CURRICULUM VITAE DATE: January 2, 2015 Employee ID Number: 241750 NAME AND TITLES: Anish Bhardwaj, M.D., M.B.A., C.P.E. FAHA, FCCM, FAAN, FANA PRESENT POSITION(S): Chairman, Department of Neurology John Sealy Chair of Neurology Professor of Neurology, Neurosurgery, Neuroscience and Cell Biology Associate Dean for Faculty Affairs University of Texas Medical Branch (UTMB) OFFICE ADDRESS: Department of Neurology, UTMB 9.128 John Sealy Annex, Route 0539 301 University Boulevard Galveston, TX 77555 E-mail: [email protected] HOME ADDRESS: 2 Porch Street Galveston, Texas 77554 OFFICE PHONE NUMBER: 409-772-8068 FAX : 409-772-6940 E-MAIL ADDRESS: [email protected] CITIZENSHIP: United States MARITAL STATUS: Married; Spouse – Carissa Bhardwaj Daughter – Lara Marika Bhardwaj Page 1 EDUCATION September 1975- June 1978 “Advanced” Level (Biology, Chemistry, Physics); Federal School of Arts and Science, Sokoto, Nigeria September 1978- June 1984 College of Medicine, University of Ibadan, Nigeria March 2011- January 2013 Masters in Business Administration (MBA), D’Amore-McKim School of Business, Northeastern University, Boston, MA February 2013 Program for Chiefs of Clinical Services, Department of Health Policy and Management, Harvard School of Public Health, Boston, MA July 2013 Physician Executive Certification (C.P.E) Program, Certifying Commission in Medical Management (CCMM), Denver, CO September 2014 Executive Development Seminar for Associate Deans and Department Chairs, American Academy of Medical Colleges (AAMC), Tempe, AZ BOARD CERTIFICATIONS 2013 Certified Physician Executive (C.P.E.), CCMM 2011-2021 Diplomate, American Board of Psychiatry and Neurology; Recertification, # 49954 2008-2018 Diplomate, Vascular Neurology; American Board of Psychiatry and Neurology, # 402 2007-2017 Subspecialty Certification in Neurocritical Care; United Council on Neurologic Specialties , # NCC00208-07 2001-2011 Diplomate, American Board of Psychiatry and Neurology, # 49954 LICENSURES 2013 Texas State medical License, # P8118 (Active) 2009 Massachusetts State Medical License, # 240533 (Active) 2005 Oregon State Medical License, # MD 26074 (Inactive) 1994 Maryland State Medical License, # D46058 (Inactive) 1992 New York State Medical License, # 190482-1 (Inactive) Page 2 LICENSURES (CONT’D) 1988 Federal licensing Examination (FLEX), # 00131 1987 Educational Commission for Foreign Medical Graduates (ECFMG) # 416-218-6 1985 Permanent Member, Nigeria Medical Council (NMC) PROFESSIONAL WORK HISTORY POSTDOCTORAL TRAINING 1984-1985 Internship, University College Hospital, Ibadan, Nigeria 1987-1989 Research Fellow, Department of Neurology, Mount Sinai School of Medicine (SOM), New York, NY 1989-1990 Internship in Internal Medicine, Elmhurst Hospital, Mount SOM, New York, NY 1990-1992 Resident in Neurology, Mount Sinai SOM, New York, NY 1992-1993 Chief Resident in Neurology, Mount Sinai SOM, New York, NY 1993-1995 Fellow, Neuroscience Critical Care, Johns Hopkins University SOM, Baltimore, Maryland 1994-1995 Fellow, National Stroke Association, Johns Hopkins University SOM, Baltimore, Maryland ACADEMIC APPOINTMENTS 1995-1996 Instructor, Departments of Neurology, Neurological Surgery, Anesthesiology and Critical Care Medicine, Johns Hopkins University SOM, Baltimore, Maryland 2000 - 2001 Associate Director, Neurosciences Critical Care Division, Johns Hopkins University SOM, Baltimore, Maryland 1996-2002 Assistant Professor, Department of Neurology, Johns Hopkins University SOM, Baltimore, Maryland 1996-2002 Assistant Professor, Department of Neurological Surgery, Johns Hopkins University SOM, Baltimore, Maryland 1996-2002 Assistant Professor, Anesthesiology and Critical Care Medicine, Johns Hopkins University SOM, Baltimore, Maryland Page 3 ACADEMIC APPOINTMENTS (CONT’D) 1996-2005 Director, Neurosciences Critical Care Fellowship Training Program, Johns Hopkins University SOM, Baltimore, Maryland 2003-2005 Vice Chairman, Department of Neurology, Johns Hopkins University SOM, Baltimore, Maryland 2003-2005 Associate Professor, Department of Neurology, Johns Hopkins University SOM, Baltimore, Maryland 2003-2005 Associate Professor, Department of Neurological Surgery, Johns Hopkins University SOM, Baltimore, Maryland 2003-2005 Associate Professor, Anesthesiology and Critical Care Medicine, Johns Hopkins University SOM, Baltimore, Maryland 2001-2005 Co-Director, Neurosciences Critical Care Division, Johns Hopkins University SOM, Baltimore, Maryland 2006-2009 Professor, Department of Neurology, Oregon Health & Science University, Portland, Oregon 2006-2009 Professor, Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon 2006-2009 Professor, Department of Anesthesiology and Peri-operative Medicine, Oregon Health & Science University, Portland, Oregon 2006-2009 Founding Director, Neurosciences Critical Care Program, Oregon Health & Science University, Portland, Oregon 2006-2009 Director, Neuroscience Stroke laboratory, Oregon Health & Science University, Portland, Oregon 2008 - 2009 Vice Chairman, Department of Neurology, Oregon Health & Science University, Portland, Oregon 2009- 2013 Chairman, Department of Neurology, Tufts University SOM, Boston, Massachusetts 2009-2013 Professor, Department of Neurology, Tufts University SOM, Boston, Massachusetts 2009-2013 Professor, Department of Neurosurgery, Tufts University SOM, Boston, Massachusetts 2009- 2013 Professor, Department of Neuroscience, Tufts University SOM, Boston, Massachusetts Page 4 ACADEMIC APPOINTMENTS (CONT’D) 2013-Present John Sealy Chairman of Neurology, University of Texas Medical Branch (UTMB), Galveston, Texas 2013-Present Professor of Neurology (Tenured), UTMB, Galveston, Texas 2013-Present Professor of Neurosurgery, UTMB, Galveston, Texas 2013-Present Professor of Neuroscience and Cell Biology, UTMB, Galveston, Texas 2013-2014 Assistant Dean for Faculty Affairs, UTMB, Galveston, Texas 2013-2014 Acting Director, George & Cynthia Mitchell Center for Neurodegenerative Disorders, Department of Neurology, UTMB, Galveston, Texas 2014-Present Associate Dean for Faculty Affairs, UTMB, Galveston, Texas HOSPITAL APPOINTMENTS 1985-1986 Medical Officer, Sokoto Clinic, Sokoto, Nigeria 1995-2005 Staff Attending, Neuroscience Critical Care Unit, Johns Hopkins Hospital, Baltimore, Maryland 2000-2005 Staff Attending, Neuroscience Critical Care Unit, Bayview Medical Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 2006-2009 Staff Attending, Neuroscience Critical Care Program, Oregon Health & Science University, Portland, Oregon 2006-2009 Founding Director, Neurocritical Care Unit, Oregon Health & Science University, Portland, Oregon 2009- 2013 Neurologist-in-Chief, Tufts Medical Center, Boston, Massachusetts 2011- 2013 Founding Director, Michael Neely Neuroscience Center, Tufts Medical Center, Boston, Massachusetts 2013-Present Attending Neurologist, UTMB, Galveston, Texas 2013-Present Founding Director, Neurosciences Critical Care Unit, UTMB, Galveston, Texas Page 5 TEACHING AND MENTORSHIP 2013-Present Chairman Lectures and Morning Report, Department of Neurology, UTMB, Galveston, Texas 2009-2013 Chairman Lectures and Morning Report, Department of Neurology, Tufts University SOM, Boston, Massachusetts 2011 – 2013 Director, Neuroscience Critical Care Fellowship Training Program, Tufts University SOM, Boston, Massachusetts 2009 – 2013 Lecturer, Neuroscience Course for second year medical students, Tufts University SOM, Boston, Massachusetts 2006-2009 Director, Neuroscience Critical Care Fellowship Training Program, Oregon Health & Science University, Portland, Oregon 1996-2005 Director, Neuroscience Critical Care Fellowship Training Program, Johns Hopkins University SOM, Baltimore, Maryland 1995-2005 Coordinator, Medical student and Resident elective rotations in the Neurosciences Critical Care Division, Johns Hopkins University SOM; Didactic teaching/lectures to house staff fellows 1993-1995 Coordinator, Clinical and Didactic Training of Neurology, Neurosurgery, and Anesthesiology Residents, Neurosciences Critical Care Division, Johns Hopkins University SOM; Supervisor, Neurocritical Care Fellows-in-Training 1990-1993 Mount Sinai SOM - Coordinated Clinical and Scientific Training of Neurology, Neurosurgery, and Psychiatry Residents and Interns; Didactic Lectures for Senior Medical Students Page 6 MENTORING AND TRAINING OF GRADUATE STUDENTS/POST-DOCTORAL FELLOWS TRAINEES PRESENT POSITION Theodore Stiefel Research Assistant June-September 1994 The Johns Hopkins Hospital Baltimore, Maryland Not Known Renata Rusa, M.D. Neurocritical Care Fellow 1996-1998 Jose I. Suarez, M.D. Neurocritical Care Fellow 1996-1998 Associate Professor Department of Anesthesiology Oregon Health & Science University Portland, Oregon Director, Neuro-ICU and Vascular Neurology Professor of Neurology Baylor College of Medicine Cleveland, Ohio *Adnan I. Qureshi, M.D. Neurocritical Care Fellow 1996-1998 Har Hiu Dawn Lam, Ph.D. Fellowship, Visiting Graduate Student, University of Cambridge, United Kingdom 07/96-09/96; 9/97-01/98 Ophthalmologist Stanford University, California Masahiko Sawada, M.D. PhD Post-Doctoral Fellow 9/96-06-98 Assistant Professor of Neurology University of Saitama, Japan *J. Ricardo Carhuapoma, M.D. Neurocritical Care Fellow 1997-1999 Professor, Neurology and Interventional Neuroradiology University of Minnesota, MN *Recepient of Dalland Fellowship, American Philosophical Society, 1997-1999 Assistant Professor of Neurology, Neuro-ICU Attending Johns Hopkins University SOM Baltimore, Maryland * Recipient of Dalland Fellowship, American Philosophical Society, 1998-2000 Page 7 TRAINEES PRESENT POSITION * Romergryko Geocadin, M.D. Neurocritical Care Fellow 1997-1998 Associate Professor, Department of Neurology, The Johns Hopkins Hospital, Baltimore, Maryland * Recipient of the Corporate Rountable Fellowship Award American Academy of Neurology, 2000-2002. *Parag D. Parekh Undergraduate Last position: Medical Student Clinical Research student University of Pennsylvania 1996-1998 Present Position: Not Known *Recipient of the Student Scholarship in Cerebrovascular Disease, American Heart Association, 1998. Panyanoitis Varelas, M.D. Neurocritical Care Fellow 1998-2000 Abutaher M. Yahia, M.D. Neurocritical Care Fellow 1998-2000 Christine Wijman, M.D. (Posthumus 2013) Neurocritical Care Fellow 6/1998 – 12/1998 Professor, Neurology and Neurological Surgery Director, Neuro-ICU Henry Ford Hospital, Detroit, MI Last position: Assistant Professor of Neurology, Ohio State University Present Position: Not Known Director, Neurocritical Care Program Associate Professor Stanford University, California *Michel Torbey, M.D., M.P.H. Neurocritical Care Fellow 1999-2001 Director, Stroke Critical Care Program; Professor of Neurology Ohio state University, Ohio *Recipient of the Postdoctoral Fellowship Award, Mid-Atlantic Affiliate, American Heart Association, 2000 Wendy Ziai, M.D., M.P.H. Neurocritical Care Fellow NCC Division Fellow 1999-2001 *Patricia Waters Mentored Summer Fellowship *Recipient of the Student Scholarship, American Heart Association, 1999. Page 8 Associate Professor Attending, Neuro-ICU The Johns Hopkins Hospital Baltimore, Maryland TRAINEES PRESENT POSITION Veronica Chiang, M.D. Neurocritical Care 01-07/2000 Assistant Professor Neurological Surgery Yale University SOM, Connecticut Mitzi Hemstreet, M.D., Ph.D. Neurocritical Care Fellow 2000-2002 Anesthesiologist Philadelphia, PA Toru Goyagi, M.D., Ph.D. Post-Doctoral Fellow 09/1999-06/2001 Assistant Professor of Anesthesiology University of Saitama, Japan Chere Monique-Chase, M.D., M.H.S. Neurocritical Care Fellow 2001-2003 Director, Stroke and Neurocritical Care, The Johns Hopkins Hospital Foresyth Medical Institutions, North Carolina Diana chandos-Green, M.D. Neurocritical Care Fellow 2001-2002 Agnieszka Aldelt, M.D., Ph.D. Neurocritical Care Fellow 2002-2004 Neurologist Greater Baltimore Medical Center Baltimore, Maryland Assistant Professor of Neurology Attending Physician Neurosciences Critical Care Division University of Chicago Connie L. Chen, M.D. Attending Neurologist Presbyterian Hospital of Dallas Texas Neurocritical Care Fellow 2002-2004 Assistant Professor Co-Director, Neuro-ICU Grady Hospital, Emory University School of Medicine, Atlanta Wendy L. Wright, M.D. Neurocritical Care Fellow 2002-2004 Zhizheng Zhang, M.D. Post-Doctoral Research Fellow Last Position: Post-Doctoral 2002-2003 Research Fellow Oregon Health & Science University, Portland, Oregon Present Position: Not Known Page 9 TRAINEES PRESENT POSITION Tsung-Ying Chen, M.D. Post-Doctoral Research Fellow Associate Professor of Neurology 2002-2003 Attending Anesthesiologist University of Taiwan, Taiwan Yi Chang, M.D. Assistant Professor Post-Doctoral Research Fellow Attending Anesthesiologist 2002-2003 Shin Kong Wu ho-Su Memorial Hospital, Taiwan Attending Neurologist Director, Neurocritical Care Joao Gomes, M.D. Neurocritical Care Fellow 2003-2005 Hartford Hospital Center, Connecticut Neurologist Christopher Milford, M.D. Neurocritical Care Fellow 2003-2004 Clark County Medical Center, Las Vegas, Nevada Julio A. Chelala, M.D. Neurocritical Care Fellow 2003-2005 Associate Professor Director, Neurocritical Care Program Medical University of South Carolina, Charleston Neeraj Naval, M.D. Neurocritical Care Fellow 2004-2006 Assistant Professor Director, Neuro-ICU Bayview Medical Center, The Johns Hopkins Medical Institutions Baltimore, Maryland Abhijt Lele, M.D. Neurocritical Care Fellow 2004-2005 Anesthesiologist Richmond, VA. Lunei Fitzsimmons, M.D. Neurocritical Care Fellow 2004-2006 Anesthesiologist Washington D.C. Chih-Hung Chen, M.D. Assistant Professor of Neurology Post-Doctoral Research Fellow University of Taiwan, Tainen, 2004-2006 Taiwan Page 10 TRAINEES PRESENT POSITION Emil Zeynalov, M.D. Post-Doctoral Research Fellow Last Position: Johns Hopkins 2004-2006 University SOM, Baltimore, Maryland Present Position: Not Known Matthew Koenig, M.D. Neurocritical Care Fellow 2005-2007 Assistant Professor of Neurology Attending, Neuro-IVU Queen Hospital, Honolulu, Hawaii Tamer Abdelhak, M.D. Neurocritical Care Fellow 2005-2007 Assistant Professor of Neurology Attending, Henry Ford Hospital Detroit, MI Xiaoqin Liu, M.D. Post-Doctoral Research Fellow Last Position: Oregon Health & 2006-2008 Science University, Portland, OR Present Position: Not Known Bing Zhang, M.D. Post-Doctoral Research Fellow Last