoshikawa H, Narukawa K, Obika S,
Ono J, Ohta S, Izuhara K, Kono T, Ishibashi T
Invest. Ophthalmol. Vis. Sci., 52, 5670-5678 (2011)
Benzylidene acetal type bridged nucleic acids: changes in properties upon cleavage of the bridge
triggered by external stimuli
Morihiro K, Kodama T, Obika S
Chem. Eur. J., 17, 7918-7926 (2011)
Bridged nucleic acid conjugates at 6’-thiol: synthesis, hybridization properties and nuclease
resistances
Mori K, Kodama T, Baba T, Obika S
Org. Biomol. Chem., 9, 5272-5279 (2011)
A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase for a CG base pair in triplex
DNA
Hari Y, Akabane M, Hatanaka Y, Nakahara M, Obika S
Chem. Commun., 47, 4424-4426 (2011)
Synthesis and triplex-forming ability of oligonucleotides bearing 1-substituted 1H-1,2,3-triazole
nucleobases
Hari Y, Nakahara M, Pang J , Akabane M, Kuboyama T, Obika S
Bioorg. Med. Chem., 19, 1162-1166 (2011)
2’-O,4’-C-Aminomethylene-bridged nucleic acid modification with enhancement of nuclease
resistance promotes pyrimidine motif triplex nucleic acid formation at physiological pH
Torigoe H, Rahman SMA, Takuma H, Sato N, Imanishi T, Obika S, Sasaki K
Chem. Eur. J., 17, 2742-2751 (2011)
Interrupted 2’-O,4’-C-aminomethylene bridged nucleic acid modification enhances pyrimidine
motif triplex-forming ability and nuclease resistance under physiological condition
Torigoe H, Rahman SMA, Takuma H, Sato N, Imanishi T, Obika S, Sasaki K
Nucleosides Nucleotides Nucleic Acids, 30, 63-81 (2011)
Stoichiometry-focused 18F-labeling of alkyne-substituted oligodeoxynucleotides using
azido([18F]fluoromethyl)benzenes by Cu-catalyzed Huisgen reaction
Kuboyama T, Nakahara M, Yoshino M, Cui Y, Sako T, Wada Y, Imanishi T, Obika S, Watanabe Y,
Suzuki M, Doi H
Bioorg. Med. Chem., 19, 249-255 (2011)
Design and facile synthesis of novel 2’,4’-bridged nucleic acid
10
Shrestha AR, Hari Y, Yahara A, Osawa T, Obika S
Collection Symp. Ser., 12, 144-147 (2011)
Antisense drug discovery and development (Review)
Yamamoto T, Nakatani M, Narukawa K, Obika S
Future Med. Chem., 3, 339-365 (2011)
2’-O,4’-C-Methyleneoxymethylene bridged nucleic acids (2’,4’-BNACOC) (Review)
Hari Y, Kodama T, Imanishi T, Obika S
Therapeutic Oligonucleotides: Methods and Protocols (Methods in Mol. Biol. 764) (Humana Press),
31-57 (2011)
BNA (LNA) の開発とその応用 (Review)
小比賀聡, 今西武
核酸化学のニュートレンド(化学同人), 181-187 (2011)
細胞生理学 (Molecular and Cellular Physiology)
Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to
maintain satellite cell number
Fukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev M, Motohashi N, Ito T,
Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H
Development, 138, 4609-4619 (2011)
Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle
Uezumi A, Ito T, Morikawa D, Shimizu N, Yoneda T, Segawa M, Yamaguchi M, Ogawa R, Matev
MM, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Tsuchida K, Yamamoto H, Fukada S
J. Cell Sci., 124, 3654-3664 (2011)
Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding
site
Okada Y, Nobori H, Shimizu M, Watanabe M, Yonekura M, Nakai T, Kamikawa Y, Wakimura A,
Funahashi N, Naruse H, Watanabe A, Yamasaki D, Fukada S, Yasui K, Matsumoto K, Sato T,
Kitajima K, Nakano T, Aird WC, Doi T
PLoS One, 6, e24837 (2011)
Generation of induced pluripotent stem (iPS) cells derived from a murine model of Pompe
disease and differentiation of Pompe-iPS cells into skeletal muscle cells
Kawagoe S, Higuchi T, Meng XL, Shimada Y, Shimizu H, Hirayama R, Fukuda T, Chang H, Nakahata
T, Fukada S, Ida H, Kobayashi H, Ohashi T, Eto Y
Molecular Genetics Metabolism, 104, 123-128 (2011)
11
Suppression of ovalbumin-induced allergic diarrhea by diminished intestinal peristalsis in
RAMP1-deficient mice
Yoshikawa R, Mikami N, Otani I, Kishimoto T, Nishioka S, Hashimoto N, Miyagi Y, Takuma Y, Sueda
K, Fukada S, Yamamoto H, Tsujikawa K
Biochem. Biophys. Res. Commun., 410, 389-393 (2011)
Calcitonin gene-related peptide is an important regulator of cutaneous immunity: Effect on
dendritic cell and T cell functions
Mikami N, Matsushita H, Kato T, Kawasaki R, Sawazaki T, Kishimoto T, Ogitani Y, Watanabe K,
Miyagi Y, Sueda K, Fukada S, Yamamoto H, and Tsujikawa K
J. Immunol., 186, 6886-6893 (2011)
Muscle injury-induced thymosin β4 acts as a chemoattractant for myoblasts
Tokura Y, Nakayama Y, Fukada S, Nara N, Yamamoto H, Matsuda R, Hara T
J. Biochem., 149, 43-48 (2011)
ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung
cancer
Tasaki M, Shimada K, Kimura H, Tsujikawa K, Konishi N
Br. J. Cancer, 104, 700-706 (2011)
神経ペプチド CGRP による皮膚過敏症の増強 (Review)
三上統久，辻川和丈
臨床免疫・アレルギー科, 56, 736-741 (2011)
骨格筋幹細胞の機能維持に係わる遺伝子の同定 (Review)
深田宗一朗
YAKUGAKU ZASSHI, 131, 1329-1332 (2011)
骨格筋内在性の間葉系前駆細胞 (Review)
上住聡芳, 深田宗一朗, 土田邦博
生体の科学, 62, 157-160 (2011)
骨格筋内脂肪形成のメカニズム (Review)
上住聡芳, 深田宗一朗, 土田邦博
Modern Physician, 31, 1313-1315 (2011)
毒性学 (Toxicology and Safety Science)
Acute phase proteins as biomarkers for predicting the exposure and toxicity of nanomaterials
12
Higashisaka K, Yoshioka Y, Yamashita K, Morishita Y, Fujimura M, Nabeshi H, Nagano K, Abe Y,
Kamada H, Tsunoda S, Yoshikawa T, Itoh N, Tsutsumi Y
Biomaterials, 32, 3-9 (2011)
Development of an antibody proteomics system using a phage antibody library for efficient
screening of biomarker proteins
