Brassinosteroid Metabolic Pathway in Arabidopsis
sterol biosynthesis
DET2
HO
O
DWF4
DWF4
OH
O
(24R)-ergost-4-en-3-one
(4-en-3-one)
campesterol (CR)
H (24R)-5-ergostan-3-one
HO
H
DWF4
OH
HO
campestanol(CN)
(3-one)
DWF4
OH
HO
6-oxoCN
DWF4
OH
OH
DET2
HO
O
O
22-hydroxyCR
HO
H
22-hydroxy-3-one
22-hydroxy-4-en-3-one
H
CYP90C1
CYP90D1
HO
OH
H
DET2
OH
22,23-dihydroxyCR
H
O
OH
OH
OH
OH
BR6ox1, 2
HO
teasterone (TE)
HO
6-deoxoTE
H
3-epi-6-deoxoCT CYP90C1
CYP90D1
OH
OH
OH
BR6ox1, 2
CYP90C1
CYP90D1
OH
cathasterone(CT)
O
OH
CYP90C1
CYP90D1
HO
H
CYP90C1
CYP90D1
OH
OH
CYP90C1
CYP90D1
HO
6-deoxoCT
O
O
22,23-dihydroxy-4-en-3-one
O
H
6-deoxo3DT
OH
HO
3-dehydroteasterone
(3DT)
OH
OH
OH
OH
OH
OH
OH
HO
H
6-deoxoCS
H
BR6ox1, 2
OH
O
edited by
HO
S. Fujioka &
Y. Shimada
HO
Glc
H
UGT73C5
OH
CS-23-O-glucoside
H
O
typhasterol(TY)
BAS1
HO
BR6ox2
OH
HO
O
castasterone(CS)
H
O
26-hydroxyCS
BAS1
OH
HO
H
HO
HO
OH
HO
HO
O
HO
6-deoxoTY
OH
OH
BR6ox1, 2
HO
HO
OH
OH
O
UGT73C5
brassinolide (BL)
HO
HO
O
OH
O
HO
HO
HO
Glc
HO
O
BL-23-O-glucoside
26-hydroxyBL