Curriculum Vitae
Zhen Y. Jiang, Ph.D.
Departments of Pharmacology & Experimental Therapeutics and Medicine,
The Whitaker Cardiovascular Institute, Boston University School of Medicine
700 Albany Street, W-607 Boston, MA 02118
Tel: 617-638-4302; E-mail: [email protected]
Academic Training:
1993 Ph.D.
University College, University of London, U.K.-Biochemistry
1988 M.Sc.
Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union
Medical College, Beijing, China-Pharmacology
1983 M.D.
Jiangxi Medical College, Nanchang, Jiangxi, China -Medicine
Additional Training:
1996 - 2000
Research Fellow, Joslin Diabetes Institute/Harvard Medical School, Boston, MA
1994 - 1995
Research Fellow, Department of Pharmacology, University of London, London, UK
Academic Appointments:
2008 - 2013
Associate Professor, Diabetes and Obesity Research lab, Departments of Pharmacology
& Experimental Therapeutic & Medicine, Whitaker Cardiovascular Institute, Boston
University School of Medicine, Boston, MA
2008 - 2013
Assistant Professor, Diabetes and Obesity Research Center, Sanford-Burnham Medical
Research Institute at Lake Nona, Orlando, FL
2001 - 2008
Research Assistant Professor, Program in Molecular Medicine, University of
Massachusetts Medical School, Worcester, MA
Hospital Appointments or Other Employment:
1983 – 1985
Physician, Internal Medicine, Jingdezhen Municipal Hospital, Jingdezhen, Jiangxi, China
Honors:
2003 - 2006
1998 - 1999
1997 – 1998
1993 – 1994
1989 – 1993
American Diabetes Association Junior Faculty Award. Project: Using small interfering
RNA (siRNA)-induced gene silencing to analyze insulin signaling on Akt pathway and
its roles in glucose transport and in insulin-sensitive cells
NIH Training Fellowship-Project: Using IRS-1 knockout vascular cells and mice to study
insulin’s effect on VEGF expression and angiogenesis.
Mary K. Iacocca Research Fellowship-Project: Analyzing insulin signaling in vascular
tissue and liver in insulin resistant obese Zucker fa/fa rats
Fight for Sight (UK) Research Fellowship-Project: Using competitive RT-PCR technique
to study gene expression in retina and nerve of streptozotocin-induced diabetic rats
Research into Aging (UK) Scholarship-Project: Oxidative stress in diabetic
complications
Licenses and Certification:
N/A
Departmental and University Committees:
2011 - 2013
Member of the Institutional Animal Care and Use Committee (IACUC), StanfordBurnham Medical Research Center at Lake Nona, Orlando, FL
Teaching Experience and Responsibilities:
2008 – 2013
Teaching N/A, but did give regular faculty seminar at Sanford-Burnham Medical
Research Institute
Major Mentoring Activities:
Zhen Y. Jiang, Ph.D.
11/2008-6/2013
1/2009-9/2011
4/2010-6/2012
6/2011-1/2012
6/2009-6/2010
8/2012- Present
11/2012- Present
1/2014 – Present
1/2014 – Present
1/2014 – Present
1/2014 – Present
1/2014 – Present
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Xiangyang Xie PhD, Post-doctoral Fellow, Now a research scientist at Scripps Research
Institute, Florida.
Zhenwei Gong, PhD, Post-doctoral Fellow, Now a research associate at Albert Einstein
College of Medicine of Yeshiva University, Bronx, New York.
Virginie Mansuy-Aubert, PhD, Post-doctoral Fellow, Now an Instructor at University of
Texas Southwestern Medical School, Dallas.
Abdul R. Khan, PhD, Visiting PhD Student, Now Lecturer at Allied Hospital, Punjab
Medical College, Faisalabad 38800, Pakistan.
Daniel Sehrt, BA, Intern, Now a medical school student at University of Center Florida
Medical School, Orlando.
