Fluorine and thyroid gland function: A review of the literature

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Klinische Wochenschrift
15. Juni 1984, Volume 62, Issue 12, pp 564-569
Fluorine and thyroid gland function: A review of the literature
Summary
The increasing use of fluoride for prevention of dental caries poses the problem as to whether this halogen
has antagonistic properties towards iodine, whereby it could hamper the success of iodine prophylaxis of
endemic goitre. Review of the literature shows that some authors have found an inhibition by fluoride of
various steps of thyroid hormone biosynthesis in animal experiments. By and large, the inhibition was
only slight and it was elicited only with fluoride doses greatly in excess of those recommended for caries
prevention. The inhibition was not consistently present and other authors could not confirm it in
comparable experiments. There is no convincing evidence that fluoride produces true goitres with
epithelial hyperplasia in experimental animals. There are some reports based on casual observations that
fluoride is goitrogenic in man. On the other hand, several good studies with adequate exposed and control
populations failed to detect any goitrogenic effect of fluoride in man. It is noteworthy in particular that
fluoride does not potentiate the consequences of iodine deficiency in populations with a borderline or low
iodine intake. Published data fail to support the view that fluoride, in doses recommended for caries
prevention, adversely affects the thyroid.
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3 Citations
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Fluorine and thyroid gland function: A review of the literature - Springer
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Title
Fluorine and thyroid gland function: A review of the literature
Journal
Klinische Wochenschrift
Volume 62, Issue 12 , pp 564-569
Cover Date
1984-06-01
DOI
10.1007/BF01728174
Print ISSN
0023-2173
Online ISSN
1432-1440
Publisher
Springer-Verlag
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Topics
Molecular Medicine
Internal Medicine
Keywords
Fluorine
Thyroid gland
Goitre
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Authors
H. Bürgi (1)
L. Siebenhüner (1)
E. Miloni (1)
Author Affiliations
1. Medizinische Klinik am Bürgerspital, Solothurn und Laboratorium für
Endokrinologie der Medizinischen Universitätsklinik Inselspital, Bern, Schweiz
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