Giao Q. Phan, M.D., F.A.C.S.
Associate Professor, Division of Surgical Oncology, Department of Surgery
Virginia Commonwealth University / Massey Cancer Center
1200 E. Broad Street, P.O. Box 980011, Richmond, VA 23398-0011
Email: [email protected]; Office: (804) 828-9325
Updated: July 18, 2014
SPECIALTY
Surgical oncology, endocrine surgery, and immunotherapy
EDUCATION
Sept 1989 – May 1993
Columbia University: Columbia College, New York, New York
Bachelor of Arts, Biochemistry
Sept 1993 – May 1997
Johns Hopkins University School of Medicine, Baltimore, Maryland
Doctor of Medicine
POSTDOCTORAL TRAINING
July 1997 – June 1999
Ohio State University Medical Center, Columbus, Ohio
General Surgery Residency: PGY-1 and PGY-2
July 1999 – June 2004
Surgery Branch, National Cancer Institute
National Institutes of Health, Bethesda, Maryland
Immunotherapy and Surgical Oncology Research Fellowship
July 2004 – June 2007
Washington University School of Medicine, St. Louis, Missouri
General Surgery Residency: PGY-3/PGY-4/PGY-5
July 2007 – June 2009
Moffitt Cancer Center, Tampa, Florida
Surgical Oncology Fellowship
CERTIFICATIONS
2007
SAGES Fundamentals of Laparoscopic Surgery
2009
American Board of Surgery
2009
American College of Surgeons - Thyroid and Parathyroid Ultrasound
MEDICAL LICENSURE
1999 – 2000
Ohio
2000 – Present
Maryland
2014 – Present
Virginia
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GIAO Q. PHAN, M.D., F.A.C.S.
AWARDS / HONORS
1992–1993
National Science Foundation Undergraduate Research Fellowship
Department of Chemistry, Columbia University, New York, New York
2002
American Society of Clinical Oncology Merit Award
“Quality of life in patients with metastatic renal cell cancer receiving
different regimens of interleukin-2: A randomized trial”
Preceptor: James C. Yang, National Cancer Institute
2003
American Society of Clinical Oncology Merit Award
“Cancer regression and autoimmunity induced by CTLA-4 blockade in
patients with metastatic melanoma”
Preceptor: Steven A. Rosenberg, National Cancer Institute
2004
NIH Fellows Award for Research Excellence
2007
Medical Student Teaching Award
Department of Surgery, Washington University, St. Louis, Missouri
2010
Team Science Award, Cancer Immunotherapy and Biological Therapy
Society for Immunotherapy of Cancer (SITC) 25th Annual Meeting
EMPLOYMENT
July 2009 – June 2014
Staff Clinician
Surgery Branch, National Cancer Institute
National Institutes of Health, Bethesda, Maryland
July 2014 – Present
Associate Professor
Division of Surgical Oncology, Department of Surgery
Virginia Commonwealth University, Richmond, Virginia
July 2014 – Present
General Surgeon (Surgical Oncology and Endocrine Surgery)
McGuire Veterans Administration Medical Center, Richmond, Virginia
TEACHING ACTIVITIES
July 2009 – June 2014
Faculty, Immunotherapy & Surgical Oncology Fellowships
Surgery Branch, National Cancer Institute
National Institutes of Health, Bethesda, Maryland
July 2014 – Present
Associate Professor
Department of Surgery, Division of Surgical Oncology
Virginia Commonwealth University, Richmond, Virginia
COMMITTEES
2009 – 2012
American Society of Clinical Oncology: Professional Development
Committee; Career Development Subcommittee
2014
Guest judge, NIH Graduate Student Research Symposium
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GIAO Q. PHAN, M.D., F.A.C.S.
