プレスリリース

2015 5 11 †WBGh‡8*6
@qg8*6Rl
U
UfHX~… QM[VY.7:)1%<4-#2xSHX€`‘ITbM’A?C=‹dbPn\db)-#<
2;'$db)-1!:;$9db€+<6HX†W
ziDO_LYas
@BGh‡‘qgh‡’8*6
~…
_Jm
UfHX
z
€_pITbMˆ>{iDO_LYKuxwY‡‚LY|H„O€I
Nƒ
_pZoBGh‡cŒr}^Eke
TyŠv
l]m€_p/$,LY‰":(0:-;35<&:
7$:t5j8gFŽ
1
)*,&#
.$
Ê%æf%]#& ª $ 1 ¤%TBQùª¤TBQú8r.fk¥Þù ª ¤ ¥Þúi7
,ª¤¥Þ&ÆÅXÜîTBQ%aPUSW%o±1bá²t%q—#0ïÚ"•s8¨
,ª¤TBQ¹
"ÏÉÀ›%v#0"5
ÆÅõŽ%aÖ´"!%¼²ÔÁ8“ä
Ý76,,µc†%‚ƒ#¼š5‡%t¶&
5·Œ%ŠÎ#%-Ó®²t8Ù
Ç36468ŠÎÓ®
}(,t¶ŠÎ
%…u8œx4Ó®²t8ACYG5ô#0ª¤¥Þó\,ª¤TB
Q8؁#q—5o‰òÂ6'LG%¬"À›%j¦#•Í"t¶%Ó®²
t8؁#q—52#"5
§–6,
*_ö%ª¤¥Þ%ÈÌ& 1990 ‘b%¥Þìe‰%ÂÛ8ˆ­
葘é#‹
~*_ö%ª¤TBQ& 4 %]©Ã"¥Þìe‰2(%çlÕß½¶5¥ÞCWK>
ã#2^#q—65
7,4 %¥Þìe‰ù¥ÞCWK>ãú&6
6 Clock (CLOCK), Bmal1 (BMAL1), Per (PER), Cry (CRY)
}'6ìe‹Xo‰¼¶‹#25:OVY
D#2{Œ6,ù€ 1úª¤¥Þ%R=IBQ
CLOCKBMAL1 %`ðfPer
Cry %[³% E-box
,çl%hë2(Õß#24¼¥ÞCWK>ã PER
%hë8Ù CLOCK
&&/#¥ÞCWK>ã
}'65íp#Òzçl%hë8Ù
CRY &`ðf8”žØ3%çl
BMAL1 %`ðf)Òzçl%hë%Ÿq8Ù,ù€ 1ú%
¥ÞCWK>ã#25²™u ŸqÙ765M;YHJE>UYO 1 ¤#Ð 1 |5
¬"¼»ºâ#5ª¤TBQ¼-n6,
!32'$
%-1"0+.%-/ CRY (
" KL001
ª¤¥Þ%]©8«ž5¥ÞCWK>ã#Ä¡g¾q—5o‰òÂ6'fk¥Þ%È
Ì8÷åÃ#ë5
,%2"o‰&6,*
9!Ç36,9
%2"¸°%]º ITbM #È̍8«
5AF;YNX@<¢ ’¿¯·dm¢ 3&2012 ‘#LG„øÑ×8¾uz¶A>TYIW?ùÐ 6 ZËö%uz¶ú3¥ÞCWK
>ã CRY #Ä¡g¾ª¤TBQ%|§8ñ5o‰ KL001 8ÂÛ,ùScience 2012, 337,
1094-1097ú
ù€ 1ú"3KL001 %o‰«êª¤TBQ#w+àÑ1£"²™o‰%y
2
´…*+!- ITbM T¡\¬l†gy»
wgyÌŸ›yf›Ÿy½­gy,¶l¦ª;RJ,°†2 ~boÒj
(¯"v#!°’KL001 •Äš…¤Í,Ž')$”N9Jn‘,&
(Ê(¥()`x,¢º)†e!
