川崎病における全身性血管炎の サイトカイン特異性

a (ng/mg protein)
MMP-9
b
1800
**
1400
1200
**
**
1200
**
**
1000
1000
800
800
600
600
**
400
400
200
200
0
plasma
0.7
±1.7
(ng/ml)
0
granulo lymphocytes platelets
cytes
monocytes
212.0
±314.9
46.6
±62.2
11.9
±28.2
plasma
granulo
cytes
0.9
±1.2
(ng/ml)
d
lymphocytes platelets
monocytes
7.0
±12.0
16.1
±37.4
237.8
±265.0
1500
5000
4000
* **
**
** **
1000
1500
750
1000
**
** **
500
0
*
**
**
**
250
0
Kawasaki disease Purulent
Febrile Afebrile
Group Group Group
meningitis controls controls
1
2
3
54.0
±26.1
Kawasaki disease Purulent Febrile Afebrile
GroupGroup Group
meningitis controls controls
1
2
3
740.0 389.6 411.1
386.0 299.8 140.8
±429.2±467.7±336.6 ±275.3 ±195.2 ±61.4
MMP-9/TIMP-1
8
7
**
6
5
4
*
3
**
*
**
*
**
*
2
1
0
**
500
** **
**
212.1 139.7 130.4
1964.7 488.4
±1761.1 ±260.1 ±150.9 ±97.3 ±81.8
*
1250
2000
e
**: p<0.01 *: p<0.05
1400
1600
c
TIMP-1
(ng/mg protein)
Kawasaki disease
Group
1
Group
2
Group
3
2.5
±1.5
2.5
±2.2
0.5
±0.7
Purulent
meningitis
Febrile
controls
Afebrile
controls
0.6
±0.7
0.4
±0.3
0.4
±0.4