Cover Page The handle http://hdl.handle.net/28940 holds

Cover Page
The handle http://hdl.handle.net/1887/28940 holds various files of this Leiden University
dissertation.
Author: Benard, Erica L.
Title: Key innate immune components controlling intracellular infection
Issue Date: 2014-09-25
Key innate immune
components controlling
intracellular infection
Erica L. Benard
Printed and bound by: Wöhrmann print service
ISBN: 978-94-6203-657-4
Key innate immune components controlling intracellular infection
Proefschrift
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden
op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op donderdag 25 september 2014
klokke 13.45 uur
door
Erica L. Benard
geboren te Westville, Zuid Afrika
op 5 maart 1986
Promotiecommissie:
Promotor: Prof. Dr. H.P. Spaink
Co-promotor: Dr. A.H. Meijer
Overige leden: Prof. Dr. C.J. ten Cate
Prof. Dr. T.H.M. Ottenhoff (Leids Universitair Medisch Centrum)
Prof. Dr. Ir. G.F. Wiegertjes
(Wageningen University)
Dr. P.M. Elks
(University of Sheffield)
Table of contents
Chapter 1 Outline of the thesis
11
Chapter 2 Infection of zebrafish embryos with intracellular
bacterial pathogens
17
Chapter 3
A morpholino knockdown screen for genes involved
in mycobacterium infection
35
Chapter 4 Time-resolved transcriptome profiling of the
zebrafish host innate immune response to
mycobacterium infection
59
Chapter 5 Phagocytosis of mycobacteria by zebrafish
macrophages is dependent on the scavenger
receptor Marco, a key control factor of proinflammatory signalling
97
Chapter 6 The macrophage-expressed perforins Mpeg1 and
Mpeg1.2 have anti-bacterial functions in zebrafish
125
Chapter 7 Summary and discussion 159
Samenvatting
169
List of publications
173
Curriculum vitae175
“Science knows no country, because knowledge belongs to humanity,
and is the torch which illuminates the world”
- Louis Pasteur

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