JOURNAL REVIEWS / Ad-hoc Reviewer
Journal of Immunotherapy
Cancer Therapy
Clinical Cancer Research
Head and Neck
The Cancer Journal: Principles and Practice of Oncology
BMC Cancer
Annals of the New York Academy of Sciences
Science Translational Medicine
BJC - British Journal of Cancer
PROFESSIONAL MEMBERSHIPS
American Association for Cancer Research (AACR)
American Association of Endocrine Surgeons (AAES)
American College of Surgeons (ACS)
American Society of Clinical Oncology (ASCO)
American Thyroid Association (ATA)
Association for Academic Surgery (AAS)
Association of Women Surgeons (AWS)
International Association of Endocrine Surgeons (IAES)
International Society of Surgery (ISS)
Society for Immunotherapy of Cancer (SITC)
Society of Surgical Oncology (SSO)
The Endocrine Society
PEER-REVIEWED PUBLICATIONS
1.
Ying-zi X, Phan G, Yakushijin K, Horne DA. A synthesis of (±) hymenin. Tetrahedron Letters
1994; 35(3): 351-354.
2.
Phan GQ and Heitmiller RF. Intramural esophageal dissection: Case report and review of the
literature. Annals of Thoracic Surgery 1997; 63(6): 1785-1786.
3.
Phan GQ, Yeo CJ, Cameron JL, Maher MM, Hruban RH, Udelsman R. Pancreaticoduodenectomy
for selected periampullary neuroendocrine tumors: 50 patients. Surgery 1997; 122(6): 989-997.
4.
Phan GQ, Yeo CJ, Hruban RH, Lillemoe KD, Pitt HA, Cameron JL. Surgical experience with
pancreatic and peripancreatic neuroendocrine tumors: 125 patients. Journal of Gastrointestinal
Surgery 1998; 2(5): 472-482.
5.
Ohnmacht GA, Phan GQ, Mavroukakis SA, Steinberg SA, Shea YR, Witebsky FG, McIntyre LS,
Goodwin RS, Muehlbauer PM, Morton KE, Rogers-Freezer LJ, Seipp CA, Rosenberg SA, Marincola
FM. A prospective, randomized, double-blind, placebo-controlled trial evaluating the impact of
nystatin on the development of oral irritation in patients receiving high-dose intravenous interleukin2. Journal of Immunotherapy 2001; 24(2): 188-192.
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GIAO Q. PHAN, M.D., F.A.C.S.
6.
Phan GQ, Attia P, Steinberg SM, White DE, Rosenberg SA. Factors associated with response to
high-dose interleukin-2 in patients with metastatic melanoma. Journal of Clinical Oncology 2001;
19(15): 3477-3482.
7.
Mocellin S, Fetsch P, Abati A, Phan GQ, Wang E, Provenzano M, Stroncek D, Rosenberg SA,
Marincola FM. Laser scanning cytometry evaluation of MART-1, gp100, and HLA-A2 expression in
melanoma metastases. Journal of Immunotherapy 2001; 24(6): 447-458.
8.
Panelli MC, Wang E, Phan G, Puhlmann M, Miller L, Ohnmacht GA, Klein HG, Marincola FM.
Gene-expression profiling of the response of peripheral blood mononuclear cells and melanoma
metastases to systemic IL-2 administration. Genome Biology 2002; 3(7): 0035.
9.
Attia P, Phan GQ, Duray PH, Rosenberg SA. Parathyroid hormone-related protein and
hypercalcemia in patients with metastatic melanoma: Case report and review. American Journal of
Clinical Oncology 2003; 26(1): 42-45.
10.
Bettinotti MP, Panelli MC, Ruppe E, Mocellin S, Phan GQ, White DE, Marincola FM. Clinical and
immunological evaluation of patients with metastatic melanoma undergoing immunization with the
HLA-Cw*0702 associated epitope MAGE-A12:170-178. International Journal of Cancer 2003;
105(2): 210-216.
11.
Phan GQ, Touloukian CE, Yang JC, Restifo NP, Sherry RM, Hwu P, Topalian SL, Schwartzentruber
DJ, Seipp CA, Freezer LJ, Morton KE, Mavroukakis SA, White DE, Rosenberg SA. Immunization
of patients with metastatic melanoma using both class I- and class II-restricted peptides from
melanoma-associated antigens. Journal of Immunotherapy 2003; 26(4): 349-356.