Karla Candelaria BA, Currently Intern in the lab
Boris Jun-Yuan Huang PhD, Currently Post-doctoral Fellow in the lab
Maria Valero Munoz, PhD, Currently Post-doctoral Fellow in the lab
Ye Song, PhD, Currently Visiting Scientist in the lab
William Pellegrini, BU undergraduate student in the lab
Danielle Conneely, BU undergraduate student in the lab
Andria Sharma, BU undergraduate student in the lab
Course Teaching:
04/2014 – Present Diabetic Pharmacology: Boston University School of Medicine, PhD System
Pharmacology II - Endocrinology, Diabetes and hypoglycemics
Major Administrative Responsibilities:
06/2011-08 2013 Sanford-Burnham Medical Research Institute (Orlando) IACUC member
Other Professional Activities:
Professional Societies: Memberships, Offices, and Committee Assignments:
7/1996 – present American Diabetes Association
1990 – 1995
Editorial Boards:
2012 – Present
British Diabetes Association
Adipocyte Editorial Board Member
Services
2011 - 2013: IACUC member at Sanford-Burnham Medical Research Institute at Lake Nona
2012 - Present: Adipocyte Editorial Board Member
2014: Organizing Committee Chair – Immune Cells and Metabolism (Boston University Interdisciplinary
Symposium, 11/21/2014)
2014: Section Chair for “ Adipose Tissue Development and Metabolic Signaling, ADA’s 74th scientific
Sessions, June 14, 2014 in San Francisco, CA
2014: Moderator for “ Hormonal and Cellular Signaling in Diabetes”, ADA’s 74th scientific
Sessions, June 16, 2014 in San Francisco, CA
Major Committee Assignments:
American Diabetes Association, Grant review occasionally
American Heart Association, Grant review occasionally
Diabetes UK, Grant review occasionally
Zhen Y. Jiang, Ph.D.
3
Other Support:
Current:
07/01/2012 – 05/31/2017 5 R01DK094025-02 (NIH/NIDDK) PI: Zhen Y. Jiang, Phosphoprotein CDP138
Regulates Glucose Metabolism,
07/01/2011 – 06/30/2014 American Diabetes Association Basic Science Award, PI: Zhen Y. Jiang, Novel
protein PPC2D fuctions as a converging point for GLUT4 translocation
Past:
07/01/2010 – 05/30/2012 1 R21 NS066450-01A1 (NIH/NINDS) PI: Zhen Y. Jiang, High content screening
assay for activators of glucose transporter GLUT4
07/01/2003 – 06/30/2006 American Diabetes Association Junior Faculty Award, PI: Zhen Y. Jiang, Using
small intergvering RNA (siRNA)-induced gene silencing to analyze insulin signaling on
Akt pathway and its roles in glucose transport and in insulin-sensitive cells.
Invited Lectures and Conference Presentations:
June 10, 2014
Boston Nutrition Obesity research Center Seminar: Neutrophil activation at the early
stage of inflammation in diet-induced obesity, Boston University School of Medicine.
May 23, 2013
Seleted seminar presentation for Faculty Retread: The imbalance between neutrophil
elastase and it inhibitor alpha-1-antitrypsin in obesity plays key role in metabolic
functions, Sanford-Burnham Medical Research Institute, San Diego, CA
June 13, 2012
Seminar, Identification of New Players Involved in Metabolic Functions Using Proteomic
Approaches, The Whitaker Cardiovascular Institute, Boston University School of
Medicine, Boston, MA
May 23, 2011
Seminar, Novel C2 domain containing phosphoprotein regulates glucose transport and
GLUT4 translocation. University of Central Florida, Orlando, Florida
February, 2008
Seminar: Analyzing insulin signaling networks and metabolic functions using quantitative
proteomics approach. Sanford-Burnham Medical Research Institute, San Diego, CA
March 26, 2008
Seminar: Using quantitative proteomics and RNAi-based functional analysis to identify
potential drug targets for diabetes and its complications. Chinese Academy of Sciences,
Guangzhou Institute of Biomedicine and Health, Guanzhou, China.
January, 2007
Rab3A is Required for Constitutive and Insulin-Stimulated Secretion of Adiponectin.,
Short presentation at Keystone Symposium: Diabetes: Molecular Genetics, Signaling
Pathways and Integrated Physiology (J1)
June, 2004
Identification of Protein Kinase WNK1 as a Novel Substrate of AKT/Protein Kinase B
and Regulator of Insulin-Stimulated DNA Synthesis. Oral presentation at American
Diabetes Association 64th Scientific sessions. Orlando, Florida.
June, 2003
Insulin Signaling through Akt/PKB Analyzed by siRNA-Mediated Gene Silencing. Oral
presentation at American Diabetes Association 63rd Scientific sessions. New Orleans,
Louisiana.
June, 1998
Selective Insulin Resistance in PI 3-Kinase Pathway in Vasculature of Obese Zuker fa/fa
Rats. Oral presentation at American Diabetes Association 58th Scientific sessions.
Chicago.
