David A. Sullivan, Ph.D.
1
CURRICULUM VITAE
Part I: General Information
Date Prepared:
December 2014
Name:
David A. Sullivan
Office Address:
Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114
E-Mail:
[email protected]
Place of Birth:
Medford, MA
FAX: 617-912-0101
Education:
1972 A.B., Biology
1976 M.S., Physiology
1980 Ph.D., Physiology
Boston University, Boston, MA
University of Minnesota Medical School, Minneapolis, MN
Dartmouth Medical School, Hanover, NH
Postdoctoral Training:
Research Fellowships:
1980-1982
1982-1983
1982-1983
Research Fellow, Department of Physiology, Dartmouth Medical School, Hanover,
NH
Research Fellow, Schepens Eye Research Institute
Research Fellow, Department of Ophthalmology, Harvard Medical School
Professional Appointments:
Academic Appointments:
1983-1986
1986-1995
1995-
Instructor in Ophthalmology, Harvard Medical School
Assistant Professor in Ophthalmology, Harvard Medical School
Associate Professor in Ophthalmology, Harvard Medical School
Institute Appointments:
1983-1986
1986-1991
19912007-
Assistant Scientist, Schepens Eye Research Institute
Associate Scientist, Schepens Eye Research Institute
Senior Scientist, Schepens Eye Research Institute
Margaret S. Sinon Scholar in Ocular Surface Research, Schepens Eye Research
Institute
Major Administrative Responsibilities:
David A. Sullivan, Ph.D.
2
National and International:
1984-1986
1987-1991
1988-1996
1990-2000
1994
1996-2001
2000-2001
2001-2013
2001-2013
20012003
2003-2004
2003-2004
2005-2007
2005-2007
2005-2007
2005-2006
2007
2008
2008-2011
2008-2011
2009-2010
Member, International Advisory Committee, First International Conference on
Hormones and Immunity, Toronto, Ontario, Canada
Chairman, Graduate Education Committee, Dartmouth Medical School Alumni
Council
Founding Member, Lacrimal Gland Study Group (Sarasota, FL)
Organizer, 1st (Bermuda, 1992), 2nd (Bermuda, 1996) and 3rd (Maui, 2000)
International Conference on the Lacrimal Gland, Tear Film and Dry Eye
Syndromes: Basic Science and Clinical Relevance
Participant, National Eye Institute/Industry Workshop on Clinical Trials in Dry
Eyes
Medical and Scientific Advisory Board, Sjögren’s Syndrome Foundation; 20002001, Chair
Board of Directors, Sjögren’s Syndrome Foundation
President, Tear Film & Ocular Surface Society (TFOS)
President, TFOS Governing Board
Organizer/Director, 4th (Puerto Rico, 2004), 5th (Taormina, 2007), 6th (Florence,
2010) and 7th (Taormina, 2013) International Conference on the Tear Film &
Ocular Surface: Basic Science & Clinical Relevance
Co-Organizer, Immunology of the Ocular Surface and Tear Film WorkShop,
Bavaria, Germany
Organizer, Symposium on Sex Differences in Ocular Surface Biology, International
Congress of Eye Research, Sydney, Australia
Consultant and Fundraiser, International WorkShop for the Definition, Diagnosis
and Classification of Dry Eye Syndromes (DEWS)
Co-Organizer, TFOS International Dry Eye WorkShop (DEWS)
Chair, Industry Liaison Subcommittee, TFOS DEWS
Co-Organizer, 2007 TFOS Report of the International Dry Eye WorkShop
(DEWS), published in The Ocular Surface, Volume 5, Number 2, pp. 65-204, 2007;
additional material placed online at www.TearFilm.org
Organizer, Symposium on Immunology of Dry Eye, International Congress of Eye
Research, Buenos Aires, Argentina
Organizer, Special Interest Group Meetings, Conclusions and Recommendations of
the TFOS International Dry Eye Workshop (DEWS), Association for Research in
Vision and Ophthalmology Annual Meeting (ARVO), Fort Lauderdale, FL, and
European Association for Vision and Eye Research Annual Meeting (EVER),
Portoroz, Slovenia
Organizer, TFOS Corporate Advisory Board and Associate Corporate Sponsor
Meeting
Organizer and Steering Committee Member, TFOS International Workshop on
Meibomian Gland Dysfunction
Chair, Industry Liaison Subcommittee, TFOS International Workshop on
Meibomian Gland Dysfunction
Co-Programmer and Co-Chair, Ocular Surface Disease session, World Cornea
Congress, Boston
David A. Sullivan, Ph.D.
3
2009-2010
2009-2010
20112011
20112011-2012
2011-2013
2012-2013
201320132014-
Organizer, International Regulatory Officials and Experts Meeting, “Global
Treatments for Dry Eye Syndrome: An Unmet Need,” Florence, Italy
Organizer, Special Interest Group Meetings, Conclusions and Recommendations of
the TFOS International Workshop on Meibomian Gland Dysfunction, ARVO
(Fort Lauderdale, FL), British Contact Lens Association Clinical Conference and
Exhibition (Birmingham, UK), World Ophthalmology Congress (Berlin, Germany),
EVER (Hersonissos, Crete) and the International Symposium on Ocular
Pharmacology and Therapeutics (Macau, China)
Member, ARVO Program Committee (Cornea Section)
Co-Organizer, ARVO 2012 Minisymposium on Surgical Innovations for the
Treatment of Eye Disease
Chair, TFOS Young Investigator Committee
Organizer, Session on Surgery-Induced Dry Eye, World Ophthalmology Congress
2012, Abu Dhabi
Organizer, TFOS International Workshop on Contact Lens Discomfort
Chair, Industry Liaison Subcommittee, TFOS International Workshop on Contact
Lens Discomfort
Member, TFOS Board of Directors
Chairman, TFOS Board of Directors
Organizer, TFOS International Dry Eye WorkShop II (DEWS II)
Harvard Medical School:
1982-1984
1997-1998
1998- 2001
Co-Organizer, Mucosal Immunology Seminar Series, involving Schepens Eye
Research Institute, Massachusetts General Hospital, Shriners Burns Institute,
Children’s Hospital and Tufts Medical Center (Boston)
Founding Member, Joint Clinical Research Center of the Schepens Eye Research
Institute and the Massachusetts Eye & Ear Infirmary
Founding Member, Joint Governance Committee, Joint Clinical Research Center of
the Schepens Eye Research Institute and the Massachusetts Eye & Ear Infirmary
Schepens Eye Research Institute:
1990-1994
1990-1994
1995-2006
2003-2004
2007-2012
2008-2010
Head, Immunology Unit
Research Council (Faculty Senate); 1993-1994, Head
Chair, Technology Transfer Committee
Founding Member, Corporate Alliance Program
Chair, Distinguished Alumni Committee
Director, Center for Corneal and External Eye Disease Research
Major Committee Assignments:
National and International:
1989-1991
1990
Reviewer of research grant proposals, Veteran's Administration and the North
Carolina Biotechnology Center
Member, Ad hoc NIH Study Section
David A. Sullivan, Ph.D.
4
1992-1995
1995
1996
1997
1998-2001
1998-2001
1999
2000
2001
2001
20022003
2003-2008
2004
2005-2006
2005, 2006
2007-2008
20082008
2009
2010
2011-2012
2012 -
Member, Fellowship Review Panel for the Fight for Sight Research Division of the
National Society to Prevent Blindness
Consultant, National Eye Institute/Industry Dry Eye Epidemiology Project,
Washington, DC
Consultant, CIBA Vision Ophthalmic’s 1st International Advisory Board Meeting
on Dry Eye, Bermuda
Reviewer of research grant proposal, The Wellcome Trust, England
Member, Fund Raising Committee, Sjogren's Syndrome Foundation
Member, Research Grant Program Committee, Sjogren's Syndrome Foundation
Adjunct Faculty Appointment, Promotion and Tenure Committee of the State
University of New York at Stony Brook
Consultant, Novartis’ International Advisory Board Meeting on Dry Eye, Maui
Participant, 1st National Eye Institute Initiative Workshop, Florida
Reviewer of research grant proposal, Concerted Action Program of the Ministry of
Education of Flanders
Member, Advisory Board of the Women's Eye Health Task Force
Consultant, Dry Eye / Contact Lens Blue Ribbon Panel of the Vistakon Division
of Johnson & Johnson Vision Care
Member, Scientific Advisory Board, OcuSense
Consultant, Novartis’ Advisory Board Meeting, Florida
Member, Organizing Committee, 9th International Symposium on Sjögren's
Syndrome, Washington, DC
Ad hoc member, NIH Anterior Eye Disease Study Section
Member, International Advisory Committee, 9th Congress of International Society
of Dacryology and Dry Eye, Istanbul, Turkey
Scientific Advisor, TearLab
Consultant, Pfizer Advisory Board Meeting, New York City, NY
Consultant, Pfizer Advisory Board Meeting, Fort Lauderdale, FL
Consultant, Pfizer Advisory Board Meeting, Florence, Italy
Consultant, Forest Pharmaceutical Advisory Group, Jersey City, NJ
Member, Organizing Committee, 12th International Symposium of Sjögren’s
Syndrome, Kyoto, Japan
Department of Ophthalmology, Harvard Medical School:
1989-1997
1992
1997-1998
2002
20042006
2008-2009
2010-2011
Member, Organizing Committee, 16th, 18th, 19th and 20th Biennial Cornea Research
Conference
Member, Research Retreat Steering Committee
Member, Schepens Eye Research Institute / Massachusetts Eye & Ear
Infirmary/Harvard Medical School Human Studies Center Committee
Member, Massachusetts Eye & Ear Infirmary Cornea Fellowship Review
Committee
Participant, NIH grant for Harvard Vision Clinical Scientist Development Program
Judge, Basic Science Poster Contest, HMS Department of Ophthalmology Annual
Meeting
Co-Chair, 26th Biennial Cornea Research Conference, Boston, MA
Member, Organizing Committee, 27th Biennial Cornea Research Conference,
Boston, MA
David A. Sullivan, Ph.D.