Imai S, Nagano K, Yoshida Y, Okamura T, Yamashita T, Abe Y, Yoshikawa T, Yoshioka Y, Kamada H,
Mukai Y, Nakagawa S, Tsutsumi Y, Tsunoda S
Biomaterials, 32, 162-169 (2011)
Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental
autoimmune encephalomyelitis mice
Nomura T, Abe Y, Kamada H, Shibata H, Kayamuro H, Inoue M, Kawara T, Arita S, Furuya T,
Yamashita T, Nagano K, Yoshikawa T, Yoshioka Y, Mukai Y, Nakagawa S, Taniai M, Ohta T, Serada S,
Naka T, Tsunoda S, Tsutsumi Y
J. Control. Release, 149, 8-14 (2011)
Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical
application
Nabeshi H, Yoshikawa T, Matsuyama K, Nakazato Y, Matsuo K, Arimori A, Isobe M, Tochigi S,
Kondoh S, Hirai T, Akase T, Yamashita T, Yamashita K, Yoshida T, Nagano K, Abe Y, Yoshioka Y,
Kamada H, Imazawa T, Itoh N, Nakagawa S, Mayumi T, Tsunoda S, Tsutsumi Y
Biomaterials, 32, 2713-2724 (2011)
Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in
normal lung
Yoshida Y, Yamashita T, Nagano K, Imai S, Nabeshi H, Yoshikawa T, Yoshioka Y, Abe Y, Kamada H,
Tsutsumi Y, Tsunoda S
Biochem. Biophys. Res. Commun., 405, 610-614 (2011)
Silica and titanium dioxide nanoparticles cause pregnancy complications in mice
Yamashita K, Yoshioka Y, Higashisaka K, Mimura K, Morishita Y, Nozaki M, Yoshida T, Ogura T,
Nabeshi H, Nagano K, Abe Y, Kamada H, Monobe Y, Imazawa T, Aoshima H, Shishido K, Kawai Y,
Mayumi T, Tsunoda S, Itoh N, Yoshikawa T, Yanagihara I, Saito S, Tsutsumi Y
Nat. Nanotechnol., 6, 321-328 (2011)
Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution
in murine macrophages
Nabeshi H, Yoshikawa T, Arimori A, Yoshida T, Tochigi S, Hirai T, Akase T, Nagano K, Abe Y,
Kamada H, Tsunoda S, Itoh N, Yoshioka Y, Tsutsumi Y
Nanoscale Res. Lett., 6, 93 (2011)
13
Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in
human keratinocytes
Nabeshi H, Yoshikawa T, Matsuyama K, Nakazato Y, Tochigi S, Kondoh S, Hirai T, Akase T, Nagano
K, Abe Y, Yoshioka Y, Kamada H, Itoh N, Tsunoda S, Tsutsumi Y
Part. Fibre Toxicol., 8, 1 (2011)
Promotion of allergic immune responses by intranasally-administrated nanosilica particles in
mice
Yoshida T, Yoshioka Y, Fujimura M, Yamashita K, Higashisaka K, Morishita Y, Kayamuro H, Nabeshi
H, Nagano K, Abe Y, Kamada H, Tsunoda S, Itoh N, Yoshikawa T, Tsutsumi Y
Nanoscale Res. Lett., 6, 195 (2011)
Fine tuning of receptor-selectivity for tumor necrosis factor-α using a phage display system with
one-step competitive panning
Abe Y, Yoshikawa T, Inoue M, Nomura T, Furuya T, Yamashita T, Nagano K, Nabeshi H, Yoshioka Y,
Mukai Y, Nakagawa S, Kamada H, Tsutsumi Y, Tsunoda S
Biomaterials, 32, 5498-5504 (2011)
Doxorubicin-loaded PEG-PCL copolymer micelles enhance cytotoxicity and intracellular
accumulation of doxorubicin in adriamycin-resistant tumor cells
Diao YY, Li HY, Fu YH, Han M, Hu YL, Jiang HL, Tsutsumi Y, Wei QC, Chen DW, Gao JQ
Int. J. Nanomedicine, 6, 1955-1962 (2011)
Size-dependent immune-modulating effect of amorphous nanosilica particles
Hirai T, Yoshikawa T, Nabeshi H, Yoshida T, Tochigi S, Uji M, Ichihashi K, Akase T, Yamashita T,
Yamashita K, Nagano K, Abe Y, Kamada H, Tsunoda S, Yoshioka Y, Itoh N, Tsutsumi Y
Pharmazie, 66, 727–728 (2011)
Effect of amorphous silica nanoparticles on in vitro RANKL-induced osteoclast differentiation in
murine macrophages
Nabeshi H, Yoshikawa T, Akase T, Yoshida T, Tochigi S, Hirai T, Uji M, Ichihashi K, Yamashita T,
Higashisaka K, Morishita Y, Nagano K, Abe Y, Kamada H, Tsunoda S, Itoh N, Yoshioka Y, Tsutsumi
Y
Nanoscale Res. Lett., 6, 464 (2011)
Detection of titanium dioxide particles on frozen tissue sections using synchrotron radiation
X-ray fluorescence analysis
Morishita Y, Yamashita K, Yoshikawa T, Terada Y, Nabeshi H, Yoshioka Y, Itoh N, Tsutsumi Y
Pharmazie, 66, 808–809 (2011)
Development of a novel DDS for site-specific PEGylated proteins (Review)
Yoshioka Y, Tsunoda S, Tsutsumi Y
14
Chem. Cent. J., 5, 25 (2011)
Safety evaluation study of nanomaterials aimed at promoting their acceptance by society
(Review)
Nabeshi H, Yoshikawa T, Yoshioka Y, Tsutsumi Y
Gene. Environ., 33, 21-26 (2011)
Recent topics of NanoTox studies for their safety (Review)
Tsutsumi Y , Yoshioka Y
Yakugaku Zasshi, 131, 193-194 (2011)
Development of NanoSafety forecasting system from the viewpoint of nanomaterial-protein
interaction (Review)
Yoshikawa T
Yakugaku Zasshi, 131, 209-213 (2011)
インフラマソームの活性とシリカ粒子の性状 (Review)
吉岡靖雄, 中川晋作, 堤康央
生体の科学, 62, 228-232 (2011)
食品分野におけるナノテクノロジーの安全性 (Review)
鍋師裕美，吉岡靖雄，吉川友章，堤康央
食品衛生研究, 61, 27-34 (2011)
ナノ安全科学研究の最前線 (Review)
東阪和馬, 堤康央
化学, 66(8), 72-73 (2011)
香粧品分野におけるナノマテリアルの安全性に関する国内外の報告 (Review)
森下裕貴, 吉岡靖雄, 鍋師裕美, 吉川友章, 堤康央
コスメティックステージ, 5(8), 45-49 (2011)
分子進化技術によるサイトカイン機能改変体の創製と DDS (Review)
角田慎一, 堤康央
Drug Delivery System, 26, 604-610 (2011)
不育症 over view (Review)
齋藤滋，杉浦真弓，丸山哲夫，田中忠夫，竹下俊行，山田秀人，小澤伸晃，中塚幹也，木村
正，藤井知行，下屋浩一郎，山本樹生，佐田文宏，康東天，早川智，一瀬白帝，柳原格，秦
健一郎，勝山博信，堤康央，中野有美，福井淳史，杉俊隆
産婦人科の実際, 60, 1401-1408 (2011)
15
PEG 化による腫瘍壊死因子 TNF-αの体内動態の制御と抗腫瘍効果増強 (Review)
吉岡靖雄, 吉川友章, 堤康央
遺伝子医学 MOOK (別冊), 258-263 (2011)
アジュバントとしてのサイトカインおよびその機能性変異体 (Review)
角田慎一, 堤康央
アジュバント開発研究の新展開 (シーエムシー出版), 158-163 (2011)
自己免疫疾患に対するタンパク医薬と DDS (Review)
鎌田春彦, 堤康央, 角田慎一
次世代バイオ医薬品の製剤設計と開発戦略 (シーエムシー出版), 163-169 (2011)
PEG 化 TNFα (Review)
吉岡靖雄, 角田慎一, 堤康央
次世代バイオ医薬品の製剤設計と開発戦略 (シーエムシー出版), 170-176 (2011)