Bibliography:
Original, Preer Reviewed Articles:
1. Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, Khan AR, Aubert G, Candelaria K, Thomas S,
Shin DJ, Booth S, Baig SM, Bilal A, Hwang D, Zhang H, Lovell-Badge R, Smith SR, Awan FR, Jiang
ZY. Imbalance between neutrophil elastase and its inhibitor α1-antitrypsin in obesity alters insulin
Zhen Y. Jiang, Ph.D.
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sensitivity, inflammation, and energy expenditure. Cell Metabolism 2013 Apr 2;17(4):534-48.
PMID:23562077/PMC3646573.
2. Xie X, Gong Z, Mansuy-Aubert V, Zhou QL, Tatulian SA, Sehrt D, Gnad F, Brill LM, Motamedchaboki
K, Chen Y, Czech MP, Mann M, Krüger M, Jiang ZY. C2 domain-containing phosphoprotein CDP138
regulates GLUT4 insertion into the plasma membrane. Cell Metabolism 2011 Sep 7;14(3):378-89.
PMID: 21907143.
3. Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J,
Nicoloro S, Chawla A, Czech MP. A novel pleckstrin homology domain-containing protein enhances
insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem. 2010 Sep
3;285(36):27581-9. PMID: 20587420.
4. Zhou QL, Jiang ZY, Holik J, Chawla A, Hagan GN, Leszyk J, Czech MP. Akt substrate TBC1D1
regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes. Biochem J. 2008 May
1;411(3):647-55. PMID: 18215134.
5. Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP. Identification of
WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis
in 3T3-L1 cells. J Biol Chem. 2005 Jun 3;280(22):21622-8. PMID: 15799971.
6. Zhou QL, Park JG, Jiang ZY, Holik J, Mitra P, Semitz S, Guilherme A, Powelka AM, Tang X,
Virbasius J, Czech MP. Analysis of insulin signaling by si RNA-b ased gene Silencing. Biochemical
Soc. Transactions 32:817-21. 2004.
7. Jiang ZY, Zhou QL, Coleman KA, Chouinard M, Boese Q, Czech MP. Insulin signaling through
Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U
S A. 2003 Jun 24;100(13):7569-74. PMID: 12808134.
8. Jiang ZY, He Z, King BL, Kuroki T, Opland DM, Suzuma K, Suzuma I, Ueki K, Kulkarni RN, Kahn
CR, King GL. Characterization of multiple signaling pathways of insulin in the regulation of vascular
endothelial growth factor expression in vascular cells and angiogenesis. J. Biol.Chem.278:31964-71.
2003.
9. Bose A, Guilherme A, Robida SI, Nicoloro SM, Zhou QL, Jiang ZY, Pomerleau DP, Czech MP.
Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Nature. 2002 Dec
19-26;420(6917):821-4. PMID: 12490950.
10. Jiang ZY, Chawla A, Bose A, Way M, Czech MP. A PI 3-kinase-independent Insulin Signaling
Pathway through N-WASP-Arp2-3/F-Actinin Required for GLUT4 Glucose Transporter Recycling. J.
Biol. Chem. 277:509-515. 2002.
11. Jiang ZY, Zhou QL, Chatterjee A, Feener EP, Myers MG Jr, White MF, King GL. Endothelin-1
modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle
cells. Diabetes. 1999 May;48(5):1120-30. PMID: 10331419.
12. Jiang ZY, Zhou QL, Eaton JW, Koppenol WH, Hunt JV, Wolff SP. Spirohydantoin inhibitors of aldose
reductase inhibit iron- and copper-catalysed ascorbate oxidation in vitro. Biochem Pharmacol. 1991
Aug 22;42(6):1273-8.PMID: 1909528.
13. Kuboki K, Jiang ZY, Takahara N, Ha SW, Igarashi M, Yamauchi T, Feener EP, Herbert TP, Rhodes
CJ, King GL. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial
cells and in vivo : a specific vascular action of insulin. Circulation. 2000 Feb 15;101(6):676-81. PMID:
10673261.
14. Cai W, Rook SL, Jiang ZY, Takahara N, Aiello LP. Mechanisms of hepatocyte growth factor-induced
retinal endothelial cell migration and growth. Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1885-93.
PMID: 10845613.
15. Goldfine AB, Patti ME, Zuberi L, Goldstein BJ, LeBlanc R, Landaker EJ, Jiang ZY, Willsky GR, Kahn
CR. Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in
vivo and in vitro studies. Metabolism. 2000 Mar;49(3):400-10. PMID: 10726921.
16. Jiang ZY, Lin YW, Clermont AC, Feener EP, Hein KD, Igarashi M, Yamauchi T, White MF, King GL.
Selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J. Clin. Invest.
