Program - Nederlandse federatie voor nefrologie

NAJAARSSYMPOSIUM 2014 – FALL SYMPOSIUM 2014
NEDERLANDSE FEDERATIE VOOR NEFROLOGIE – DUTCH FEDERATION OF NEPHROLOGY
(93STE WETENSCHAPPELIJKE VERGADERING)
Date
Friday, October 10th, 2014
Venue
Bethelkerk Utrecht
Address
Burgemeester Norbruislaan 1
3555 ED, Utrecht
1
Directions
ROUTE BETHELKERK UTRECHT – MET DE AUTO
Vanaf de A2 (Voor verkeer uit de richtingen Amsterdam, Den Haag, en Den Bosch):
-Neem de afslag Ring Utrecht-Noord [afslag 6]
-Ga na 500 m de Zuilense ring (N230) op richting Maarssen (N230)
-Neem na 2.5 km de afslag richting Utrecht (N404)
-300 m rechtsaf op de Sweserengseweg richting Utrecht (N404)
-Na 1.8 km rijdt u op de Burgemeester Norbruislaan
-Na ca. 1 kilometer, bij de verkeerslichten, ziet u de Bethelkerk aan uw linker zijde op de hoek.
Vanaf de A27 (Voor verkeer uit de richtingen Hilversum, Amersfoort en Gorinchem)
-Neem de afslag Ring Utrecht[afslag 31] richting Maarssen (N230)
-Neem na 2.5 km de eerste afslag op de rotonde (rechtdoor) richting Maarssen (N230)
-Neem na 1.4 km de vierde afslag (linksaf) op de rotonde en volg de Franciscusdreef
-Na 3 km, na de brug over de Vecht, rijdt u op de J.M. de Muinck Keijzerlaan
-Na ca. 300 meter, bij de verkeerslichten, ziet u de Bethelkerk aan uw rechter zijde op de hoek.
OV-REISINFORMATIE (vanaf Utrecht Centraal):
Van: Busstation Stadsvervoer
Naar: Utrecht Prins Bernhardplein (Busstation)
Met: stadsbus lijnen 3, 26 of 36 (GVU), richting Zuilen of Maarssen.
De Bethelkerk bevindt zich op de hoek van de J.M de Muick Keijzerlaan en de Burgemeester
Norbruislaan, direkt tegenover het busstation aan het Prins Bernhardplein.
Contact
Dr.T. Nijenhuis ([email protected]; 024-3614761)
Program – NfN Fall Symposium 2014
NAJAARSSYMPOSIUM 2014 – FALL SYMPOSIUM 2014
NEDERLANDSE FEDERATIE VOOR NEFROLOGIE – DUTCH FEDERATION OF NEPHROLOGY
(93STE WETENSCHAPPELIJKE VERGADERING)
Program at a glance
Welcome
10.00-10.30
Welcome with coffee and tea
Morning session & Poster Highlights
10.30-11.00
Junior invited lecture:
MEMBRANOUS NEPHROPATHY AND ANTI-PLA2R: ARE WE THERE YET?
Dr. J.M. Hofstra
Dept. of Nephrology, Radboud university medical center, Nijmegen
11.00-12.24
12.24-12.42
Oral abstract presentations
Short (3-minute) plenary oral presentations of selected posters
Break & Poster Discussion
12.45-13.30
13.30-14.30
Lunch and time for discussion
Moderated parallel poster sessions A, B and C
Afternoon Session & Awards
14.30-15.00
Senior invited lecture:
HYDROGEN SULFIDE IN RENAL DISEASE AND TRANSPLANTATION
Dr. H. van Goor
Dept. of Nephrology, University Medical Centre Groningen
15.00-16.24
16.24-16.35
16.35-16.45
16.45-17.30
Oral abstract presentations
News from PLAN (Platform AIO’s Nefrologie)
Prizes for best oral presentations and poster will be awarded
PLAN drink (“borrel”)
Friday October 10th, 2014
Bethelkerk
Burgemeester Nobruislaan 1
3555 ED Utrecht
Program – NfN Fall Symposium 2014
2
Full Program
Welcome
10.00-10.30
Welcome with coffee and tea
Morning session
Chair: Dr. R.T. Gansevoort
10.30-11.00
Junior invited lecture:
MEMBRANOUS NEPHROPATHY AND ANTI-PLA2R: ARE WE THERE YET?