神経薬理学 (Molecular Neuropharmacology)
Cerulein-induced acute pancreatitis in PACAP knockout mice
Sakurai Y, Shintani N, Arimori A, Hamagami K, Higuchi N, Inoue H, Ikeda K, Hayata A, Hashimoto
H, Baba A
J. Mol. Neurosci., 43, 8-15 (2011)
Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse
Endo K, Nakamachi T, Seki T, Kagami N, Wada Y, Nakamura K, Kishimoto K, Hori M, Tsuchikawa D,
Shinntani N, Hashimoto H, Baba A, Koide R, Shioda S
J. Mol. Neurosci., 43, 22-29 (2011)
Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in
isolation-reared mice
Kawasaki T, Ago Y, Yano K, Araki R, Washida Y, Onoe H, Chaki S, Nakazato A, Hashimoto H, Baba
A, Takuma K, Matsuda T
Neuropharmacology, 60, 397-404 (2011)
Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal
neurogenesis
Ago Y, Yoneyama M, Ishihama T, Kataoka S, Kawada K, Tanaka T, Ogita K, Shintani N, Hashimoto
H, Baba A, Takuma K, Matsuda T
Neuroscience, 172, 554-561 (2011)
Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) show increased
16
susceptibility to in vivo renal ischemia/reperfusion injury
Szakaly P, Laszlo E, Kovacs K, Racz B, Horvath G, Ferencz A, Lubics A, Kiss P, Tamas A, Brubel R,
Opper B, Baba A, Hashimoto H, Farkas J, Matkovits A, Magyarlaki T, Helyes Z, Reglodi D
Neuropeptides, 45, 113-121 (2011)
The melanocortin system is involved in regulating autonomic nerve activity through central
pituitary adenylate cyclase-activating polypeptide
Tanida M, Shintani N, Hashimoto H
Neurosci. Res., 70, 55-61 (2011)
PACAP centrally mediates emotional stress-induced corticosterone responses in mice
Tsukiyama N, Saida Y, Kakuda M, Shintani N, Hayata A, Morita Y, Tanida M, Tajiri M, Hazama K,
Ogata K, Hashimoto H, Baba A
Stress, 14, 368-375 (2011)
Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced
hyperlocomotion and increase in prefrontal serotonergic neurotransmission
Ago Y, Araki R, Yano K, Hiramatsu N, Kawasaki T, Chaki S, Nakazato A, Onoe H, Hashimoto H,
Baba A, Takuma K, Matsuda T
Psychopharmacology, 217, 443-452 (2011)
Pituitary adenylate cyclase-activating polypeptide plays an anti-inflammatory role in
endotoxin-induced airway inflammation: In vivo study with gene-deleted mice
Elekes K, Sandor K, Moricz A, Kereskai L, Kemeny A, Szoke E, Perkecz A, Reglodi D, Hashimoto H,
Pinter E, Szolcsanyi J, Helyes Z
Peptides, 32, 1439-1446 (2011)
Role of endogenous pituitary adenylate cyclase activating polypeptide (PACAP) in myelination
of the rodent brain: Lessons from PACAP-deficient mice
Vincze A, Reglodi D, Helyes Z, Hashimoto H, Shintani N, Ábrahám H
Int. J. Dev. Neurosci., 29, 923-935 (2011)
Trophic effects of PACAP on pancreatic islets: A mini-review (Review)
Sakurai Y, Shintani N, Hayata A, Hashimoto H, Baba A
J. Mol. Neurosci., 43, 3-7 (2011)
PACAP is implicated in the stress axes (Review)
Hashimoto H, Shintani N, Tanida M, Hayata A, Hashimoto R, Baba A
Curr. Pharm. Des., 17, 985-989 (2011)
精神疾患のトランスレーショナルリサーチ－統合失調症－ (Review)
橋本亮太, 安田由華, 大井一高, 福本素由己, 山森英長, 新谷紀人, 橋本均, 馬場明道, 武田
17
雅俊
日薬理誌, 137, 79-82 (2011)
薬剤学 (Biotechnology and Therapeutics)
Structure-activity relationship of T-cell receptors based on alanine scanning
Narimatsu S, Yoshioka Y, Morishige T, Yao X, Tsunoda S, Tsutsumi Y, Nishimura MI, Mukai Y, Okada
N, Nakagawa S
Biochem. Biophys. Res. Commun., 415, 558-562 (2011)
Induction of endoplasmic reticulum-endosome fusion for antigen cross-presentation induced by
poly (γ-glutamic acid) nanoparticles
Mukai Y, Yoshinaga T, Yoshikawa M, Matsuo K, Yoshikawa T, Matsuo K, Niki K, Yoshioka Y, Okada
N, Nakagawa S
J. Immunol., 187, 6249-6255 (2011)
Compositional optimization and safety assessment of a hydrogel patch as a transcutaneous
immunization device
Matsuo K, Ishii Y, Quan YS, Kamiyama F, Asada H, Mukai Y, Okada N, Nakagawa S
Biol. Pharm. Bull., 34, 1835-1840 (2011)
Lysine-deficient lymphotoxin-α mutant for site-specific PEGylation
Narimatsu S, Yoshioka Y, Watanabe H, Masano T, Morishige T, Yao X, Tanabe A, Tsunoda S, Tsutsumi
Y, Mukai Y, Okada N, Nakagawa S
Cytokine, 56, 489-493 (2011)
Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene
therapy
Yao X, Yoshioka Y, Morishige T, Eto Y, Narimatsu S, Kawai Y, Mizuguchi H, Gao JQ, Mukai Y,
Okada N, Nakagawa S
Mol. Ther., 19, 1619-1625 (2011)
Intranasal immunization with poly(γ-glutamic acid) nanoparticles entrapping antigenic proteins
can induce potent tumor immunity
Matsuo K, Koizumi H, Akashi M, Nakagawa S, Fujita T, Yamamoto A, Okada N
J. Control. Release, 152, 310-316 (2011)
Modifying the antigen-immunization schedule improves the variety of monoclonal antibodies
obtained from immune-phage antibody libraries against HIV-1 Nef and Vif
Yoshikawa M, Mukai Y, Tsunoda S, Tsutsumi Y, Yoshioka Y, Okada N, Nakagawa S
J. Biosci. Bioeng., 111, 597-599 (2011)
18
Characterization of transcutaneous protein delivery by a hydrogel patch in animal, human, and
tissue-engineered skin models
Matsuo K, Ishii Y, Quan YS, Kamiyama F, Mukai Y, Okada N, Nakagawa S
Biol. Pharm. Bull., 34, 586-589 (2011)
Transcutaneous vaccination using a hydrogel patch induces effective immune responses to
tetanus and diphtheria toxoid in hairless rat
Matsuo K, Ishii Y, Quan YS, Kamiyama F, Mukai Y, Yoshioka Y, Okada N, Nakagawa S
J. Control. Release, 149, 15-20 (2011)