5
2014-2015
2012-
Member, Organizing Committee, 29th Biennial Cornea Research Conference,
Boston, MA
Member, Distinguished Achievements Department Awards Committee
Schepens Eye Research Institute:
1984-1990
1985-1994
1986
1987-1990
1988
1990-1999
1991-1996
1993
1994-1995
1994-1995
1995
1995, 2002
1995-1997
1996-1997
1996
1996
1998
1999-2000
1998-2002
1998-2004
1999-2001
2000
2000-2001
2002-2003
2003-2004
2003-2006
2004
2004-2005
2005-2010
2005-2006
2006-2012
2006
2007-2010
20072009
2009
Radioisotope Safety Committee; 1988-1990, Chair
Member, Broadhurst Lecture Committee
Member, Search Committee for an Institute Molecular Biologist
Member, NIH Shared Instrument Grants Committee
Member, Search Committee for a Mast Cell Biologist
Member, Postdoctoral Fellow Training Committee
Member, Appointments and Promotions Committee
Member, Technology Transfer Committee
Member, Ad Hoc Committee on Indirect Costs
Member, Training Advisory Group to the Director of Research
Member, Visiting Professor Committee
Presenter, seminars for Development Department in Andover (MA) and Florida
Leader, Immunity, Inflammation and Transplantation Focus Group
Member, Research Advisory Group to the Director of Research
Member, Public Relations and Development Advisory Group to the Director of
Research
Member, Public Relations and Development Committee
Member, Ad Hoc Telescience Center Committee
Coordinator and Co-Program Chairperson, Schepens Eye Research 50th
Anniversary Clinical Science Symposium
Member, Dry Eye Focus Group
Scientific Communications Center Committee; 1998, Chair
Member, Strategic Issue Subcommittee
Member, Ad Hoc Committee on a Proposed Center for Development and Testing
of Ophthalmic Therapeutics
Member, DNA Microarray Committee
Member, Seminars Committee
Member, Ad Hoc Committee on Corporate Sponsorship Program
Invited presenter, research overview to Trustees and Corporators
Participant, Planning Grant for Exploratory Center for Interdisciplinary Research
on Blinding Diseases
Member, Governance Evaluation Committee
Member, Faculty Retreat Committee
Member, Committee to explore possible joint interests of the Schepens Eye
Research Institute and the Retina Associates
Member, Human Studies Committee
Co-Organizer, Cornea & External Disease Focus Group
Member, Seminars Committee
Presenter, dry eye treatment overview for Corporate Alliance Program visitors
Member, Committee to address Director of Research position description
Invited presenter, Center for Corneal and External Eye Disease Research seminar
series
David A. Sullivan, Ph.D.
6
2010
2010-2011
2013
20132014-
Invited presenter, SERI Faculty Retreat
Member, Faculty Recruitment Committee
Judge, SERI “Best Paper” contest
Member, Training Committee
Chair, Distinguished Lecture Series Committee
Massachusetts Eye and Ear:
2013
Invited presentation to the Leadership Group
Harvard Medical School Department of Ophthalmology:
2013
Invited presentation for the November New Frontiers in Corneal Research
meeting
Memberships, Offices and Committee Assignments in Professional Societies:
19821984-2011
1984-1993
1984-1995
1987-2001
1990-1991
1996-2012
2000-
2013-
Association for Research in Vision and Ophthalmology
The American Association of Immunologists
The New York Academy of Sciences
The American Association for the Advancement of Science
Society for Mucosal Immunology
International Society for Neuroimmunomodulation
Endocrine Society
Founding Member, Tear Film & Ocular Surface Society (TFOS); 2001-2013,
President. The purpose of this Society is to [a] advance the research, literacy, and
educational aspects of the scientific field of the tear film and ocular surface; [b]
organize and coordinate international conferences, meetings, seminars, events and
workshops to promote better understanding of the tear film and ocular surface; and
[c] stimulate interactions among members, and attract new members with diverse
disciplinary interests and expertise throughout the world. Since the Society’s
incorporation, and during the course of my Presidency, I organized 4 International
Conferences, organized 3 International Workshops on Dry Eye Disease,
Meibomian Gland Dysfunction and Contact Lens Discomfort, oversaw the
awarding of more than 200 Young Investigator Travel Awards and helped raise
over 5.0 million dollars from industry to fund the Society. The Society has also
sponsored, and promoted the growth and recognition of, the peer-reviewed
journal, The Ocular Surface. This Society has a distribution to ~ 5,000 basic
scientists, clinical researchers and industry representatives from over 80 countries. I
receive no compensation for my TFOS service.
Chair, TFOS Board of Directors
Community Service:
19832000
Speaker and Participant, Lion's Club meetings and events in Acton (MA),
Springfield (MA), Boston, and the Schepens Eye Research Institute
Invited speaker; Eastern Massachusetts Sjögren’s Syndrome Chapter; Brookline,
MA
David A. Sullivan, Ph.D.
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2004
2006
Invited speaker & Moderator; Sjogren's Syndrome Foundation Regional Seminar,
Braintree, MA
Invited speaker; Fall meeting of the Greater Boston Chapter of the Sjogren’s
Syndrome Foundation, Boston
Editorial Boards:
1983-
2001-2004
2002-2013
2003
2006-2008
2011-
Ad Hoc Reviewer and/or Guest Editor: Acta Ophthalmologica Scandinavia,
Archives of Ophthalmology, Arthritis Journal, Arthritis Research & Therapy,
Biochimie, Biology of Reproduction, Breast Cancer Research and Treatment,
British Journal of Ophthalmology, Cornea, Current Eye Research, Drugs,
Evidence-Based Complementary and Alternative Medicine, Experimental Eye
Research, Human Reproduction, International Archives Allergy & Immunology,
Investigative Ophthalmology & Visual Science, JAMA Ophthalmology, Journal of
Anatomy, Journal of Clinical Investigation, Journal of Immunology, Journal of
Nutrition, Journal of Rheumatology, Journal of Steroid Biochemistry & Molecular
Biology, Life Sciences, Lupus, Maturitas, Molecular Vision, Ocular Immunology &
Inflammation, Ophthalmic Research, Ophthalmology, Optometry & Vision
Science, Oral Diseases, Physiological Genomics, PLoS ONE, Psychiatry Research,
Regional Immunology, Survey of Ophthalmology
Editorial Board Member, Cornea
Editorial Board Member, The Ocular Surface
Editorial Board Member, Middle East Journal of Ophthalmology
Editorial Board Member, Eye & Contact Lens
Editorial Board Member, Archivos de la Sociedad Española de Oftalmologia
Awards and Honors:
1974
1974-1977
1997
1997
20072009
2010
2011
2013
2013
University of Minnesota Graduate School Academic Scholarship
Dartmouth College Graduate School Academic Scholarships
Inductee, Matignon High School Achievement Hall of Fame, Cambridge, MA
Invited participant, Research to Prevent Blindness National Science Writers
Seminar
Margaret S. Sinon Scholar in Ocular Surface Research, Schepens Eye Research
Institute
Best Paper of Ocular Surface Disease Session, Middle East and African Congress
of Ophthalmology, Manama, Kingdom of Bahrain
Lifetime Achievement Award, Tear Film & Ocular Surface Society
Carel C. Koch Memorial Medal Award, American Academy of Optometry
Silver Fellow Honor, ARVO Class of 2013
Honorary Member, French Society of Ophthalmology
David A. Sullivan, Ph.D.
8
Part II: Research and Teaching Contributions
A. Narrative Report of Research and Teaching Contributions
I am a medical research scientist with training in physiology, endocrinology and immunology. I was
recruited into ophthalmology in 1982. To summarize my laboratory’s research accomplishments, I would
like to place them in the context of our overall hypotheses and discoveries. Thus, we have discovered that
sex and sex steroid hormones are critical factors in the regulation of ocular surface tissues, as well as in the
pathogenesis of dry eye disease. We have also discovered that androgens may suppress, and that estrogens
may promote, aqueous-deficient and/or evaporative dry eye. More specifically:
• we have shown that sex and sex steroids, as well as neuropeptides and cytokines, regulate the secretory
immune system of the eye. This system is designed to protect the ocular surface against bacterial
colonization, viral adhesion, parasitic infestation and toxin-induced damage, thereby preserving corneal
integrity and preventing severe visual impairment. Our results support our hypothesis that the
endocrine, neural and immune systems govern ocular mucosal immunity. To help conduct these
experiments we developed a defined culture system for the long term maintenance of responsive acinar
epithelial cells from the lacrimal gland. This accomplishment was commended as one of the foremost
achievements in ocular surface research by an NEI National Plan for Vision Research.
• we have shown that androgens reduce the inflammation in, and enhance the functional activity of,
lacrimal glands in mouse models of Sjögren’s syndrome. These findings are extremely significant, given
that no clinical therapy currently exists for this debilitating autoimmune disease, which occurs almost
exclusively in women and is one of the leading causes of aqueous-deficient dry eye disease in the world.
The mechanism(s) involved in this androgen-induced immunosuppression is unknown. However, our
evidence indicates that this hormone action is a unique, tissue-specific effect, that is initiated through
androgen binding to receptors in lacrimal gland epithelial cells. In addition, we hypothesize that this
androgen interaction then causes the altered expression and/or activity of specific genes and proteins in
lacrimal tissue, resulting in the reduction of immunopathological lesions and an improvement in
glandular function. Our research has supported this hypothesis, which, if true, may lead to the
development of unique, therapeutic strategies to safely and effectively treat this chronic and visionthreatening disease;
• we have shown that androgens regulate the meibomian gland, which is the primary tissue involved in
maintaining tear film stability and preventing tear film evaporation. This finding is also very significant,
given that almost no other information exists concerning the physiological control of this tissue, and
that meibomian gland dysfunction is the major cause of evaporative dry eye disease throughout the
world. Based upon our research, we hypothesize that: [a] androgens regulate meibomian gland function,
improve the quality and/or quantity of lipids produced by this tissue and promote the formation of the
tear film’s lipid layer; and [b] androgen deficiency, such as occurs during menopause, aging, Sjögren's
syndrome, complete androgen insensitivity syndrome and the use of anti-androgen medications, leads to
meibomian gland dysfunction, altered lipid profiles in meibomian gland secretions, decreased tear film
stability and evaporative dry eye. Our data support these hypotheses, and have significantly increased
our understanding of the physiological mechanisms controlling the meibomian gland in both health and
disease;
• in collaboration with Drs. Debra A. Schaumberg, M. Reza Dana and Julie E. Buring, we have shown
that dry eye disease occurs predominantly in women and that estrogen replacement therapy increases
David A. Sullivan, Ph.D.