position: Oregon Health & 2006-2008 Science University, Portland, Oregon Present Position: Not Known Post-Doctoral Research Fellow Last position: Oregon Health & 2007-2009 Science University, Portland, Oregon Shin Nakayama, M.D. Elton Migliati, Ph.D. Last position: Oregon Health & Post-Doctoral Research Fellow Science University, Portland, 2007-2009 Oregon Kuroiwa, Masayuki, Ph.D. Post-Doctoral Research Fellow Last position: Oregon Health & 2007-2009 Science University, Portland, Oregon Ines Koerner, M.D., PH.D. Neurocritical Care Fellow 2007-2008 Assistant Professor of Anesthesiology and Neurology Oregon Health & Science University, Portland, Oregon Kamila Vagnerova, M.D. Neurocritical Care Fellow 2008-2009 Assistant Professor of Anesthesiology and Neurology OHSU, Portland, Oregon Page 11 PRESENT POSITION TRAINEES Jeremy Fields, M.D. Venkata Dandamudi, M.D. Neurocritical Care Fellow 2008-2009 Neurocritical Care Fellow 2011-2013 Assistant Professor of Neurology Oregon Health & Science University, Portland, Oregon Assistant Professor of Neurology and Radiology; UTMB THESIS ADVISOR Role: Candidate: Project: Program: Dates: Faculty Advisor Benjamin Levin Chronic Traumatic Encephalopathy: Clinical considerations of a long term complication in high contact sports Degree of Masters of Science in Biomedical Science Tufts University SOM 2011-2012 Page 12 RESEARCH MAJOR LABORATORY RESEARCH FOCUS AND INTERESTS In vivo pathophysiological mechanisms of ischemic neuronal injury in appropriate animal models of cerebral ischemia In vivo regional neurochemistry in brain injury paradigms Pathophysiological mechanisms in cerebral ischemia-evoked cerebral edema Pharmacological neuroprotection in ischemic stroke Osmotherapy in brain injury PREVIOUS RESEARCH GRANT SUPPORT Grant Title: Funding Agency: Amount: Role: Period: Osmotherapy in Acute Ischemic Stroke National Institutes of Health - RO1 NINDS $ 231, 250; Total: $1,156,250 Principal Investigator 01/04/04-03/31/2009 (No cost extension until 03/31/2010) Grant Title: Brain Research/Acute Interventions: Neurological Emergencies Treatment Trials (NeTS - Networking Technology and Systems) National Institute of Neurological Disorders and Stroke (U10) $1,401,750 Co-Investigator (Principal Investigator: Bob Lowe) 10/2007 – 08/2012 Funding Agency: Amount: Role: Period: Grant Title: Funding Agency: Amount: Role: Period: Award: Role: Source: Title: Dates: Effort: Amount: Hemodynamic Monitoring by Transpulmonary Thermodilution (PiCCO) Compared to Pulmonary Artery Catheterization in Patients with Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage Medical Research Foundation, Oregon Health & Science University $19,565 Sponsor and Mentor (Principal Investigator: Zachary Litvack) 12/1/2008 – 11/30/2009 Program Project-Cellular and Molecular Mechanisms Regulating Nutritive Blood Flow (D.R. Harder, Program Director) Co-Investigator, Project 3 NIH/NHLBI Role of Cytochrome P450 Epoxygenase Activity in the Cerebral Circulatory response to Neuronal Activation 04/01/99 - 03/31/2004 40% $166,446 (Subcontract) Page 13 PREVIOUS RESEARCH GRANT SUPPORT (CONT’D) Award: Role: Source: Title: Dates: Percent Effort: 5PO1 NS20020 Mechanisms of Regulation of Cerebral Blood Flow Program Director: Richard J. Traystman, PhD Co-Investigator, Project 1 National Institutes of Health Sigma Receptor signaling in Focal Cerebral Ischemia 12/1/97-11/30/2002 20% Award: Role: Source: Title: Dates: Effort: Amount: RO1 NS33668 P.I. Patricia D. Hurn, RN, PhD Co-Investigator NIH/NHLBI Cerebral Ischemia in the Female 04/01/99- 03/31/2002 10% $161,816 Award: Role: Source: Title: Dates: Effort: Amount: Scientist Development Award Co-Investigator; P.I. Stephanie Murphie, VMD, PhD American Heart Association Female reproductive steroids and experimental stroke in reproductively senescent rats 01/01/2000 - 12/31/2004 5% $ 260,000 Award: Role: Source: Title: Dates: Amount: Clinician-Scientist Award Principal Investigator American Heart Association Role of Nitric Oxide in Excitotoxic and Ischemia Induced Neuronal Injury 1996-2001 $ 200,000 Award: Role: Source: Title: Fellowship Career Development Award Principal Investigator National Stroke Association Nitric Oxide, Excitatory Amino Acids and Adenosine as Modulators of Cerebral Blood Flow and Metabolism in Cerebral Ischemia. 07/94-06/96 $ 46,000 Dates: Amount: Page 14 PREVIOUS RESEARCH GRANT SUPPORT (CONT’D) Award: Role: Source: Title: Dates: Amount: Richard S. Ross Clinician Scientist Award Principal Investigator The Johns Hopkins University SOM Role of Nitric Oxide in Excitotoxic and Ischemia Induced Neuronal Injury 01/96-12/97 $ 50,839 Award: Role: Source: Title: Dates: Amount: Initiation Award Principal Investigator American Heart Association Hyperosmolar therapy in acute experimental Focal Ischemia 1999-2000 $ 36,300 Award: Role: Source: Title: Student Scholarship in Cerebrovascular Disease - Parag D. Parekh Faculty Preceptor American Heart Association Cerebral Edema in Intracerebral Hemorrhage: Time Course and Effect of Hypertonic Saline 02/98 - 01/99 $ 2,000 Dates: Amount: TRAINING GRANT PARTICIPATION Award: Role: Source: Title: Dates: Amount: Award: Role: Source: Title: Dates: Amount: Clinical Research Grant Faculty Mentor and Preceptor; P.I. Michel T. Torbey, MD, MPH. Anesthesiology/Critical Care Medicine, Johns Hopkins University SOM Markers and Outcome Predictors of Brain Injury in Patients following Cardiac Arrest 04/01/2000 – 03/31/2001 $ 5000 Post-Doctoral Fellowship award Mentor and Preceptor; P.I. Michel T. Torbey, MD, MPH. Mid-Atlantic Affiliate, American Heart Association Markers and Outcome Predictors of Brain Injury in Patients following Cardiac Arrest 07/01/2000 -6/30/2002 $ 60,000 Page 15 TRAINING GRANT PARTICIPATION (CONT’D) Award: Role: Source: Title: Dates: Amount: Student Scholarship in Cerebrovascular Disease (Student: Parag D. Parekh) Faculty Preceptor American Heart Association Cerebral Edema in Intracerebral Hemorrhage: Time Course and Effect of Hypertonic Saline 02/98 - 01/99 $ 2,000 CLINICAL RESEARCH Special interest in: 1) neuroprotective clinical trials in focal cerebral ischemia; 2) Monitoring techniques in critically ill patients with acute brain injury from diverse etiologies Study: Role: Dates: Source: Study: Role: Dates: Source: Study: Role: Dates: Source: Study: Role: Dates: Source: Safety and Efficacy of IV Ancrod in acute ischemic stroke (Parallel, Group sequential, Double-blind, Randomized, Placebo-controlled, Multi-Center Trial). Principal Investigator 10/96-01/98 Knoll Pharmaceuticals Safety and Efficacy Study of Tirilizad Mesylate in North American Women with Subarachnoid Hemorrhage (MultiCenter Trial, Placebo-controlled, Double-Blind Trial). Co-Investigator 06/95-12/96 UpJohn, Kalamazoo, MI Safety and Efficacy Study of SB-238592-DB (Bradykinin antagonist) in Patients with Severe Traumatic Brain Injury (Multi-Center, Placebo-controlled, Double-Blind Trial). Co-Investigator 04/96-12/96 SmithKline Beach Safety and Efficacy of Zeneca ZD0859#1 (propofol) Injection for sedation in postsurgical ICU patients (Double-blind, Placebocontrolled Comparative, Randomized) Co-Investigator 06/95-12/95 Zeneca Ltd. Page 16 CLINICAL RESEARCH (CONT’D) Study: Role: Dates: Source: Study: Role: Dates: Source: Study: Role: Dates: Study: Role: Dates: Source: Study: Role: Dates: Source: Study: Role: Dates: Source: Effect of Urokinase on resolution of Intraventricular Hemorrhage (Double-blind, Placebo-controlled, Comparative, Randomized). Co-Investigator 06/95-06/97 Abbott Laboratories Cost Analysis of the Routine Use of Parenteral IM Fosphenytoin Versus IV Fosphenytoin in the management of seizures within the hospital setting Co-Investigator 06/96-01/97 Parke-Davis Double-Blind,Time-Stratified, Randomized, Placebo-Controlled, Dose Escalation Study of the Safety and Efficacy of IV Reopro in acute Ischemic Stroke Co-Investigator 03/97-07/97 A Double-Blind, Placebo-controlled, Parallel-group, 3-day treatment and 3-month follow-up, Multicenter study to evaluate the safety and efficacy of IV Fosphenytoin (Cerebyx) in patients with acute ischemic stroke (Protocol 982-25) Co-Investigator 03/97-06/97 Parke-Davis Pharmaceuticals Assessment of cerebral vasomotor reactivity after subarachnoid hemorrhage Co-Investigator 04/97-06/98 The Johns Hopkins University School of Medicine Study of differences in Vasomotor reactivity of Anterior and Posterior circulation Co-Investigator 06/97-12/97 Neuroscience Critical Care Division, The Johns Hopkins University SOM Page 17 CLINICAL RESEARCH (CONT’D) Study: Role: Dates: Source: Study: Role: Dates: Source: Study: Clomethiazole Acute Stroke Study in Ischemic Stroke (CLASS-1): A double blind, parallel group, multinational, multicenter study of the efficacy and safety of IV Clomethiazole compared to placebo in patients with acute cerebral ischemia Principal Investigator 12/97-01/2000 Astra Inc. Warfarin-Aspirin Symptomatic Intracranial Disease (WASID): A double blind, placebo-controlled, multicenter study of the efficacy and safety of warfarin versus aspirin in patients with symptomatic intracranial vascular disease Co-Investigator 01/99-12/2002 Emory University/NIH Role: Dates: Source: A Double Blind, Placebo-Controlled, safety, Efficacy, and Dose Response Trial of Two intravenous Doses of BMS-204352 in Patients with Acute Stroke Co-Investigator 02/99-12/01 Bristol-Myers Squibb Study: Role: Dates: Source: Markers and Outcome Predictors in patients following Cardiac Arrest Co-Investigator; PI: Michel T. Torbey, M.D., M.P.H. 04/01/2000-03/31/2002 American Heart associate, Mid-Atlantic Affiliate Study: Role: Dates: Source: A study of platelet function in patients with Intracerebral Hemorrhage Co-Investigator; PI: Wendy C. Ziai, M.D. 03/16/2000-03/01/2003 Johns Hopkins University SOM Study: Role: Dates: Source: Intraoperative Hypothermia for Aneurysm Surgery trial Part 2 (IHAST 2) Co-Investigator; PI: Michael Todd, M.D. 01/01/2001-12/31/2004 Zeneca Ltd. Study: Effect of Recombinant Tissue Plasminogen Activator (rt-PA) on Resolution of Intraventricular Hemorrhage Co-Investigator; PI: Daniel F. Hanley, M.D. 01/01/2000-12/31/2002 Food and Drug Administration-Office of Orphan Drug Development Role: Dates: Source: Page 18 CLINICAL RESEARCH (CONT’D) Study: Role: Dates: Source: Study: Role: Dates: Source: Early Identification of Neurocognitive Impairment following Aneurysmal SAH: Blinded, Prospective Study Co-Investigator 09/14/2000-08/15/2004 Neurosciences Critical Care Division, The Johns Hopkins University SOM A prospective randomized, controlled multicenter clinical study to evaluate the safety and effectiveness of the COOLGARDTM System in reducing fever in Neuro-intensive care unit patients Co-Investigator 10/2000-09/2002 Alsius Co., Irvine, California Pending Study: The major goals of this center grant is to conduct basic and clinical research on ways for elderly Americans to lead a more independent life for as long as possible. The center is focused on the effect of aging on skeletal muscle and protein metabolism. The ability of androgens and nutritional supplements to reduce the loss of muscle in the elderly is tested. Role: Dates: Internal Advisory Committee; PI (Volpi E) 05/01/15-04/30/20 Source: NIH/NIA; UTMB Claude D. Pepper Older Americans Independence Center (OAIC) Page 19 COMMITTEE RESPONSIBILITIES NATIONAL, HOSPITAL, MEDICAL SCHOOL, AND UNIVERSITY COMMITTEE ASSIGNMENTS 1998 - 2005 Multidisciplinary Critical Care Committee, Johns Hopkins University School of Medicine 1997- 2005 Coordinator, Mortality and Morbidity, Neurosciences Critical Care Division, Johns Hopkins University School of Medicine 2003 – 2005 Chairman, Inpatient Neurosciences Committee, Departments of Neurology and Neurological Surgery, Johns Hopkins University School of Medicine 2006 – 2009 Member, Executive Committee, Department of Neurology, Oregon Health & Science University 2006 - 2009 Member, Promotions and Tenure Committee, Department of Neurology, Oregon Health & Science University 2006 - 2009 Member, Critical Care Steering Committee, Oregon Health & Science University 2006 - 2009 Member, Organ Donation Committee, Oregon Health & Science University 2006 - 2009 Advisory Board Member, Pacific Northwest Transplant Bank Committee, Oregon Health & Science University 2006 - 2009 Member, Neuroscience Best Practice Committee, Oregon Health & Science University 2008- 2009 Member, Promotions and Tenure Committee, School of Medicine, Oregon Health & Science University 2008 – 2009 Neuroscience Executive Advisory Board, Oregon Health & Science University 2008 – 2013 Member, Professional Board, Oregon Health & Science University 2009 – 2013 Member, Professional Board, Tufts Medical Center 2009 – 2013 Member, Physician Advisory Board, Tufts Medical Center 2010 - 2013 Member, Pharmacy Committee, Tufts Medical Center 2013 – Present Member, Faculty Group Practice Clinical Operations Committee, University of Texas Medical Branch (UTMB) Page 20 NATIONAL, HOSPITAL, MEDICAL SCHOOL, OR UNIVERSITY COMMITTEE ASSIGNMENTS (CONT’D) 2013 – Present Member, Clinical Leadership Committee 2013 – Present Member, Academy of Research Mentors, UTMB 2013 – Present Member, Executive Committee of Medical Board, UTMB 2013 – Present Ex Officio Member, Promotions, Appointments, and Tenure Committee, UTMB 2013 – Present Member, Research Education and Training Council, UTMB 2013 – Present Member, Council of Chairs, UTMB 2013 – Present Member, Oversight Committee, UTMB 2013 – Present Member, Medical Service, Research, and Development Plan (MSRDP) Board of Directors, UTMB 2013 – Present Dean’s Representative and Coordinator, Departmental Reviews, School of Medicine, UTMB 2013-2014 Member, Search Committee for Chief Financial Officer, UTMB 2014 – Present Member, Committee on Endowed Faculty Positions, UTMB OFFICE AND COMMITTEE ASSIGNMENTS IN NATIONAL AND INTERNATIONAL PROFESSIONAL SOCIETIES 2002- 2004 Education Committee, American Neurological Association 2004 – 2009 Nominating Committee, Neurocritical Care Society 2006 - 2012 Board Member, Neurocritical Care Society 2010 Advisory Board, Princeton Stroke Conference MEMBERSHIP IN SCIENTIFIC SOCIETIES/PROFESSIONAL ORGANIZATIONS PROFESSIONAL SOCIETIES 2014 Association of University Professors of Neurology (AUPN) 2014 Member, American College of Healthcare Executives (ACHE) 2007 Oregon Medical Association Page 21 PROFESSIONAL SOCIETIES (CONT’D) 2005 *Elected