Effective transcutaneous immunization by antigen-loaded flexible liposome in vivo
Li N, Peng LH, Chen X, Nakagawa S, Gao JQ
Int. J. Nanomedicine, 6, 3241-3250 (2011)
Current targeting strategies for adenovirus vectors in cancer gene therapy
Yao XL, Nakagawa S, Gao JQ
Current Cancer Drug Targets, 11, 810-825 (2011)
Transcutaneous vaccines: novel advances in technology and delivery for overcoming the barriers
(Review)
Li N, Peng LH, Chen X, Nakagawa S, Gao JQ
Vaccine, 29, 6179-6190 (2011)
マイクロニードル型経皮ワクチン製剤 (貼るワクチン) の開発 (Review)
松尾一彦, 岡田直貴, 中川晋作
綜合臨牀, 60, 2211-2214 (2011)
感染症予防対策に資する経皮免疫製剤 (貼るワクチン) の開発 (Review)
松尾一彦, 岡田直貴, 中川晋作
日本臨牀, 69, 1561-1566 (2011)
経皮ワクチン製剤の実用化に向けた取り組み (Review)
廣部祥子, 岡田直貴, 中川晋作
バイオ・ゲノム関連医薬品開発におけるニーズ・技術動向・開発ノウハウ (技術情報協会),
189-196 (2011)
感染症予防対策に資する画期的経皮免疫製剤 (貼るワクチン) の開発 (Review)
松尾一彦, 岡田直貴, 中川晋作
次世代バイオ医薬品の製剤設計と開発戦略 (シーエムシー出版), 231-237 (2011)
新規経皮ワクチンデバイスを応用した経皮ワクチン製剤 (貼るワクチン) の開発 (Review)
19
松尾一彦, 岡田直貴, 中川晋作
次世代経皮吸収型製剤の開発と応用 (シーエムシー出版), 177-184 (2011)
微粒子キャリアを用いた腫瘍関連抗原タンパク質デリバリーとその癌ワクチン療法への応用
(Review)
岡田直貴
ペプチド・タンパク性医薬品の新規 DDS 製剤の開発と応用 (遺伝子医学 MOOK 別冊)(メディカ
ルドゥ), 234-242 (2011)
親水性ゲルパッチを用いたワクチン抗原タンパク質のデリバリーと経皮吸収型ワクチン製剤
の開発 (Review)
岡田直貴
ペプチド・タンパク性医薬品の新規 DDS 製剤の開発と応用 (遺伝子医学 MOOK 別冊)(メディカ
ルドゥ), 220-226 (2011)
天然物化学 (Natural Products Chemistry)
Anti-angiogenic effect of triterpenoidal saponins from Polygala senega
Arai M, Hayashi A, Sobou M, Ishida S, Kawachi T, Kotoku N, Kobayashi M
J. Nat. Med., 65, 149-156 (2011)
Antiproliferative and antiangiogenic activities of smenospongine, a marine sponge sesquiterpene
aminoquinone
Kong D, Yamori T, Kobayashi M, Duan H
Marine Drugs, 9, 154-161 (2011)
Stereoselective synthesis of core structure of cortistatin A
Kotoku N, Sumii Y, Kobayashi M
Org. Lett., 13, 3514-3517 (2011)
DedA protein relates to action-mechanism of halicyclamine A, a marine spongean macrocyclic
alkaloid, as an anti-dormant mycobacterial substance
Arai M, Liu L, Fujimoto T, Setiawan A, Kobayashi M
Marine Drugs, 9, 984-993 (2011)
Synthetic study of carbocyclic core of cortistatin A, an anti-angiogenic steroidal alkaloid from
marine sponge
Kotoku N, Sumii Y, Hayashi T, Kobayashi M
Heterocycles, 83, 1535-1552 (2011)
Concise synthesis and structure-activity relationship of furospinosulin-1, a hypoxia-selective
20
growth inhibitor from marine sponge
Kotoku N, Fujioka S, Nakata C, Yamada M, Sumii Y, Kawachi T, Arai M, Kobayashi M
Tetrahedron, 67, 6673-6678 (2011)
Action-mechanism of trichoderin A, an anti-dormant mycobacterial aminolipopeptide from
marine sponge-derived Trichoderma sp.
Pruksakorn P, Arai M, Liu L, Moodley P, Jacobs WR Jr, Kobayashi M
Biol. Pharm. Bull., 34, 1287-1290 (2011)
Inhibitory effect of cyclic trihydroxamate siderophore, desferrioxamine E, on the biofilm
formation of Mycobacterium species
Ishida S, Arai M, Niikawa H, Kobayashi M
Biol. Pharm. Bull., 34, 917-920 (2011)
Antiproliferative effect of aaptamine on human chronic myeloid leukemia K562 cells
Jin M, Zhao W, Zhang Y, Kobayashi M, Duan H, Kong D
Int. J. Mol. Sci., 12, 7352-7359 (2011)
薬物治療学 (Medicinal Pharmacology)
Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal
neurogenesis
Ago Y, Yoneyama M, Ishihama T, Kataoka S, Kawada K, Tanaka T, Ogita K, Shintani N, Hashimoto
H, Baba A, Takuma K, Matsuda T
Neuroscience, 172, 554-561 (2011)
Involvement of decreased muscarinic receptor function in prepulse inhibition deficits in mice
reared in social isolation
Koda K, Ago Y, Yano K, Nishimura M, Kobayashi H, Fukada A, Takuma K, Matsuda T
Br. J. Pharmacol., 162, 763-772 (2011)
Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in
isolation-reared mice
Kawasaki T, Ago Y, Yano K, Araki R, Washida Y, Onoe H, Chaki S, Nakazato A, Hashimoto H, Baba
A, Takuma K, Matsuda T
Neuropharmacology, 60, 397-404 (2011)
Fluvoxamine
enhances
prefrontal
dopaminergic
neurotransmission
in
adrenalectomized/castrated mice via both 5-HT reuptake inhibition and σ 1 receptor activation
Ago Y, Yano K, Hiramatsu N, Takuma K, Matsuda T
Psychopharmacology, 217, 377-386 (2011)
21
Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced
hyperlocomotion and increase in prefrontal serotonergic neurotransmission
Ago Y, Araki R, Yano K, Hiramatsu N, Kawasaki T, Chaki S, Nakazato A, Onoe H, Hashimoto H,
Baba A, Takuma K, Matsuda T
Psychopharmacology, 217, 443-452 (2011)
Pharmacological aspects of the acetylcholinesterase inhibitor galantamine
Ago Y, Koda K, Takuma K, Matsuda T
J. Pharmacol. Sci., 116, 6-17 (2011)
The specific Na+/Ca2+ exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in
SH-SY5Y cells
Nashida T, Takuma K, Fukuda S, Kawasaki T, Takahashi T, Baba A, Ago Y, Matsuda T
Neurochem. Int., 59, 51-58 (2011)
Donepezil, but not galantamine, blocks muscarinic receptor-mediated in vitro and in vivo
responses
Ago Y, Koda K, Ota Y, Kita Y, Fukada A, Takuma K, Matsuda T
Synapse, 65, 1373-1377 (2011)
Preventive effects of an enriched environment on rodent psychiatric disorder models
Takuma K, Ago Y, Matsuda T
J. Pharmacol. Sci., 117, 71-76 (2011)
SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an
MPTP mouse model of Parkinson's disease
Ago Y, Kawasaki T, Nashida T, Ota Y, Cong Y, Kitamoto M, Takahashi T, Takuma K, Matsuda T
Neuropharmacology, 61, 1441-1451 (2011)
Nicotine ameliorates impairment of working memory in methamphetamine-treated rats