9
the prevalence of dry eye signs and symptoms in postmenopausal women. This latter finding is
extraordinary, given that many millions of women worldwide are prescribed estrogen to alleviate
menopausal symptoms and are therefore at heightened risk of developing dry eye. The precise
mechanism(s) underlying the sex-related difference in, and the estrogen effect on, dry eye prevalence is
unclear. However, we hypothesize that: [a] androgen deficiency and estrogen use are key factors in the
predominance of dry eye disease in women; and [b] sex, androgen and estrogen effects are mediated
through the regulation of gene expression in the cornea and the lacrimal and meibomian glands. Our
research supports these hypotheses, which, if correct, may be translated into new insights into how
estrogens influence ocular tissues, and how these hormones may contribute to the etiology of dry eye
disease.
•
in addition to these findings, we have discovered that: [a] lubricin, a boundary lubricant, is transcribed,
translated, and expressed by human ocular surface epithelia; [b] lubricin presence significantly reduces
friction between the human cornea and conjunctiva; and [c] lubricin deficiency may play a role in
promoting corneal damage. Overall, we believe that lubricin may be an important barrier to the
development of corneal and conjunctival epitheliopathies that may occur in dry eye disease and contact
lens wear.
In summary, our research has addressed the sex steroid regulation of the ocular surface and adnexa,
the interrelationships between sex, sex steroids and dry eye disease, as well as the role of a boundary
lubricant on the ocular surface. Our studies have involved basic, clinical and epidemiological aspects, and
have required the establishment of new and unique experimental approaches (e.g. lipid analytical,
proteomic and molecular biological methods). Of particular interest, our research findings have led to the
development of topical treatments (i.e. androgen, lubricin) that may serve as a potential therapy for both
aqueous-deficient and evaporative dry eye disease.
In terms of teaching, I have served as a preceptor for 27 postdoctoral fellows and 4 students, been
invited to present numerous research seminars, organized 7 International Conferences on the tear film and
ocular surface, and acted as a Chairman of the Graduate Education Committee of the Dartmouth Medical
School Alumni Council. I am also a Founding Member and President of the Tear Film & Ocular Surface
Society, which we created to advance the research, literacy, and educational aspects of the scientific field of
the tear film and ocular surface throughout the world.
B. Research Funding Information:
Past:
1983-1988
NIH/R01
Associate Investigator
The secretory IgA system of the eye
1985-1988
NIH/R01
PI
Endocrine control of the ocular secretory immune system
1988-1994
NIH/R01
PI
Endocrine control of the ocular secretory immune system
1988-1991
NIH/R01
Co-PI
The secretory IgA system of the eye
1991-1993
NIH/R01
PI
David A. Sullivan, Ph.D.
10
The secretory IgA system of the eye
1991-1993
MA Lion's Fund
PI
Ocular immunology and immunopathology
1992-1994
Allergan Inc.
PI
Ocular androgen therapy for dry eye in Sjögren's syndrome
1994-1996
Allergan Inc.
PI
Ocular androgen therapy for dry eye in Sjögren's syndrome
1994-1998
NIH/R01
PI
Neuroendocrinimmune control of lacrimal gland immunity
1996-1997
MA Lion’s Fund
Co-PI
New strategies for controlling ocular inflammation
1996-1999
Allergan Inc.
PI
Ocular androgen therapy for dry eye syndromes
1998-2001
NIH/R01
PI
Gender, sex steroids and dry eye syndromes
1999-2000
Allergan
Co-PI
Prevalence of dry eye syndromes
1999-2000
SERI/MEEI
Co-PI
Gender and dry eye syndromes
1999-2005
Allergan Inc.
PI
Ocular androgen therapy for dry eye syndromes
2000-2001
NIH/SERI
PI
Influence of estrogen and progesterone on gene expression
in the lacrimal and meibomian glands
2001-2005
NIH/R01
PI
Gender, sex steroids and dry eye syndromes
2005
NIH/R01 (Supplement) PI
Gender, sex steroids and dry eye syndromes
2005-2010
NIH/R01
PI
Sex, sex steroids and dry eye syndromes
2007-2010
Alcon Laboratories
PI
Regulation of the meibomian gland in health & disease
David A. Sullivan, Ph.D.
11
Current:
2010-2014
NIH/R01
PI
Sex, sex steroids and dry eye syndromes
2014
GlaxoSmithKline
PI
Modulation of human meibomian gland epithelial cells
C. Report of Current Research Activities:
Project
Role
Sex, sex steroids and dry eye syndromes
PI
Modulation of human meibomian gland epithelial cells
PI
D. Report of Teaching:
1. Local Contributions
a. Local invited teaching presentations
1981-1982
Lectures on clinical endocrinology to critical care nurses of New Hampshire and
Vermont, Dartmouth Hitchcock Medical Center, Hanover, NH
1981-1982
Instructed in a laboratory course devoted to methodological techniques in physiology
and immunology, Dartmouth Medical School, Hanover, NH
1982-
Schepens Eye Research Institute Seminar Series
1982-1984
Mucosal Immunology Seminar Series, Massachusetts General Hospital
1988
Combined Program in Pediatric Gastroenterology and Nutrition at Massachusetts
General and Children's Hospitals
1989
Immunology Department, Massachusetts Eye and Ear Infirmary
1989
Immunology Graduate Student Lecture Series, Harvard Medical School
1991
Forsyth Dental Center
1991
Department of Ophthalmology Retreat, Harvard Medical School
1993
Department of Pathology, Beth Israel Hospital
1995
19th Biennial Cornea Research Conference
1998
Clinical Research Jumpstart Program, New England College of Optometry
David A. Sullivan, Ph.D.
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1999
Schepens Eye Research Institute Symposium on Sjögren’s Syndrome and Allied
Disorders
1999
21st Biennial Cornea Conference
1999
Research Lecture Series, New England College of Optometry
2000
1st International Congress For Research on the Aging Eye, Boston
2001
Second Symposium on Sjögren’s Syndrome, Boston
2003
Cornea Department, Massachusetts Eye & Ear Infirmary
2003
Invited discussant, Women's Eye Health Task Force meeting, Boston
2005
Harvard Department of Ophthalmology Annual Meeting
2006
1st Annual Ocular Immunology & Uveitis Foundation Physician Education
Conference, Boston
2012
Harvard Department of Ophthalmology Annual Meeting
b. Advisory and supervisory responsibilities
1987-1992
Preceptor for 3 NIH Training Grant Fellowship Awards
1988-1991
Preceptor for 3 Fight for Sight-Prevent Blindness Fellowship Awards
1992-1993
Preceptor for Sjögren's Syndrome Foundation Fellowship Award
1992-1993
Sponsor for Bausch & Lomb Postdoctoral Fellowship Award
1994-1995
Sponsor for Uehara Memorial Foundation Postdoctoral Fellowship Award
1995-1996
Preceptor for Sjögren's Syndrome Foundation Fellowship Award
1999
Invited jury member of a graduate student’s Ph.D. thesis (addressing androgenresponsive enhancers and gene regulation), Katholieke Universiteit Leuven, Leuven,
Belgium
1999-2000
Preceptor for Sjögren's Syndrome Foundation Fellowship Award
1999-2001
Preceptor for Allergan Postdoctoral Fellowship Award
1999 -2001
Sponsor for Deutsche Forschungsgemeinschaft Postdoctoral Fellowship Award
2000-2003
Preceptor for Allergan (Japan) Postdoctoral Fellowship Award
David A. Sullivan, Ph.D.
13
2002-2003
Preceptor for Bausch & Lomb Postdoctoral Fellowship Award
2002-2003
Preceptor for Japanese Eye Bank Association Postdoctoral Fellowship Award
2008-2009
Preceptor for Fellowship Award from the Harvard Medical School Postdoctoral
Training Program in the Molecular Bases of Eye Disease
2009-2011
Preceptor for Turkish Postdoctoral Fellowship Awards
2009-2010
Preceptor for ARVO/Pfizer Postdoctoral Fellowship Award
2012-2013
Preceptor for AFER/Vistakon Dry Eye Fellowship Award
2013-2014
Sponsor for ARVO/Merck Collaborative Research Fellowship Award to Geeta K.
Vemuganti, DNB, FAMS, MD (University of Hyderabad, India)
c. Professional leadership roles related to teaching
1975-1976
Organizer, graduate/medical student course on parturition, Dartmouth Medical
School, Hanover, NH
1982-1984
Co-Organizer, Mucosal Immunology Seminar Series, involving Schepens Eye
Research Institute, Massachusetts General Hospital, Shriners Burns Institute,
Children’s Hospital and Tufts Medical Center (Boston)
1989-1990
Director, Immunology Unit Research Series, Schepens Eye Research Institute
1991-1992
Organizer, Journal Club series on Ocular Inflammation, Schepens Eye Research
Institute
d. Names of advisees or trainees
Postdoctoral Fellows:
1987
Marie T. Girard, Ph.D.
Project: Development of rat/mouse hybridomas and monoclonal antibodies
Current Position: Associate Director, R&D Project Management, Boehringer
Ingelheim Pharmaceuticals, Inc. Ridgefield, CT
1988-1989
Hiroko Ariga, M.D.
Project: Androgen influence on lacrimal gland autoimmune disease
Current Position: Ophthalmologist, National Hospital, Sapporo, Japan
1988-1990
Robin S. Kelleher, Ph.D.
Project: Neural, endocrine and immune regulation of the ocular secretory immune
system
Current Position: Senior Scientific Associate, Schepens Eye Research Institute,
Boston
David A. Sullivan, Ph.D.
14
1988-1989
Ana Cristina Vendramini, M.D.