Fellow, American College of Critical Care Medicine (FCCM\) 2003 Member, Neurocritical Care Society 2001 Member, Society of Critical Care Medicine (SCCM) 1997 Member, Society of Neurosurgical Anesthesia and Critical Care (SNAAC) 1997 * Elected Fellow, Stroke Council, American Heart Association (AHA) 1994 Member, Society for Neuroscience 1994 Member, National Stroke Association (NSA) 1994 Member, American Medical Association (AMA) 1990 Member, American Academy of Neurology (AAN) 1984 Permanent Member, Nigeria Medical Council (NMC) GRANT REVIEW COMMITTEES AND STUDY SECTIONS 2002-2005 Member, National Institutes of Health- FO1 Fellowship Study Section in Brain Disorders and Clinical Neuroscience 2002-2006 Member, American Heart Association – Brain 1/Stroke Study Group 2004-2009 Member, NINDS Brain Injury and Neurovascular Pathologies ZRG1 BDCN-L (90) 2004 Ad-hoc Reviewer, Alberta Heritage Foundation for Medical Research 2005 Member, Study Section, Bugher Foundation Award, American Heart Association 2007-2008 Chair, Brain 1 Study Section, National American Heart Association Page 22 AWARDS AND HONORS 2013 John Sealy Chair (Endowed) in Neurology, University of Texas Medical Branch (UTMB), Galveston, Texas 2012 *Elected Fellow, American Neurological Association (FANA) 2012 The “Lester” Teaching Award by Neurology Residents, TUSM, 2012 2011, 2012 U.S. News & World Report, America’s Top Doctors 2009 *Elected Fellow, American Academy of Neurology (FAAN) 2008 Professional Staff Chair’s Award for Outstanding Contributions to Innovation in New Models of Clinical Care, Oregon Health and Science University (OHSU) 2006 Medical/Professional Staff Chairman’s Award for Outstanding Contribution in Clinical Care Quality, OHSU 2005 *Elected Fellow, American College of Critical Care Medicine (FCCM) 2002 *Elected Member, American Neurological Association (ANA) 2001 Fellow, American Heart Association (FAHA) 2001-2004 Established Investigator Award, American Heart Association (AHA) 1996, 1997 Richard S. Ross Clinician-Scientist Award, Johns Hopkins University, SOM 1996 * Elected Fellow, Stroke Council, American Heart Association (AHA) 1996-2001 Clinician-Scientist Award, American Heart Association (AHA) 1995 Honorable Mention-Robert G. Siekert Young Investigator Award in Stroke, American Heart Association 1994-1996 Fellowship Career Development Award, National Stroke Association 1993 Resident of the Year, Department of Neurology, Mount Sinai SOM, NY 1993 Bella Trachtenberg/Association of Attending Staff Award for House Staff Excellence, Mount Sinai SOM, New York 1992 Chief Resident, Department of Neurology, Mount Sinai SOM, New York 1984 Alice Moboade Akinyele Memorial Prize in Medicine, College of Medicine, University of Ibadan, Nigeria Page 23 EDITORIAL BOARDS AND PEER-REVIEW JOURNAL ACTIVITY 2003- 2005 Member, Editorial Board – American Journal of Physiology 2002- 2008 Guest Editor – Stroke 2004-Present Member, Editorial Board – Critical Care Medicine 2004-2012 Member, Editorial Board – Journal of Cerebral Blood Flow and Metabolism 2005-2013 Member, Editorial Board – Stroke 2008-Present International Editor, Tzu Chi Medical Journal 2008-Present Member, Editorial Board, Neurocritical Care 2008-Present Member, Editorial Board, Case Reports in Medicine 2009-Present Member, Editorial Board, Translational Stroke Research 2009-Present Member, Editorial Board, Hospital Practice AD-HOC REVIEWER FOR SCIENTIFIC AND CLINICAL JOURNALS Critical Care Medicine Stroke Journal of Cerebral Blood Flow and Metabolism Anesthesia and Analgesia Neurology Archives of Physical Medicine and Rehabilitation Neurocritical Care Journal of Trauma Pediatric Research Journal of Neurochemistry Pediatric Research Medical Science Monitor Journal of Clinical Investigation Annals of Neurology American Institute of Biological Sciences Metabolism Page 24 BIBLIOGRAPHY ARTICLES IN PEER-REVIEWED JOURNALS 1. Bhardwaj A, Brannan T, Martinez-Tica J, Weinberger J. Ischemia in the dorsal hippocampus is associated with acute extracellular release of dopamine and norepinephrine. Journal of Neural Transm, 80:195-201;1990. 2. Brannan T, Bhardwaj A, Martinez-Tica J, Weinberger J, Yahr M. Striatal L-dopa metabolism studied in vivo in rats with nigrostriatal lesions. Journal of Neural Transm, 2:1522;1990. 3. Bhardwaj A, Brannan T, Weinberger J. Pentobarbital inhibits extracellular release of dopamine and norepinephrine in the ischemic striatum. Journal of Neural Transm, 82:111117;1990. 4. Brannan T, Bhardwaj A, Yahr M. L-threodops increases extracellular norepinephrine levels in the brain: An in vivo study. Neurology, 40:1134-1135;1990. 5. Gumaste V, Sereny G, Dave P, Bhardwaj A, Gumaste S. Serum Lipase levels in chronic alcoholics. Journal of Clinical Gastroenterol, 13(4);407-410; 1991. 6. Lapin EP, Maker HS, Bhardwaj A. Ethanol enhancement of the motor stimulating effect of nicotine in the rat. Alcohol, 12(3):217-220, 1995. 7. Bhardwaj A, Northington FJ, Koehler RC, Stiefel T, Hanley DF, Traystman RJ. Adenosine modulates N-Methyl-D-Aspartate stimulated hippocampal nitric oxide production in vivo. Stroke 26(9):1627-1633, 1995. 8. Minahan RE, Bhardwaj A, Traill TA, Hanley DF. Stimulus evoked sinus arrest in severe Guillain-Barré syndrome. Neurology, 47:1239-1242, 1996. 9. Minahan RA, Bhardwaj A, Williams MA. ICU monitoring for Cerebrovascular disease, in Critical Care of Stroke, New Horizons, Vol. 5, (4), 406-421, 1997. 10. Bhardwaj A, Northington FJ, Martin LJ, Hanley DF, Traystman RJ, Koehler RC. Characterization of metabotropic glutamate receptor mediated nitric oxide production in vivo. J Cereb Blood Flow Metab, 17(2):153-160, 1997. 11. Bhardwaj A, Northington FJ, Ichord RN, Hanley DF, Traystman RJ, Koehler RC. Characterization of ionotropic glutamate receptor mediated nitric oxide production in vivo in rats. Stroke, 28:850-857, 1997. Page 25 ARTICLES IN PEER-REVIEWED JOURNALS (CONT’D) 11. Kirsch JR, Bhardwaj A, Hanley DF, Traystman RJ. Neither L-arginine or L-NAME alter neurologic outcome following global ischemia in cat. Stroke, 28:2259-2265:1997. 12. Deibert E, Bhardwaj A, Staats PS, Ulatowski JA. Chronic intrathecal baclofen administration for the treatment of severe generalized tetanus via a synchronized infusion pump. Neuromodulation, 1:2-5:1997. 13. Minahan RA, Bhardwaj A, Williams MA. ICU monitoring for Cerebrovascular disease, in Critical Care of Stroke, New Horizons, Vol. 5, (4), 406-421, 1997. 14. Qureshi AI, Suarez JI, Bhardwaj A, Mirski MA, Schnitzer MS, Hanley DF, Ulatowski JA. Use of hypertonic (3%) saline/acetate infusion in the treatment of cerebral edema: effect on intracranial pressure and lateral displacement of the brain. Crit Care Med, 26;440446:1998. 15. Qureshi AI, Suarez JI, Parekh PD, Sung G, Bhardwaj A, Tamargo RJ, Ulatowski JA. Acquired risk factors for multiple intracranial aneurysms. Neurosurgery, 43:22-27, 1998. 16. Suarez JI, Qureshi AI, Bhardwaj A, Williams MA, Hanley DF, Ulatowski JA. Treatment of resistant intracranial hypertension with 23.4% saline. Crit Care Med, 26;1118-1122:1998. 17. Harukuni I, Traystman RJ, Bhardwaj A, Koehler RC, Kirsch JR. Intravenous BFGF does not ameliorate brain injury resulting from transient focal ischemia in cats. J Neurosugical Anesthesiology, 10:160-165, 1998. 18. Qureshi AI, Suarez JI, Bhardwaj A. Malignant cerebral edema in patients with hypertensive intracerebral hemorrhage associated with hypertonic saline infusion. A rebound phenomenon? J Neurosurgical Anesthesiology 10;188-192, 1998. 19. Bhardwaj A, Sawada M, London ED, Koehler RC, Traystman RJ, Kirsch JR. Potent σ1receptor ligand PPBP [4-Phenyl-1-(4-phenylbutyl) piperidine] modulates basal and Nmethyl-D-aspartate-evoked Nitric Oxide production in vivo. Stroke, 29;2404-2411, 1998. 20. Lam HD, Bhardwaj A, O’Connell MA, Hanley DF, Traystman RJ, Sofroniew MV. Nerve growth factor rapidly suppresses basal, NMDA and AMPA-evoked nitric oxide production in rat hippocampus in vivo. Proc Natl Acad Sci, USA 95;10926-10931, 1998. 21. Harukuni I, Bhardwaj A, Traystman RJ, London ED, Kirsch JR. Neuroprotection from focal ischemia by 4-Phenyl-1-(4-Phenylbutyl) Perperidine (PPBP) is dependent on treatment duration in rats. Anesthesia and Analgesia, 87(6):1299-1305, 1998. Page 26 ARTICLES IN PEER-REVIEWED JOURNALS (CONT’D) 22. Koehler RC, Kirsch JR, Bhardwaj A, Takahashi H, Traystman RJ. Preventing postischemic injury during reperfusion, in Update in Intensive Care and Emergency Medicine,Vol 27, Steiner et al. Proedit, Heidelberg, 1998. 23. Fasciano JW, Ripple M, Suarez JI, Bhardwaj A. Central Nervous System Aspergillosis: Case Report and Review of Literature. Hospital Physician, 35(4): 63-70, 1999. 24. Toung TJ, Bhardwaj A, Dawson VL, Dawson TM, Traystman RJ, Hurn PD. Immunosuppressant FK506 affords focal ischemic neuroprotection without altering nitric oxide production in vivo. Stroke, 30 (6): 1279-1285, 1999. 25. Suarez JI, Qureshi AI, Parekh PD, Razumovsky A, Tamargo RJ, Bhardwaj A, Ulatowski JA. Administration of hypertonic (3%) sodium chloride/acetate in hyponatremic patients with symptomatic vasospasm following subarachnoid hemorrhage. J Neurosurg Anesthesiol, 11:178-184; 1999. 26. Qureshi AI, Suarez JI, Castro A, Bhardwaj A. The use of hypertonic saline infusion in treatment of cerebral edema in patients with head trauma. Experience at a single center. J Trauma, 47:659-665, 1999. 27. Slusher BS, Vornov JJ, Thomas AG, Hurn PD, Harukuni I, Bhardwaj A, Traystman RJ, Robinson MB, Britton P, Tortella FC, Woznaik KM, Jackson PF. Reduction of extracellular glutamate via NAALADase inhibition is neuroprotective. Nature Medicine, 5(12):1396-1402, 1999. 28. Bhardwaj A, Ulatowski JA. Cerebral edema: hypertonic saline solutions, in Current Treatment Options in Neurology 1999, 1:179-187. 29. Toung TJ, Bhardwaj A, Wang M, Kirsch JR, Traystman RJ. Neuroprotective effects of antioxidant LY231617 following global cerebral ischemia in dogs. Critical Care Medicine, 28:196-201;2000. 30. Harukuni I, Takahashi H, Traystman RJ, Bhardwaj, Kirsch JR. Oxotremorine induced hyperemia does not predict infarction volume in spontaneously hypertensive stroke prone rats. Critical Care Medicine, 28:190-195;2000. 31. Qureshi AI, Suarez JI, Parekh PD, Bhardwaj A. Prediction and timing of tracheostomy in patients with infratentorial lesions of the brain. Critical Care Medicine, 28:1383-1387; 2000. 32. Qureshi AI, Suarez JI, Bhardwaj A, Tamargo RJ, Ulatowski JA. Early predictors of patients receiving hypervolemic and hypertensive therapy for symptomatic vasospasm after subarchnoid hemorrhage. Critical Care Medicine, 28:824-829, 2000. Page 27 ARTICLES IN PEER-REVIEWED JOURNALS (CONT’D) 33. Naff NJ, Carhuapoma JR, Williams MA, Bhardwaj A, Ulatowski JA, Bederson J, Bullock R, Schmutzhard E, Fausler B, Keyl PM, Tuhrim S, Hanley DF. Treatment of intraventricular hemorrhage with urokinse:Effects on 30-day survival. Stroke, 31(4):841-847, 2000. 34. Varelas P, Bhardwaj A, Eleff SM. Critical Care Management of subarachnoid hemorrhage, in Brunei International Medical Journal, 2, 77-91, 2000. 35. Torbey MT, Bhardwaj A. What is the approach to blood pressure management with hydralazine in patients with acute ischemic stroke. J Critical Illness,15:590, 2000. 36. Bhardwaj A, Wu Y, Kirsch JR, Hurn PD, Traystman RJ. Selective Endothelin ReceptorA antagonist does not improve stroke damage in cat. J Cerebral Blood Flow Metab, 20:499504, 2000. 37. Harukuni I, Bhardwaj A, Shavitz A, DeVries C, Hurn PD, Traystman RJ, Kirsch JR. Sigmareceptor ligand, PPBP [4-Phenyl-1-(4-Phenylbutyl) Piperidine] affords neuroprotection from focal ischemia with prolonged reperfusion. Stroke, 31(4): 976-982, 2000. 38. Bhardwaj A, Northington FJ, Carhuapoma JR, Falck RJ, Harder DR, Traystman RJ, Koehler RC. Cytochrome P450 epoxygenase inhibitors block cerebral blood flow response to Nmethyl-D-aspartate in rat striatum. American Journal of Physiology, 279:H1616-H1624, 2000. 39. Bhardwaj A, Harukuni I, Murphy SJ, Alkayed NJ, Koehler RC, Hurn PD, Traystman RJ. Continuous hypertonic saline infusion worsens infarct volume after transient focal ischemia in rats. Stroke, 31(7):1694-1701, 2000. 40. Torbey MT, Bhardwaj A. Blood pressure management in critically ill neurological patients. J Critical Illness, 16:179-192, 2001. 41. Razumovsky AY, Wityk RJ, Geocadin RG, Bhardwaj A, Ulatowski JA. Cerebral vasculitis: Diagnosis and follow-up with transcranial Doppler Ultrasonography. J Neuroimaging, 11; 333-335;2001. 42. Goyagi T, Goto S, Bhardwaj A, Dawson VL, Hurn PD, Kirsch JR. Neuroprotective effect of σ1-receptor ligand PPBP [4-Phenyl-1-(4-Phenylbutyl) Piperidine] is linked to reduced neuronal nitric oxide production. Stroke, 32(7):1613-1620; 2001. 43. Torbey MT, Bhardwaj A. Blood pressure management in critically ill neurological patients. J Critical Illness, 16:179-192; 2001. 44. Bhardwaj A, Long DM, Ducker TB, Toung TJK. Neurological deficits following cervical Page 28 laminectomy in the prone. J Neurosurgical Anesthesiology, 13:314-319; 2001. ARTICLES IN PEER-REVIEWED JOURNALS (CONT’D) 45. Bhardwaj A, Castro A III, Alkayed NJ, Hurn PD, Kirsch JR. Anesthetic Choice of Halothane versus Propofol. Impact on experimental perioperative stroke. Effect of anesthetic agent on brain injury from transient focal ischemia in awake rats. Stroke, 32:1920-1925; 2001. 46. Torbey MT, Hauser T-K, Bhardwaj A, Williams MA, Ulatowski JA, Mirski MA, Razumovsky A. Age is an important determinant of cerebral blood flow velocities and vasospasm following subarchnoid hemorrhage. Stroke, 32:2005-2011; 2001. 47. Bhardwaj A. Assessment of regional acute stroke care. Stroke, 33;1339-1340: 2002. (Invited Editorial) 48. Toung TJK, Hurn PD, Traystman RJ, Bhardwaj A. Global brain water increases after experimental focal cerebral ischemia: Effect of hypertonic saline. Critical Care Medicine, 30: 644-649; 2002. 49. Toung TJK, Tyler B, Brem H, Traystman RJ, Hurn PD, Bhardwaj A. Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor. J Neurosurgical Anesthesiology 14:187-193; 2002. 50. Carhuapoma JR, Qureshi AI, Bhardwaj A, Williams MA. Interhemispheric Intracranial Pressure Gradients in Massive Cerebral Infarction. J Neurosurgical Anesthesiology, 14; 200303:2002. 51. Geocadin R, Razumovsky A, Wityk RJ, Bhardwaj A, Ulatowski JA. Intracerebral hemorrhage and post-partum vasculopathy. J Neurological Sciences, 205(1); 29-34:2002. 52. Peng X, Carhuapoma JR, Bhardwaj A, Alkayed NJ, Falck JR, Harder DR, Traystman RJ, Koehler RC. Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors. American Journal of Physiology, 283(5);H 2029-H 2037:2002. 53. Harukuni I, Kirsch JR, Bhardwaj A. Cerebral Resuscitation: Role of Osmotherapy. Journal of Anesthesia, 16; 229-237, 2002. 54. Peng X, Carhuapoma JR, Bhardwaj A, Alkayed NJ, Harder DR, Traystman RJ, Koehler RC. Regulation of the cerebral circulation by cytochrome P450 epoxygenase activity. Brain Activation and Cerebral Blood Flow Control, Tokyo, Minuro Tomito (Ed). Excerpta Medica International Congress Series 911 Elsevier Science B.V. Amsterdam, pp. 289-295, 2002. 55. Varelas PN, Chua HC, Natterman J, Barmadia L, Zimmerman P, Yahia A, Ulatowski J, Bhardwaj A, Williams MA, Hanley DF. Ventilatory care in myasthenia gravis crisis: Page 29 Assessing the baseline adverse event rate. Crit Care Med 30;2663-2668:2002. ARTICLES IN PEER-REVIEWED JOURNALS (CONT’D) 56. Harukuni I, Kirsch JR, Bhardwaj A. Cerebral Resuscitation: Role of Osmotherapy. Journal of Anesthesia, 16;229-237, 2002. 57. Bhardwaj A, Alkayed NJ, Kirsch JR, Hurn PD. Mechanisms of Ischemic Brain Damage. Current Cardiology Reports, 5;160-167, 2003. 58. Stevens RD, Bhardwaj A, Kirsch JR, Mirski MA. Critical care and perioperative management in spinal cord injury. J Neurosurgical Anesthesiology 15 (3); 215-29: 2003. 59. Ziai WC, Port J, Cowan J, Garonzik I, Bhardwaj A, Rigamonti D. Decompressive hemicraniectomy for intractable cerebral edema: Experience at a single center. J Neurosurgical Anesthesiology, 15:25-32, 2003. 60. Goyagi T, Bhardwaj A, Traystman RJ, Koehler RC, Hurn PD, Kirsch JR. Potent σ1-receptor ligand PPBP [4-Phenyl-1-(4-Phenylbutyl) Piperidine] (PPBP) provides ischemic neuroprotection without altering dopamine accumulation in vivo. Anesthesia and Analgesia, 96:532-8, 2003. 61. Bhardwaj A, Alkayed NJ, Kirsch JR, Hurn PD. Mechanisms of Ischemic Brain Damage. Current Cardiology Reports, 5;160-167, 2003. 62. Moghaddam M-A, Otsuka T, Hurn PD, Traystman RJ, Haug F-M, Froehner SC, Adams ME, Neely JD, Agre P, Ottersen OP, Bhardwaj A. Aquaporin-4 in perivascular astroglial endfeet confers bi-directional water transport between blood and brain: Disturbed brain water homeostasis in mice lacking -syntrophin. Proc Natl Acad Sci, USA, 100; 2106-2111, 2003. 63. Goyagi T, Toung TJK, Kirsch JR, Traystman RJ, Koehler RC, Hurn PD, Bhardwaj A. Neuroprotective selective kappa (κ) receptor agonist, BRL 52537 attenuates ischemiaevoked nitric oxide production in vivo in rats. Stroke 34(6):1533-8: 2003. 64. Stevens RD, Bhardwaj A, Kirsch JR, Mirski MA. Critical care and perioperative management in spinal cord injury. J Neurosurgical Anesthesiology 15 (3): 215-29: 2003. 65. Zhang Z, Chen T-Y, Kirsch JR, Toung TJK, Traystman RJ, Koehler RC, Hurn PD, Bhardwaj A. Kappa opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats. Anesthesia and Analgesia, 97;1776-83: 2003. 66. Ziai WC, Torbey MT, Kickler C, Bhardwaj A, Wityk R. Effect of platelet function in spontaneous intracerebral hemorrhage. J Stroke and Cerebrovasc Diseases, 12; 4: 201-206, 2003. Page 30 ARTICLES IN PEER-REVIEWED JOURNALS (CONT’D) 67. Bhardwaj A. SAH-Induced cerebral vasospasm: Unraveling molecular mechanisms of a complex disease Stroke, 34:427-433; 2003. (Invited Editorial). 68. Chen T-Y, Goyagi T, Toung TJK, Kirsch JR, Hurn PD, Koehler RC, Bhardwaj A. Prolonged therapeutic window for ischemic neuroprotection with selective kappa opioid receptor agonist, BRL 52537 in rats. Stroke, 35(5):1180-5, 2004. 69. Amiry-Moghaddam M, Xue R, Haug F-M, Neely J, Bhardwaj A, Agre P, Adams M, Froehner S, Mori S, Ottersen OP. A molecular basis for hyponatremic brain edema: selective removal of perivascular aquaporin-4 by alpha-syntrophin deletion delays edema in three different brain regions. FASEB Journal, 18(3);542-4:2004. 70. Bhardwaj A, Ulatowski JA. Hypertonic Saline Solutions in Brain Injury. Current Opinions in Critical Care, 10 (2); 126-131: 2004. 71. Toung TJK, Chang Y, Williams M, Crain BJ, Traystman RJ, Bhardwaj A. Experimental spinal cord ischemia: Model characterization and amelioration of neurological deficits with arterial hypertension. Critical Care Medicine, 32; 1346-1351:2004. 72. Torbey MT, Geocadin R, Bhardwaj A. Brain arrest outcome Scale (BrANOS) predicting mortality following cardiac arrest. Resuscitation, 63(1):55-63, 2004. 73. Luft AR, Buitrago MM, Torbey M, Bhardwaj A, Razumovsky A. Biphasic cerebral blood flow velocity profile in patients with aneurysmal subarachnoid hemorrhage. J of Neurocritical Care, 1(4):455-460, 2004. 74. Stevens RD, Bhardwaj A, Mirski MA. Critical Care of Patients with Traumatic Brain Injury. Contemporary Critical Care 2 (7):1-12, 2004. 75. Toung TJK, Chang Y, Lin J, Bhardwaj A. Increases in lung and brain water following ischemic stroke: Effect of osmotherapy with hypertonic saline. Critical Care Medicine, 33;203-208: 2005. 76. Ziai WC, Sherman DL, Bhardwaj A, Zhang N, Mirski MA. Neurochemical changes by anticonvulsant thalamic-deep brain stimulation. Epilepsia, 46(6):878-88, 2005. 77. Gomes JA, Stevens RD, Mirski MA, Bhardwaj A. Corticosteroid therapy in neurologic critical care. Crit Care Med, 33(6):1214-1224, 2005. 78. Chen C-H, Toung TJK, Kirsch JR, Hurn PD, Koehler RC, Bhardwaj A. Ischemic neuroprotection with selective kappa-opioid receptor agonist is gender specific. Stroke, 36: 1557-61, 2005. Page 31 ARTICLES IN PEER-REVIEWED JOURNALS (CONT’D) 79. Bhardwaj A, Brem H. Accompanying editorial comment to article “Expression of the aquaporin-1 water channel in human glial tumors”. Neurosurgery 56; 375-381: 2005. (Invited editorial). 80. Torbey MT, Geocadin R, Bhardwaj A. Predicting outcome after cardiac arrest: Time for innovation. Resuscitation ;66:109-10; 2005. (Invited Editorial). 81. Stevens RD, Bhardwaj A. Evolving paradigms in the management of severe traumatic brain injury. Crit Care Med 33(10); 2415-7: 2005. (Invited Editorial). 82. Zeynalov E, Nemoto A, Hurn PD, Koehler RC, Bhardwaj A. Neuroprotective effect of selective kappa-opioid receptor agonist is gender specific and linked to reduced neuronal nitric oxide. J Cereb Blood Flow Metab, 26(3):414-20, 2006. Chang Y, Chen T-Y, Chen C-H, Toung TJK, Bhardwaj A. Temporal profile of plasma arginine-vasopressin following experimental stroke: Effect of osmotherapy. J Appl Physiol, 100(5):1445-51, 2006. 83. 84. Naval N, Stevens RD, Mirski MA, Bhardwaj A. Controversies in the management of subarachnoid hemorrhage. Crit Care Med, 34(2):511-24, 2006. 85. Bhardwaj A. Neurologic impact of vasopressin dysregulation and hyponatremia in central nervous system disorders. Annals of Neurology, 59(2):229-36, 2006. 86. Stevens RD, Bhardwaj A. Approach to the comatose patient. Crit Care Med 34(1):31-41, 2006. 87. Chen C-H, Toung TJK, Sapirstein A, Bhardwaj A. Effect of duration of osmotherapy on blood brain barrier disruption and regional cerebral edema following experimental stroke. J Cereb Blood Flow Metab 26(7):951-8; 2006. 88. Vagnerova K, Hurn PD, Bhardwaj A, Kirsch JR. Sigma 1 receptor agonists act as neuroprotective drugs through inhibition of inducible nitric oxide synthase. Anesth Analg, 103(2):430-4, 2006. 89. Frydenlund DS, Bhardwaj A, Otsuka T, Mylonakou MN, Yasumura T, Davidson KGV, Zeynalov E, Skare O, Laake P, Haug F-M, Rash JE, Agre P, Ottersen OP, AmiryMoghaddam M. Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice. Proc Natl Acad Sci USA, 103(36):13532-6, 2006. 90. Fang SY, Tseng CC, Yang YL, Lee EJ, Chen HY, Bhardwaj A, Chen TY. Nitric oxide scavenger carboxy-PTIO reduces infarct volume following permanent focal ischemia. Acta Anaesthesiol Taiwan 44(3):141-6, 2006. Page 32 ARTICLES IN PEER-REVIEWED JOURNALS (CONT’D) 91. Harukuni I, Bhardwaj A. Mechanisms of brain injury after global cerebral ischemia. In Cardiac Arrest and Brain Injury. Ed. Geocadin RG, Neurologic Clinics of North America. Neurol Clin 24(1):1-21, 2006. 92. Toung TJK, Chen C-H, Lin C, Bhardwaj A. Osmotherapy with hypertonic saline attenuates water content in brain and extra-cerebral organs. Crit Care Med, 35(2):526-31, 2007. 93. Yang S, Bhardwaj A, Hurn PD, Kirsch JR. Sigma receptor mediated ischemic neuroprotection is afforded via post-synaptic and post-apoptotic mechanisms. Anesth Analg 104(5):1179-84, 2007. 94. Ziai WC, Toung TJK, Bhardwaj A. Hypertonic saline: First-line therapy for cerebral edema? In Update in Neurocritical Care; Eds. Carhuapoma JR, Coplin WM, Mirski MA. J Neurological Sciences, 261:157-166, 2007. 95. Chen C-H, Xue R, Zhang J, Li X, Mori S, Bhardwaj A. Effect of osmotherapy with hypertonic saline on regional cerebral edema following experimental stroke: A study utilizing magnetic resonance imaging. Neurocritical Care, 7(1):92-100, 2007. 96. Raslan A, Bhardwaj A. Medical Management of Cerebral Edema. Neurosurgical Focus 22 (5):E12, 2007. 97. Liu K, Bhardwaj A. Use of prophylactic anticonvulsants in neurologic critical care: A critical appraisal. Neurocritical Care 7(2):175-84; 2007. 98. Bhardwaj A. Osmotherapy in Neurocritical Care. Currt Neurol and Neurosci Rpts 7(6):51321; 2007. 99. Hunt M, Bhardwaj A. Caveats for triple-H therapy for vasospasm following aneurysmal subarachnoid hemorrhage. Crit Care Med 35(8); 1985-6: 2007. (Invited Editorial). 100. Stevens RD, Bhardwaj A. Eryrthropoietin and the promise of ischemic multi-organ protection. Crit Care Med 36(8); 2446-7: 2008. Invited Editorial). 101. Zeynalov E, Chen C-H, Adams M, Froehner S, Ottersen OP, Amiry-Moghaddam M, Bhardwaj A. The perivascular pool of Aquaporin-4 mediates the effect of osmotherapy in post-ischemic edema. Crit Care Med 36(9):2634-40, 2008. 102. Liu X, Zhang W, Alkayed NJ, Froeher SC, Adams ME, Amiry-Moghaddam M, Ottersen OP, Hurn PD, Bhardwaj A. Lack of Sex-Linked Differences in Cerebral Edema and Aquaporin4 Expression after Experimental Stroke. J Cereb Blood Flow Metab 28(12):1898-906, 2008. Page 33 ARTICLES IN PEER-REVIEWED JOURNALS (CONT’D) 103. McDaneld L, Fields JD, Bourdette DN, Bhardwaj A. Immunomodulatory therapies in Neurologic Critical Care. Neurocrit Care; 12(1):132-43; 2009. 104. Stevens RD, Bhardwaj A. Improving the Assessment Score in Spontaneous Intracerebral Hemorrhage. Crit Care Med 37(3); 1152-1153: 2009. (Invited Editorial). 105. Fields JD, Bhardwaj A. Antiedema effects of hypertonic saline following spinal cord injury. Crit Care Med, 37(7):2306-7: 2009. (Invited Editorial). 106. Fields JD, Bhardwaj A. Non-Peptide Arginine-Vasopressin Antagonists for the treatment of hyponatremia in Neurocritical Care: A new alternative? Neurocrit Care, 11(1):1-4; 2009. (Invited Editorial). 107. Raslan A, Fields J, Bhardwaj A. Prophylaxis for venous thrombo-embolism in Neurocritical Care: A Critical Appraisal. Neurocrit Care; 12(2):297-309; 2010. 108. Liu X, Nakayama S, Amiry-Moghaddam M, Ottersen OP, Bhardwaj A. Arginine-vasopressin V1 but not V2 receptor antagonism modulates infarct volume, brain water content and aquaporin-4 expression following experimental stroke. Neurocrit Care; 12(1):124-31; 2010. 109. Migiliati E, Amiry-Moghaddam M, Adams M, Froeher S, Ottersen OP, Bhardwaj A. Na+-K+2Cl- cotransport inhibitor attenuates cerebral edema following experimental stroke via the perivascular pool of aquaporin-4. Neurocrit Care;13(1):123-31; 2010. 110. Schirmer CM, Heilman CB, Bhardwaj A. Pneumocephalus: Case Illustrations and Review. Neurocrit Care; 13(1):152-8; 2010. 111. Bhardwaj A. Molecular targets for ameliorating early brain injury post subarachnoid hemorrhage: A new focus. Crit Care Med, 38(2):727-8; 2010. (Invited Editorial). 112. Bhardwaj A. Experimental studies on ischemic neuroprotection: Criterion for translational significance. Crit Care Med, 39(5):1230-1; 2011. (Invited Editorial). 113. Kornbluth J, Bhardwaj A. Evaluation of Coma: A Critical Appraisal of Popular Scoring Systems. Neurocrit Care; 14(1):134-43; 2011. 114. Pustavoitau A, Bhardwaj A, Stevens RD. Analytical Review: Neurological Complications of Transplantaion. J Intensive Care Med; 26(4); 209-222; 2011. 115. Schirmer CM, Kornbluth J, Heilman CB, Bhardwaj A. Gastrointestinal Prophylaxis in Neurocritical Care. Neurocrit Care; 16(1):184-93; 2012. Page 34 ARTICLES IN PEER-REVIEWED JOURNALS (CONT’D) 116. Bhardwaj A. Statins as neuroprotectants after subarachnoid hemorrhage. Critic Care Med, 40(2):695-7; 2012. (Invited Editorial). 117. Prins RC, Galdwin MT, Brod LS, Bhardwaj A, Hunter AJ. Chance Favors the Prepared Mind. J Hosp Med; 7(9):717-20; 2012. 118. Levin B, Bhardwaj A. Chronic Traumatic Encephalopathy. Neurocritical Care; 20(2):334-44; 2014. INVITED BOOK CHAPTERS 1. Hanley DF, Bhardwaj A, Ulatowski JA, Razumovsky A, Mirski MA. Coma and Intensive Care Neurology, in Atlas of Clinical Neurology, 4.1 - 4.32, 1997;Current Medicine, MA. 2. Qureshi AI, Bhardwaj A, Ulatowski JA. Neurocritical Care, in ICU Care, Williams & Wilkins, Baltimore, 1998. 3. Koehler RC, Kirsch JR, Bhardwaj A, Takahashi H, Traystman RJ. Preventing postischemic injury during reperfusion, in Update in Intensive Care and Emergency Medicine, 1998, Vol 27, Steiner et al. Proedit, Heidelberg. 4. Hurn PD, Alkayed NJ, Bhardwaj A, Koehler RC, Kirsch JR, Littleton-Kearney MT, McCullough LD, Murphy SJ, Rossberg MI, Toung TJK, Traystman RJ. Cerebral Ischemia: Pathophysiology and Neuroprotection in Yearbook of Intensive Care Medicine and Emergency Medicine: 2001. Vincent JL (ed). Springer-Verlag Publishing, Heidelberg, 2001. 5. Rossberg MT, Hurn PD, Bhardwaj A, Kirsch JR. Principals of Cerebroprotection in Critical Care Medicine: Perioperative Management (2nd edition) Murray MJ, Coursin DB, Pearl RG, Prough DS (eds.), Raven Press, New York, 2002. 6. Peng X, Carhuapoma JR, Bhardwaj A, Alkayed NJ, Harder DR, Traystman RJ, Koehler RC. Regulation of the cerebral circulation by cytochrome P450 epoxygenase activity. Brain Activation and Cerebral Blood Flow Control, Tokyo, Minuro Tomito (Ed). Excerpta Medica International Congress Series 911 Elsevier Science B.V. Amsterdam, pp. 289-295, 2002. 7. Torbey MT, Bhardwaj A. Cerebral Blood Flow Physiology and Monitoring in Critical Care Neurology and Neurosurgery, Humana Press Inc., Ed. JI Suarez, pp 23-37, 2004. 8. Bhardwaj A. Subarachnoid hemorrhage. In Handbook of Neurocritical Care. p 45-62, Eds. Bhardwaj A, Mirski MA, Ulatowski JA. Humana Press Inc, pp 45-61, 2004. Page 35 INVITED BOOK CHAPTERS (CONT’D) 9. Bhardwaj A. Cerebral Edema and Intracranial hypertension. In Handbook of Neurocritical Care. p 63-72, Eds. Bhardwaj A, Mirski MA, Ulatowski JA. Humana Press Inc, pp 63-72, 2004. 