Dr. J.M. Hofstra
Dept. of Nephrology, Radboud university medical center, Nijmegen
11.00-11.12
O1. SOLUBLE ACTIVIN TYPE IIB RECEPTOR TREATMENT EFFECTIVELY BLOCKS CYST
FORMATION IN A MOUSE MODEL FOR ADPKD
1
1
1
2
1
W.N. Leonhard , Steven Kunnen , Fatiha el Bouazzaoui , K. Veraar , M.H. Breuning , E. De
2
3
1
Heer , Olli Ritvos , D.J.M. Peters
1
2
3
Depts. of Human Genetics and Pathology, Leiden University Medical Center, Leiden, Helsinki
University of Technology
11.12-11.24
O2. BELIMUMAB AFTER RITUXIMAB AS MAINTENANCE THERAPY IN LUPUS
NEPHRITIS: A CASE SERIES
1
1
2
Y.K.O. Teng , T. Kraaij , T.W.J. Huizinga , T.J. Rabelink
1
1
3
2
Depts. of Nephrology and Rheumatology, Leiden University Medical Center, Leiden
11.24-11.36
O3. TOWARDS AN IMPROVED GENETIC TEST FOR CAKUT: TARGETED SEQUENCING OF 208 CANDIDATE GENES IN 460 CAKUT PATIENTS
1
1
1
1
1
Kirsten Y. Renkema , Nayia Nicolaou , Isaac J. Nijman , Glenn van de Hoek , Glen Monroe ,
2
3
1
4
Wout F.J. Feitz , Michiel F. Schreuder , Albertien M. van Eerde , Tom P.V.M. de Jong ,
1
1
5
6,7,8
Marlies R. Havenith , Susan Zwakenberg , Loes F.M. van der Zanden , Geert Poelmans ,
3
9
7,8
3,5
Elisabeth A.M. Cornelissen , Marc R. Lilien , Barbara Franke , Nel Roeleveld , Iris A.L.M.
5
10
1
8
1
van Rooij , Rachel H. Giles , Edwin Cuppen , Ernie M.H.F. Bongers , Nine V.A.M. Knoers
1
2
Dept. of Medical Genetics, Center for Molecular Medicine, UMC Utrecht, Utrecht, Depts. of Urology
3
4
and Pediatrics, Amalia Children’s Hospital, Radboudumc, Nijmegen, Depts. of Urology and
10
5
6
Nephrology and Hypertension, UMC Utrecht, Utrecht, Depts. of Health Evidence, Molecular Animal
7
8
9
Physiology, Cognitive Neuroscience and Human Genetics, Radboudumc, Nijmegen, Dept. of
Pediatric Nephrology, Wilhelmina Children’s Hospital, UMC Utrecht, Utrecht
11.36-11.48
O4. MICROVASCULAR DYSFUNCTION IS ASSOCIATED WITH AN INCREASED RISK
OF (MICRO)ALBUMINURIA – THE MAASTRICHT STUDY
1,2
3,4
3,4
Remy J.H. Martens , Ronald M.A. Henry , Carla J.H. van der Kallen , Abraham A.
3,4
3,4
3,4
3,4
Kroon , Miranda T. Schram , Simone J.S. Sep , Nicolaas C. Schaper , Pieter C.
4,5,6
3,4
3,4
1,2
Dagnelie , Dennis M.J. Muris , Alfons J.H.M. Houben , Jeroen P. Kooman , Coen D.A.