Project: Androgen impact on lacrimal gland autoimmune disease
Current Position: Ophthalmologist and Eye Bank Coordinator, Hospital Ofir
Loyola, Belem, Brazil
1989-1991
Elcio H. Sato, M.D.
Project: Effects of immunosuppressive agents on lacrimal gland autoimmune
disease
Current Position: Professor, São Paulo Federal University, São Paulo, Brazil;
Medical Director, São Paulo Hospital Eye Bank; President, Pan-American
Association of Eye Banks
1990-1993
Ross William Lambert, Ph.D.
Project: Neuroendocrinimmune control of secretory component production by
lacrimal gland epithelial cells
Current Position: Associate Professor, Department of Kinesiology, Western Illinois
University, Macomb, IL
1991-1993
Zhiyan (James) Huang, M.D.
Project: Impact of viral infection on the ocular secretory imune system
Current Position: Associate Professor, Oakland University-William Beaumont
School of Medicine; Pathologist and Associate Medical Director, Flow Cytometry,
William Beaumont Hospital, Royal Oak, MI
1991-1992
Flavio Jaime Rocha, M.D.
Project: Endocrine influence on the normal and autoimmune lacrimal gland
Current Position: Chairman & Associate Professor, Department of
Ophthalmology, University of Uberlandia Medical School, Uberlandia, Brazil;
Director of the Eye Bank - University Federal of Uberlandia
1992-1994
Masafumi Ono, M.D.
Project: Regulation of androgen receptors in the lacrimal gland
Current Position: Assistant Professor, Department of Ophthalmology, Nippon
Medical School, Tokyo, Japan
1993-1994
Janethe D.O. Pena, M.D., Ph.D.
Project: Hormonal control of the lacrimal gland
Current Position: Senior Medical Scientific Expert, Novartis Pharma, Florham
Park, New Jersey
1994-1997
Ikuko Toda, M.D.
Project: Sex and androgen influence on lacrimal gland autoimmune disease
Current Position: Director, Minamiaoyama Eye Clinic, Tokyo, Japan
1995-1996
Kathleen L. Krenzer, O.D., Ph.D.
Project: Effect of androgen deficiency on the human meibomian gland and ocular
surface
David A. Sullivan, Ph.D.
15
Current Position: Principal Scientist, Bausch and Lomb, Rochester, NY
1995-1997
Eduardo M. Rocha, M.D., Ph.D.
Projects: Androgen regulation of pro- and anti-inflammatory cytokines in the
lacrimal gland; Identification of androgen receptors in human ocular suface tissues
Current Position: Associate Professor, Department of Ophthalmology, São Paulo
University, Ribeirao Preto, Brazil
1997-1999
Jennifer M. Cermak, Ph.D.
Project: Influence of complete androgen insensitivity syndrome on the human
meibomian gland and ocular surface; Nutrient intake in women with Sjögren’s
syndrome
Current Position: Senior Director, Portfolio Management at Sirtris, Director of
Portfolio Management at Sirtris, GSK Company, Cambridge, MA
1998-2000
Hiroko Yamagami, M.D., Ph.D.
Project: Sex and androgen influence on gene expression in the meibomian gland
Current Position: Associate Professor, Department of Ophthalmology, Jichi
Medical School, Omiya Medical Center, Saitama, Japan
1999-2001
Meng Liu, M.D., Ph.D.
Project: Androgen regulation of gene expression in the lacrimal gland
Current Position: Director of Molecular Pathology, General Manager, OriGene
Beijing eTown Site, OriGene Technologies, Inc, Rockville, MD
1999-2002
Frank Schirra, M.D., Ph.D.
Project: Androgen regulation of gene expression in the meibomian gland;
Identification of steroidogenic enzyme mRNAs in the lacrimal gland, meibomian
gland, cornea and conjunctiva
Current Position: Attending in Ophthalmology and Director of Outpatient
Division, Universitätsklinikum des Saarlandes, Homburg, Germany
2000-2003
Tomo Suzuki, M.D., Ph.D.
Project: Estrogen and progesterone influence on gene expression in the meibomian
gland; Effect of estrogens on human corneal epithelial cells
Current Position: Ophthalmologist, Kyoto Municipal Hospital, and Researcher,
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto,
Japan
2002-2005
Nathaniel S. Treister, D.M.D., D.MSc.
Project: Sex and androgen influence on gene expression in the salivary glands
Current Position: Assistant Professor, Division of Oral Medicine, Infection, and
Immunity at the Harvard School of Dental Medicine, Boston, MA; Associate
Surgeon, Division of Oral Medicine and Dentistry, Brigham and Women's
Hospital, Boston, MA
2004-2005
Patricia S. Tsai, M.D.
Project: Proteomic analysis of human meibomian gland secretions
David A. Sullivan, Ph.D.
16
Current Position: Ophthalmologist, Cornea and External Diseases, Kaiser
Permanente, Woodland Hills, CA
2006-2011
Shaohui Liu, M.D., Ph.D.
Project: Regulation of the meibomian gland in health and disease
Current Position: Ophthalmology Resident, Louisiana State University Health
Science Center, Shreveport, LA
2008-2010
Payal Khandelwal, Ph.D.
Project: Endocrine regulation of the ocular surface and adnexa
Current Position: Product Manager, BioVision, Milpitas, CA
2008-2009
Shaun Murphy, Ph.D.
Project: Identification, function and regulation of surfactant-associated proteins on
the ocular surface and adnexa
Current Position: Preclinical studies consultant, Abpro, Woburn, MA
2009-2011
Raheleh Rahimi Darabad, M.D.
Project: Immortalization and physiological control of human corneal epithelial cells
Current Position: Anesthesiology Resident, Advocate Illinois Masonic Medical
Center, Chicago, IL
2009-2011
Afsun Sahin, M.D.
Project: Analysis of inflammatory pathways in human ocular surface epithelial cells
Current Position: Assistant Professor of Ophthalmology, Eskisehir Osmangazi
University Medical School, Eskisehir, Turkey
2011-2013
Juan Ding, Ph.D.
Project: Influence of retinoic acid on the meibomian gland
Current Position: Investigator, Schepens Eye Research Institute, and Instructor,
Harvard Medical School
2012-
Yang Liu, M.D.
Project: Endocrine regulation of ocular surface and adnexal tissues
2014-
Bing Niu, PhD
Project: Identification, function and regulation of surfactant-associated proteins
and collectins on the ocular surface and adnexa
2015-
Chi Zhang, M.D.
Project: To be determined
Visiting Scientists:
2012
Hikmet Basmak, M.D.
Medical Students:
David A. Sullivan, Ph.D.
17
1999
Ward R. Bijlsma, Dutch Medical Student
Project: Androgen influence on lymphocyte gene expression
Current Position: Assistant Professor, Department of Ophthalmology, University
Medical Center Utrecht, Utrecht, The Netherlands
1999
Bart A. R. Tonino, Dutch Medical Student
Project: Androgen influence on lymphocyte gene expression
Current Position: Radiologist, Nijmegen, Netherlands
College Students:
1992-1994
Amy Gallant Sullivan, Acton, MA
Project: Translation of French medical literature (book, articles) into English
Current Position: Executive Director, Tear Film & Ocular Surface Society, Paris,
France
2010
Kimberly Topilow, Barnard, NYC, NY
Project: Leukotriene B4 in ocular surface epithelial cells
High School Students:
1986
Linda A. Block, Scarsdale Alternative School, NY
Project: Hormonal influence on lacrimal gland morphology
1991-1993
Benjamin D. Sullivan, Acton, MA
Project: Computer assistance, graphics and slide generation, image and statistical
analyses
Current Position: Founder, Chief Scientific Officer, TearLab, Corp, San Diego;
Founder and Director, Singularis/Lµbris LLC; Founding Inventor, Biological
Dynamics, Inc., Founder and Director, Code Fluidics LLC; Earned MS and PhD
degrees in Biomedical Engineering from the University of California San Diego
2. Regional, National and International Contributions
a. Invited presentations
1986
Invited speaker; First International Conference on Hormones and Immunity,
Toronto, Canada
1987
Invited speaker; Department of Immunology and Microbiology, Wayne State
University Medical School
1988
Invited speaker; International Symposium on Interactions Between the
Neuroendocrine and Immune Systems, Montepaone Lido, Italy
Invited speaker; Immunology Workshop, American Uveitis Society and the American
Society of Veterinary Ophthalmologists, Las Vegas, Nevada
David A. Sullivan, Ph.D.
18
1989
Invited speaker; Eighth International Symposium of the Journal of Steroid
Biochemistry, Las Palmas, Grand Canary Island
Invited speaker; Lacrimal Gland Study Group Lecture Series, Association for
Research in Vision and Ophthalmology Meeting, Sarasota, Florida
Invited speaker; Fifth International Congress of Mucosal Immunology, London,
England
1990
Selected presenter; 1st International Congress on Neuroimmunomodulation,
Florence, Italy
Invited participant; Workshop on Research Perspectives in
Psychoneuroimmunology, Rochester, NY
1992
Invited speaker; Hans Selye Symposium on Neuroendocrinology and Stress,
Budapest, Hungary
Invited speaker; Allergan, Los Angeles, CA
Invited speaker; International Conference on the Lacrimal Gland, Tear Film and Dry
Eye Syndromes: Basic Science and Clinical Relevance, Southampton, Bermuda
1993
Selected presenter; 11th International Symposium of the Journal of Steroid
Biochemistry and Molecular Biology, Seefeld, Austria
Invited speaker; Keio University School of Medicine, Tokyo, Japan
Invited speaker; 4th International Symposium on Sjögren's Syndrome, Tokyo, Japan
Invited speaker; Allergan, Los Angeles, CA
Invited speaker; American Academy of Optometry Meeting, Boston, MA
1994
Invited speaker; Special Minisymposium/Workshop, entitled "New Insights into the
Cause of Tear Deficiency," Association for Research in Vision and Ophthalmology
Meeting, Sarasota, FL
1995
Invited speaker; International Conference on Ocular Infections, Jerusalem, Israel
Invited keynote speaker; Ocular Cell & Molecular Biology Symposium II, San Diego,
CA
Invited speaker; International Workshop on the Immunology of Oculo-MucoCutaneous Disorders, Berlin, Germany
Invited speaker; Allergan, Los Angeles, CA
David A. Sullivan, Ph.D.