10. Chen CL, Bhardwaj A. Intracerebral Hemorrhage. In Stroke Eds. Wityk RJ and Linas R. American College of Physicians, PA, 2006. 11. Bhardwaj A. The unconscious patient. In Current Therapy in Neurologic Disease. Eds. Johnson RT, MacArthur J, Griffin JW. Mosby Inc. 2006. 12. Nyquist P, Bhardwaj A. Stroke and Neurocritical Care Units: A critical Appraisal. pp 405415; In Acute Stroke: Bench to Bedside. Eds. Bhardwaj A, Alkayed NJ, Kirsch JR, Tryastman RJ. Informa Healthcare, 2006. 13. Gomes JA, Bhardwaj A. Normal intracranial pressure physiology. In Cerebrospinal Fluid in Human Health and Disease. P19-25, First Edition. Ed. Irani DN. Sauders (Elsevier), Philadelphia, PA, 2009. 14. Raslan A, Bhardwaj A. Cerebral Edema and Intracranial Pressure. Neurocritical Care. Ed. Torbey MT, Cambridge University Press, New York, NY, 2010. 15. Fields JD, Bhardwaj A. Cerebral Blood Flow and Metabolism: Physiology and Monitoring. In Handbook of Neurocritical Care, 2nd Edition, Eds. Bhardwaj A, Mirski MA, Humana Press, Totowa, NJ, 2009. 16. Naval N, Bhardwaj A. Ischemic Stroke. In Handbook of Neurocritical Care, 2nd Edition, Eds. Bhardwaj A, Mirski MA, Humana Press, Totowa, NJ, 2009. 17. Fields JD, Bhardwaj A. Neuromuscular Disorders. In Handbook of Neurocritical Care, 2nd Edition, Eds. Bhardwaj A, Mirski MA, Humana Press, Totowa, NJ, 2009. Page 36 BOOKS AUTHORED/EDITED 1. Bhardwaj A, Williams MA, Hanley DF (Guest Editors), Luce JM (Series Editor). Critical Care of Stroke, New Horizons, Vol. 5, No. 4, 294-435, 1997, Society for Critical Care Medicine. Williams & Wilkins. 2. Bhardwaj A, Mirski MA, Ulatowski JA (Editors). Handbook of Neurocritical Care. Humana Press, 2004. 3. Bhardwaj A, Alkayed NJ, Kirsch JR, Traystman RJ (Editors). Acute Stroke: Bench to Bedside. Informa Helathcare, Inc. 2006. 4. Bhardwaj A, Elagalla D, Kirsch JR (Editors). Management of Acute Brain and Spinal Cord Injury : Evolving paradigms and management. Informa Healthcare Inc. 2008. 5. Bhardwaj A, Mirski MA (Editors). Handbook of Neurocritical Care. 2nd Edition, Springer, New York, 2010. Page 37 PUBLISHED ABSTRACTS 1. Bhardwaj A, Brannan T, Martinez-Tica J, Weinberger J. Increase in extracellular dopamine and norepinephrine in the ischemic hippocampus: A study using cerebral dialysis. Neurology 38 (suppl 1), 218, 1989. 2. Weinberger J, Bhardwaj A, Brannan T. Pentobarbital inhibits the acute massive release of dopamine in the ischemic striatum - A study utilizing cerebral dialysis. Annals of Neurology, 26, 130, 1989. 3. Berl S, Clarke DD, Bhardwaj A, Brannan T. Determination of the formation and acetylcholine by microdialysis utilizing [14C]-choline. Presented at the First International Symposium on Microdialysis, Indianapolis, 1989. Current Separations 9, 98, 1989. 4. Knott P, Brannan T, Bhardwaj A. Bilateral microdialysis monitoring of striatal dopamine release and metabolism in response to L-dopa. Presented at the Fourth British Meeting of Electrochemical Detection, HPLC and In Vivo Monitoring in the Biosciences, Nottingham, UK, 1989. Journal of Neuroscience Methods 29, 293, 1989. 5. Brannan T, Bhardwaj A, Martinez-Tica J, Knott P, Weinberger J. Acute massive release of dopamine into the extracellular space of the ischemic striatum - Characterization and prevention with pentobarbital. Presented at the Fourth British Meeting of Electrochemical Detection, HPLC and In Vivo Monitoring in the Biosciences, Nottingham, UK, 1989. Journal of Neuroscience Methods 29, 293, 1989. 6. Brannan T, Bhardwaj A, Yahr M. Increased extracellular norepinephrine levels following Lthreodops administration. Presented at the First International Congress of Movement Disorders, Washington, D.C., 1990. Movement Disorders 5 (Suppl.1), 89, 1990. 7. Brannan T, Bhardwaj A, Martinez-Tica J, Weinberger J, Yahr M. L-threodops increases extracellular norepinephrine levels in the brain: An In Vivo study. Neurology, 40 (suppl 1), 224, 1990. 8. Bhardwaj A, Northington FJ, Hanley DF, Traystman RJ. Adenosine attenuates the NMethyl-D-Aspartate (NMDA) induced Nitric Oxide Synthase (NOS) activity in the hippocampus: A study utilizing in vivo cerebral microdialysis. Presented at the 46th Annual Meeting of the American Academy of Neurology, Washington, D.C., May 1-7, 1994. Neurology, 44 (suppl 2), 250. 9. Bhardwaj A, Northington FJ, Koehler RC, Hanley DF, Traytsman RJ. In vivo Characterization of nitric oxide (NO) production in the hippocampus with N-Methyl-D-Aspartate (NMDA) and α-Amino-3-Hydroxy-5-Methylisoxazole-4-propionic acid (AMPA) receptor stimulation and blockade. Presented at the 24th Annual Meeting, Society for Neuroscience, Miami, Florida, November 10-13, 1994. Soc. Neurosci. Abst. 20(1):650. Page 38 PUBLISHED ABSTRACTS (CONT’D) 10. Bhardwaj A, Northington FJ, Koehler RC, Hanley DF, Traytsman RJ. Adenosine A 1 receptor stimulation attenuates the N-Methyl-D-Aspartate (NMDA) induced nitric oxide (NO) production in the hippocampus: An In Vivo Microdialysis Study. Presented at the 20th International Joint Conference on Stroke and Cerebral Circulation, American Heart Association, Charleston, South Carolina, February 8-11, 1995. Stroke 26;(1) 168. 11. Bhardwaj A, Northington FJ, Hanley DF, Traystman RJ, Koehler RC. Characterization of NMethyl-D-Aspartate induced Nitric Oxide production: An In Vivo microdialysis study. Presented at the 47th American Academy of Neurology 1995 Scientific Program, Seattle, Washington, May 7-13, 1995. Neurology 45(4), A391 12. Bhardwaj A, Northington FJ, Hanley DF, Traytsman RJ, Koehler RC. Modulation of glutamate receptor mediated nitric oxide production: Studies utilizing IN VIVO cerebral microdialysis. Presented at the XVII International Symposium on Cerebral Blood Flow and Metabolism (Brain '95), Cologne, Germany, July 2-6, 1995. J. Cereb. Blood Flow Metab. 15 (Suppl. 1), S84. 13. Bhardwaj A, Northington FJ, Hanley DF, Traytsman RJ, Koehler RC. Modulatory effects of adenosine and excitatory amino acids on glutamate receptor mediated nitric oxide production: Studies utilizing IN VIVO cerebral microdialysis. Presented at the 1995 North American Stroke Meeting, Denver, Colorado, June 8-11, 1995. J. Stroke Cerebrovas. Dis., Vol. 5 (2), 1995. 14. Northington FJ, Bhardwaj A, Traytsman RJ, Koehler RC. Adenosine A1 receptor stimulation attenuates N-Methyl-D-Aspartate (NMDA) mediated nitric oxide release. Presented at the Society for Pediatric Research Annual Meeting Atlanta, GA, May 6-13, 1995. 15. Bhardwaj A, Northington FJ, Hanley DF, Traystman RJ, Koehler RC. Effect of glutamate metabotropic receptor stimulation and blockade on nitric oxide production in vivo. Presented at the 120th Annual meeting of the American Neurological Association (ANA), Washington, D.C., October 22-25, 1995. Ann. Neurol. 38(2):308-309. 16. Bhardwaj A, Northington FJ, Hanley DF, Traystman RJ, Koehler RC. Metabotropic glutamate receptor activation mediates nitric oxide (NO) production in the hippocampus in vivo. Presented at the Society for Neuroscience 25th Annual Meeting, San Diego, CA, November 11-16, 1995. Soc. Neurosci. Abst. 21(1):499.1. 17. Kirsch JR, Bhardwaj A, Hanley DF, Traystman RJ. Neither L-arginine or L-NAME alter neurologic outcome following global ischemia in cat. Presented at the Society for Neuroscience 25th Annual Meeting, San Diego, CA, November 11-16, 1995. Soc. Neurosci. Abst. 21(2):393. Page 39 PUBLISHED ABSTRACTS (CONT’D) 18. Kirsch JR, Bhardwaj A, Hanley DF, Traystman RJ. Neither L-arginine or L-NAME alter neurologic outcome following global ischemia in cat. Presented at the Society for Neurosurgical Anesthesia and Critical Care (SNACC) 1995 Annual Meeting, Atlanta, GA, October 20-25, 1995. 19. Minahan RE, Bhardwaj A, Traill TA, Hanley DF. Stimulus evoked sinus arrest in severe Guillian-Barré syndrome. Presented at the 48th Annual Meeting of the American Academy of Neurology, San Francisco, CA, March 23-30, 1996. Neurology P02.140 A209, 46(2). 20. Deibert E, Bhardwaj A, Staats PS, Ulatowski JA. Intrathecal baclofen for the treatment of severe generalized tetanus. Presented at the 121st Annual meeting of the American Neurological Association (ANA), Miami, Florida, October 13-16, 1996. Annals of Neurology 40:3:M89. 21. Bhardwaj A, Northington FJ, Hanley DF, Traystman RJ, Koehler RC. Striatal Nitric Oxide (NO) production is enhanced in focal cerebral ischemia: An In Vivo microdialysis study. Presented at the 26th Annual Meeting of the Society for Neuroscience, Washington, D.C. November 16-21, 1996. Soc. Neurosci. Abst. 22(2):563.15. 22. Bhardwaj A, Northington FJ, Hanley DF, Traystman RJ, Koehler RC. Striatal Nitric Oxide (NO) production is enhanced in focal cerebral ischemia: An In Vivo microdialysis study. Presented at the meeting on Emergency Management and Critical Care of Stroke, Heidelberg, Germany, September 5-7, 1996. 23. Bhardwaj A, Kirsch JR, Koehler RC, London ED, Traystman RJ. The sigma ligand (+)Pentazocine attenuates N-Methyl-D-Aspartate enhanced striatal nitric oxide production in vivo. Presented at the 22nd International Joint Conference on Stroke and Cerebral Circulation, Anaheim, CA, February 6-8, 1997. Stroke 28:(1)125. 24. Bhardwaj A, Kirsch JR, London ED, Koehler RC, Traystman RJ. The sigma ligand (+)Pentazocine attenuates N-Methyl-D-Aspartate enhanced nitric oxide production in vivo. Presented at the 49th Annual Meeting of the Academy of Neurology (AAN), Boston, MA, April 15-17, 1997. Neurology 48(3) S03.002, 1997. 25. Qureshi AI, Razumovsky AY, Williams MA, Bhardwaj A, Hanley DF, Ulatowski JA. Effect of controlled CSF drainage on cerebral hemodynamics in patients with normal pressure hydrocephalus. Presented at the 10th International Conference on Intracranial Pressure, Williamsburg, VA, May 10, 1997. 26. Bhardwaj A, Kirsch JR, Sawada M, London ED, Koehler RC, Traystman RJ. Sigma ligands modulate N-Methyl-D-Aspartate evoked nitric oxide production: Studies utilizing in vivo cerebral microdialysis. Presented at the XVIII symposium on Cerebral Blood Flow and Metabolism (Brain97), Baltimore, MD. July 5-10, 1997. J.Cereb. Blood Flow Metab. 17(1):S408. Page 40 PUBLISHED ABSTRACTS (CONT’D) 27. Toung TJ, Hurn PD, Bhardwaj A, Dawson VL, Traystman RJ. Immunosuppressive agent FK506 reduces experimental stroke injury. Presented at the XVIII symposium on Cerebral Blood Flow and Metabolism (Brain97), Baltimore, Maryland. July 5-10, 1997. J.Cereb. Blood Flow Metab. 17(1):S617. 28. Suarez JI, Qureshi AI, Bhardwaj A, Williams MA, Ulatowski JA, Hanley DF. Treatment of resistant intracranial hypertension with 23.4% saline. Presented at the XVI World Congress of Neurology, Buenos Aires, Argentina. September 14-19, 1997. J. Neurological Sciences 150: 4-26-07. 29. Qureshi AI, Suarez JI, Bhardwaj A, Choudry A, Ulatowski JA, Hanley DF. Use of hypertonic (3%) saline infusion in the treatment of cerebral edema: Effect on intracranial pressure and mass effect. Presented at the XVI World Congress of Neurology, Buenos Aires,Argentina. September 14-19, 1997. J. Neurological Sciences 150: 4-26. 30. Harukuni I, Bhardwaj A, Hurn PD, Slusher BS, Traystman RJ. Novel NAALADase inhibitor, PMPA, improves infarct volume in experimental stroke. Presented at the 27th Annual meeting of Society for Neuroscience, New Orleans, La. October 25-30, 1997. Soc. Neurosci. Abst. 23(2)898.3. 31. Suarez JI, Bhardwaj A, Qureshi AI, Williams MA, Ulatowski JA, Hanley DF. Hypertonic saline as a treatment modality for cerebral edema and intracranial hypertension - Clinical and radiographic correlation. Presented at the 122nd Annual Meeting of the American Neurological Association (ANA), San Diego, CA, September 28-October 1, 1997. Ann. Neurol. 42(3):T315. 32. Qureshi AI, Suarez JI, Parekh P, Bhardwaj A, Sung G, Tamargo RJ, Rigamonti D, Ulatowski JA. Multiple intracranial aneurysms are associated with cigarette smoking. Presented at the 122nd Annual Meeting of the American Neurological Association (ANA), San Diego, CA, September 28-October 1, 1997.Ann. Neurol. 42(3):T167. 33. Qureshi AI, Ling GSF, Bhardwaj A, Wilson DA, Hanley DF, Traystman RJ. Expression of tissue necrosis factor in the cerebrospinal fluid after experimental intracerebral hemorrhage. Presented at the 27th Annual meeting of Society for Neuroscience, New Orleans, La. October 25-30, 1997. Soc. Neurosci. Abst.23(2):855.1. 34. Suarez JI, Qureshi AI, Bhardwaj A, Williams MA, Hanley DF, Ulatowski JA. 23.4% saline as treatment for refractory intracranial hypertension. Presented at the annual meeting of the Society for Neurosurgical Anesthesia and Critical Care (SNACC), San Diego, CA, October 17, 1997. J Neurosurgical Anesthesiology 9(4):601. Page 41 PUBLISHED ABSTRACTS (CONT’D) 35. Qureshi AI, Suarez JI, Bhardwaj A, Hanley DF, Ulatowski JA. Treatment of cerebral edema with hypertonic (3%) saline infusion. Presented at the annual meeting of the Society for Neurosurgical Anesthesia and Critical Care (SNACC), San Diego, CA, October 17, 1997. J Neurosurgical Anesthesiology 9(4):604. 36. Bhardwaj A, Northington FJ, Carhuapoma R, Traystman RJ, Koehler RC. Inhibition of arachidonic acid epoxygenase activity attenuates intraparenchymal blood flow response evoked by N-methyl-D-aspartate in the striatum. Presented at the 50th Annual meeting of the Academy of Neurology (AAN), Minneapolis, MN, April 28-30, 1997; Neurology 50:S59.004. 37. Geocadin R, Qureshi AI, Suarez JI, Parekh PD, Tamargo RJ, Bhardwaj A, Ulatowski JA. Effect of Cerebrovascular risk factors on the risk of Symptomatic Vasospasm after Aneurysmal Subarachnoid hemorrhage. Presented at the 50th Annual meeting of the Academy of Neurology (AAN), Minneapolis, MN, April 28-30, 1997;Neurology 50:P06.119. 38. Bhardwaj A, Sawada M, London ED, Koehler RC, Traystman RJ, Kirsch JR. Potent σ1receptor ligand PPBP [4-Phenyl-1-(4-phenylbutyl) piperidine] modulates basal and Nmethyl-D-aspartate evoked Nitric Oxide production in vivo. Presented at the Society of Neurosurgical Anesthesia and Critical Care 26th Annual Meeting (SNACC), Orlando, Fl, October 16, 1998. J Neurosurgical Anesthesiology 9(4):604. 39. Harukuni I, Bhardwaj A, Traystman RJ, London ED, Kirsch JR. Focal Ischemic Neuroprotection with σ1-Receptor ligand PPBP [4-Phenyl-1-(4-Phenyl) Perperidine] is time dependent. Presented at the Society of Neurosurgical Anesthesia and Critical Care 26th Annual Meeting (SNACC), Orlando, Fl, October 16, 1998. J Neurosurgical Anesthesiology 10 (4):603. 