3,4
Stehouwer
1
2
Dept. of Internal Medicine, Div. of Nephrology, School for Nutrition, Toxicology and Metabolism
3
4
5
(NUTRIM), Dept. of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM),
6
Dept. of Epidemiology, School for Public Health and Primary Care (CAPHRI), Maastricht University
Medical Center+, Maastricht
11.48-12.00
O5. REDUCTION IN ALBUMINURIA IN DIABETIC NEPHROPATHY BY ATRASENTAN
IS ASSOCIATED WITH RESTORATION OF THE GLOMERULAR ENDOTHELIAL
GLYCOCALYX
1
1,2
1
1
Margien G.S. Boels , Cristina M. Avramut , Angela Koudijs , Martijn J.C. Dane , Dae Hyun
1
3
1
1
Lee , Johan van der Vlag , Abraham J. Koster , Anton Jan van Zonneveld , Ernst van
1
4
1
1
Faassen , Herman-Josef Gröne , Bernard M. van den Berg , Ton J. Rabelink
1
2
3
4
Nephrology & Molecular Cell Biology, LUMC, Leiden, Nephrology, Radboudumc, Nijmegen, Cellular
and Molecular Pathology, DKFZ, Heidelberg, Germany
Program – NfN Fall Symposium 2014
12.00-12.12
O6. GENETIC ENDOTHELIAL HYALURONAN DELETION RESULTS IN GLOMERULAR
INJURY AND ALBUMINURIA
1
1
1,2
3
4
Bernard van den Berg , Margien Boels , Cristina Avramut , Erik Jansen , Sacha Meldner ,
1
5
6
2
Martijn Dane , Johan van der Vlag , Hans Vink , Abraham Koster , Anton Jan van
1
4
1,3
1
Zonneveld , Herman-Josef Gröne , Eelco de Koning & Ton Rabelink
1
2
3
Nephrology & Molecular Cell Biology, LUMC, Leiden#; Hubrecht Institute for Developmental Biology
4
and Stem Cell Research, Utrecht#; Cellular and Molecular Pathology, DKFZ, Heidelberg, Germany;
5
6
Nephrology, RUNMC, Nijmegen#; Physiology, MUMC, Maastricht
12.12-12.24
O7. HEPARANASE DEFICIENCY IMPROVES RENAL FUNCTION DURING
EXPERIMENTAL GLOMERULONEPHRITIS
1
1
2
3
4
5
1
1
M Garsen , M Benner , T van Kuppevelt , JP Li , M Elkin , H Dijkman , J Berden , A Rops , J
1
van der Vlag
1
2
5
Depts. of Nephrology, Matrix Biochemistry and Pathology, Radboud university medical center,
3
4
Nijmegen. Dept of Medical Biochemistry and Microbiology, Uppsala University, Uppsala. Sharett
Institute, Hadassah-Hebrew University Medical Center, Jerusalem
Poster Highlights (plenary session)
Chair: Dr. R.T. Gansevoort
12.24-12.27
P10. THE OVERLOOKED ANTIHYPERTENSIVE POTENCY OF SULODEXIDE - A SYSTEMATIC REVIEW AND META-ANALYSIS
1
1
3,
3
RHG Olde Engberink , NMG Rorije , HJ Lambers-Heerspink D de Zeeuw , BJH van den
2
1
Born , L Vogt
1
2
Depts. of Nephrology and Vascular Medicin, Academic Medical Center, Amsterdam, Dept. of Clinical
3,
Pharmacy and Pharmacology University Medical Center Groninge, Groningen
12.27-12.30
P17. FUNCTIONAL CHARACTERIZATION OF AN ALTERNATIVE SPLICE VARIANT OF