Mizoguchi H, Ibi D, Takase F, Nagai T, Kamei H, Toth E, Sato J, Takuma K, Yamada K
Behav. Brain Res., 220, 159-163 (2011)
Matrix
metalloproteinase-9
contributes
to
kindled
seizure
development
in
pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus
Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S,
Takuma K, Sawada M, Sato J, Yamada K
J. Neurosci., 31, 12963-12971 (2011)
Ca2+ influx through reverse mode Na+/Ca2+ exchange is critical for vascular endothelial growth
factor-mediated extracellular signal-regulated kinase (ERK) 1/2 activation and angiogenic
22
functions of human endothelial cells
Andrikopoulos P, Baba A, Matsuda T, Djamgoz MBA, Yaqoob MM, Eccles SA
J. Biol. Chem., 286, 37919-37931 (2011)
The Na+/Ca2+-exchanger: An essential component in the mechanism governing cardiac
steroid-induced slow Ca2+ oscillations
Feldmann T, Shahar M, Baba A, Matsuda T, Lichtstein D, Rosen H
Cell Calcium, 50, 424-432 (2011)
臨床薬効解析学 (Clinical Pharmacology and Pharmacogenomics)
Cigarette smoke extract induces CYP2B6 through constitutive androstane receptor in
hepatocytes
Washio I, Maeda M, Sugiura C, Shiga R, Yoshida M, Nonen S, Fujio Y, Azuma J
Drug Metab. Dispos., 39, 1-3 (2011)
Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via
HGF/c-met signaling
Shioyama W, Nakaoka Y, Higuchi K, Minami T, Taniyama Y, Nishida K, Kidoya H, Sonobe T,
Naito H, Arita Y, Hashimoto T, Kuroda T, Fujio Y, Shirai M, Takakura N, Morishita R,
Yamauchi-Takihara K, Kodama T, Hirano T, Mochizuki N, Komuro I
Circ. Res., 108, 664-675 (2011)
Safe and successful treatment with erlotinib after gefitinib-induced hepatotoxicity: difference in
metabolism as a possible mechanism
Kijima T, Shimizu T, Nonen S, Furukawa M, Otani Y, Minami T, Takahashi R, Hirata H, Nagatomo I,
TakedaY, Kida H, Goya S, Fujio Y, Azuma J, Tachibana I, Kawase I
J. Clin. Oncol., 29, e588-590 (2011)
Association between osteopontin promoter variants and diastolic dysfunction in hypertensive
heart in the Japanese population
Nakayama H, Nagai H, Matsumoto K, Oguro R, Sugimoto K, Kamide K, Ohishi M, Katsuya T,
Okamoto H, Maeda M, Komamura K, Azuma J, Rakugi H, Fujio Y
Hypertension Res., 34, 1141-1146 (2011)
STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac
resident Sca-1 + cells both in vitro and in vivo
Iwakura T, Mohri T, Hamatani T, Obana M, Yamashita T, Maeda M, Katakami N, Kaneto H, Oka T,
Komuro I, Azuma J, Nakayama H, Fujio Y
J. Mol. Cell. Cardiol., 51, 207-214 (2011)
23
IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental
autoimmune myocarditis
Yamashita T, Iwakura T, Matsui K, Kawaguchi H, Obana M, Hayama A, Maeda M, Izumi Y, Komuro
I, Ohsugi Y, Fujimoto M, Naka T, Kishimoto T, Nakayama H, Fujio Y
Cardiovas. Res., 91, 640-648 (2011)
Calpain protects the heart from hemodynamic stress
Taneike M, Mizote I, Morita T, Watanabe T, Hikoso S, Yamaguchi O, Takeda T, Oka T, Tamai T,
Oyabu J, Murakawa T, Nakayama H, Nishida K, Takeda J, Mochizuki N, Komuro I, Otsu K
J. Biol. Chem., 286, 32170-32177 (2011)
Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy
Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K,
Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR
J. Mol. Cell. Cardiol., 50, 460-470 (2011)
ニコチン依存の遺伝子解析
前田真貴子, 藤尾慈, 東純一
日本臨床 69, 1887-1890 (2011)
Glycoprotein 130 cytokine signal as a therapeutic target against cardiovascular diseases (Review)
Fujio Y, Maeda M, Mohri T, Obana M, Iwakura T, Hayama A, Yamashita T, Nakayama H, Azuma J
J. Pharmacol. Sci., 117, 213-222 (2011)
禁煙治療薬の個別化適正投与法確立に向けたゲノム薬理学的研究 (Review)
前田真貴子, 藤尾慈, 東純一
臨床薬理の進歩, 32, 127-135 (2011)
インターロイキン 6
藤尾慈, 中山博之
血管生物医学事典 (朝倉書店), 242-243 (2011)
インターフェロン調節因子
中山博之, 藤尾慈
血管生物医学事典 (朝倉書店), 394-396 (2011)
分子生理病態学 (Molecular Pathophysiology)
Impairment of ubiquitin-proteasome system by E334K cMyBPC modifies channel proteins,
leading to electrophysiological dysfunction
Bahrudin U, Morikawa K, Takeuchi A, Kurata Y, Miake J, Mizuta E, Adachi K, Higaki K, Yamamoto
24
Y, Shirayoshi Y, Yoshida A, Kato M, Yamamoto K, Nanba E, Morisaki H, Morisaki T, Matsuoka S,
Ninomiya H, Hisatome I
J. Mol. Biol., 413, 857-878 (2011)
Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox
Nishizuka T, Fujita Y, Sato Y, Nakano A, Kakino A, Ohshima S, Kanda T, Yoshimoto R, Sawamura T
Proc. Jpn. Acad. Ser. B, 87, 104-113 (2011)
Associations of atherosclerotic risk factors with oxidized low-density lipoprotein evaluated by
LOX-1 ligand activity in healthy men
Uchida K, Suehiro A, Nakanishi M, Sawamura T, Wakabayashi I
Clin. Chim. Acta, 412, 1643-1647 (2011)
LOX-1 deletion improves neutrophil responses, enhances bacterial clearance, and reduces lung
injury in a murine polymicrobial sepsis model
Wu Z, Sawamura T, Kurdowska AK , Ji HL, Idell S, Fu J
Infect. Immun., 79, 2865-2870 (2011)
An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) utilization of anti-LOX-1 single-chain antibody fused to apoB fragment
Iwamoto S, Fujita Y, Kakino A, Yanagida K, Matsuda H, Yoshimoto R, Sawamura T
J. Atheroscler. Thromb., 18, 818-828 (2011)
The discovery of LOX-1, its ligands and clinical significance
Yoshimoto R, Fujita Y, Kakino A, Iwamoto S, Takaya T, Sawamura T
Cardiovasc. Drugs Ther., 25, 379-391 (2011)
LOX-1: a new target for therapy for cardiovascular diseases