19
Invited speaker; American Academy of Optometry Meeting, New Orleans, LA
1996
Invited speaker; Department of Immunology and Microbiology, Wayne State
University School of Medicine, Detroit, MI
Invited speaker; Special Minisymposium/Workshop, entitled "Ocular Changes
Associated with Normal Physiological Variation in Women," Association for
Research in Vision and Ophthalmology Meeting, Fort Lauderdale, FL
Invited speaker; MGI PHARMA, Minnetonka, MN
Invited keynote speaker; Second International Conference on the Lacrimal Gland,
Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance,
Southampton, Bermuda
Invited speaker; CIBA Vision Ophthalmic’s 1st International Advisory Board
Meeting on Dry Eye, Bermuda
1997
Invited keynote speaker; 9th International Congress of Mucosal Immunology,
Sydney, Australia
Invited speaker; Cooperative Research Centre for Eye Research and Technology, The
University of New South Wales, Sydney, Australia
Invited speaker; Special Minisymposium/Workshop, Association for Research in
Vision and Ophthalmology Meeting, Fort Lauderdale, FL
Invited speaker; Allergan, Los Angeles, CA
Invited speaker; Research to Prevent Blindness National Science Writers Seminar,
Los Angeles, CA
Invited keynote speaker; International Symposium on Sjögren’s Syndrome, Avon,
Connecticut
Invited speaker; Ocular Mucosal Immunology Meeting, Bavaria, Germany
1998
Invited speaker; OHSA/Casey Eye Institute, Portland, Oregon
Selected presenter; The First International Conference on the Neuroendocrine
Immune Basis of Rheumatic Diseases, Genoa, Italy
1999
Invited participant; Roundtable discussion entitled “Classification, Diagnosis and
Treatment of Dry Eye,” sponsored by Ocular Surgery News and Allergan, Kona, HI
Invited keynote speaker; Association for Ocular Pharmacology and Therapeutics,
Irvine, CA
David A. Sullivan, Ph.D.
20
Invited speaker; Katholieke Universiteit Leuven, Leuven, Belgium
Invited speaker; Workshop on the Meibomian Gland and its Disease, Coral Gables,
FL
Invited keynote speaker; Dry Eye Research Meeting, Japanese Academy of
Ophthalmology, Tokyo, Japan
Invited keynote speaker; Symposium on the Mucosa Associated Lymphoid Tissue of
the Ocular Surface, Palma de Mallorca, Spain
Selected presenter; 5th International Congress of The International Society of
Dacryology, Jerusalem, Israel
Invited keynote speaker; VIIth International Symposium on Sjögren’s Syndrome,
Venice, Italy
2000
Invited speaker; Allergan, Los Angeles, CA
Invited speaker; University of Florida School of Dentistry, Gainesville, FL
Invited speaker; Meibomian Gland Conference, Boca Raton, FL
Invited speaker; International Congress of Eye Research, Santa Fe, New Mexico
2001
Invited speaker; The Second International Conference on the Neuroendocrine
Immune Basis of Rheumatic Diseases, Santa Margherita, Italy
2002
Invited speaker; Imunology of the Ocular Surface and Tearfilm Workshop, Bavaria,
Germany
Invited speaker; Conference on Sex and Gene Expression, San Jose, CA
Invited speaker; Kyoto Prefectural University of Medicine, Kyoto, Japan
Invited keynote speaker; VIIIth International Symposium on Sjögren’s Syndrome,
Kanazawa, Japan
Invited speaker; Novartis Ophthalmics, Basel, Switzerland
Invited speaker; Societa Industria Farmaceutica Italiana SpA, Aci Sant’ Antonio,
Sicily, Italy
Invited speaker; Symposium on Functional Anatomy of the Ocular Surface, Joint
European Research Meetings in Ophthalmology and Vision, Alicante, Spain
Invited speaker; Symposium on Major Advances in Dry Eye Research, Joint
European Research Meetings in Ophthalmology and Vision, Alicante, Spain
David A. Sullivan, Ph.D.
21
Invited speaker; The Third International Conference on Sex Hormones, Pregnancy
and the Rheumatic Diseases, New Orleans, LA
2003
Invited speaker; Dry Eye / Contact Lens Blue Ribbon Panel of the Vistakon
Division of Johnson & Johnson Vision Care, Jacksonville, FL
Invited speaker; First Singapore Eye Research Institute-Association for Research and
Vision and Ophthalmology Meeting, Singapore (note: given by fellow)
Invited speaker; Allergan's American Androgen Tears Investigators Meeting, New
Orleans, LA
Invited speaker; European Research Group of Oral Biology meeting, Fislisbach,
Switzerland
Invited speaker; L'Oreal Recherche, Paris, France
Invited speaker; Allergan's European Androgen Tears Investigators Meeting, Lisbon,
Portugal
Invited speaker; American College of Rheumatology Sjögren's Syndrome Study
Group Meeting, Orlando, FL
Invited speaker; ARVO/AAO Research Symposium of the American Academy of
Optometry, Dallas, TX
2004
Invited speaker; Vistakon Division of Johnson & Johnson Vision Care, Jacksonville,
Florida
Invited speaker; Mexican Congress of Ophthalmology, Vera Cruz, Mexico
Invited speaker; International Congress for Eye Research, Sydney, Australia
Invited speaker; 40th Annual Meeting of the Department of Ophthalomology,
Ribeirao Preto Medical, School, University of Sao Paulo, Ribeirao Preto, Brazil
2005
Invited speaker; Seminars in Basic Ocular Biology Series, Mount Sinai School of
Medicine, New York City
Invited speaker; Societa Industria Farmaceutica Italiana SpA, Aci Sant’ Antonio,
Sicily, Italy
2006
Invited speaker; Alcon Laboratories, Fort Worth, TX
Invited speaker; Symposium on Dry Eye, Fermo, Italy
David A. Sullivan, Ph.D.
22
Invited speaker; Symposium on Immunology of Dry Eye, International Congress of
Eye Research, Buenos Aires, Argentina
2007
Invited speaker; The 2nd World Congress on Gender-Specific Medicine and Aging:
The Endocrine Impact, Rome, Italy
Invited speaker; Pfizer, La Jolla, CA
Invited introductory speaker; International Dry Eye Workshop Symposium,
Association for Research in Vision and Ophthalmology Meeting, Fort Lauderdale,
FL
Invited speaker; Resolvyx Pharmaceuticals, Bedford, MA
Invited speaker; Pfizer, New York City, NY
Invited speaker; International Dry Eye WorkShop Symposium, European
Association for Vision and Eye Research Meeting, Portoroz, Slovenia
Invited speaker; American Academy of Optometry/Association for Research in
Vision and Ophthalmology Symposium on Advances in Dry Eye Disease: Women,
Nutrition, and Impact on Vision and Quality of Life, Tampa, FL
2008
Invited speaker; Glasgow Caledonian University, Glasgow, Scotland
Invited Conference speaker; 9th Congress of the International Society of Dacryology
and Dry Eye, Istanbul, Turkey
Invited keynote speaker; Brazilian Research Association of Vision and
Ophthalmology Annual Meeting, Brazil
Invited Speaker; Wyeth Pharmaceuticals, Cambridge, MA
Invited Speaker; Tear Film & Ocular Surface Society Corporate Advisory Board and
Associate Corporate Sponsor meeting, Rome, Italy
Invited Speaker; Alcon Laboratories, Fort Worth, TX
Invited Speaker; Inaugural Steering Committee Meeting of the International
Workshop on Meibomian Gland Dysfunction, Atlanta, GA
Invited Speaker; Association for Research in Vision and Ophthalmology
Headquarters, Rockville, MD
2009
Selected speaker; Middle East and African Congress of Ophthalmology, Manama,
Kingdom of Bahrain
David A. Sullivan, Ph.D.
23
Invited speaker; Meet the Experts Breakfast, sponsored by Pfizer Ophthalmics for
the Vision Care Media, Fort Lauderdale, FL
2010
Invited speaker; World Ophthalmology Congress, Berlin, Germany
Introductory speaker; International Regulatory Officials and Experts Meeting
(“Global Treatments for Dry Eye Syndrome: An Unmet Need”), Florence, Italy
Invited speaker; European Association for Vision and Eye Research Meeting,
Hersonissos, Crete
Invited speaker; American Academy of Optometry Meeting, San Francisco, CA
Invited Keynote speaker; Japanese Dry Eye Society Meeting, Kobe, Japan
Invited speaker; International Symposium on Ocular Pharmacology and
Therapeutics, Macau, China
2011
Invited Speaker; ARVO Foundation for Eye Research Investor Seminar, Fort
Lauderdale, FL
Invited Speaker; Ocular Surface Society of Optometry Meeting, Salt Lake City, UT
Invited Speaker; American Optometric Association Meeting, Salt Lake City, UT
Invited Speaker; Vistakon, Jacksonville, FL
Invited Speaker; 16th Congress of Chinese Ophthalmological Society, Guangzhou,
China
Invited Speaker; Shandong Eye Institute, Qingdao, China
Invited Speaker; Eye and ENT Hospital of Fudan University, Shanghai, China
Invited Speaker; Ocular surface disease: A problem seeking an innovative treatment,
Vienna, Austria
Invited Speaker; 11th International Symposium on Sjögren’s Syndrome, Athens,
Greece
Invited Speaker; Optometric Council on Refractive Technology Meeting, Boston
Invited Speaker; European Regulatory Ophthalmology Meeting, sponsored by the
European Medicines Agency and the Swedish Medicinal Agency, London, UK
Invited Speaker; Global Contact Lens Summit: Past & Current Perspectives, New
Research and Future Implications, Seattle
David A. Sullivan, Ph.D.