THE THIAZIDE-SENSITIVE NaCl COTRANSPORTER
Omar A.Z. Tutakhel, Sabina Jeleń, Joost G.J. Hoenderop, and René J.M. Bindels,
Department of Physiology, Radboud university medical center, Nijmegen
12.30-12.33
P16. PRECISION-CUT KIDNEY SLICES (PCKS): A NOVEL MODEL TO STUDY
DEVELOPMENT AND TREATMENT OF RENAL FIBROSIS EX VIVO
1
2
1
3
1
2
F. Poosti , B.T.Pham , S. Huitema ,K. Poelstra ,H. van Goor , P. Olinga , J.L. Hillebrands
1
1
2
Depts. Pathology, University Medical Center Groningen, and Pharmaceutical Technology and
3
Biopharmacy, Pharmacokinetics,Toxicology and Targeting, University of Groningen, Groningen
12.33-12.36
P15. A HUMAN RENAL PROXIMAL TUBULE CELL LINE PREDICTIVE FOR DRUGINDUCED NEPHROTOXICITY
Tom TG Nieskens, Katja Jansen, Thom K van der Made, Martijn J Wilmer, Rosalinde
Masereeuw
Department of Pharmacology and Toxicology, Radboudumc, Nijmegen
12.36-12.39
P11. ENDOCRINE-CEREBRO-OSTEODYSPLASIA SYNDROME IS A CILIARY DISORDER
1
1
2-4
1
Machteld M. Oud , Dorus A. Mans , C Anthony Rupar , Nathalie de Wagenaar , Piya
5
6
2,7
1
2-4
Lahiry , Greg Pazour , Robert A. Hegele , Ronald Roepman , Vicky Siu* , Heleen H.
1,2,7
Arts*
1
2
Dept. of Human Genetics, Radboud University Medical Centre, Nijmegen, Dept. of Biochemistry,
3
University of Western Ontario, London, Ontario, Canada; Medical Genetics Program, London Health
4
Sciences Centre, London, Ontario, Canada; Children’s Health Research Institute, London, Ontario,
5
6
Canada; Dept. of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada; Program in
Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA;
7
Robarts Research Institute, London, Ontario, Canada. * Equal contribution
12.39-12.42
P13. HUMAN PROXIMAL TUBULE EPITHELIAL CELLS CULTURED ON HOLLOW FIBERS: LIVING MEMBRANES THAT ACTIVELY TRANSPORT ORGANIC CATIONS
123
5
123
1
4
J Jansen , IE De Napoli , CM Schophuizen , MJ Wilmer , JFM Wetzels , LP van den Heu3
2
5
1
vel , JG Hoenderop , D Stamatialis , R Masereeuw
1
2
3
4
Department of Pharmacology and Toxicology, Physiology, Pediatrics and Nephrologu, Radboud
5
University Medical Centre, Nijmegen, Dept. of Biomaterials Science and Technology, MIRA - Biomedical Technology and Technical Medicine, University of Twente, 7500 AE, Enschede
Program – NfN Fall Symposium 2014
4
Break
12.45-13.30
Lunch and time for discussion
Poster Discussion (parallel sessions)
13.30-14.30
Poster sessions A, B and C (maximal 7 minutes per poster)
(See page 7 - 9 of the program for details)
Afternoon Session
Chair: Dr. R.T. Gansevoort
14.30-15.00
Senior invited lecture:
HYDROGEN SULFIDE IN RENAL DISEASE AND TRANSPLANTATION
Dr. H. van Goor
Dept. of Nephrology, University Medical Centre Groningen
15.00-15.12
O8. SILDENAFIL (VIAGRA) REDUCES PODOCYTE INJURY VIA PPARγ-MEDIATED
TRPC6 DOWNREGULATION
1,2
2
1
1
Ramon Sonneveld , Joost G. Hoenderop , Jack F. Wetzels , Jo H. Berden , Johan van der
1
1
Vlag , Tom Nijenhuis
1
2
Departments of Nephrology and Physiology, Radboud university medical center, Nijmegen
15.12-15.24
O9. TARGETING TUBULOINTERSTITIAL REMODELING IN EXPERIMENTAL
PROTEINURIC NEPHROPATHY
1
1
1
2
Saleh Yazdani *, Ryanne S Hijmans *, Gerjan Navis , Harry van Goor , Jacob van den Born
1
1
2
Depts. of Nephrology and Pathology, University Medical Center Groningen. *Contributed equally
15.24-15.36
O10. QUANTIFYING VANISHED SODIUM AFTER HYPERTONIC SALINE INFUSION IN
HEALTHY SUBJECTS
1,2
1,2
1
2
NMG Rorije , RHG Olde Engberink , JJ Homan v/d Heide , BJ van den Born , L Vogt
1
1
2
Division of Nephrology and Division of Vascular Medicine, Academic Medical Center, Amsterdam
15.36-15.48
O11. MIR-132 REGULATES DIURESIS THROUGH VASOPRESSIN AND
PROSTAGLANDIN-DEPENDENT ALTERATION OF AQUAPORIN-2 LOCALIZATION
1,3
2
1
1
1
R. Bijkerk , C. Trimpert , R.G. de Bruin , C. van Solingen , T.J. Rabelink , B.D. Humphreys
2
1
P.M.T Deen and A.J. van Zonneveld
1
3
Dept. of Nephrology and the Einthoven Laboratory for Experimental Vascular Medicine, Leiden
2
University Medical Center, Leiden, Dept. of Physiology, Radboud University Nijmegen Medical Centre,
3
Nijmegen, Renal Division, Dept. of Medicine, Brigham & Women’s Hospital and Harvard Medical
School, Boston, Massachusetts, USA
15.48-16.00
O12. ALKALINE PHOSPHATASE PROTECTS AGAINST RENAL INFLAMMATION
THROUGH DEPHOSPHORYLATION OF LPS AND ATP
1,2
3
1
Peters E , Gretz N , Pickkers P , Masereeuw R
1
2
2
Depts. of Intensive Care Medicine and Pharmacology and Toxicology, Radboudumc, Nijmegen,
3
Medical Research Centre, University of Heidelberg, Mannheim, Germany
16.00-16.12
O13. ENVIRONMENT-GRAFT INTERACTION ON CARDIAC INJURY IN KIDNEY
TRANSPLANTATION
Diana A. Papazova, Nynke R. Oosterhuis, Jaap A. Joles and Marianne C. Verhaar
Dept. of Nephrology & Hypertension, UMC Utrecht, Utrecht
16.12-16.24
O14. AN OFFER YOU CAN’T REFUSE: KIDNEYS FROM UNCONTROLLED DONORS
AFTER CARDIAC DEATH – A 10-YEAR EVALUATION IN THE NETHERLANDS
1
1
2
Hessel Peters-Sengers , Jaap J. Homan van der Heide , Martin B.A. Heemskerk , Ineke
1
1
3
4
R.J.M. ten Berge , Fred C.W. Ultee , Mirza M. Idu , Michiel G.H. Betjes , Arjan D. van
5
6,
7
8
Zuilen , Maarten H. Christiaans Luuk B. Hilbrands , Aiko P.J. de Vries , Azam S.