!KL001 •Äš…¤Í,Ž'q 2 ¨l†Œ™,§«u– KL001 ¿
|[l†,·!}Ágl›&( 3 —Î KL001 6.֓ 2 ,l†!!B
M8/J»w&) C-H 2<GNP5&'u–¿|[Ø4 % 5Ù,l†)†e
! C-H 2<GNP5 )BM8/J»wØA BÙi„c&²
Šs,|])Z²,z^a‚)
!œ;1F0PžØq±µÆ`Ù 4 Z
ň£²Šs,]*)
)»wYU‹‰'5ORG 2011 ~Ë¢BM8/
J»w BØÇÈBM8/J2,2’-DEN8O2,2,6,6-=>MK;OEHN8P 1-137OÙ"(
m5ORGL?R4l†»w‡¸Vp_m¦ª˜{£€d,’¼!
¦ª5ORGq 2 l†Œ™50 ©ÓXS¿|[,ÂÃl†!'*
'`x”N9Jh
Ðؚ…Ù,C>rÔ®³, Ÿ›š…¾Õ&Ž'
!•Äš…¤ÍØKL001 ¿|[Æ`•Äš…ɹٔ¹,q 3 ¨!
!2OA:ROÆZØqϵÆ`ÙN9JtÀš…ƒÑÆZ)+(!
[email protected]ÆZØq×µÆ`Ù%FMPžQ;1F0PžÆZØq±µÆ`ٚ…
˜{£É¹W$²
Š)k´)+(!'C-H 2
3
6>BD1#=AD€E5.=-D€ePq^¨]›‘¡S©B3?_™¤…
*™r&¡I&*Š|
ŽfB3?_™*M¡IN§ScWmv
}¦zJQu—ThScœž„•V%] 3 G\„•
B3?*¤&Sc…&ScH“L*‡LGO214 KL001 #%!B3
?*¤GO044 " GO211 B3?*…
$G\„•sScK‚{y*t$
&
—ŒUdn~x˜(
Yw*¤&Sc¨GO214©!…&Sc¨GO044 " GO211©! KL001 Xz CRY 4D;0
š FAD¨=A<D+79D2:0C.58©ŽW8@,DŽWK‚&Vl‡Z'
¨] 4©
Gg
iaScyŸ #B3?_™¤…l*R
ƒ[*t$
&j”%C-H /6>BD1–bvO‹WmUdo’
't$
'
l¢”K‚‰¥*Š|
CRY K‚B3?*…
&Sc„•*MGg†ˆ`p£*F&!k)'
4
);:0.!6&* GO214 (,) 73)2&* GO0448') 139 CRY
#4#"$
#KL0018#95
(
%-+/
%1STITbM >4#NB(U/;.7\5.7-ILK7AbLI
7]V.7O+aY/ST$cG?"
!3>+6QZ
;
,
;F8E'*A]<`HP:)Cd=2M_J
D9%1QZ+6'*A]0DR&X[@
'*A]^W>&X@
D9
5
Yz€v…
Angewandte Chemie International Editionƒ++,
wZA…
C-H Activation Generates Period-Shortening Molecules That Target the Cryptochrome in the
Mammalian Circadian Clock
ƒ1\u+yCryptochrome6gB^j
<IC-HcV=
$-Ee„
f;„
qo…
Tsuyoshi Oshima, Iori Yamanaka, Anupriya Kumar, Junichiro Yamaguchi,
Taeko Nishiwaki-Ohkawa, Kei Muto, Rika Kawamura, Tsuyoshi Hirota, Kazuhiro Yagita,
Stephan Irle, Steve A. Kay, Takashi Yoshimura, Kenichiro Itami
ƒGOxN/snAnupriya KumarN>d.|GQƒtp„HIarW
Q{}7Thb9_hDUStephan IrleSteve A. Kay@`P408.|„
wZ:~[… 2015R5]8[
A?MGJ(+-#fC<IklX (ITbM)
"-%!-: http://www.itbm.nagoya-u.ac.jp
408.|
TEL: 052-788-6098
E-mail: [email protected]
"-%!- (klK): http://synth.chem.nagoya-u.ac.jp/
@`P
TEL: 052-789-4056
E-mail: [email protected]
"-%!- (klK): http://www.agr.nagoya-u.ac.jp/~aphysiol/index.htm
A?MGJ ITbM )-*&-'+'+
L‚2iI,5rm3
TEL: +81-52-789-4999 FAX: +81-52-789-3240
E-mail: [email protected]
A?MGJSFK
TEL: +81-52-789-2016 FAX: +81-52-788-6272
E-mail: [email protected]
6