40. Toung TJ, Bhardwaj A, Hurn PD, Traystman RJ. Effect of blood pressure on Infarction Volume In transient Focal Ischemia. Presented at the Society of Neurosurgical Anesthesia and Critical Care 26th Annual Meeting (SNACC), Orlando, Fl, October 16, 1998. J Neurosurgical Anesthesiology 10(4):601. 41. Toung TJ, Bhardwaj A, Hurn PD, Traystman RJ. Effect of blood pressure on infarction volume in transient focal ischemia. Presented at the 1998 Annual Meeting of the American Society of Anesthesiologists Orlando, Fl, October 17-21, 1998. Anesthesiology 1998;89:A781. 42. Kirsch JR, Joung K, Harukuni I, Hurn PD, Bhardwaj A, Traystman RJ. Hypercapnic hyperemia is preserved following emergence from propofol or halothane anesthesia. Presented at the Society of Neurosurgical Anesthesia and Critical Care 26th Annual Meeting (SNACC), Orlando, Fl, October 16, 1998. J Neurosurgical Anesthesiology 10 (4):202. Page 42 PUBLISHED ABSTRACTS (CONT’D) 43. Kirsch JR, Bhardwaj A, London ED, Koehler RC, Traystman RJ. Potent σ1-receptor ligand PPBP [4 Phenyl-1-(4-phenylbutyl) piperidine] modulates basal and N-methyl-D-aspartate evoked Nitric Oxide production in vivo. Presented at the 28th Annual Meeting for the Society for Neuroscience, Los Angeles, CA, November 7-12, 1998. Soc. Neurosci. Abst.24(2):824.7. 44. Bhardwaj A, Northington FJ, Carhuapoma JR, Ichord RN, Harder DR, Traystman RJ, Koehler RC. Inhibition of arachidonic acid epoxygenase activity attenuates N-methyl-Daspartate evoked striatal blood flow response. Presented at the 28th Annual Meeting for the Society for Neuroscience, Los Angeles, CA, November 7-12, 1998. Soc. Neurosci. Abst.24(1):461.7. 45. Lam HHD, Bhardwaj A, O’Connell MA, Hanley DF, Traystman RJ, Sofroniew MV. Nerve growth factor rapidly suppresses basal, NMDA and AMPA-evoked nitric oxide production in rat hippocampus in vivo. Presented at the 28th Annual Meeting for the Society for Neuroscience, Los Angeles, CA, November 7-12, 1998. Soc. Neurosci. Abst.24(1):461.7. 46. Razumovsky AY, Wityk RJ, Williams MA, Bhardwaj A, Hanley DF. Emboli in acute cerebral ischemia. Presented at the meeting of the World Congess on Cerebral Embolism: Monitoring prevention and treatment. New Orleans, LA, November 12-15, 1998. Stroke 1998, 19:2231. 47. Toung TJ, Bhardwaj A, Kirsch JR, Traystman RJ. Neuroprotective effects of antioxidant LY231617 following global cerebral ischemia in dogs. Presented at the 24th American Heart Association Stroke Conference, Nashville, TN, February 5-7, 1999. Stroke 30(1):93. 48. Toung TJ, Bhardwaj A, Dawson V, Dawson TM, Traystman RJ, Hurn PD. Immunosuppressant FK506 provides focal ischemic neuroprotection without altering nitric oxide production in vivo. Presented at the 24th American Heart Association Stroke Conference, Nashville, TN, February 5-7, 1999. Stroke 30(1):P46. 49. Bhardwaj A, Koehler RC, Traystman RJ, Falck JR, Harder DR. Suppression of the NMDAevoked hyperemia by Cytochrome P450 Epoxygenase inhibitors. Presented at the XIXth International Symposium on Cerebral Blood Flow and Metabolism and Function (Brain >99), Copenhagen, June 13-17, 1999. 50. Koehler RC, Bhardwaj A, Traystman RJ, Falck JR, Harder DR. Cytochrome P450 epoxygenase inhibitors block the cerebral blood flow response to NMDA. Presented at the Annual Meeting for Experimental Biology>99, Washington D.C., April 17-21, 1999. 51. Yahia AM, Qureshi AI, Geocadin RG, Bhardwaj A, Williams MA, Ulatowski JA, Hanley DF. Cardiac arrhythmias in patients with Guillain-Barre Syndrome. Presented at the 51st Annual Academy of Neurology (AAN) Annual Meeting, Toronto, Canada, April 17-24, 1999;Neurology 52 (6):P06.087. S24.003. Page 43 PUBLISHED ABSTRACTS (CONT’D) 52. Qureshi AI, Suarez JI, Parekh PD, Bhardwaj A. Prediction and timing of tracheostomy in patients with infratentorial lesions of the brain. Presented at the 51st Annual Academy of Neurology (AAN) Annual Meeting, Toronto, Canada, April 17-24, 1999; Neurology 52 (6):S24.003. 53. Bhardwaj A, Harukuni I, Hurn PD, Koehler RC, Traytsman RJ, Kirsch JR. Continuous hypertonic saline infusion worsens tissue infarction following transient focal ischemia in the rat. Presented at the Society of Neurosurgical Anesthesia and Critical Care 27th Annual Meeting (SNACC), October, 1999; Dallas, Texas, October, 1999. Journal of Neurosurg Anesth 11;4:810. 54. Harukuni I, Bhardwaj A, DeVries AC, London ED, Hurn PD, Traystman RJ, Kirsch JR. Potent σ1-receptor ligand, PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] affords neuroprotection from focal ischemia and prolonged reperfusion. Presented at the Society of Neurosurgical Anesthesia and Critical Care 27th Annual Meeting (SNACC), Dallas, Texas, October, 1999. J Neurosurg Anesth 11;4:907. 55. Bhardwaj A, Harukuni I, Hurn PD, Koehler RC, Kirsch JR, Traystman RJ. Continuous hypertonic saline infusion worsens tissue infarction following transient focal ischemia in the rat. Presented at the 29th Annual Meeting of the Society for Neuroscience, Miami, Florida, October 23-28, 1999. Soc. Neurosci. Abst.25 (1):128.21. 56. Razumovsky AY, Wityk RJ, Williams MA, Panomarev V, Bhardwaj A, Ulatowski JA, Hanley DF. TCD in acute cerebral ischemia. Cerebrovasc Dis 9:87;1999. 57. Carhuapoma JR, Alkayed NJ, Bhardwaj A, Traystman RJ, Harder DR, Koehler RC. Functional hyperemia in the brain is inhibited by cytochrome P450 epoxygenase inhibitors. Presented at the 29th Annual Meeting for the Society for Neuroscience, Miami, Fl, October 23-28, 1999. Soc. Neurosci. Abst.25 (1):656.3. 58. Harukuni I, Bhardwaj A, Shaivitz AB, DeVries AC, London ED, Hurn PD, Traystman RJ, Kirsch JR. Potent σ1-receptor ligand, PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] affords neuroprotection from focal ischemia and prolonged reperfusion. Presented at the 29th Annual Meeting for the Society for Neuroscience, Miami, Fl, October 23-28, 1999. Soc. Neurosci. Abst.25 (1):236.1. 59. Goto S, Bhardwaj A, Hurn PD, Dawson VL, Traystman, Kirsch JR. Neuroprotective effects of Sigma1-receptor ligand [4-phenyl-1-(4-phenylbutyl) piperidine] (PPBP) is linked to reduced neuronal oxide synthase (nNOS) induced NO production. Presented at the 2000 Annual Meeting of the American Association of Neurological Surgeons, San Francisco, CA, April 8-13, 2000. Page 44 PUBLISHED ABSTRACTS (CONT’D) 60. Bhardwaj A, Harukuni I, Kirsch JR, Hurn PD, Koehler RC, Traystman RJ. Continuous hypertonic saline infusion worsens tissue infarction following transient focal ischemia in the rat. Presented at the 25th International Stroke conference, New Orleans, La, 2000. Stroke 31, 339 (P 209). 61. Suarez AI, Qureshi AI, Yahia AM, Bhardwaj A, Tamargo RJ. Temporal patterns of response to hypervolemic and hypertensive treatment in patients with symptomatic vasospasm following subarachnoid hemorrhage. Presented at the 25th International Stroke conference, New Orleans, La, 2000. Stroke 31, 324 (P 135). 62. Kirsch JR, Bhardwaj A, Castro III A, Hurn PD. Effect of anesthetic agent and duration on brain injury from transient focal ischemia in awake rats. Presented at the Annual Meeting of Association of University Anesthesiologists, May, 2000. 63. Chua HC, Varelas PN, Natterman J, Yahia A, Ulatowski JA, Bhardwaj A, Williams MA, Hanley DF. Aggressive respiratory treatment in myasthenic crisis. Presented at the 29th Educational and Scientific Symposium, Society of Critical Care Medicine, Orlando FL, February 11-15, 2000. 64. Bhardwaj A. Pharmacologic Modulation of Nitric Oxide (NO) Production In VIVO and Ischemic Neuroprotection. Presented at the American Heart Association Research Symposium, Dallas Texas, May 6, 2000. 65. Geocadin RG, Razumovsky A, Bhardwaj A, Wityk RJ, Ulatowski JA. Postpartum cerebral vasculopathy and intracerebral hemorrhage. Presented at the 52nd Annual Meeting of the Academy of Neurology, San Diego, CA, May 4, 2000. Neurology 54:A337; P 05.123. 66. Suarez JI, Qureshi AI, Bhardwaj A, Tamargo RJ, Ulatowski JA. Early predictors of outcome in patients receiving hypervolemic and hypertensive therapy for symptomatic vasospasm following subarchnoid hemorrhage. Presented at the 52nd Annual Meeting of the Academy of Neurology, San Diego, CA, May 3, 2000. Neurology, 57:A229:S36.005. 67. Naff NJ, Carhuapoma JR, Williams MA, Bhardwaj A, Ulatowski JA, Bederson J, Bullock R, Schmutzhard E, Fausler B, Keyl PM, Tuhrim S, Hanley DF. Treatment of intraventricular hemorrhage with urokinse:Effects on 30-day survival. Presented at the 52nd Annual Meeting of the Academy of Neurology, San Diego, CA, May 3, 2000. Neurology, 54:A229:S 36.003. 68. Bhardwaj A, Toung TJK, Castro III A, Traystman RJ, Hurn PD, Kirsch JR. Neuroprotective effects of Kappa Opioid Receptor Agonist in tansient focal ischemia. Presented at the Society of Neurosurgical Anesthesia and Critical Care 28th Annual Meeting, San Francisco, CA, October 13, 2000. J Neurosurg Anesth 12;4:417. Page 45 PUBLISHED ABSTRACTS (CONT’D) 69. Torbey M, Hauser T-K, Bhardwaj A, Williams M, Ulatowski JA, Mirski MA, Razumovsky A. The effect of age on cerebral blood flow velocities (CBFV) with clinical vasospasm following subarachnoid hemorrhage. Presented at the Society of Neurosurgical Anesthesia and Critical Care 28th Annual Meeting, San Francisco, CA, October 13, 2000. J Neurosurg Anesth 12;4:414. 70. Bhardwaj A, Castro III A, Hurn PD, Kirsch JR. Reduced ischemic injury in awake rats with acute halothane, but not propofol, preconditioning. Presented at the Society of Neurosurgical Anesthesia and Critical Care 28th Annual Meeting, San Francisco, CA, October 13, 2000. J Neurosurg Anesth 12;4:417. 71. Toung TJK, Bhardwaj A, Traystman RJ, Hurn PD. Temporal profile of cerebral edema following transient focal ischemia in the rat. Presented at the Society of Neurosurgical Anesthesia and Critical Care 28th Annual Meeting, San Francisco, CA, October 13, 2000. J Neurosurg Anesth 12;4:413. 72. Bhardwaj A, Castro III A, Hurn PD, Kirsch JR. Reduced ischemic injury in awake rats with acute halothane, but not propofol, preconditioning. Presented at the Society for Neuroscience 30th Annual Meeting, New Orleans, LA., November 4-9, 2000. J Neurosurg Anesth 12;4:417. 73. Goto S, Bhardwaj A, Hurn PD, Dawson VL, Traystman, Kirsch JR. Neuroprotective effects of Sigma1-Receptor Ligand [4-phenyl-1-(4-phenylbutyl) piperidine] (PPBP) is linked to reduced neuronal oxide synthase (nNOS) induced NO production. Presented at the Society of Neurosurgical Anesthesia and Critical Care 28th Annual Meeting, San Francisco, CA, October 13, 2000. J Neurosurg Anesth 12;4:390. 74. Bhardwaj A, Toung TJK, Kirsch JR, Koehler RC, Hurn PD, Traystman RJ. Neuroprotective effects of Kappa Opioid Receptor Agonist in transient focal ischemia. Presented at the 26th American Heart Association International Stroke Conference, February 14-16, 2001, Ft. Lauderdale, Florida. 75. Bhardwaj A, Castro A III, Traystman RJ, Hurn PD, Kirsch JR. Anesthetic agent choice influences outcome from experimental perioperative stroke. Presented at the 26th American Heart Association International Stroke Conference, February 14-16, 2001. Ft. Lauderdale, Florida. 76. Torbey MT, Hauser T-K, Bhardwaj A, Williams MA, Ulatowski JA, Mirski MA, Razumovsky A. Predictive model for MCA and ICA cerebral blood flow velocities (CBFV) changes following aneurysmal subarachnoid hemorrhage (SAH). Presented at the 26th American Heart Association International Stroke Conference, February 14-16, 2001. Ft. Lauderdale, Florida. Page 46 PUBLISHED ABSTRACTS (CONT’D) 77. Torbey MT, Hauser T-K, Bhardwaj A, Williams MA, Ulatowski JA, Mirski MA, Razumovsky A. Age is an important determinant in cerebral blood flow velocities (CBFV) following aneurysmal subarachnoid hemorrhage (SAH). Presented at the 26th American Heart Association International Stroke Conference, February 14-16, 2001. Ft. Lauderdale, Florida. 78. Razumovsky A, Torbey MT, Hauser T-K, Bhardwaj A, Williams MA, Ulatowski JA, Mirski MA. Cerebral blood flow velocities in older patients following aneurysmal subarachnoid hemorrhage. Presented at the 53th Annual Meeting of the Academy of Neurology, May 5-11, 2001, Philadelphia, PA. Neurology 56(3):A427, P06.074. 79. Torbey MT, Ziai W, Lin D, Guerrieri G, Bhardwaj A, Bhati N, Mirski MA, Ulatowski JA. Clinical and radiological; predictors in mechanically ventilated patients with spontaneous subarachnoid hemorrhage. Presented at the 53th Annual Meeting of the Academy of Neurology, May 5-11, 2001, Philadelphia, PA. Neurology 56(3):A428, P06.077. 80. Buitrago MM, Luft AR, Torbey MT, Bhardwaj A, Razumovsky A. Biphasic blood flow velocity profile in patients with aneurysmal subarachnoid hemorrhage. Presented at the 53th Annual Meeting of the Academy of Neurology, May 5-11, 2001, Philadelphia, PA. Neurology 56(3):A428, P06.090. 81. Bhardwaj A, Toung TK, Traystman RJ, Koehler RC, Hurn PD, Kirsch JR. Neuroprotective effects of kappa opioid receptor agonist in transient focal ischemia. Presented at the 31st Annual Meeting for the Society for Neuroscience, San Diego, CA, November 10-15, 2001. 82. Toung TJK, Brem H, Tyler B, Traystman RJ, Kirsch JR, Bhardwaj A. Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor. Presented at the 31st Annual Meeting for the Society for Neuroscience, San Diego, CA, November 10-15, 2001. 83. Bhardwaj A, Castro III J, Traystman RJ, Hurn PD, Kirsch JR. Outcome from focal ischemia after brief pre-ischemic halothane exposure is not altered by blockade of ATP-regulated potassium channels. Presented at the 29th Annual Meeting of Society of Neurosurgical Anesthesia and Critical Care, New Orleans, La., October 12, 2001. J Neurosurg Anesth 13;4:364. 84. Toung TJK, Tyler B, Brem H, Traystman RJ, Kirsch JR, Hurn PD, Bhardwaj A. Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor. Presented at the 29th Annual Meeting of Society of Neurosurgical Anesthesia and Critical Care, New Orleans, La., October 12, 2001. J Neurosurg Anesth 13;4:366. 85. Goyagi T, A Bhardwaj, PD Hurn, RJ Traystman, JR Kirsch. Neuroprotective σ1-receptors ligand, PPBP, attenuates ischemia-evoked striatal nitric oxide production in vivo. Presented at the Brain 2001 Meeting, Teipei, Taiwan, June 9-13, 2001. J Cereb Blood Flow & Metab 21 (Suppl. 1): S458, 2001. Page 47 PUBLISHED ABSTRACTS (CONT’D) 86. Toung TK, A Bhardwaj, RJ Traystman, JR Kirsch, PD Hurn. Cerebral edema persists in ischemic/nonischemic brain days after MCA occlusion. Presented at the Brain 2001 Meeting, Teipei, Taiwan, June 9-13, 2001. J Cereb Blood Flow & Metab 21 (Suppl. 