9
10
1
Nurmohamed , Stefan P. Berger , Frederike J. Bemelman
1
4
Department of Nephrology, Academic Medical Center, Erasmus University Medical Center
Program – NfN Fall Symposium 2014
5
5
6
7
Rotterdam, University Medical Center Utrecht, Leiden University Medical Center, Radboud
8
9
10
University Medical Center, Leiden University Medical Center, VU Medical Center, University
2
3
Medical Center Groningen. Organ Centre, Dutch Transplant Foundation, Leiden, Department of
Surgery, Academic Medical Center, Amsterdam
16.24-16.35
News from PLAN (Platform AIO’s Nefrologie)
Awards, Tea & Departure
16.35-16.45
Prizes will be awarded:
 500 EURO, first prize oral presentation
 250 EURO, second prize oral presentation
 100 EURO, third prize oral presentation
 100 EURO, poster prize
16.45-17.30 PLAN drink (“borrel”)
6
Program – NfN Fall Symposium 2014
Poster session A (Clinical Nephrology I-Dialysis)
Chairs: Dr. M.H. Raasveld & PLAN representative
P1. BODY COMPOSITION IN DIALYSIS PATIENTS: A FUNCTIONAL ASSESSMENT OF BIOIMPEDANCE
USING DIFFERENT PREDICTION MODELS
1
1
1
1
Natascha J.H. Broers , Remy J.H. Martens , Tom Cornelis , Nanda M.P. Diederen , Peter
2
1
1
1
Wabel , Frank M. van der Sande , Karel M.L. Leunissen , Jeroen P. Kooman
1
Department of Internal Medicine, Division of Nephrology, University Hospital Maastricht,
2
Maastricht, The Netherlands, Fresenius Medical Care D GmbH, Bad Homburg, Germany
P2. QUALITY OF LIFE IN DIALYSIS PATIENTS, A RETROSPECTIVE COHORT STUDY
1
2
1
1
2
Natascha J.H. Broers , Len A. Usvyat , Jeroen P. Kooman , Frank M. van der Sande , Eduardo Lacson, Jr , Peter
3
2
Kotanko , Franklin W. Maddux
1
Department of Internal Medicine, Division of Nephrology, University Hospital Maastricht, Maastricht, The Netherlands,
3
Fresenius Medical Care North America, Waltham, MA, USA, Renal Research Institute, NY, NY, USA
2
P3. THE ASSOCIATION OF ACCULTURATION AND DEPRESSIVE SYMPTOMS IN DIALYSIS PATIENTS.
1
1
2
2
t
G.L.G. Haverkamp , W.L. Loosman , T. Hoekstra , F.W. Dekker , C.E.H. Sieger 1, A. Honig
1
3
2
Department of Nephrology, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands, Department of Clinical
3
Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Department of Psychiatry, Sint Lucas Andreas
Hospital/VU University medical center, Amsterdam, The Netherlands
P4. PROTEIN-ENERGY WASTING AND QUALITY OF LIFE IN CHRONIC HEMODIALYSIS PATIENTS
1
1,2
1,2
3
Camiel LM de Roij van Zuijdewijn *, Muriel Grooteman , Menso Jan Nubé , Peter J. Blankestijn , Michiel
4
1,2
Bots and Pieter M. Ter Wee
1
2
Nephrology, VU university medical center, Amsterdam, Netherlands; Institute for Cardiovascular Research, VU university
3
medical center, Amsterdam, Netherlands; Nephrology, University Medical Center Utrecht, Utrecht, Netherlands and 4Julius
Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
P5. SURVIVAL, CONVECTION VOLUME AND TREATMENT TIME IN HEMODIAFILTRATION: A
SUBSTUDY OF CONTRAST
1
1,2
3
1,2
Camiel LM de Roij van Zuijdewijn *, Menso Jan Nubé , Peter J. Blankestijn , Pieter M. Ter Wee , Renee
4
5
1,2
Levesque , Michiel Bots and Muriel Grooteman
1
2
Nephrology, VU university medical center, Amsterdam, Netherlands; Institute for Cardiovascular Research, VU university
3
medical center, Amsterdam, Netherlands; Nephrology, University Medical Center Utrecht, Utrecht, Netherlands;
4
5
Nephrology, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada and Julius Center for Health
Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
P6. INFLUENCE OF TYPE D PERSONALITY ON HEALTH RELATED QUALITY OF LIFE AND PHYSICAL
ACTIVITY IN PATIENTS ON DIALYSIS
C.R. Susanto, Elkerliek hospital, Helmond; C.J.A.M. Konings,
Catharina hospital, Eindhoven
P7. INTRAVENOUS IRON IN HOME HAEMODIALYSIS PATIENTS: WHAT TO DO?
LMA Vingerhoets, HW van Hamersvelt
Radboudumc Nijmegen, the Netherlands
Program – NfN Fall Symposium 2014
7
Poster session B (Clinical Nephrology II)
Chairs: Dr. F.J. Bemelman & PLAN representative
P8. RENAL 123I-mIBG SCINTIGRAPHY DEMONSTRATES FUNCTIONAL SYMPATHETIC
REINNERVATION OF THE HUMAN KIDNEY ALLOGRAFT.