Mehta JL, Khaidakov M, Hermonat PL, Mitra S, Wang X, Novelli G, Sawamura T
Cardiovasc. Drugs Ther., 25, 495-500 (2011)
Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation
Fujita Y, Yamaguchi S, Kakino A, Iwamoto S, Yoshimoto R, Sawamura T
Clin. Chem., 57, 1398-1405 (2011)
アデニンヌクレオチド代謝と心血管疾患
森崎隆幸, 程継東, 森崎裕子
循環器病研究の進歩, 32, 54-64 (2011)
動脈硬化予防薬としての LOX-1 ブロッカーの探索
髙谷智英, 岩元真, 垣野明美, 藤田佳子, 中野厚史, 沢村達也
循環器病研究の進歩, 32, 65-72 (2011)
25
冠動脈疾患の遺伝子解析の現状と展望
森崎隆幸
日本臨牀, 69(増刊 7), 246-250 (2011)
遺伝子機能解析学 (Experimental Genome Research)
Primary screening of single nucleotide polymorphisms in human Calreticulin 3 (CALR3)
Irie S, Nakamura J, Miyagawa Y, Tsujimura A, Okuda H, Yamamoto K, Fukuhara S, Yoshioka I,
Kiuchi H, Matsuoka Y, Takao T, Nonomura N, Ikawa M, Tokuhiro K, Okabe M, Shibata T, Fujimoto
K, Wada M, Tanaka H
The Open Andrology Journal, 3, 30-35 (2011)
Acrosome-reacted mouse spermatozoa recovered from the perivitelline space can fertilize other
eggs
Inoue N, Satouh Y, Ikawa M, Okabe M, Yanagimachi R
Proc. Natl. Acad. Sci. USA, 108, 20008-20011 (2011)
Formation of a thymus from rat ES cells in xenogeneic nude mouse↔rat ES chimeras
Isotani A, Hatayama H, Kaseda K, Ikawa M, Okabe M
Genes Cells, 16, 397-405 (2011)
Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity,
fatty liver, and type 2 diabetes
Mitsutake S, Zama K, Yokota H, Yoshida T, Tanaka M, Mitsui M, Ikawa M, Okabe M, Tanaka Y,
Yamashita T, Takemoto H, Okazaki T, Watanabe K, Igarashi Y
J. Biol. Chem., 286, 28544-28555 (2011)
Mice lacking Ran binding protein 1 are viable and show male infertility
Nagai M, Moriyama T, Mehmood R, Tokuhiro K, Ikawa M, Okabe M, Tanaka H, Yoneda Y
FEBS Lett., 585, 791-796 (2011)
Targeted disruption of one of the importin α family members leads to female functional
incompetence in delivery
Moriyama T, Nagai M, Oka M, Ikawa M, Okabe M, Yoneda Y
FEBS J., 278, 1561-1572 (2011)
Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in
sphingomyelin synthase 1-null mice
Yano M, Watanabe K, Yamamoto T, Ikeda K, Senokuchi T, Lu M, Kadomatsu T, Tsukano H, Ikawa
M, Okabe M, Yamaoka S, Okazaki T, Umehara H, Gotoh T, Song WJ, Node K, Taguchi R, Yamagata
26
K, Oike Y
J. Biol. Chem., 286, 3992-4002 (2011)
Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse
model
Kumasawa K, Ikawa M, Kidoya H, Hasuwa H, Saito-Fujita T, Morioka Y, Takakura N, Kimura T,
Okabe M
Proc. Natl. Acad. Sci. USA, 108, 1451-1455 (2011)
Calsperin is a testis-specific chaperone required for sperm fertility
Ikawa M, Tokuhiro K, Yamaguchi R, Benham AM, Tamura T, Wada I, Satouh Y, Inoue N, Okabe M
J. Biol. Chem., 286, 5639-5646 (2011)
Mechanisms of fertilization—A view from the study of gene-manipulated mice (Review)
Muro Y, Okabe M
J. Androl., 32, 218-225 (2011)
The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion (Review)
Inoue N, Ikawa M, Okabe M
Asian J. Androl., 13, 81-87 (2011)
医薬基盤科学 (Biomedical Innovation)
Efficient generation of hepatoblasts from human ES cells and iPS cells by transient
overexpression of homeobox gene HEX
Inamura M, Kawabata K, Takayama K, Tashiro K, Sakurai F, Katayama K, Toyoda M, Akutsu H,
Miyagawa Y, Okita H, Kiyokawa N, Umezawa A, Hayakawa T, Furue MK, Mizuguchi H
Mol. Ther., 19, 400-407 (2011)
Efficient and directive generation of two distinct endoderm lineages from human ESCs and
iPSCs by differentiation stage-specific SOX17 transduction
Takayama K, Inamura M, Kawabata K, Tashiro K, Katayama K, Sakurai F, Hayakawa T, Furue MK,
Mizuguchi H
PLoS One, 6, e21780 (2011)
Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by
incorporation of normal cell-specific microRNA-targeted sequences
Sugio K, Sakurai F, Katayama K, Tashiro K, Matsui H, Kawabata K, Kawase A, Iwaki M, Hayakawa T,
Fujiwara T, Mizuguchi H
Clin. Cancer Res., 17, 2807-2818 (2011)
27
Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction
Suzuki-Kouyama E, Katayama K, Sakurai F, Yamaguchi T, Kurachi S, Kawabata K, Nakagawa S,
Mizuguchi H
Biomaterials, 32, 1724-1730 (2011)
Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of
RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob
Matsui H, Sakurai F, Katayama K, Kurachi S, Tashiro K, Sugio K, Kawabata K, Mizuguchi H
Virus Res., 155, 48-54 (2011)
Development of a recombinant adenovirus vector production system free of
replication-competent adenovirus by utilizing a packaging size limit of the viral genome
Suzuki T, Sasaki T, Yano K, Sakurai F, Kawabata K, Kondoh M, Hayakawa T, Yagi K, Mizuguchi H
Virus Res., 158, 154-160 (2011)
An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors
Motegi Y, Katayama K, Sakurai F, Kato T, Yamaguchi T, Matsui H, Takahashi M, Kawabata K,
Mizuguchi H
J. Control. Release, 153, 149-153 (2011)
Development of an adenovirus vector lacking the expression of virus-associated RNAs
Machitani M, Katayama K, Sakurai F, Matsui H, Yamaguchi T, Suzuki T, Miyoshi H, Kawabata K,
Mizuguchi H
J. Control. Release, 154, 285-289 (2011)
Optimization of a microRNA expression vector for function analysis of microRNA
Furukawa N, Sakurai F, Katayama K, Seki N, Kawabata K, Mizuguchi H
J. Control. Release, 150, 94-101 (2011)
Adenovirus vector-derived VA-RNA-mediated innate immune responses
Machitani M, Yamaguchi T, Shimizu K, Sakurai F, Katayama K, Kawabata K, Mizuguchi H
Pharmaceutics, 3, 338-353 (2011)