12.
Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, Restifo NP, Haworth
LR, Seipp CA, Freezer LJ, Morton KE, Mavroukakis SA, Duray PH, Steinberg SM, Allison JP, Davis
TA, Rosenberg SA. Cancer regression and autoimmunity induced by CTLA-4 blockade in patients
with metastatic melanoma. Proceedings of the National Academy of Sciences, U.S.A. 2003;
100(14): 8372-8377.
13.
Chang E, Chalikonda S, Friedl J, Xu H, Phan GQ, Marincola FM, Alexander HR, Bartlett DL.
Targeting vaccinia to solid tumors with local hyperthermia. Human Gene Therapy 2005; 16(4):
435-444.
14.
Attia P, Phan GQ, Maker AV, Robinson MR, Quezado MM, Yang JC, Sherry RM, Topalian SL,
Kammula US, Royal RE, Haworth LR, Levy C, Mavroukakis SA, Yellin MJ, Rosenberg SA.
Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with
anti-CTLA-4. Journal of Clinical Oncology 2005; 23(25): 6043-6053.
15.
Maker AV, Phan GQ, Attia P, Yang JC, Sherry RM, Topalian SL, Kammula US, Royal RE, Haworth
LR, Levy C, Kleiner D, Mavroukakis SA, Yellin M, Rosenberg SA. Tumor regression and
autoimmunity in patients treated with CTLA-4 blockade and IL-2: A phase I/II study. Annals of
Surgical Oncology 2005; 12(12): 1005-1016.
16.
Phan GQ, Weber JS, Sondak VK. CTLA-4 blockade with monoclonal antibodies in patients with
metastatic cancer: Surgical issues. Annals of Surgical Oncology 2008; 15(11): 3014-3021.
17.
Phan GQ, Messina JL, Sondak VK, Zager JS. Sentinel lymph node biopsy for melanoma:
Indications and rationale. Cancer Control 2009; 16(3): 234-239.
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GIAO Q. PHAN, M.D., F.A.C.S.
18.
Dudley ME, Gross CA, Langhan MM, Garcia MR, Sherry RM, Yang JC, Phan GQ, Kammula US,
Hughes MS, Citrin DE, Restifo NP, Wunderlich JR, Prieto PA, Hong JJ, Langan RC, Zlott DA,
Morton KE, White DE, Laurencot CM, Rosenberg SA. CD8+ enriched "young" tumor infiltrating
lymphocytes can mediate regression of metastatic melanoma. Clinical Cancer Research 2010;
16(24): 6122-6131.
19.
Mathur A, Kemp CD, Dutta U, Baid S, Ayala A, Chang RE, Steinberg SM, Papademetriou V, Lange
E, Libutti SK, Pingpank JF, Alexander HR, Phan GQ, Hughes M, Linehan WM, Pinto PA, Stratakis
CA, Kebebew E. Consequences of adrenal venous sampling in primary hyperaldosteronism and
predictors of unilateral adrenal disease. Journal of the American College of Surgeons 2010;
211(3): 384-390.
20.
Parkhurst MR, Yang JC, Langan RC, Dudley ME, Nathan DA, Feldman SA, Davis JL, Morgan RA,
Merino MJ, Sherry RM, Hughes MS, Kammula US, Phan GQ, Lim RM, Wank SA, Restifo NP,
Robbins PF, Laurencot CM, Rosenberg SA. T cells targeting carcinoembryonic antigen can mediate
regression of metastatic colorectal cancer but induce severe transient colitis. Molecular Therapy
2011; 19(3): 620-626.
21.
Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, Citrin DE, Restifo NP,
Robbins PF, Wunderlich JR, Morton KE, Laurencot CM, Steinberg SM, White DE, Dudley ME.
Durable complete responses in heavily pretreated patients with metastatic melanoma using T cell
transfer immunotherapy. Clinical Cancer Research 2011; 17(13): 4550-4557.
