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Antimicrobial Therapy in Immunocompromised and Critically Ill Patients:
Management and Perspectives
Palazzo dei Congressi - LUGANO
29-30 May 2014
BACKGROUND
The incidence and diagnosis of viral, bacterial and fungal infections in the critically ill and
immunocompromised patients has dramatically increased and the number of new,
immunocompromising therapies is also rapidly growing. New drugs for the treatment of invasive
fungal infections have joined the existing therapeutic armamentarium, yet the mortality caused by
Candida spp., mould infections is still unacceptably high. Known and emerging viral infections are
also attracting the interest of most specialists and, despite the introduction of new diagnostic tools,
they are still causing serious problems in the ICU and complicate the daily management of
immunocompromised patients. Finally, the increasing number of infections caused by multidrug
resistant bacteria jeopardizes the success of therapeutic interventions.
Treatment of infections in the critically ill and in the classical immunocompromised patient is fraught
with a number of open questions. The symposium aims at updating these issues and providing a
discussion forum for clinicians and microbiologists actively involved in the treatment of ICU and
immunocompromised patients, including haemato-oncologic diseases, solid organ and bone marrow
transplantation and autoimmune diseases.
OBJECTIVES
The symposium will discuss common issues and controversies related to the diagnosis and treatment of
infections in critically ill and immunocompromised patients, to provide real-life experience that can
easily translate into daily clinical practice.
SCIENTIFIC COMMITTEE:
Enos Bernasconi, MD
Christian Garzoni, MD
Paolo Grossi, MD
Oscar Marchetti, MD
Orlando Petrini, PhD
Francesco Scaglione, MD
Sede Legale:
Via Coremmo 1 - 6900 Lugano
Switzerland
N°.IVA 661079
PRELIMINARY PROGRAM
29 MAY - THURSDAY
10:00-10:15 Welcome, Introduction
Enos Bernasconi
SESSION I: Challenges in prevention and treatment of fungal infections
10:15-10:45 Antibacterial and antifungal stewardship - the clinical significance of laboratory
results
Robert Masterton
10:45-11:15 Azole-resistant Aspergillus species in the clinical settings – where do they come
from?
Paul Verweij
11:15-11:30
Coffee Break
11:30-11:50 Antifungal prophylaxis in high-risk patients? Yes
Tony Pagliuca
11:50-12:10 Antifungal prophylaxis in high-risk patients? No
Christian Van Delden
12:10-12:30 Q&A – Discussion
12:30-13:45 Lunch
Sede Legale:
Via Coremmo 1 - 6900 Lugano
Switzerland
N°.IVA 661079
SESSION II: Therapeutic challenges in the era of antibiotic resistance
13:45-14:15 VAP treatment: when and how
Paolo Grossi
14:15-14:45 Intra-abdominal infections: antimicrobials and surgery
Gabriele Sganga
14:45-15:15 Treatment of complicated skin and skin-structure infections
Christian Eckmann
15:15-15:45 Q&A – Discussion
15:45-16:15 Coffee Break
SESSION III: Candida infections in the ICU
16:15-16:45 What is new in Candida epidemiology
Philippe Montravers
16:45-17:15 Antifungal approaches: Any news from biomarkers?
Oscar Marchetti
17:15-17:45 Treatment options and guidelines
Philippe Eggimann
17:45-18:00 Q&A – Discussion
Sede Legale:
Via Coremmo 1 - 6900 Lugano
Switzerland
N°.IVA 661079
30 MAY - FRIDAY
SESSION IV: Viral infections – emerging threats and treatments
08:00-08:30 Respiratory viruses (Influenza? Others?)
Paolo Grossi
08:30-09:00 Immunogenetics of viral infections
Pierre Yves Bochoud
09:00-09:15 Q&A – Discussion
SESSION V: Viral infections in transplant patients
09:15-10:15 CMV infections in transplant patients – pros and cons of prophylaxis
Pascal Meylan, Hans Hirsch
10:15-10:45 Coffee Break
10:45-11:15 Infection disease burden in transplant recipients: The Swiss Transplant Cohort
Study
Nikolas Müller
11:15-11:45 New drugs for Hepatitis C in the transplant patient
Patrizia Burra
11:45-12:15 Meeting the challenge of HIV, HCV in transplantation: a pharmacologic nightmare
Beat Müllhaupt
12:15-12:45 Q&A – Discussion
12:45-14:00 Lunch break
Sede Legale:
Via Coremmo 1 - 6900 Lugano
Switzerland
N°.IVA 661079
SESSION VI: Interactive cases
14:00-16:00 Presentation of cases
Sede Legale:
Via Coremmo 1 - 6900 Lugano
Switzerland
N°.IVA 661079

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