Human herpesvirus 6 major immediate early promoter has strong activity in T cells and is useful
for heterologous gene expression
Matsuura M, Takemoto M, Yamanishi K, Mori Y
Virol. J., 8, 9 (2011)
ナノマテリアルの皮膚透過性・体内動態と急性毒性 (Review)
角田慎一
薬学雑誌, 131, 203-207 (2011)
28
ナノマテリアルの細胞内動態と遺伝毒性 (Review)
阿部康弘
薬学雑誌, 131, 215-219 (2011)
非晶質ナノシリカの動態特性と生殖発生毒性 (Review)
長野一也
薬学雑誌, 131, 225-228 (2011)
ファージ表面提示法を駆使した機能性人工タンパク質の創製 (Review)
阿部康弘
Drug Delivery System, 26, 632-633 (2011)
衛生・微生物学 (Environmental Science and Microbiology)
Rapid, semiautomated quantification of bacterial cells in freshwater by using a microfluidic
device for on-chip staining and counting
Yamaguchi N, Torii M, Uebayashi Y, Nasu M
Appl. Environ. Microbiol., 77, 1536-1539 (2011)
Rapid enumeration of low numbers of moulds in tea based drinks using an automated system
Tanaka K, Yamaguchi N, Baba T, Amano N, Nasu M
Int. J. Food Microbiol., 145, 365-369 (2011)
Inactivation of bacteria in freshwater by momentary decompression following high
pressurization
Baba T, Yamaguchi N, Tani K, Nasu M
Microbes Environ., 26, 92-94 (2011)
Genotypic characterization and in vitro activities of tigecycline and polymyxin B for members of
the Enterobacteriaceae with decreased susceptibility to carbapenems
Zhang R, Cai JC, Zhou HW, Nasu M, Chen GX
J. Med. Microbiol., 60, 1813-1819 (2011)
Environmental disease: environmental alteration and infectious disease
Yamaguchi N, Ichijo T, Nasu M
Ecol. Res., 26, 893-896 (2011)
国際宇宙ステーションから回収した機器における細菌の現存量
山口進康，稗田はつき，一條知昭，那須正夫
第 27 回宇宙利用シンポジウム 発表論文集, 221-223 (2011)
29
微生物迅速検出法の現状と応用（Review）
山口進康，那須正夫
ソフト・ドリンク技術資料, 165, 277-294 (2011)
生命情報解析学 ( Molecular Medicine )
New protein purification system using gold-magnetic beads and a novel peptide tag, “the
methionine tag”
Okada Y, Takano TY, Kobayashi N, Hayashi A, Yonekura M, Nishiyama Y, Abe T, Yoshida T,
Yamamoto TA, Seino S, Doi T
Bioconjug. Chem., 22, 887-893 (2011)
Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal
muscle
Liu J, Yuan L, Molema G, Regan E, Janes L, Beeler D, Spokes KC, Okada Y, Minami T, Oettgen P,
Aird WC
Blood, 117, 342-351 (2011)
Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα
-independent mechanisms
Yamasaki D, Kawabe N, Nakamura H, Tachibana K, Ishimoto K, Tanaka T, Aburatani H, Sakai J,
Hamakubo T, Kodama T, Doi T
Eur. J. Cell Biol., 90, 657-664 (2011)
Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding
site
Okada Y, Nobori H, Shimizu M, Watanabe M, Yonekura M, Nakai T, Kamikawa Y, Wakimura A,
Funahashi N, Naruse H, Watanabe A, Yamasaki D, Fukada S, Yasui K, Matsumoto K, Sato T, Kitajima
K, Nakano T, Aird WC, Doi T
PLoS One, 6, e24837 (2011)
情報・計量薬学 (Pharmainformatics and Pharmacometrics)
Factors predicting requirement of high-dose transdermal fentanyl in opioid switching from oral
morphine or oxycodone in patients with cancer pain
Kanbayashi Y, Hosokawa T, Okamoto K, Fujimoto S, Konishi H, Otsuji E, Yoshikawa T, Takagi T,
Miki T, Taniwaki M
Clin. J. Pain, 27, 664-667 (2011)
Acquisition of human-type receptor binding specificity by new H5N1 influenza virus sublineages
30
during their emergence in birds in Egypt
Watanabe Y, Ibrahim MS, Ellakany HF, Kawashita N, Mizuike R, Hiramatsu H, Sriwilaijaroen N,
Takagi T, Suzuki Y, Ikuta K
PLoS Pathogens, 7, e1002068 (2011)
環境病因病態学 (Clinical and Experimental Pathophysiology)
Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription
factor-based in vivo bioluminescence imaging
Kadonosono T, Kuchimaru T, Yamada S, Takahashi Y, Murakami A, Tani T, Watanabe H, Tanaka T,
Hirota K, Inoue M, Tsukamoto T, Toyoda T, Urano K, Machida K, Eto T, Ogura T, Tsutsumi H, Ito M,
Hiraoka M, Kondoh G, Kizaka-Kondoh S
PLoS One, 6, e26640 (2011)
Decreased expression of LMO7 and its clinicopathological significance in human lung
adenocarcinoma
Nakamura H, Hori K, Tanaka-Okamoto M, Higashiyama M, Itoh Y, Inoue M, Morinaka S, Miyoshi J
Exper. ther. med., 2, 1053-1057 (2011)
Counterbalancing angiogenic regulatory factors control the rate of cancer progression and
survival in a stage-specific manner
Xie L, Duncan MB, Pahler J, Sugimoto H, Martino M, Lively J, Mundel T, Soubasakos M, Rubin K,
Takeda T, Inoue M, Lawler J, Hynes RO, Hanahan D, Kalluri R
Proc. Natl. Acad. Sci. USA, 108, 9939-9944 (2011)
Retaining cell-cell contact enables preparation and culture of spheroids composed of pure
primary cancer cells from colorectal cancer
Kondo J, Endo H, Okuyama H, Ishikawa O, Iishi H, Tsujii M, Ohue M, Inoue M
Proc. Natl. Acad. Sci. USA, 108, 6235-6240 (2011)
Cellular hypoxia of pancreatic β-cells due to high levels of oxygen consumption for insulin
secretion in vitro
Sato Y, Endo H, Okuyama H, Takeda T, Iwahashi H, Imagawa A, Yamagata K, Shimomura I, Inoue M
J. Biol. Chem., 286, 12524-12532 (2011)
大腸がんの新しい培養法 : 多様性の理解への入り口
井上正宏
大腸癌 Frontier, 4, 169-173 (2011)
低酸素環境と Cancer Dormancy (Review)
奥山裕照, 井上正宏
31
癌と化学療法, 38, 1559-1564 (2011)
医療薬学教育研究部 (Clinical Pharmacy Research and Education)
Therapeutic effects of novel sphingosine-1-phosphate receptor agonist W-061 in murine DSS
colitis
Sanada Y, Mizushima T, Kai Y, Nishimura J, Hagiya H, Kurata H, Mizuno H, Uejima E, Ito T
PLoS One, 6, e23933 (2011)
Can milnacipran used for neuropathic pain in patients with advanced cancer cause
neuromuscular and somatosensory disorders?