22.
Kitano M, Millo C, Rahbari R, Herscovitch P, Gesuwan K, Webb RC, Venkatesan AM, Phan GQ,
Hughes MS, Libutti SK, Nilubol N, Linehan WM, Kebebew E. Comparison of 6-18F-Fluoro-LDOPA, 18F-2-deoxy-D-glucose, CT, and MRI in patients with pancreatic neuroendocrine neoplasms
with von Hippel-Lindau disease. Surgery 2011; 150(6): 1122-1128.
23.
Kochenderfer JN, Dudley ME, Feldman SA, Wilson WH, Spaner DE, Maric I, Stetler-Stevenson M,
Phan GQ, Hughes MS, Sherry RM, Yang JC, Kammula US, Devillier L, Carpenter R, Nathan DA,
Morgan RA, Laurencot C, Rosenberg SA. B-cell depletion and remissions of malignancy along with
cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T
cells. Blood 2012; 119(12): 2709-2720.
24.
Prieto PA, Yang JC, Sherry RM, Hughes MS, Kammula US, White DE, Levy CL, Rosenberg SA,
Phan GQ. CTLA-4 blockade with ipilimumab: Long-term follow-up of 177 patients with metastatic
melanoma. Clinical Cancer Research 2012; 18(7): 2039-2047.
25.
Nilubol N, Weinstein L, Simonds WF, Jensen RT, Phan GQ, Hughes MS, Libutti SK, Marx S,
Kebebew E. Preoperative localizing studies for initial parathyroidectomy in MEN1 syndrome: Is
there any benefit? World Journal of Surgery 2012; 36(6): 1368-1374.
26.
Yavuz S, Simonds WF, Weinstein LS, Collins MT, Kebebew E, Nilubol N, Phan GQ, Libutti SK,
Remaley AT, Van Deventer M, Marx SJ. Sleeping parathyroid tumor: Rapid hyperfunction after
removal of the dominant tumor. Journal of Clinical Endocrinology & Metabolism 2012; 97(6):
1834-1841.
27.
Inchauste SM, Lanier BJ, Libutti SK, Phan GQ, Nilubol N, Steinberg SM, Kebebew E, Hughes MS.
Rate of clinically significant postoperative pancreatic fistula in pancreatic neuroendocrine tumors.
World Journal of Surgery 2012; 36(7): 1517-1526.
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GIAO Q. PHAN, M.D., F.A.C.S.
28.
Buck CB, Phan GQ, Raiji MT, Murphy PM, McDermott DH, McBride AA. Complete genome
sequence of a tenth human polyomavirus. Journal of Virology 2012; 86(19): 10887.
29.
Turcotte S, Turkbey B, Barak S, Libutti SK, Alexander HR, Linehan WM, Hughes MS, Nilubol N,
Gesuwan K, Millo C, Quezado M, Choyke PL, Kebebew E, Phan GQ. von Hippel-Lindau diseaseassociated solid microcystic serous adenomas masquerading as pancreatic neuroendocrine neoplasms.
Surgery 2012; 152(6): 1106-1117.
30.
Schaub NP, Alimchandani M, Quezado M, Kalina P, Eberhardt JS, Hughes MS, Beresnev T, Hassan
R, Bartlett DL, Libutti SK, Pingpank JF, Royal RE, Kammula US, Pandalai P, Phan GQ,
Stojadinovic A, Rudloff U, Alexander HR, Avital I. A novel nomogram for peritoneal mesothelioma
predicts survival. Annals of Surgical Oncology 2013; 20(2): 555-561.
31.
Morgan RA, Chinnasamy N, Abate-Daga D, Gross A, Robbins PF, Zheng Z, Dudley ME, Feldman
SA, Yang JC, Sherry RM, Phan GQ, Hughes MS, Kammula US, Miller AD, Hessman CJ, Stewart
AA, Restifo NP, Quezado MM, Alimchandani M, Rosenberg AZ, Nath A, Wang T, Bielekova B,
Wuest SC, Akula N, McMahon FJ, Wilde S, Mosetter B, Schendel DJ, Laurencot CM, Rosenberg SA.