24
Invited Speaker; Genzyme, Cambridge, MA
Invited Speaker; New England Ophthalmology Society Meeting, Boston
2012
Invited Speaker; Greater Boston Sjögren’s Syndrome Support Group Meeting,
Boston
Invited Speaker; Journées de Réflexions Ophtalmologiques (JRO) Congress, Paris,
France
Invited Speaker; Symposium on Dry eye: New scientific concepts and novel
solutions, Paris, France
Invited Speaker; TFOS Asia 2012 Meeting, Kamakura, Japan
Invited Speaker; Santen Symposium, Kamakura, Japan
Invited Speaker; Steering Committee meeting of the TFOS International Workshop
on Contact Lens Discomfort, San Diego, CA
Invited Speaker; Neurobiology of discomfort and pain Subcommittee meeting, TFOS
Workshop on Contact Lens Discomfort, New York City
Invited Speaker; Trial design and outcomes Subcommittee meeting, TFOS
Workshop on Contact Lens Discomfort, Boston
Invited Speaker; Contact lens materials, design & care Subcommittee meeting, TFOS
Workshop on Contact Lens Discomfort, Boston
Invited Speaker; Management & therapy Subcommittee meeting, TFOS Workshop
on Contact Lens Discomfort, Boston
Invited Speaker; Contact lens interactions with the ocular surface & adnexa
Subcommittee meeting, TFOS Workshop on Contact Lens Discomfort, London, UK
Invited Speaker; Contact Lens Interactions with the tear film Subcommittee meeting,
TFOS Workshop on Contact Lens Discomfort, London, UK
Invited Speaker; Epidemiology Subcommittee meeting, TFOS Workshop on Contact
Lens Discomfort, New York City
Invited Speaker; Definition & classification Subcommittee meeting, TFOS Workshop
on Contact Lens Discomfort, Houston
Invited Speaker, European Association for Vision and Eye Research Congress, Nice,
France
Invited Speaker; Farabi Eye Hospital, Tehran, Iran (date to be determined)
David A. Sullivan, Ph.D.
25
Invited Speaker; The 3rd Biennial Scientific Meeting of the Asia Cornea Society,
Manila, Philippines
2013
Invited Speaker; Industry Liaison Subcommittee meeting, TFOS Workshop on
Contact Lens Discomfort, Houston
Invited Speaker; Boynton Colloquium Series, Center for Visual Science, University of
Rochester, NY
Invited Speaker; Distinguished Lecture and Grand Rounds, Jules Stein Eye Institute,
Los Angeles
Invited Speaker; University of Southern California, Los Angeles
Invited Speaker; French Society of Ophthalmology Annual Meeting, Paris, France
Invited Speaker; 7th International Conference on the Tear Film & Ocular Surface:
Basic Science & Clinical Relevance, Taormina, Sicily
Invited Speaker; Romanian National Congress of Ophthalmology, Sinaia, Romania
2014
Invited Speaker; 14th International Congress of Ophthalmology and Optometry
China, Shanghai, China
Invited Speaker; Optician’s Association of Massachusetts Education Meeting,
Worcester, MA
Invited Speaker; Dompé, Milan, Italy
Invited Speaker; Conference on Ocular Surface Science and Dry Eye, Sydney,
Australia
Invited Speaker; New Zealand National Eye Centre, Auckland, New Zealand
Invited Speaker; Sanofi Fovea Pharmaceuticals, Paris, France
Invited Speaker; The 19th Congress of the Chinese Ophthalmological Society, Xi’an,
China
Invited Speaker; The 17th Afro-Asian Congress of Ophthalmology, Xi’an, China
Invited Keynote Speaker; European Association for Vision and Eye Research
Congress, Nice, France
Invited Speaker; Department of Ophthalmology, Dartmouth-Hitchcock Medical
Center, Lebanon, NH
David A. Sullivan, Ph.D.
26
Invited Speaker; Henry Schroeder Visiting Scientist, Department of Physiology and
Neurobiology, Dartmouth Medical School, Lebanon, NH
2015
Invited Speaker; Grand Rounds, Department of Ophthalmology, Tufts University
School of Medicine, Boston (January 2015)
Invited Speaker; National Congress of the Argentine Council of Ophthalmology,
Buenos Aires, Argentina (May 2015)
b. Professional leadership roles related to teaching
1990-1992
Organizer, International Conference on the Lacrimal Gland, Tear Film and Dry
Eye Syndromes: Basic Science and Clinical Relevance (Bermuda, 1992)
1994-1996
Organizer, Second International Conference on the Lacrimal Gland, Tear Film and
Dry Eye Syndromes: Basic Science and Clinical Relevance (Bermuda, 1996)
1998-2000
Organizer, Third International Conference on the Lacrimal Gland, Tear Film and
Dry Eye Syndromes: Basic Science and Clinical Relevance (Maui, 2000)
2002-2004
Organizer, 4th International Conference on the Lacrimal Gland, Tear Film, Ocular
Surface and Dry Eye Syndromes: Basic Science and Clinical Relevance (Puerto
Rico, 2004)
2003
Co-Organizer, Immunology of the Ocular Surface and Tear Film WorkShop,
Bavaria, Germany
2003-2004
Organizer, Symposium on Sex Differences in Ocular Surface Biology, International
Congress of Eye Research, Sydney, Australia
2005-2007
Organizer, 5th International Conference on the Tear Film & Ocular Surface: Basic
Science and Clinical Relevance (Taormina, Sicily, 2007)
2005-2007
Organizer, Symposium on Immunology of Dry Eye, International Congress of Eye
Research, Buenos Aires, Argentina
2007
Organizer, Special Interest Group Meeting, Conclusions and Recommendations of
the TFOS International Dry Eye Workshop (DEWS), ARVO, Fort Lauderdale, FL
2007-
Co-Organizer, 2007 TFOS Report of the International Dry Eye WorkShop
(DEWS), published in The Ocular Surface, Volume 5, Number 2, pp. 65-204, 2007;
additional material placed online at www.TearFilm.org
2007
Organizer, Special Interest Group Meeting, Conclusions and Recommendations of
the TFOS International Dry Eye WorkShop (DEWS), EVER, Portoroz, Slovenia
2008-2010
Director, 6th International Conference on the Tear Film & Ocular Surface: Basic
Science and Clinical Relevance (Florence, Italy, 9/10)
David A. Sullivan, Ph.D.
27
2009-2010
Co-Programmer and Co-Chair, Ocular Surface Disease session, World Cornea
Congress, Boston
2009-2010
Organizer, Special Interest Group Meeting, Conclusions and Recommendations of
the TFOS International Workshop on Meibomian Gland Dysfunction, ARVO,
Fort Lauderdale, FL
2009-2010
Organizer, Special Interest Group Meeting, Conclusions and Recommendations of
the TFOS International Workshop on Meibomian Gland Dysfunction, British
Contact Lens Association Clinical Conference and Exhibition, Birmingham, UK
2009-2010
Organizer, Special Interest Group Meeting, Conclusions and Recommendations of
the TFOS International Workshop on Meibomian Gland Dysfunction, World
Ophthalmology Congress, Berlin
2009-2010
Organizer, Special Interest Group Meeting, Conclusions and Recommendations of
the TFOS International Workshop on Meibomian Gland Dysfunction, European
Association for Vision and Eye Research Annual Meeting, Hersonissos, Crete
2009-2010
Organizer, Special Interest Group Meeting, Conclusions and Recommendations of
the TFOS International Workshop on Meibomian Gland Dysfunction, ISOPT,
Macau, China
2011
Co-Organizer, ARVO 2012 Minisymposium on Surgical Innovations for the
Treatment of Eye Disease
2011-2012
Organizer, Session on Surgery-Induced Dry Eye, World Ophthalmology Congress
2012, Abu Dhabi
2011-2013
Director, 7th International Conference on the Tear Film & Ocular Surface: Basic
Science and Clinical Relevance (Taormina, Italy, 9/13)
Note: These series of 7 “Tear Film” Conferences were designed to: [a] Assess the current knowledge and
'state of the art' research on the structure and function of tear film-producing tissues, tears and the
ocular surface in both health and disease; and [b] Promote an international exchange of information
that would be of value to basic scientists involved in eye research, to clinicians in the eye care
community, and to pharmaceutical companies with an interest in the treatment of lacrimal gland, tear
film or ocular surface disorders. The first 3 Conferences were also created to generate books, which
would contain summaries of the Conference's presentations, and provide an educational foundation
and scientific reference for research on the tear film, ocular surface and dry eye syndromes. These
books were published, cited in Index Medicus, and contained 729 (1992), 1,051 (1996) and 1,385
(2004) pages. Participation in these Conferences grew from 1992 (n ~ 175 people), to 1996 (n ~ 235),
to 2000 (n ~ 335), to 2004 (n ~ 380), to 2007 (n ~ 500) and to 2010 (n ~ 600). The number of
participants in 2013 exceeded 500 people. Numerous travel awards have been given in these
Conferences to students, fellows and young investigators.
David A. Sullivan, Ph.D.
28
2013-2014
Organizer, Special Interest Group Meeting, Conclusions and Recommendations of
the TFOS International Workshop on Contact Lens Discomfort, Orlando, FL
David A. Sullivan, Ph.D.
29
Part III: Bibliography
Original Articles:
1.
Sullivan DA, Wira CR. Sex hormone and glucocorticoid receptors in the bursa of Fabricius of
immature chicks. J Immunology 1979;122:2617-2623.
2.
Wira CR, Hyde E, Sandoe CP, Sullivan DA, Spencer S. Cellular aspects of the rat uterine IgA
response to estradiol and progesterone. J Steroid Biochem 1980;12:451-459.
3.
Sullivan DA, Wira CR. Estradiol regulation of secretory component in the female reproductive tract.
J Steroid Biochem 1981;15:439-444.
4.
Sullivan DA, Wira CR. Hormonal regulation of immunoglobulins in the rat uterus: Uterine response
to a single estradiol treatment. Endocrinology 1983;112:260-268.
5.
Sullivan DA, Wira CR. Variations in free secretory component levels in mucosal secretions of the rat.
J Immunology 1983;130:1330-1335.
6.
Sullivan DA, Underdown BJ, Wira CR. Steroid hormone regulation of free secretory component in
the rat uterus. Immunology 1983;49:379-386.