Nakagawa S, Okamoto Y, Tsuneto S, Tanimukai H, Goya S, Matsuda Y, Oono Y, Tsugane M, Uejima
E
J. Palliat. Med., 14, 403-405 (2011)
トリアムシノロン水懸注の腹腔内投与が悪性腹水の症状緩和に有効であった 4 症例
長瀬未恵, 岡本禎晃, 恒藤暁, 中川左理, 松田陽一, 谷向仁, 沖代奈央, 大野由美子, 田川高巳,
津金麻実子, 上島悦子
緩和ケア, 21, 343-348 (2011)
化学療法剤および抗生物質に関する文献紹介（60）(Review)
上島悦子
化学療法の領域, 27, 404-406 (2011)
化学療法剤および抗生物質に関する文献紹介（62）(Review)
上島悦子
化学療法の領域, 27, 828-830 (2011)
化学療法剤および抗生物質に関する文献紹介（64）(Review)
上島悦子
化学療法の領域, 27, 1532-1534 (2011)
化学療法剤および抗生物質に関する文献紹介（66）(Review)
上島悦子
化学療法の領域, 27, 1924-1926 (2011)
化学療法剤および抗生物質に関する文献紹介（68）(Review)
上島悦子
化学療法の領域, 27, 2416-2418 (2011)
化学療法剤および抗生物質に関する文献紹介（70）(Review)
32
上島悦子
化学療法の領域, 27, 2792-2794 (2011)
がん疼痛 診療・治療ガイドライン活用指南(第 22 回) (Review)
岡本禎晃
月刊薬事, 53, 255-262 (2011)
緩和ケアにおける薬剤師との連携事例
岡本禎晃
臨牀看護, 37, 201-205 (2011)
－薬剤師の立場から－ (Review)
オピオイドが効かないときの鎮痛補助薬の使い方 (Review)
岡本禎晃
がん看護シリーズ, 1, 56-61 (2011)
応用環境生物学 (Applied Environmental Biology)
Toxicological characterization of N-methyl-N-nitrosourea-induced cataract in rats by
LC/MS-based metabonomic analysis
Miyazono Y, Harada K, Sugiyama K, Ueno M, Torii M, Kato I, Matsuura H, Hirata K
J. Appl. Toxicol., 31, 655-662 (2011)
Molecular cloning and partial characterization of a peroxidase gene expressed in the roots of
Portulaca oleracea cv., one potentially useful in the remediation of phenolic pollutants
Matsui T, Nomura Y, Takano M, Imai S, Nakayama H, Miyasaka H, Okuhata H, Tanaka S, Matsuura H,
Harada K, Bamba T, Hirata K, Kato K
Biosci. Biotechnol. Biochem., 75, 882-890 (2011)
Isolation and partial characterization of the Chlamydomonas reinhardtii γ-glutamyl kinase
Miyoshi K, Matsuura H, Kumon T, Matsuda K, Yoshikawa T, Bamba T, Harada K, Hirata K
J. Biosci. Bioeng., 112, 75-78 (2011)
Comparison of three Chlamydomonas strains which show distinctive oxidative stress tolerance
Tanaka S, Ikeda K, Miyasaka H, Shioi Y, Suzuki Y, Tamoi M, Takeda T, Shigeoka S, Harada K, Hirata
K
J. Biosci. Bioeng., 112, 462-468 (2011)
微生物共生系を利用した廃バイオマスの再資源化 (Review)
原田和生，平田收正
生物工学会誌, 89, 124-127 (2011)
33
環境浄花：植物による環境ホルモン分解と排水処理への応用 (Review)
松浦秀幸，原田和生，宮坂均，平田收正
植物機能のポテンシャルを活かした環境保全・浄化技術 －地球を救う超環境適合・自然調和
型システム (シーエムシー出版), 31-37 (2011)
微細藻類による排水からの有害金属除去 (Review)
平田收正，永瀬裕康
植物機能のポテンシャルを活かした環境保全・浄化技術 －地球を救う超環境適合・自然調和
型システム (シーエムシー出版), 38-45 (2011)
微細藻類による煙道排気ガスの処理 (Review)
平田收正，永瀬裕康
植物機能のポテンシャルを活かした環境保全・浄化技術 －地球を救う超環境適合・自然調和
型システム (シーエムシー出版), 133-139 (2011)
光合成微生物を用いたバイオマスの有用物質への変換 (Review)
原田和生，平田收正
植物機能のポテンシャルを活かした環境保全・浄化技術 －地球を救う超環境適合・自然調和
型システム (シーエムシー出版), 239-245 (2011)
融合研究部 (Research Division)
A new treatment method to remove organic pollutants from water by photodegradation,
polymerization and filtration
Nagase H
Management of water in a changing world: lessons learnt and innovative perspectives, 232-233 (2011)
微細藻類による排水からの有害金属除去 (Review)
平田收正，永瀬裕康
植物機能のポテンシャルを活かした環境保全・浄化技術 －地球を救う超環境適合・自然調和
型システム (シーエムシー出版), 38-45 (2011)
微細藻類による煙道排気ガスの処理 (Review)
平田收正，永瀬裕康
植物機能のポテンシャルを活かした環境保全・浄化技術 －地球を救う超環境適合・自然調和
型システム (シーエムシー出版), 133-139 (2011)
機能性核酸化学 (Functional Nucleic Acid Chemistry)
Synthesis and properties of a bridged nucleic acid with a perhydro-1,2-oxazin-3-one ring
34
Shrestha AR, Hari Y, Yahara A, Osawa T, Obika S
J. Org. Chem., 76, 9891-9899 (2011)
A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase for a CG base pair in triplex
DNA
Hari Y, Akabane M, Hatanaka Y, Nakahara M, Obika S
Chem. Commun., 47, 4424-4426 (2011)
Synthesis and triplex-forming ability of oligonucleotides bearing 1-substituted 1H-1,2,3-triazole
nucleobases
Hari Y, Nakahara M, Pang J, Akabane M, Kuboyama T, Obika S
Bioorg. Med. Chem., 19, 1162-1166 (2011)
2’-O,4’-C-Methyleneoxymethylene bridged nucleic acids (2’,4’-BNACOC)
Hari Y, Kodama T, Imanishi T, Obika S
Therapeutic Oligonucleotides: Methods and Protocols (Methods in Mol. Biol. 764) (Humana Press),
31-57 (2011)
1-Diazo-1-silylalkanes
Hari Y, Aoyama T, Shioiri T
Science of Synthesis Knowledge Updates 2010/4 (Georg Thieme Verlag), 25-68 (2011)
生命分子合成化学 (Synthetic Organic and Medicinal Chemistry)
The reaction of acetal-type protective groups in combination with TMSOTf and 2,2’-bipyridyl;
mild and chemoselective deprotection and direct conversion to other protective groups
Fujioka H, Minamitsuji Y, Kubo O, Senami K, Maegawa T
Tetrahedron, 67, 2949-2960 (2011)
Reversing the reactivity of carbonyl functions with phosphonium salts: enantioselective total
synthesis of (+)-centrolobine
Fujioka H, Yahata K, Kubo O, Sawama Y, Hamada T, Maegawa T
Angew. Chem. Int. Ed., 50, 12232-12235 (2011)
Direct conversion of acetals to esters with high regioselectivity via O,P-acetals
Maegawa T, Otake K, Goto A, Fujioka H
Org. Biomol. Chem., 9, 5648-5651 (2011)
An unusual reaction of α-alkoxyphosphonium salts with Grignard reagents under an O 2
atmosphere
Fujioka H, Goto A, Otake K, Kubo O, Sawama Y, Maegawa T
35
Chem. Commun., 47, 9894-9896 (2011)
Palladium on carbon-catalyzed solvent-free and solid-phase hydrogenation and Suzuki-Miyaura
reaction
Monguchi Y, Fujita Y, Hashimoto S, Ina M, Takahashi T, Ito R, Nozaki K, Maegawa T, Sajiki H
Tetrahedron, 67, 8628-8634 (2011)
Facile hydrogenation of ketones catalyzed by platinum on carbon under ordinary pressures and
temperatures
Fujiwara Y, Iwasaki Y, Maegawa T, Monguchi Y, Sajiki H
ChemCatChem, 3, 1624-1628 (2011)
(+)-Sorangicin A: evolution of a viable synthetic strategy
Smith AB, III, Dong S, Fox RJ, Brenneman JB, Vanecko JA, Maegawa T
Tetrahedron, 67, 9809-9828 (2011)
36

Culture Agenda as of December 3 2014 JPN