Incidence of Grade 2+ neuropathy (%) C HR=1.731 ( 0.982-3.049) P=0.056 Data Cutoff 6 Apr 2012 100 90 Goshajinkigan N=74 80 70 60 50 40 30 Placebo N=68 20 10 HR=1.908 ( 1.181-3.083) P=0.007 Data Cutoff 21 Dec 2012 (%) Incidence of Grade 2+ neuropathy A 100 90 Goshajinkigan N=89 80 70 60 50 40 30 Placebo N=93 20 10 0 0 0 1 2 3 4 5 6 7 8 0 9 10 11 12 1 2 3 4 Time (month) 90 80 70 60 50 40 Placebo N=68 30 20 10 0 0 1 2 3 4 5 6 7 7 8 9 10 11 12 8 Time (month) 9 10 11 12 HR=1.771 ( 1.066-2.941) P=0.025 Data Cutoff 21 Dec 2012 (%) Incidence of Grade 2+ neuropathy Incidence of Grade 2+ neuropathy D Goshajinkigan N=74 100 6 Time (month) HR=2.022 ( 1.083-3.776) P=0.025 Data Cutoff 6 Apr 2012 (%) B 5 Goshajinkigan N=89 100 90 80 70 60 50 40 Placebo N=93 30 20 10 0 0 1 2 3 4 5 6 7 8 Time (month) 9 10 11 12 (%) Incidence of Grade 1+ neuropathy A 100 90 80 70 Goshajinkigan N=89 60 50 40 30 HR=1.450 (1.029-2.042) P=0. 051 Placebo N=93 20 10 0 0 1 2 3 4 5 6 7 8 9 10 11 12 Time (course) B Incidence of Grade 2+ neuropathy (%) 100 90 80 HR=1.774 (1.104-2.853) P=0.018 70 Goshajinkigan N=89 60 50 Placebo N=93 40 30 20 10 0 0 1 2 3 4 5 6 7 8 9 10 11 12 Time (course) C Incidence of Grade 3+ neuropathy (%) 100 90 HR=1.437 (0.640-3.228) P=0. 80 70 Goshajinkigan N=89 60 50 Placebo 40 30 20 10 0 0 1 2 3 4 5 6 7 8 9 10 11 12 Time (course) N=93
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