1): S456, 2001. 87. Ziai WC, Port J, Cowan J, Bhardwaj A, Goranzik I, Rigamonti D. Decompressive hemicraniectomy for intractable cerebral edema: Experience at a single center. Presented at the 31st Critical Care Congress of the Society of Critical Care Medicine. San Diego, CA, January 26-30, 2001. Critical Care Medicine, 29 (12):108/S23, 2002. 88. Ziai WC, Torbey MT, Pindrick J, Bhardwaj A. Surgical versus medical therapy for large hemispheric infarctions: A decision analysis. Presented at the 31st Critical Care Congress of the Society of Critical Care Medicine. San Diego, CA, January 26-30, 2001. Critical Care Medicine, 29 (12):406/S165, 2002. 89. Torbey MT, Geocadin RG, Bhardwaj A. Brain arrest neurologic outcome scale (BRANOS): Predicting mortality following cardiac arrest. Presented at the 31st Critical Care Congress of the Society of Critical Care Medicine. San Diego, CA, January 26-30, 2001. Critical Care Medicine, 29 (12):597/M250, 2002. 90. Buitrago M., Luft A., Torbey M.T., Bhardwaj A., Razumovsky A.Y., Biphasic blood flow velocity profile in patients with aneurysmal subarachnoid hemorrhage. Poster presentation, 25th Annual Meeting of the American Society of Neuroimaging. Tampa Bay, Florida, March 7-10, 2002. J Neuroimaging 2002; 12 (2): 195. 91. Chase CM, Bhardwaj A, Torbey MT. Intracerebral hemorrhage in Maryland: Role of a specialty Intensive Care Unit. Presented at the 54th Annual Meeting of the Academy of Neurology, Denver, CO, April 30-20, 2002. Neurology 58;7; A136, P02.097. 92. Geocadin RG, Flores-Gumiran O, Torbey MT, Bhardwaj A, Mirski MA. Cerebral herniation syndrome: Clinical course and immediate outcome. Presented at the 54th Annual Meeting of the Academy of Neurology, Denver, CO, April 30-20, 2002. Neurology 58;7; A135, P02.095. 93. Torbey MT, Geocadin RG, Bhardwaj A. Brain arrest neurologic outcome scale (BrANOS): A strong predictor of outcome following cardiac arrest. Presented at the 54th Annual Meeting of the Academy of Neurology, Denver, CO, April 30-20, 2002. Neurology 58;7; A158, S19.001. 94. Bhardwaj A, Goyagi T, Hurn PD, Traystman RJ, Koehler RC, Kirsch JR. Potent σ1receptor ligand PPBP [4-Phenyl-1-(4-Phenylbutyl) Piperidine] (PPBP) provides ischemic neuroprotection without altering dopamine accumulation in vivo. Presented at the 54th Annual Meeting of the Academy of Neurology, Denver, CO, April 30-20, 2002. Neurology 58;7; A366, P05.071. Page 48 PUBLISHED ABSTRACTS (CONt’D) 95. Bhardwaj A, Toung TJK, Traystman RJ, Koehler RC, Hurn PD, Kirsch JR. Selective Kappa (κ) receptor agonist, BRL 52537 attenuates stroke volume following transient focal ischemia in rat. Presented at the 54th Annual Meeting of the Academy of Neurology, Denver, CO, April 30-20, 2002. Neurology 58;7; A365, P05.070. 96. Ziai WC, Sherman DL, Bhardwaj A, Zhang N, Mirski MA. Microchemical changes induced by anticonvulsant thalamic deep brain stimulation (DBS). Presented at the 54th Annual Meeting of the Academy of Neurology, Denver, CO, April 30-20, 2002. Neurology 58;7; A370, P05.082. 97. Otsuka T, Hurn PD, Mori S, Traystman RJ, Froeher SC, Adams ME, Agre P, Bhardwaj A. Infarction volume is attenuated in mice lacking alpha-syntrophin following transient focal cerebral ischemia. Presented at the 32nd Annual Meeting of the Society for Neuroscience, Orlando, FL, November 2-6, 2002. 98. Bhardwaj A, Toung TJK, Traystman RJ, Hurn PD, Kirsch JR. Neuroprotective Kappa opioid receptor agonist, BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo. Presented at the 127th Annual Meeting of the American Neurological Association, New York, October 13-16, 2002. Ann Neurol 52 (3):S25, 2002. 99. Otsuka T, Hurn PD, Mori S, Traystman RJ, Froeher SC, Adams ME, Agre P, Bhardwaj A. Infarction volume is attenuated in mice lacking alpha-syntrophin following transient focal cerebral ischemia. Presented at the 28th International Stroke Conference, Phoenix, AZ, February 13-15, 2003. Stroke 34, 300 (P 243). 100. Ziai WC, Sherman DL, Bhardwaj A, Xhang N, Mirski MA. Comparative profiles of anterior thalamic deep brain stimulation (DBS) and local serotonergic receptor activation on anticonvulsant action and catecholamine microchemistry. Presented at the 54th Annual Meeting of the American Academy of Neurology, Honolulu, Hawaii, April 2003. 101. Zhang Z, Chen T-Y, Goyagi T, Toung TJK, Kirsch JR, Koehler RC, Traystman RJ, Hurn PD, Bhardwaj A. Characterization of ischemic neuroprotection with selective kappa opioid receptor agonist, BRL 52537. Presented at the Brain ’03 , Calgary, Canada, June 2003. 102. Chen T-Y, Toung TJK, Koehler RC, Kirsch JR, Bhardwaj A. Prolonged Therapeutic Window for Ischemic Neuroprotection with Selective Kappa-opioid Receptor Agonist, BRL 52537 in Rat. Presented at the Annual Meeting of the American Society of Anesthesiologists, San Francisco, CA October 11-15, 2003. 103. Chen T-Y, Toung TJK, Koehler RC, Kirsch JR, Bhardwaj A. Prolonged Therapeutic Window for Ischemic Neuroprotection with Selective Kappa-opioid Receptor Agonist, BRL 52537 in Rat. Presented at the 128th Annual meeting of the American Neurological Association, San Francisco, CA October 2003. Ann Neurol 54; S66-S66: 2003. Page 49 PUBLISHED ABSTRACTS (CONt’D) 104. Zhang Z, Kirsch JR, Toung TJK, Koehler RC, Traystman RJ, Hurn PD, Bhardwaj A. KappaOpioid Receptor selectivity for Ischemic neuroprotection With BRL-52537 In Rats. Presented at the 128th Annual meeting of the American Neurological Association, San Francisco, CA October 2003. Ann Neurol 54; S26-S26:2003. 105. Chang Y, Toung TJK, Bhardwaj A. Serum arginine vasospressin increases following transient focal ischemia in rats. Presented at the 128th Annual meeting of the American Neurological Association, San Francisco, CA October 2003. Ann Neurol 54; S64-S65: 2003. 106. Chen TY, Toung TJ, Kirsch JR, Traystman RJ, Hum PD, Koehler RC, Bhardwaj A. Selective kappa-opioid receptor agonist BRL 52537 confers a long therapeutic window for neuroprotection following transient focal ischemia in rat. Presented at the 29th International Stroke Conference, San Diego, CA, February 5-7, 2004. Stroke 35; 277-277: 2004. 107. Ziai W, Stevens RD, Pradilla G, Bhardwaj A, Mirski MA. C-reactive protein in subarachnoid hemorrhage. Presented at Annual meeting of the Society of Critical Care Medicine, Orlando, Fl, February 2004; Critic Care Med 31 (12); 46: 2003. 108. Mirski MA, Ziai WC, Bhardwaj A, Zhang N, Anderson M, Sherman D. The role of serotoninergic systems in the anticonvulsant mechanism of thalamic-Deep Brain Stimulation. Presented at the 2nd Annual meeting of the Neurocritical Care Society, San Diego, CA February 7-8, 2004. 109. Chen TY, Toung TJ, Kirsch JR, Traystman RJ, Hum PD, Koehler RC, Bhardwaj A. Selective kappa-opioid receptor agonist BRL 52537 confers a long therapeutic window for neuroprotection following transient focal ischemia in rat. Presented at the 2nd Annual meeting of the Neurocritical Care Society, San Diego, CA February 7-8, 2004. 110. Zhang Z, Chen T-Y, Toung TJK, Traystman RJ, Kirsch JR, Hurn PD, Koehler RC, Bhardwaj A. Ischemic neuroprotection by kappa opioid agonist BRL 52537 is receptor selective. Presented at the 2nd Annual meeting of the Neurocritical Care Society, San Diego, CA February 7-8, 2004. Neurocritical Care, 1; 263, 2004. 111. Toung TJK, Chang Y, Traystman RJ, Crain BJ, Bhardwaj A. Effect of systemic blood pressure on neurological outcome following spinal cord ischemia. Presented at the 2nd Annual meeting of the Neurocritical Care Society, San Diego, CA February 7-8, 2004. Neurocritical Care, 1; 263, 2004. 112. Stevens RD, Quiroga A, Resse E, Wityk RJ, Bhardwaj A, Restrepo L. Troponin I levels do not correlate with outcome following ischemic stroke. Presented at the 2nd Annual meeting of the Neurocritical Care Society, San Diego, CA, February 7-8, 2004. Neurocritical Care, 1; 281, 2004. Page 50 PUBLISHED ABSTRACTS (CONt’D) 113. Stevens RD, Quiroga A, Wityk RJ, Bhardwaj A, Restrepo L. Elevations in Troponin I do not correlate with ischemic stroke involving the insular cortex. Presented at the 2nd Annual meeting of the Neurocritical Care Society, San Diego, CA, February 7-8, 2004. Neurocritical Care, 1; 281, 2004. 114. Ziai WC, Stevens RD, Pradilla G, Bhardwaj A, Mirski MA. C-Reactive protein in subarachnoid hemorrhage. Presented at the 2nd Annual meeting of the Neurocritical Care Society, San Diego, CA, February 7-8, 2004. Neurocritical Care, 1; 268, 2004. 115. Stevens RD, Quirogo A, Wityk RJ, Bhardwaj A, Restrepo L. Myocardial injury in ischemic stroke involving the insular cortex. Presented at the 56th Annual Meeting of the American Academy of Neurology, San Francisco, CA, April 24-May 1, 2004. Neurology 62; A141, 2004. 116. Toung TJK, Lin J, Chang Y, Bhardwaj A. Increases in Lung Water following experimental stroke: Effect of hypertonic saline. Presented at the 2004 Annual meeting of American Society of Anesthesiologists, Las Vegas, Nevada, October 23-27, 2004. 117. Toung TJK, Lin J, Chang Y, Bhardwaj A. Lung water is increased following experimental stroke: Effect of treatment with hypertonic saline. Presented at the American Neurological Association 129th Annual Meeting, October 3-6, Toronto, Canada. Annals of Neurology 56: S14-S14 Suppl. 8, 2004. 118. Toung TJK, Chang Y, Lin J, Bhardwaj A. Increases in Lung and Brain Water following Experimental Ischemic Stroke: Effect of Osmotherapy with Hypertonic Saline. Presented at the 25 th International Stroke Conference, February 2-4, 2005, New Orleans, La. Stroke 36;513:2005. 119. Chen C-H, Toung TJK, Kirsch JR, Hurn PD, Koehler RC, Bhardwaj A. Ischemic Neuroprotection with Selective Kappa Opioid Receptor Agonist is Gender Specific. Presented at the 25 th International Stroke Conference, February 2-4, 2005, New Orleans, La. Stroke 36;509:2005. 120. Vagernova K, Noppens R, Hurn PD, Kirsch JR, Bhardwaj A. Common neuroprotective mechanism for σ1 receptor agonist and iNOS inhibitor. Presented at the 2005 Critical Care Congress, January 15-19, Phoenix, AZ. Critical Care Medicine 32; 12: A98, 2004. 121. Toung TJK, Chen C-H, Bhardwaj A. Effect of duration of osmotherapy on blood brain barrier disruption and regional cerebral edema following experimental stroke. Presented at the 2005 Annual meeting of American Society of Anesthesiologists, Las Vegas, Nevada, October 23-27, 2005. Page 51 PUBLISHED ABSTRACTS (CONT’D) 122. Zeynalov E, Nemoto M, Hurn PD, Koehler RC, Bhardwaj A. Neuroprotective effect of selective kappa opioid receptor agonist is gender specific and linked to reduced neuronal nitric oxide. Presented at the 26th International Stroke Conference, February 17, 2006, Kissemmee, FL. 123. Toung TJ, Bhardwaj A, Mirski MA. Comparison of the Effects of Equiosmolar Mannitol and Hypertonic Saline on Cerebral and Visceral Organ Water in an Uninjured Rodent Model. Presented at the 34th Annual Meeting of Society of Neurosurgical Anesthesia and Critical Care, October 2006. 124. Toung TJ, Bhardwaj A, Mirski MA. Comparison of the Effects of Progressive, Equiosmotic Hypertonic Saline Concentration on Cerebral and Visceral Organ Water in an Uninjured Rodent Model. Presented at the 34th Annual Meeting of Society of Neurosurgical Anesthesia and Critical Care, October 2006. 125. Liu X, Zhang W, Alkayed NJ, Hurn PD, Bhardwaj A. No gender differences in strokeassociated cerebral edema: role of aquaporin-4. Presented at the Annual Meeting of the Society for Neuroscience, San Diego, CA, October 2007. 126. Liu X, Zhang W, Froehner SC, Alkayed NJ, Adams ME, Amiry-Moghaddam M, Ottersen OP, Hurn PD, Bhardwaj A. Lack of Gender-linked Differences in cerebral edema and Aquaporin-4 expression After Experimental Stroke. Presented at the International Stroke Conference 2008, New Orleans, La, February 2008. 127. Koroiwa M, Herson PS, Traystman RJ, Bhardwaj A. Role of perivascular pool of Aquaporin-4 in cerebral edema following experimental cardiac arrest. Presented at the 2008 Annual meeting of the American Association of Anesthesiologists, October 18-22, Orlando, FL. 128. Nakayama S, Bhardwaj A. Hypertonic saline attenuates cerebral edema following experimental cardiac arrest: Role of aquaporin-4. Presented at the 2008 Annual meeting of the American Association of Anesthesiologists, October 18-22, Orlando, FL. 129. Migliati E, Bhardwaj A. The Na+-K+-Cl- Cotransport Inhibitor, Bumetanide Attenuates Cerebral Edema following Experimental Stroke via the Perivascular Pool of Aquaporin-4. Presented at the International Stroke Conference 2009, San Diego, CA, February 2009. 130. Nakayama S, Migliati E, Bhardwaj A. Osmotherapy with Hypertonic Saline Ameliorates Cerebral Edema following Experimental Cardiac Arrest via Perivascular Pool of Aquaporin4. Presented at the International Stroke Conference 2009, San Diego, CA, February 2009. Page 52 PUBLISHED ABSTRACTS (CONT’D) 131. Nakayama S, Bhardwaj A. Conivaptan, A Selective Arginine Vasopressin V1a/V2 Receptor Antagonist Attenuates Cerebral Edema Following Cardiac Arrest via Perivascular Pool of Aquaporin-4. Presented at the Annual meeting of the International Anesthesia Research Society (IARS), Honolulu, Hawaii, 2010. SELECTED INVITED LECTURES 1. Anesthesiology Research Grand Rounds, Johns Hopkins University School of Medicine, "Modulation of In Vivo Nitric Oxide Production," June 18, 1995. 2. Neurology Grand Rounds, University of Heidelberg, Germany "Pharmacologic Modulation of In Vivo Nitric Oxide Production”, July 18, 1995. 3. Seminar, National Institute of Health, Stroke Division, Bethesda “Characterization of glutamate induced nitric oxide production in vivo”, September 20, 1996. 4. Seminar, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, “Applications of Microdialysis in the Neurosciences”, February 28, 1997. 5. American Thoracic Society/American Lung Association International Conference, San Francisco, CA “Microdialysis in the Neurosciences”, May 17, 1997. 6. Research Seminar, University of Vermont School of Medicine, Burlington, VT “Modulation of Nitric Oxide Production in vivo”, July 16, 1997. 7. Neurology Grand Rounds, Neuroscience Institute, Seaton Hal University, New Jersey “Interactions of Adenosine, Glutamate and Nitric Oxide in vivo”, September 24, 1997. 8. Neuroscience Grand Rounds, University of Vermont School of Medicine, Burlington, VT “ Hypertonic Saline as a Treatment Modality for Cerebral Edema and Intracranial Hypertension” January 22, 1998. 9. 