1
2
3,
1
1
Linn C. Dobrowolski , Hein J. Verberne , Bert Jan van den Born Ineke J.M. ten Berge , Frederike J. Bemelman ,
1
C.T. Paul Krediet
1
Academic Medical Center at the University of Amsterdam, the Netherlands. Department of Internal Medicine – Nephrology
2
3
and Kidney Transplant Unit. Department of Nuclear Medicine. Department of Internal Medicine- Vascular Medicine
P9. HUMAN CYTOMEGALOVIRUS INFECTION INDUCES VIRAL CHEMOKINE RECEPTOR US28
EXPRESSION IN RENAL ALLOGRAFTS AND DEDIFFERENTIATION OF INFECTED CELLS
1
3
2
4
2
Wouter Lollinga *, Raymond H de Wit , Afsar Rahbar , Annelies Riezebos-Brilman , Cecilia Söderberg-Naucler ,
1
1
3
1
Willem van Son , Johannes S. Sanders , Martine J. Smit and Jacob van den Born
1
2
Department of Nephrology, UMC Groningen, Groningen, the Netherlands, Department of Medicine, Karolinska Institutet,
3
4
Stockholm, Sweden, Department of Medicinal Chemistry, VU University, Amsterdam, the Netherlands, Department of
Medical Microbiology, UMC Groningen, Groningen, the Netherlands
P10. THE OVERLOOKED ANTIHYPERTENSIVE POTENCY OF SULODEXIDE - A SYSTEMATIC REVIEW
AND META-ANALYSIS
1
1
3
3
2
RHG Olde Engberink , NMG Rorije , HJ Lambers-Heerspink , D de Zeeuw , BJH van den Born , L Vogt
1
1
2
Department of Nephrology and Vascular Medicine , AMC Amsterdam, Department of Clinical Pharmacy and
3
Pharmacology , UMCG Groningen
P11. ENDOCRINE-CEREBRO-OSTEODYSPLASIA SYNDROME IS A CILIARY DISORDER
1
1
2-4
1
5
6
Machteld M. Oud , Dorus A. Mans , C Anthony Rupar , Nathalie de Wagenaar , Piya Lahiry , Greg Pazour ,
2,7
1
2-4
1,2,7
Robert A. Hegele , Ronald Roepman , Vicky Siu* , Heleen H. Arts*#
1
Dept. of Human Genetics, Radboud Institute for Molecular Life Sciences and Radboud Institute for Health Sciences, Radboud
2
University Medical Centre, Nijmegen, The Netherlands; Dept. of Biochemistry, University of Western Ontario, London,
3
4
Ontario, Canada; Medical Genetics Program, London Health Sciences Centre, London, Ontario, Canada; Children’s Health
5
Research Institute, London, Ontario, Canada; Dept. of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada;
6
7
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA; Robarts
Research Institute, London, Ontario, Canada. * Equal contribution
P12. KOUNCIL: KIDNEY-ORIENTED UNDERSTANDING OF CORRECTING CILIOPATHIES
1
1
2
2
3
Kirsten Y. Renkema , Marijn F. Stokman , Machteld M. Oud , Jeroen van Reeuwijk , Marc R. Lilien , Nicole C.
