第８回 生体分子物性セミナー ì ì ì 講師 Prof. Junqiu LIU State Key Lab of Supramolecular Structure and Materials, College of Chemistry, Jilin University 演題: Enzyme Design by RecogniDon and Self -‐ assembly ì 日時：2015年6月15日（月）16:00~17:30 ì 場所：B2棟 426号室（大会議室） ì 要 旨 ： E n z y m e s e x h i b i t h i g h s u b s t r a t e -‐ specificity and significantly accelerate reacDon rates. The substrate bin ding and the intracomplex interacDons of enzymes play important role s in strong catalyDc ability. As one of a series of anDoxidaDve selenoenz ymes in living organisms, glutathione peroxidase (GPx) catalyzes the re ducDon of harmful hydroperoxide by glutathione and protect biological molecules from oxidaDve stress in cells. We specify the development o f arDficial selenoenzyme based on molecular recogniDon and self-‐ assembly, several strategies containing chemical, biological and supra molecular strategies or the combinaDon of them have been developed to design selenoenzyme with high specificity and acDvity by using anDb ody, proteins, cyclodextrins, dandrimers, nanoparDcles and recently su pramolecular nanostructures as scaffolds. ì Acc. Chem. Res. 2012, 45, 239. Chem. Soc. Rev., 2012, 41, 7890. ì 連絡先：上野 隆史 内線5844
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