7.
Wira CR, Sullivan DA, Sandoe CP. Epithelial cell involvement in the estradiol-stimulated
accumulation of IgA in the rat uterus. J Steroid Biochem 1983;19:469-474.
8.
Sullivan DA, Richardson GS, McLaughlin DT, Wira CR. Variations in the levels of secretory
component in human uterine secretions during the menstrual cycle. J Steroid Biochem 1984;20:509513.
9.
Sullivan DA, Wira CR. Hormonal regulation of immunoglobulins in the rat uterus: Uterine response
to multiple estradiol treatments. Endocrinology 1984;114:650-658.
10. Sullivan DA, Bloch KJ, Allansmith MR. Hormonal influence on the secretory immune system of the
eye: Androgen regulation of secretory component levels in rat tears. J Immunology 1984;132:11301135.
11. Sullivan DA, Bloch KJ, Allansmith MR. Hormonal Influence on the secretory immune system of the
eye: Androgen control of secretory component production by the rat exorbital gland. Immunology
1984;52:239-246.
12. Sullivan DA, Allansmith MR. Source of IgA in tears of rats. Immunology 1984;53:791-799.
13. Wira CR, Sullivan DA. Estradiol and progesterone regulation of IgA, IgG and secretory component
in vaginal secretions of the rat. Biol Reprod 1985;32:90-95.
14. Gudmundsson OG, Sullivan DA, Bloch KJ, Allansmith MR. The ocular secretory immune system of
the rat. Exp Eye Res 1985;40:231-238.
David A. Sullivan, Ph.D.
30
15. Sullivan DA, Allansmith MR. Hormonal influence on the secretory immune system of the eye:
Androgen modulation of IgA levels in tears of rats. J Immunology 1985;134:2978-2982.
16. Cornell-Bell AH, Sullivan DA, Allansmith MR. Gender-related differences in the morphology of the
lacrimal gland. Invest Ophthalmol Vis Sci 1985;26:1170-1175.
17. Sullivan DA, Allansmith MR. Hormonal modulation of tear volume in the rat. Exp Eye Res
1986;42:131-139.
18. Sullivan DA, Colby E, Hann LE, Allansmith MR, Wira CR. Production and utilization of a mouse
monoclonal antibody to rat IgA: Identification of gender-related differences in the secretory immune
system. Immunol Invest 1986;15:311-318.
19. Sullivan DA, Allansmith MR. Hormonal influence on the secretory immune system of the eye:
endocrine interactions in the control of IgA and secretory component levels in tears of rats.
Immunology 1987;60:337-343.
20. Allansmith MR, Gudmundsson OG, Hann LE, Keys C, Bloch KJ, Sullivan DA. The immune
response of the lacrimal gland to antigenic exposure. Curr Eye Res 1987;6:921-928.
21. Sullivan DA. Influence of the hypothalamic-pituitary axis on the androgen regulation of the ocular
secretory immune system. J Steroid Biochem 1988;30:429-433.
22. Sullivan DA, Allansmith MR. The effect of aging on the secretory immune system of the eye.
Immunology 1988;63:403-410.
23. Sullivan, DA, Hann LE, Vaerman JP. Selectivity, specificity and kinetics of the androgen regulation of
the ocular secretory immune system. Immunol Invest 1988;17:183-194.
24. Hann LE, Allansmith MR, Sullivan DA. Impact of aging and gender on the Ig-containing cell profile
of the lacrimal gland. Acta Ophthalmologica 1988;66:87-92.
25. Gudmundsson OG, Bjornsson J, Olafsdottir K, Bloch KJ, Allansmith MR, Sullivan DA. T cell
populations in the lacrimal gland during aging. Acta Ophthalmologica 1988;66:490-497.
26. Hann LE, Tatro J, Sullivan DA. Morphology and function of lacrimal gland acinar cells in primary
culture. Invest Ophthalmol Vis Sci 1989;30:145-158.
27. Harmatz PR, Carter EA, Sullivan DA, Hatz RA, Baker R, Breazeale E, Grant K, Bloch KJ. Effect of
thermal injury in the rat on transfer of IgA protein into bile. Annals Surgery 1989;210:203-207.
28. Ariga H, Edwards J, Sullivan DA. Androgen control of autoimmune expression in lacrimal glands of
MRL/Mp-lpr/lpr mice. Clin Immunol Immunopathol 1989;53:499-508.
29. Sullivan DA, Hann LE. Hormonal influence on the secretory immune system of the eye: endocrine
impact on the lacrimal gland accumulation and secretion of IgA and IgG.J Steroid Biochem 1989;
34:253-262.
David A. Sullivan, Ph.D.
31
30. Sullivan DA, Hann LE, Yee L, Allansmith MR. Age- and gender-related influence on the lacrimal
gland and tears. Acta Ophthalmologica 1990;68:188-194.
31. Entwistle ML, Hann LE, Sullivan DA, Tatro JB. Characterization of functional melanotropin
receptors in lacrimal glands of the rat. Peptides 1990;11:477-483.
32. Taubman MA, Halazonetis TD, Stack SE, Smith DJ, Sullivan DA. Thyroid influence on the salivary
secretory immune system. In: Advances in Mucosal Immunology. London: Kluwer Academic
Publishers; 1990. p.497-499.
33. Sullivan DA, Yee L, Conner AS, Hann LE, Olivier M, Allansmith MR. Influence of ocular surface
antigen on the postnatal accumulation of immunoglobulin-containing cells in the rat lacrimal gland.
Immunology 1990;71:573-580.
34. Sullivan DA, Kelleher RS, Vaerman JP, Hann LE. Androgen regulation of secretory component
synthesis by lacrimal gland acinar cells in vitro. J Immunology 1990;145:4238-4244.
35. Kelleher RS, Hann LE, Edwards JA, Sullivan DA. Endocrine, neural and immune control of secretory
component output by lacrimal gland acinar cells. J Immunology 1991;146:3405-3412.
36. Hann LE, Kelleher RS, Sullivan DA. Influence of culture conditions on the androgen control of
secretory component production by acinar cells from the lacrimal gland. Invest Ophthalmol Vis Sci
1991;32:2610-2621.
37. Sullivan DA, Hann LE, Soo CH, Yee L, Edwards JA, Allansmith MR. Neural-immune
interrelationship: effect of optic, sympathetic, temporofacial or sensory denervation on the secretory
immune system of the lacrimal gland. Regional Immunology 199l;3:204-212.
38. Vendramini AC, Soo C, Sullivan DA. Testosterone-induced suppression of autoimmune disease in
lacrimal tissue of a mouse model (NZB/NZW F1) of Sjogren's Syndrome. Invest Ophthalmol Vis Sci
1991;32:3002-3006.
39. Cappeller WA, Bloch KJ, Hatz RA, Carter EA, Fagundes J, Sullivan DA, Harmatz PR. Reduction in
biliary IgA after burn injury: Role of diminished delivery via the thoracic duct and of enhanced loss
from the systemic circulation. Annals Surgery 1992;215:338-343.
40. Sato EH, Ariga H, Sullivan, DA. Impact of androgen therapy in Sjögren's syndrome: Hormonal
influence on lymphocyte populations and Ia expression in lacrimal glands of MRL/Mp-lpr/lpr mice.
Invest Ophthalmol Vis Sci 1992;33:2537-2545.
41. Cappeller WA, Bloch KJ, Fagundes J, Carter EA, Sullivan DA, Harmatz PR. Effect of thermal injury
on transfer of IR22 IgA myeloma protein into bile in the rat. Liver 1992;12:124-131.
42. Sullivan DA, Vaerman JP and Soo C. Influence of severe protein malnutrition on rat lacrimal, salivary
and gastrointestinal immune expression during development, adulthood and aging. Immunology
1993;78:308-317.
David A. Sullivan, Ph.D.
32
43. Rocha FJ, Wickham LA, Pena JDO, Gao J, Ono M, Lambert RW, Kelleher RS, Sullivan DA.
Influence of gender and the endocrine environment on the distribution of androgen receptors in the
lacrimal gland. J Steroid Biochem Mol Biol 1993;46:737-749.
44. Lambert RW, Kelleher RS, Wickham LA, Vaerman JP, Sullivan DA. Neuroendocrinimmune
modulation of secretory component production by rat lacrimal, salivary and intestinal epithelial cells.
Invest Ophthalmol Vis Sci 1994;35:1192-1201.
45. Sato EH, Sullivan DA. Comparative influence of steroid hormones and immunosuppressive agents
on autoimmune expression in lacrimal glands of a female mouse model of Sjögren’s syndrome. Invest
Ophthalmol Vis Sci 1994;35:2632-2642.
46. Rocha FJ, Sato EH, Sullivan BD, Sullivan DA. Effect of androgen analogue treatment and androgen
withdrawal on lacrimal gland inflammation in a mouse model (MRL/Mp-lpr/lpr) of Sjögren’s
syndrome. Reg Immunol 1994;6:270-277.
47. Gao J, Lambert RW, Wickham LA, Banting G, Sullivan DA. Androgen control of secretory
component mRNA levels in the rat lacrimal gland. J Steroid Biochem Mol Biol 1995;52:239-249.
48. Ono M, Rocha FJ, Sullivan DA. Immunocytochemical location and hormonal control of androgen
receptors in lacrimal tissues of the female MRL/Mp-lpr/lpr mouse model of Sjögren’s syndrome. Exp
Eye Res 1995;61:659-666.
49. Sullivan DA, Edwards JA, Wickham LA, Pena JDO, Gao J, Ono M, Kelleher RS. Identification and
endocrine control of sex steroid binding sites in the lacrimal gland. Curr Eye Res 1996;15:279-291.
50. Huang Z, Lambert RW, Wickham A, Sullivan DA. Analysis of cytomegalovirus infection and
replication in acinar epithelial cells of the rat lacrimal gland. Invest Ophthalmol Vis Sci 1996;37:11741186.
51. Sullivan DA, Block L, Pena JDO. Influence of androgens and pituitary hormones on the structural
profile and secretory activity of the lacrimal gland. Acta Ophthalmol Scand 1996;74:421-435.