Cancer regression and neurologic toxicity following anti-MAGE-A3 TCR gene therapy. Journal of
Immunotherapy 2013; 36(2): 133-151.
32.
Dudley ME, Gross CA, Somerville RPT, Hong Y, Schaub NP, Rosati SF, White DE, Nathan D,
Restifo NP, Steinberg SM, Wunderlich JR, Kammula US, Sherry RM, Yang JC, Phan GQ, Hughes
MS, Laurencot CM, Rosenberg SA. Randomized selection design trial evaluating CD8+-enriched
versus unselected tumor-infiltrating lymphocytes for adoptive cell therapy of patients with melanoma.
Journal of Clinical Oncology 2013; 31(17):2152-2159.
33.
Nilubol N, Weisbrod AB, Weinstein LS, Simonds WF, Jensen RT, Phan GQ, Hughes MS, Libutti
SK, Marx S, Kebebew E. Utility of intraoperative parathyroid hormone monitoring in patients with
multiple endocrine neoplasia type 1-associated primary hyperparathyroidism undergoing initial
parathyroidectomy. World Journal of Surgery 2013; 37(8):1966-1972.
34.
Phan GQ and Rosenberg SA. Adoptive cell transfer for patients with metastatic melanoma: The
potential and promise of cancer immunotherapy. Cancer Control 2013; 20(4):289-297.
35.
Pastrana DV, Fitzgerald PC, Phan GQ, Raiji MT, Murphy PM, McDermott DH, Velez D, Bliskovsky
V, McBride AA, Buck CB. A divergent variant of the eleventh human polyomavirus species, Saint
Louis polyomavirus. Genome Announcements 2013; 1(5):e00812-e00813.
36.
Lee P, Linderman JD, Smith S, Brychta RJ, Wang J, Idelson C, Perron RM, Werner CD, Phan GQ,
Kammula US, Kebebew E, Pacak K, Chen KY, Celi FS. Irisin and FGF21 Are Cold-Induced
Endocrine Activators of Brown Fat Function in Humans. Cell Metabolism 2014; 19(2):302-309.
37.
Kochenderfer JN, Dudley ME, Kassim SH, Somerville RPT, Carpenter RO, Stetler-Stevenson M,
Yang JC, Phan GQ, Hughes MS, Sherry RM, Raffeld M, Feldman SA, Lu L, Li YF, Ngo LT, Goy A,
Feldman T, Spaner DE, Wang M, Chen CC, Kranick SM, Nath A, Nathan DA, Morton KE, Toomey
MA, Rosenberg SA. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell
malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric
antigen receptor. Journal of Clinical Oncology (in press).
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GIAO Q. PHAN, M.D., F.A.C.S.
INVITED PUBLICATIONS
1.
Wang E, Phan GQ, Marincola FM. T-cell-directed cancer vaccines: The melanoma model. Expert
Opinion on Biological Therapy 2001; 1(2): 277-290.
2.
Phan GQ, Wang E, Marincola FM. T-cell-directed cancer vaccines: Mechanisms of immune escape
and immune tolerance. Expert Opinion on Biological Therapy 2001; 1(3): 511-524.
3.
Phan GQ. Breaking bad news. ASCO Connection March 2012: 38-39.
BOOK CHAPTERS
1.
Phan GQ, Vaughann A, Aft RL. Breast Diseases. In: Klingensmith ME, Chen E, Glasgow SC, et
al (Eds.), The Washington Manual of Surgery, Fifth Edition. Philadelphia: Lippincott Williams
and Wilkins, 2008: 453-470.
2.
Phan GQ. Non-specific immune activation. In: DeVita VT, Jr., Lawrence TS, and Steven A.
Rosenberg SA (Eds.), Cancer: Principles and Practice of Oncology, Tenth Edition : Lippincott
Williams and Wilkins (in press).
