A CCAAT---N9----CCACG GGTTA---N9----GGTGC ERSE consensus mCRELD2-ALG12 ERSE -254 CCAATTGAGGCTCGCCACG -236 mCRELD2-ALG12 ERSE m1 CCAATTGAGGCTCGgatgt mCRELD2-ALG12 ERSE m2 gactaTGAGGCTCGCCACG B Tg 0 pGL3b ALG12 ERSE -361/+11 Relative luciferase activity 50 100 150 200 250 + + -361+11 m1 +-361/+11m2 +- C Tg 0 pGL3b CRELD2 + -229/-396 + -229/-396 m1 + -229/-396 m2 + Relative luciferase activity 10 20 30 40
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