4
1
2
1
2
5
van de Kar , Isaac J. Nijman , Christian Gilissen , Hester Y. Kroes , Ernie H.M.F. Bongers , Niels Geijsen , Erik-Jan
2
1,5
2
6
2
1
Kamsteeg , Edwin Cuppen , Ronald Roepman , Rachel H. Giles , Heleen H. Arts , Nine V.A.M. Knoers ,
KOUNCIL Consortium
1
2
3
Dept. of Medical Genetics, UMC Utrecht, Utrecht; Dept. of Human Genetics, Radboudumc, Nijmegen; Dept. of Pediatric
4
Nephrology, Wilhelmina Children’s Hospital, UMC Utrecht, Utrecht; Dept. of Pediatric Nephrology, Radboudumc, Nijmegen;
5
6
Hubrecht Institute, Utrecht; Dept. of Nephrology and Hypertension, UMC Utrecht, Utrecht
Program – NfN Fall Symposium 2014
8
Poster session C (Fundamental)
Chairs: Prof.dr. R. Goldschmeding & PLAN representative
P13. HUMAN PROXIMAL TUBULE EPITHELIAL CELLS CULTURED ON HOLLOW FIBERS: LIVING MEMBRANES THAT ACTIVELY TRANSPORT ORGANIC CATIONS
123
5
123
1
4
3
2
J Jansen , IE De Napoli , CM Schophuizen , MJ Wilmer , JFM Wetzels , LP van den Heuvel , JG Hoenderop , D
5
1
Stamatialis , R Masereeuw
1
2
3
4
Department of Pharmacology and Toxicology, Physiology, Pediatrics and Nephrology. Nijmegen Centre for Molecular Life
5
Sciences, Radboud University Medical Centre, 6500 HB, Nijmegen, The Netherlands. Department of Biomaterials Science
and Technology, MIRA - Biomedical Technology and Technical Medicine, University of Twente, 7500 AE, Enschede, The Netherlands
P14. THE ROLE OF YAP AND TAZ IN RENAL CYSTIC DISEASE
1
2
3
2
1
Sandra Kunnen , Steven Wink , Emile de Heer , Bob van de Water , and Dorien J.M. Peters
1
2
Dept of Human Genetics, Leiden University Medical Center, The Netherlands, Dept of Toxicology, Leiden Academic Centre
3
for Drug Research, The Netherlands, Dept of Pathology, Leiden University Medical Center, The Netherlands
P15. A HUMAN RENAL PROXIMAL TUBULE CELL LINE PREDICTIVE FOR DRUG-INDUCED
NEPHROTOXICITY
Tom TG Nieskens, Katja Jansen, Thom K van der Made, Martijn J Wilmer, Rosalinde Masereeuw
Department of Pharmacology and Toxicology, Radboudumc, Nijmegen, The Netherlands
P16. PRECISION-CUT KIDNEY SLICES (PCKS): A NOVEL MODEL TO STUDY DEVELOPMENT AND
TREATMENT OF RENAL FIBROSIS EX VIVO
1
2
1
3
1
2
F. Poosti , B.T.Pham , S. Huitema ,K. Poelstra ,H. van Goor , P. Olinga , J.L. Hillebrands
1
1
2
Depts. Pathology, University Medical Center Groningen, and Pharmaceutical Technology and Biopharmacy,
Pharmacokinetics,Toxicology and Targeting, University of Groningen, Groningen, the Netherlands.
3
P17. FUNCTIONAL CHARACTERIZATION OF AN ALTERNATIVE SPLICE VARIANT OF THE THIAZIDESENSITIVE NACL COTRANSPORTER
Omar A.Z. Tutakhel, Sabina Jeleń, Joost G.J. Hoenderop, and René J.M. Bindels,
Department of Physiology, Radboud university medical center, The Netherlands
P18. BLOCKING OF INFLAMMATORY HEPARAN SULFATE DOMAINS BY SINGLE CHAIN ANTIBODIES IS
NOT PROTECTIVE IN EXPERIMENTAL ANTI-GBM GLOMERULONEPHRITIS.
1
1
1
2
1
3
van Gemst J.J. , Rops A.L. , Passmann N. , van Kuppevelt T. , Berden J. , Rabelink T. , van der Vlag J.
1
2
1
Department of Nephrology, Department of Biochemistry, Radboud university medical center, Nijmegen, The Netherlands.
Einthoven Laboratory for Vascular Medicine, Department of Nephrology, Leiden University Medical Center, Leiden, The
Netherlands
3
Program – NfN Fall Symposium 2014
9
Abstracts – see separate abstract book
10
Program – NfN Fall Symposium 2014

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