NATIONAL PRESENTATIONS (as First Author or Senior Author)
1997
Phan GQ, Yeo CJ, Cameron JL, Maher MM, Hruban RH, Udelsman R.
“Pancreaticoduodenectomy for selected periampullary neuroendocrine tumors: 50 patients.”
Presented at the 18th Annual Meeting of the American Association of Endocrine Surgeons,
Baltimore, Maryland, April 6-8, 1997.
1997
Phan GQ, Yeo CJ, Hruban RH, Lillemoe KD, Pitt HA, Cameron JL. “Surgical experience
with pancreatic and peripancreatic neuroendocrine tumors: 125 patients.”
Presented at the 38th Annual Meeting of the Society for Surgery of the Alimentary Tract,
Washington D.C., May 11-14, 1997.
2001
Phan GQ, Attia P, Steinberg SM, White DE, Rosenberg SA. “Factors associated with
response to high-dose interleukin-2 in patients with metastatic melanoma.”
Presented at the 37th Annual Meeting of the American Society of Clinical Oncology, San
Francisco, California, May 12-15, 2001.
2002
Phan GQ, Morton KE, Liewehr DJ, Steinberg SM, Rosenberg SA, Yang JC. “Quality of life
in patients with metastatic renal cell cancer receiving different regimens of interleukin-2: A
randomized trial.”
Presented at the 38th Annual Meeting of the American Society of Clinical Oncology,
Orlando, Florida, May 18-21, 2002 (Merit Award).
2003
Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, Restifo NP,
Haworth LR, Seipp CA, Freezer LJ, Morton KE, Mavroukakis SA, Duray PH, Steinberg SM,
Allison JP, Davis TA, Rosenberg SA. “Cancer regression and autoimmunity induced by
CTLA-4 blockade in patients with metastatic melanoma.”
Presented at the 39th Annual Meeting of the American Society of Clinical Oncology,
Chicago, Illinois, May 31-June 3, 2003 (Merit Award).
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GIAO Q. PHAN, M.D., F.A.C.S.
2009
Phan GQ, Williams VL, Padhya TA. “Thyroid cancer in the U.S. Hispanic population.”
Presented at the 62nd Annual Meeting of the Society of Surgical Oncology, Phoenix,
Arizona, March 4-8, 2009.
2010
Prieto PA, Yang JC, Sherry RM, Hughes MS, Kammula US, White DE, Levy CL, Rosenberg
SA, Phan GQ. “Cytotoxic T lymphocyte-associated antigen 4 blockade with ipilimumab:
Long-term follow-up of 179 patients with metastatic melanoma.”
Presented at the 46th Annual Meeting of the American Society of Clinical Oncology,
Chicago, Illinois, June 4-10, 2010.
2011
Park TS, Lagisetty KH, Sherry RM, Yang JC, Hughes MS, White DE, Morton KE, Klionsky
YM, Rosenberg SA, Phan GQ. “Routine imaging to detect recurrences in high-risk melanoma
patients.”
Presented at the 47th Annual Meeting of the American Society of Clinical Oncology,
Chicago, Illinois, June 3-7, 2011.
2012
Turcotte S, Turkbey B, Barak S, Libutti SK, Alexander HR, Linehan WM, Hughes MS,
Nilubol N, Gesuwan K, Millo C, Quezado M, Choyke PL, Kebebew E, Phan GQ.
“von Hippel-Lindau disease-associated solid microcystic adenomas masquerading as pancreatic
neuroendocrine tumors.”
Presented at the 33rd Annual Meeting of the American Association of Endocrine Surgeons,
Iowa City, Iowa, April 29-May 1, 2012.
2014
Ilyas S, Wang HW, Condarco T, Klemen N, Sharma ST, Filie A, Quezado MM, Phan GQ.
“Hyalinizing trabecular tumor of the thyroid in a patient with metastatic melanoma.”
To be presented at the 84th Annual Meeting of the American Thyroid Association,
Coronado, California, October 29-November 2, 2014.
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