104:447-57. 1999.
Zhen Y. Jiang, Ph.D.
5
17. Jiang ZY, Zhou QL, Chatterjee A, Feener EP, Myers Jr. MG, White MF, King GL. Endothelin-1
modulates insulin signaling through PI3-kinase pathway in vascular smooth muscle cells. Diabetes
48:1120 -30, 1999.
18. Igarashi M, Wakasaki H, Takahara N, Ishii H, Jiang ZY, Yamauchi T, Kuboki K, Meier M, Rhodes CJ,
King GL. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J
Clin Invest. 1999 Jan;103(2):185-95. PMID: 9916130.
19. Fang C, Jiang Z, Tomlinson. Expression of constitutive cyclo-oxygenase (COX-1) in rats with
streptozotocin-induced diabetes; effects of treatment with evening primrose oil or an aldose reductase
inhibitor on COX-1 mRNA levels. Prostaglands, Leukotrienens and Essential Fatty Acits 56:167-63,
1997.
20. Xia P, Aiello, Jiang ZY, Park DJ, Robinson GS, Takagi H, Newsome WP, Jirousek MR, King GL.
Characterization of vascular endothelial growth factor’s effect on the activation of protein kinase C, its
isoforms and endothelial cell growth. J. Clin. Invest. 98:2018-2026, 1996.
21. Takagi C, Bussell S-E, Lin Y-W, Takagi H, Duh E, Jiang Z, Clermont AC, King GL. Regulation of
retinal hemodynamics in diabetic rats by increased expression and action of ET-1. Investigative
Ophthalmology Visual Science 37: 2504-18, 1996.
22. Jiang Z, Xie MZ. The hypoglycemic effect of AH—9. Zhongguo Yi Xue Ke Hue Yuan Xue Bao.
15(4):235-41, 1993. (Chinese.)
23. Jiang Z, Xie MZ. The antioxidant action of AH-9. Zhongguo Yi Xue Ke Hue Yuan Xue Bao. 15(4):2914, 1993. (Chinese.)
24. Hunt JV, Jiang ZY, Wolff SP. Formation of hydrogen peroxide by lens proteins: protein-derived
hydrogen peroxide as a potential mechanism of oxidative insult to the lens. Free Radic Biol Med. 1992
Oct;13(4):319-23. PMID: 1398215.
25. Jiang ZY, Hunt JV, Wolff SP. Ferrous ion oxidation in the presence of xylenol orange for detection of
lipid hydroperoxide in low density lipoprotein. Anal Biochem. 1992 May 1;202(2):384-9. PMID:
1519766.
26. Jiang ZY, Zhou QL, Eaton JW, Koppenol WH, Hunt JV, Wolff SP. Spirohydantoin inhibitors of aldose
reductase inhibit iron- and copper-catalysed ascorbate oxidation in vitro. Biochem Pharmacol. 1991 Aug
22;42(6):1273-8. PMID: 1909528.
27. Jiang ZY, Woollard AC, Wolff SP. Hydrogen peroxide production during experimental protein
glycation. FEBS Lett. 1990 Jul 30;268(1):69-71. PMID: 2384174.
28. Wolff SP, Jiang ZY. Free radical and cataract: direct chemical damage or exaggerated physiological
response? In “Eye lens membranes and Aging,” Eds. Vrensen GFJM, Clauweaert J, Eurage, The
Netherland, pp. 221-31. 1991.
Reviews and Chapters:
Editorials and Critical Reviews:
1. Zhou QL, Park JG, Jiang ZY, Holik JJ, Mitra P, Semiz S, Guilherme A, Powelka AM, Tang X,
Virbasius J, Czech MP. Analysis of insulin signalling by RNAi-based gene silencing. Biochem Soc
Trans. 2004 Nov;32(Pt 5):817-21. Review. PMID: 15494023.
2. Wolff SP, Jiang ZY, Hunt JV. Protein glycation and oxidative stress in diabetes mellitus and ageing.
Free Radic Biol Med. 1991;10(5):339-52. Review. PMID: 1855674.
Textbook Chapters:
1. Jiang ZY, Towler HMA, Luthert P, Lightman SL. Pathophysiology of diabetic retinopathy. A review
chapter in “Diabetes Mellitus: A Fundamental and Clnical Text.” Eds: LeRoith D, Taylor SI, Olefsky
JM. Lippincott-Raven Publisher, Philadelphia, PA. pp. 719-27. 1996.

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