28th Society of Critical Care Medicine, San Francisco, CA “Brain attack - Making the Right Diagnosis”, January 24, 1999. 10. North American Stroke Meeting, Aspen, CO “Medical management of Subarachnoid Hemorrhage”, September 7, 1999. Page 53 SELECTED INVITED LECTURES (CONT’D) 11. 29th Society of Critical Care Medicine Annual Meeting, Orlando, FL “Clinical Pitfalls in Neurologic Patients - Blood Pressure Management”, February 13, 2000. 12. Seminar, Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, “Hypertonic Saline in Acute Brain Injury”, September 25, 2000. 13. Advanced Clinical Topics in Neuroscience Nursing, Johns Hopkins University School of Medicine, “Neurologic Assessment: Assessment of the Unconscious Patient and Evaluating Complex Motor Responses”, May 1, 2001. 14. Grand Rounds, Department of Anesthesiology, Water Reed Medical Center, Bethesda, “Osmotherapy in Acute Brain Injury”, October 30, 2001. 15. Grand Rounds, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, “Hypertonic Saline Therapy in Acute Brain Injury: Clinical and Experimental Evidence” , November 29, 2001. 16. Grand Rounds, Department of Neurology, Medical University of South Carolina, Charleston, AHypertonic Saline Therapy in Acute Brain Injury: Clinical and Experimental Evidence@, December 6, 2001. 17. Grand Rounds, Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, “Osmotherapy in Acute Brain Injury: Clinical and Experimental Evidence”, February 14, 2002. 18. Grand Rounds, Departments of Neurology and Neurosurgery, University of California, Irvine, “Hypertonic Saline Therapy in Acute Brain Injury: Clinical and Experimental Evidence”, February 20, 2002. 19. Invited Speaker, “Cerebrovascular Emergencies”, Johns Hopkins University School of Medicine, “Emerging Therapies in Critical Care of Ischemic Stroke”, September 18, 2002. 20. Invited Speaker, Joint Meeting of the AANS/CNS Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology, “Management of Symptomatic Vasospasm”, February 18, 2003. 21. Invited Speaker, Special Seminar, Oregon Health Sciences University, Portland, Oregon, “Hypertonic Saline Therapy in Acute Brain Injury: Clinical and Experimental Evidence”, March 6th, 2003. 22. Invited Speaker, Special Seminar, Oregon Health Sciences University, Portland, Oregon, “Emerging Therapies in Critical Care of Ischemic Stroke”, March 6th, 2003. Page 54 SELECTED INVITED LECTURES (CONT’D) 23. Grand Rounds, Department of Anesthesiology, Water Reed Medical Center, Bethesda, “Hypertonic Saline Therapy in Acute Brain Injury: Clinical and Experimental Evidence”, April 29th, 2003. 24. Grand Rounds, Department of Neurology, Johns Hopkins University School of Medicine, “Emerging Concepts in Cerebral Edema Associated with Ischemic Stroke”, December 18, 2003. 25. Grand Rounds, Departments of Neurology and Neurosurgery, University of Utah School of Medicine, “Emerging Concepts in Cerebral Edema Associated with Ischemic Stroke”, March 24, 2004. 26. Grand Rounds, Departments of Neurology, Neurosurgery and Anesthesiology/Perioperative Medicine Oregon Health & Science University, “Emerging Concepts in evolution of Cerebral Edema Associated with Ischemic Stroke”, July 19, 2004. 27. Invited Speaker, Tiantan International Stroke Conference, Bejing, China, “Emerging Concepts in evolution of Cerebral Edema Associated with Ischemic Stroke”, September 24, 2004. 28. Grand Rounds, Department of Neurology, University of Maryland School of Medicine, “Management of Cerebral Edema”, February 9, 2005. 29. Special Seminar, Wake Forest University School of Medicine,“Pathogenesis of management of cerebral edema”, April 25, 2005. 30. Neurosurgery Grand Rounds, Oregon Health & Science University, “Hypertonic Saline Therapy for brain injury: Clinical and Experimental Evidence”, January 23, 2006. 31. Neuroscience Grand Rounds, Oregon Health & Science University, “Kappa and Sigma Receptor Agonists in Experimental Ischemic Stroke”, March 1, 2006. 32. Neurosurgery Grand Rounds, Oregon Health & Science University, “Controversies in the management of Subarachnoid hemorrhage”, March 20, 2006. 33. Invited Speaker, Oregon Medical Association, Portland, OR, “Management of large ischemic strokes”, April 29, 2006. 34. Visiting Professor, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, Research Conference “Hypertonic Saline Therapy for brain injury: Clinical and Experimental Evidence”, July 18, 2006. Page 55 SELECTED INVITED LECTURES (CONT’D) 35. Visiting Professor, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, Grand Rounds “Emerging Concepts in the Evolution of Cerebral Edema: Bedside to the Bench”, July 19, 2006. 36. Invited Speaker, Synapse Conference, Oregon Health & Science University, “Evolution of Ischemia-Evoked Cerebral Edema: From Bedside to the Bench”, August 22, 2006. 37. Invited Speaker, Neurology Advancements for the 21st century: Clinical & Research Updates for 2006, “Blood Pressure management in Acute Ischemic Stroke and Intracerebral Hemorrhage”, Marriott Portland Downtown Waterfront, Portland, OR, September 15, 2006. 38. Invited Speaker, 33rd Annual Critical Care Symposium “Blood Pressure management in Acute Ischemic Stroke and Intracerebral Hemorrhage”, Holiday Inn, Portland, OR, November 16, 2006. 39. Invited Speaker, Department of Pulmonary and Critical Care Grand Rounds, Oregon Health and Science University, Portland “Emerging Concepts in the Evolution of Cerebral Edema: Bedside to the Bench”, December 12, 2006. 40. Invited Speaker, Providence Microsurgical Group, Roundtable Discussion “Use of hypertonic saline in Brain Injury”, January 18, 2007. 41. Invited Speaker, 2nd Year Medical student Curriculum, Oregon Health and Science University, Portland “Stupor and Coma”, February 5, 2007. 42. Invited Speaker, Cardene Advisory Board, San Francisco, CA “Nicardipine in Neurocritical Care: Future Directions”, February 10, 2007. 43. Invited Speaker, Anesthesiology and Peri-Operative Medicine Research Seminar, Oregon Health and Science University “Emerging concepts in the evolution of ischemia-evoked cerebral edema; From Bench to the bedside”, April 4, 2007. 44. Invited Speaker, Physician Assistant Lecture Series, Oregon Health and Science University “Encephalitis, Coma and Brain Death” OHSU, Physician Assistant Training Program, April 24, 2007. 45. Invited Speaker, Oregon Stroke Network, Oregon Museum of Science and Industry, Portland “Management of large ischemic stroke: A critical Appraisal” Portland, May 12, 2007. 46. Visiting Professor, Department of Neurology, University of Pittsburgh, PA, Grand Rounds “Emerging Concepts in the Evolution of Cerebral Edema: Bedside to the Bench”, September 6, 2007. Page 56 SELECTED INVITED LECTURES (CONT’D) 47. Invited Speaker, 2nd Year Medical student Curriculum, Oregon Health and Science University, Portland “Stupor and Coma”, February 4, 2008. 48. Invited Speaker, OptumHealth, New Orleans, La Challenging Cases in Acute Blood Pressure management: Putting the Guidelines into Practice; Acute Blood Pressure management in Neurocritical Care: A focus on ICH and SAH, OptumHealth, February 21, 2008. 49. Invited Speaker, Neurology Synapse Research Forum, Department of Neurology, Oregon Health and Science University, Portland “Role of Aquaporin-4 in Cerebral Edema following Ischemia” May 27, 2008. 50. Invited Speaker, University of Florida, Gainsville, FL “Emerging concepts in the evolution of ischemia-evoked cerebral edema; From Bench to the bedside”, August 26, 2008. 51. Invited Speaker, University of Medicine and Dentistry, New Jersey, “Emerging concepts in the evolution of ischemia-evoked cerebral edema; From Bench to the bedside”, January 12, 2009. 52. Invited Speaker, Anesthesiology and Peri-Operative Medicine Grand Rounds, Oregon Health and Science University “Emerging concepts in the evolution of ischemia-evoked cerebral edema; From Bedside to the bench”, May 11, 2009. 53. Invited Speaker, Neuroscience Grand Rounds, Tufts University School of Medicine “Emerging concepts in the evolution of ischemia-evoked cerebral edema; From Bedside to the bench”, September 10, 2009. 54. Invited Speaker, Neurology Grand Rounds, The Lahey Clinic, Tufts University School of Medicine “Newer concepts in the evolution of ischemia-evoked cerebral edema; From Bedside to the bench”, September 17, 2009. 55. Invited Speaker, Neurology Grand Rounds, Brigham Women’s Hospital, Harvard Medical School, Boston, MA “Emerging concepts in the evolution of ischemia-evoked cerebral edema; From Bedside to the bench”, October 28, 2009. 56. Invited Speaker, Neurology Grand Rounds, Massachusetts General Hospital, Harvard Medical School, Boston, MA “Emerging concepts in the evolution of ischemia-evoked cerebral edema; From Bedside to the bench”, October 29, 2009. 57. Invited Speaker, Neurology Grand Rounds, Morton Hospital, Tauton, MA “Emerging concepts in the evolution of ischemia-evoked cerebral edema; From Bedside to the Bench”, December 1, 2009. Page 57 SELECTED INVITED LECTURES (CONT’D) 58. Invited Speaker, Neurology Grand Rounds, Baystate Medical Center, Springfield, MA “Emerging concepts in the evolution of ischemia-evoked cerebral edema; From Bedside to the Bench”, January 27, 2010. 59. Invited Speaker, North Eastern University, Boston MA, “Role of Aquaporin-4 in Cerebral Edema following Ischemia”, February 18, 2010. 60. Invited Speaker, Department of Medicine Grand Rounds, Tufts University School of Medicine, Boston MA, “Role of Aquaporin-4 in Cerebral Edema following Ischemia”, February 19, 2010. 61. Invited Speaker, Lawrence General Hospital, Lawrence MA, “Encephalopathy, Coma and Brain Death”, March 2, 2010. 62. Invited Speaker, Newton Wellsley Hospital, Newton MA, “Encephalopathy, Coma and Brain Death”, April 21, 2010. 63. Invited Speaker, Neuroscience Research Seminar, Boston University, Boston, MA “Emerging concepts in the evolution of ischemia-evoked cerebral edema; From Bedside to the Bench”, April 29, 2010. 64. Invited Speaker, Grand Rounds, General Medical Associates, Department of Medicine, Tufts Medical Center “Delirium”, June 15, 2010. 65. Invited Speaker, Stroke Conference, Baystate Medical Center, Springfield, MA, “Intracerebral and Subarachnoid Hemorrhage”, October 26, 2010. 66. Invited Speaker, Boston Society for Neurology and Psychiatry, Beth Israel Deaconess Hospital, Boston, MA “Neurocritical Care: Historical perspective, Outcomes and Future Directions”, November 11, 2010. 67. Invited Speaker, Department of Medicine, Grand Rounds Lahey, Burlington, MA “Neurocritical Care: Historical perspective, Outcomes and Future Directions”, November 12, 2010. 68. Invited Speaker, Department of Anesthesiology Grand Rounds, Tufts Medical Center, Boston, Massachusetts “Neurocritical Care: Historical perspective, Outcomes and Future Directions”, January 24, 2011. 69. Invited Speaker, MetroWest Medical Center/Leonard Morse Hospital, “Role of Neurocritical Care Units in Current Medical Practice”, March 28, 2011. Page 58 SELECTED INVITED LECTURES (CONT’D) 70. Invited Speaker, Neurological and Neurosurgical Intensive Care, Harvard Medical School CME Course, “Management of Intracranial Pressure Associated with large Hemispheric Infractions” May 17-19, 2012, Boston, Massachusetts. 71. Invited Speaker, Department of Psychiatry Grand Rounds, Tufts Medical Center, Boston Massachusetts “Neurocritical Care: History, Outcomes and Future Directions”, May 22, 2012. 72. Invited Speaker, Neuroscience Grand Rounds, University of Texas Medical Branch (UTMB), Galveston, Texas “Neurocritical Care: History, Outcomes and Future Directions”, April 16, 2014. 73. Invited Speaker, Grand Rounds, Department of Internal Medicine, University of Texas Medical Branch (UTMB), Galveston, Texas “Neurocritical Care: History, Outcomes and Future Directions”, May 1, 2014. 74. Invited Speaker, Grand Rounds, Department of Internal Medicine, University of Texas Medical Branch (UTMB), Galveston, Texas “Neurocritical Care: History, Outcomes and Future Directions”, October 27, 2014. INVITED PANELS 2013 Invited member, Focused Group for Neuroscience Research Development, University of Texas System, Austin 2012 Moderator, Intracerebral Hemorrhage for Neurological and Neurosurgical Intensive Care, Harvard Medical School CME Course, May 17-19, Boston, Massachusetts 2012 Moderator, International Stroke Conference 2012 Invited Session #110: Volatile Anesthetics as Neuroprotective Agents, New Orleans, Louisiana 2011 Symposium Chair, 9th World Congress on Neurohypophysial Hormones, Northeastern University, Boston, Massachusetts 2007-2010 Abstracts Review Committee, International Stroke Conferences, American Heart Association 2007 Cardene Advisory Board, PDL Pharma, San Francisco, California 2006 Abstracts Review Committee, 59th Annual Meeting for the American Academy of Neurology, Boston, Massachusetts Page 59 INVITED PANELS (CONT’D) 2004 Abstracts Review Committee, XXIInd International Symposium on Cerebral Blood Flow, Metabolism, and Function & VIIth International Conference on Quantification of Brain Function with PET, Vrije Universiteit, Amsterdam, The Netherlands. 2004 Moderator and Session Chair, “Aura linked to Stroke”, 29th International Stroke Conference. San Diego, California 2002 Abstract Review Committee, 56th Annual Meeting of the Academy of Neurology 2003-2007 Abstracts Review Committee, International Stroke Conferences, American Heart Association 2003 Faculty, Joint Meeting of the AANS/CNS Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology, Florida 2000 Program Committee, North American Stroke Meeting, Toronto, Canada 2000 Invited Professor Walk Rounds Brain Injury: Experimental Studies, Society of Critical Care Medicine, Orlando, Florida 2000 Moderator and Session Chair, Clinical Pitfalls in Neurologic Patients, Society of Critical Care Medicine, Orlando, Florida 1999 Program Committee and Faculty, North American Stroke Meeting, Aspen, Colorado 1998 Faculty Group Leader, 26th Annual Meeting of the Society of Neurosurgical Anesthesia and Critical Care 1998- 2000 Faculty, Lecture Series on A Update on Stroke Prevention, Strategic Implications International. 1998- 2000 Faculty, Continuing Lecture Series on Antiplatelet Agents in Stroke Prevention, Scientific Exchange Inc. 1996 Faculty, Neurocritical Care Workshop, 48th Annual Meeting of the American Academy of Neurology, San Francisco, California Updated: January 2, 2015 Page 60
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