2015 5 11 WBGh8*6 @qg8*6Rl U UfHX~ QM[VY.7:)1%<4-#2xSHX`ITbMA?C=dbPn\db)-#< 2;'$db)-1!:;$9db+<6HXW ziDO_LYas @BGhqgh8*6 ~ _Jm UfHX z _pITbM>{iDO_LYKuxwYLY|HOI N _pZoBGhcr}^Eke Tyv l]m_p/$,LY":(0:-;35<&: 7$:t5j8gF 1 )*,&# .$ Ê%æf%]#& ª $ 1 ¤%TBQùª¤TBQú8r.fk¥Þù ª ¤ ¥Þúi7 ,ª¤¥Þ&ÆÅXÜîTBQ%aPUSW%o±1bá²t%q#0ïÚ"s8¨ ,ª¤TBQ¹ "ÏÉÀ%v#0"5 ÆÅõ%aÖ´"!%¼²ÔÁ8ä Ý76,,µc%#¼5%t¶& 5·%Î#%-Ó®²t8Ù Ç36468ÎÓ® }(,t¶Î % u8x4Ó®²t8ACYG5ô#0ª¤¥Þó\,ª¤TB Q8Ø#q5oòÂ6'LG%¬"À%j¦#Í"t¶%Ó®² t8Ø#q52#"5 §6, *_ö%ª¤¥Þ%ÈÌ& 1990 b%¥Þìe%ÂÛ8 èé# ~*_ö%ª¤TBQ& 4 %]©Ã"¥Þìe2(%çlÕß½¶5¥ÞCWK> ã#2^#q65 7,4 %¥Þìeù¥ÞCWK>ãú&6 6 Clock (CLOCK), Bmal1 (BMAL1), Per (PER), Cry (CRY) }'6ìeXo¼¶#25:OVY D#2{6,ù 1úª¤¥Þ%R=IBQ CLOCKBMAL1 %`ðfPer Cry %[³% E-box ,çl%hë2(Õß#24¼¥ÞCWK>ã PER %hë8Ù CLOCK &&/#¥ÞCWK>ã }'65íp#Òzçl%hë8Ù CRY &`ðf8Ø3%çl BMAL1 %`ðf)Òzçl%hë%q8Ù,ù 1ú% ¥ÞCWK>ã#25²u qÙ765M;YHJE>UYO 1 ¤#Ð 1 |5 ¬"¼»ºâ#5ª¤TBQ¼-n6, !32'$ %-1"0+.%-/ CRY ( " KL001 ª¤¥Þ%]©8«5¥ÞCWK>ã#Ä¡g¾q5oòÂ6'fk¥Þ%È Ì8÷åÃ#ë5 ,%2"o&6,* 9!Ç36,9 %2"¸°%]º ITbM #ÈÌ8« 5AF;YNX@<¢ ¿¯·dm¢ 3&2012 #LGøÑ×8¾uz¶A>TYIW?ùÐ 6 ZËö%uz¶ú3¥ÞCWK >ã CRY #Ä¡g¾ª¤TBQ%|§8ñ5o KL001 8ÂÛ,ùScience 2012, 337, 1094-1097ú ù 1ú"3KL001 %o«êª¤TBQ#w+àÑ1£"²o%y 2 ´ *+!- ITbM T¡\¬lgy» wgyÌyfy½gy,¶l¦ª;RJ,°2 ~boÒj (¯"v#!°KL001 Ä ¤Í,')$N9Jn,& (Ê(¥()`x,¢º)e! !KL001 Ä ¤Í,'q 2 ¨l,§«u KL001 ¿ |[l,·!}Ágl&( 3 Î KL001 6.Ö 2 ,l!!B M8/J»w&) C-H 2<GNP5&'u¿|[Ø4 % 5Ù,l)e ! C-H 2<GNP5 )BM8/J»wØA BÙic&² s,|])Z²,z^a) !;1F0PØq±µÆ`Ù 4 Z Å£²s,]*) )»wYU'5ORG 2011 ~Ë¢BM8/ J»w BØÇÈBM8/J2,2’-DEN8O2,2,6,6-=>MK;OEHN8P 1-137OÙ"( m5ORGL?R4l»w¸Vp_m¦ª{£d,¼! ¦ª5ORGq 2 l50 ©ÓXS¿|[,ÂÃl!'* '`xN9Jh ÐØ Ù,C>rÔ®³, ¾Õ&' !Ä ¤ÍØKL001 ¿|[Æ`Ä É¹Ù¹,q 3 ¨! !2OA:ROÆZØqϵÆ`ÙN9JtÀ ÑÆZ)+(! [email protected]ÆZØq×µÆ`Ù%FMPQ;1F0PÆZØq±µÆ`Ù {£É¹W$² )k´)+(!'C-H 2 3 6>BD1#=ADE5.=-DePq^¨]¡S©B3?_¤ *r&¡I&*| fB3?_*M¡IN§ScWmv }¦zJQuThScV%] 3 G\ B3?*¤&Sc &ScHL*LGO214 KL001 #%!B3 ?*¤GO044 " GO211 B3?* $G\sScK{y*t$ & Udn~x( Yw*¤&Sc¨GO214©! &Sc¨GO044 " GO211©! KL001 Xz CRY 4D;0 FAD¨=A<D+79D2:0C.58©W8@,DWK&VlZ' ¨] 4© Gg iaScy #B3?_¤ l*R [*t$ &j%C-H /6>BD1bvOWmUdo 't$ ' l¢K¥*| CRY KB3?* &Sc*MGg`p£*F&!k)' 4 );:0.!6&* GO214 (,) 73)2&* GO0448') 139 CRY #4#"$ #KL0018#95 ( %-+/ %1STITbM >4#NB(U/;.7\5.7-ILK7AbLI 7]V.7O+aY/ST$cG?" !3>+6QZ ; , ;F8E'*A]<`HP:)Cd=2M_J D9%1QZ+6'*A]0DR&X[@ '*A]^W>&X@ D9 5 Yzv Angewandte Chemie International Edition++, wZA C-H Activation Generates Period-Shortening Molecules That Target the Cryptochrome in the Mammalian Circadian Clock 1\u+yCryptochrome6gB^j <IC-HcV= $-Ee f; qo Tsuyoshi Oshima, Iori Yamanaka, Anupriya Kumar, Junichiro Yamaguchi, Taeko Nishiwaki-Ohkawa, Kei Muto, Rika Kawamura, Tsuyoshi Hirota, Kazuhiro Yagita, Stephan Irle, Steve A. Kay, Takashi Yoshimura, Kenichiro Itami GOxN/snAnupriya KumarN>d.|GQtpHIarW Q{}7Thb9_hDUStephan IrleSteve A. Kay@`P408.| wZ:~[ 2015R5]8[ A?MGJ(+-#fC<IklX (ITbM) "-%!-: http://www.itbm.nagoya-u.ac.jp 408.| TEL: 052-788-6098 E-mail: [email protected] "-%!- (klK): http://synth.chem.nagoya-u.ac.jp/ @`P TEL: 052-789-4056 E-mail: [email protected] "-%!- (klK): http://www.agr.nagoya-u.ac.jp/~aphysiol/index.htm A?MGJ ITbM )-*&-'+'+ L2iI,5rm3 TEL: +81-52-789-4999 FAX: +81-52-789-3240 E-mail: [email protected] A?MGJSFK TEL: +81-52-789-2016 FAX: +81-52-788-6272 E-mail: [email protected] 6
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