52. Sullivan DA, Edwards J. Androgen stimulation of lacrimal gland function in mouse models of
Sjögren's syndrome. J Ster Biochem Mol Biol 1997;60:237-245.
53. Wickham A, Huang Z, Lambert RW, Sullivan DA. Effect of sialodacryoadenitis virus exposure on
acinar epithelial cells from the rat lacrimal gland. Ocular Immunol Immunopathol 1997;5:181-195.
54. Toda I, Wickham LA, Sullivan DA. Gender and androgen treatment influences the expression of
proto-oncogenes and apoptotic factors in lacrimal and salivary tissues of MRL/lpr mice. Clin
Immunol Immunopath 1998;86:59-71.
55. Haendler B, Toda I, Sullivan DA, Schleuning W-D. Expression of cysteine-rich proteins (CRISPs) in
the murine lacrimal gland. J Cell Physiol 1999;178:371-378.
David A. Sullivan, Ph.D.
33
56. Sullivan DA, Krenzer KL, Sullivan BD, Tolls BD, Toda I, Dana MR. Does androgen insufficiency
cause lacrimal gland inflammation and aqueous tear deficiency? Invest Ophthalmol Vis Sci
1999;40:1261-1265.
57. Toda I, Sullivan BD, Rocha EM, Silveira LA, Wickham LA, Sullivan DA. Impact of gender on
exocrine gland inflammation in mouse models of Sjögren’s syndrome. Exp Eye Res 1999;69:355-366.
58. Toda I, Sullivan BD, Wickham LA, Sullivan DA. Gender and androgen-related influence on the
expression of proto-oncogene and apoptotic factor mRNAs in lacrimal glands of autoimmune and
non-autoimmune mice. J Steroid Biochem Mol Biol 1999;71:49-61.
59. Rocha EM, Wickham LA, Silveira LA, Krenzer KL, Yu FS, Toda I, Sullivan BD, Sullivan DA.
Identification of androgen receptor protein and 5a-reductase mRNA in human ocular tissues. Brit J
Ophthalmol 2000;84:76-84.
60. Wickham LA, Gao J, Toda I, Rocha EM, Ono M, Sullivan DA. Identification of androgen, estrogen
and progesterone receptor mRNAs in the eye. Acta Ophthalmologica 2000;78:146-153.
61. Sullivan DA, Sullivan BD, Ullman MD, Rocha EM, Krenzer KL, Cermak JM, Toda I, Doane M,
Evans JE, Wickham LA. Androgen influence on the meibomian gland. Invest Ophthalmol Vis Sci
2000;41:3732-3742.
62. Krenzer KL, Dana MR, Ullman MD, Cermak JM, Tolls BD, Evans JE, Sullivan DA. Effect of
androgen deficiency on the human meibomian gland and ocular surface. J Clin Endocr Metab
2000;85:4874-4882.
63. Sullivan BD, Evans JE, Krenzer KL, Dana MR, Sullivan DA. Impact of antiandrogen treatment on
the fatty acid profile of neutral lipids in human meibomian gland secretions. J Clin Endocr Metab
2000;85:4866-4873.
64. Schaumberg DA, Buring JE, Sullivan DA, Dana MR. Hormone replacement therapy and dry eye
syndrome. JAMA 2001;286:2114-2119.
65. Sullivan BD, Evans JE, Cermak JM, Krenzer KL, Dana MR, Sullivan DA. Complete androgen
insensitivity syndrome: Effect on human meibomian gland secretions. Arch Ophthalmol
2002;120:1689-1699.
66. Cermak JM, Papas AS, Sullivan RM, Dana MR, Sullivan DA. Nutrient intake in women with primary
and secondary Sjögren’s syndrome. Eur J Clin Nutr 2003;57:328-334.
67. Schaumberg DA, Sullivan DA, Buring JE, Dana MR. Prevalence of dry eye syndrome among US
women. Am J Ophthalmol 2003;136:318-326.
68. Cermak JM, Krenzer KL, Sullivan RM, Dana MR, Sullivan DA. Is complete androgen insensitivity
syndrome associated with alterations in the meibomian gland and ocular surface? Cornea 2003;22:516521.
David A. Sullivan, Ph.D.
34
69. Sullivan DA, Bélanger A, Cermak JM, Bérubé R, Papas AS, Sullivan RM, Yamagami H, Dana MR,
Labrie F. Are women with Sjögren’s syndrome androgen deficient? J Rheumatology 2003;30:24132419.
70. Treister NS, Richards SM, Lombardi MJ, Rowley P, Jensen RV, Sullivan DA. Sex-related differences
in gene expression in salivary glands of BALB/c mice. J Dental Res 2005;84:160-165.
71. Suzuki T, Sullivan DA. Estrogen stimulation of proinflammatory cytokine and matrix
metalloproteinase gene expression in human corneal epithelial cells. Cornea 2005;24:1004-1009.
72. Richards SM, Jensen RV, Liu M, Sullivan BD, Lombardi MJ, Rowley P, Schirra F, Treister NS, Suzuki
T, Steagall RJ, Yamagami H, Sullivan DA. Influence of sex on gene expression in the mouse lacrimal
gland. Exp Eye Res 2006;82:13-23; 2005, Jun 24 [Epub ahead of print].
73. Richards SM, Liu M, Jensen RV, Schirra F, Yamagami H, Lombardi MJ, Rowley P, Treister NS,
Suzuki T, Sullivan BD, Sullivan DA. Androgen regulation of gene expression in the mouse lacrimal
gland. J Steroid Biochem Mol Biol 2005;96:401-413.
74. Schirra F, Suzuki T, Richards SM, Jensen RV, Liu M, Lombardi MJ, Rowley P, Treister NS, Sullivan
DA. Androgen control of gene expression in the mouse meibomian gland. Invest Ophthalmol Vis Sci
2005;46:3666-3675.
75. Treister NS, Richards SM, Jensen RV, Sullivan DA. Influence of androgens on gene expression in the
BALB/c mouse submandibular gland. J Dental Res 2005;84:1187-1192.
76. Suzuki T, Schirra F, Richards SM, Treister NS, Lombardi MJ, Rowley P, Jensen RV, Sullivan DA.
Estrogen and progesterone impact on gene expression in the mouse lacrimal gland. Invest
Ophthalmol Vis Sci 2006;47:158-168.
77. Schirra F, Suzuki T, Dickinson DP, Townsend DJ, Gipson IK, Sullivan DA. Identification of
steroidogenic enzyme mRNAs in the human lacrimal gland, meibomian gland, cornea and
conjunctiva. Cornea 2006;25:438-42.
78. Richards SM, Yamagami H, Schirra F, Suzuki T, Jensen RV, Sullivan DA. Sex-related effect on gene
expression in the mouse meibomian gland. Curr Eye Res 2006;31:119-128.
79. Suzuki T, Sullivan DA. Comparative effects of estrogen on matrix metalloproteinases and cytokines
in immortalized and primary human corneal epithelial cell cultures. Cornea 2006;25:454-459.
80. Tsai P, JE Evans, Green KM, Sullivan RM, Schaumberg DA, Richards SM, Dana MR, Sullivan DA.
Proteomic analysis of human meibomian gland secretions. Br J Ophthalmol 2006;90:372-377.
81. Schirra F, Richards SM, Liu M, Suzuki T, Yamagami H, Sullivan DA. Androgen regulation of
lipogenic pathways in the mouse meibomian gland. Exp Eye Res 2006;83:291-296.
82. Gulati A, Sullivan R, Buring JE, Sullivan DA, Dana R, Schaumberg DA. Validation and repeatability
of a short questionnaire for dry eye syndrome. Am J Ophthalmol 2006;142:125-131.
David A. Sullivan, Ph.D.
35
83. Treister NS, Richards SM, Rowley P, Jensen RV, Sullivan DA. Influence of testosterone on gene
expression in the ovariectomized mouse submandibular gland. Eur J Oral Sci 2006;114:328-336.
84. Sullivan BD, Evans JE, Dana MR, Sullivan DA. Influence of aging on the polar and neutral lipid
profiles in human meibomian gland secretions. Arch Ophthalmol 2006; 124:1286-1292.
85. Miljanovic B, Dana R, Sullivan DA, Schaumberg DA. Impact of dry eye syndrome on vision-related
quality of life. Am J Ophthalmol 2007;143:409-415.
86. Schirra F, Richards SM, Sullivan DA. Androgen influence on cholesterogenic enzyme mRNA levels in
the mouse meibomian gland. Curr Eye Res 2007;32:393-398.
87. Suzuki T, Schirra F, Richards SM, Jensen RV, Sullivan DA. Estrogen and progesterone control of
gene expression in the mouse meibomian gland. Invest Ophthalmol Vis Sci 2008;49:1797-1808.
88. Schaumberg DA, Dana R, Buring JE, Sullivan DA. Prevalence and risk factors for dry eye disease
among US men. Arch Ophthalmol 2009;127:763-768.
89. Richards SM, Sullivan DA. Do genetic alterations in sex steroid receptors contribute to lacrimal gland
disease in Sjögren’s syndrome? Open Endocrinol J 2009;3:5-11.
90. Sullivan DA, Jensen RV, Suzuki T, Richards SM. Do sex steroids exert sex-specific and/or opposite
effects on gene expression in lacrimal and meibomian glands? Mol Vis 2009;10:15:1553-1572.
91. Suzuki T, Richards SM, Liu S, Jensen RV, Sullivan DA. Impact of sex on gene expression in human
corneal epithelial cells. Mol Vision 2009;15:2554-2569.
92. Liu S, Khandelwal P, Hatton M, Sullivan DA. Culture, immortalization and characterization of human
meibomian gland epithelial cells. Invest Ophthalmol Vis Sci 2010;51:3993-4005.
93. Liu S, Richards SM, Lo K, Hatton M, Fay AM, Sullivan DA. Changes in gene expression in
meibomian gland dysfunction. Invest Ophthalmol Vis Sci 2011;52:2727-2740.
94. Nichols KK, Foulks GN, Bron AJ, Glasgow BJ, Dogru M, Tsubota K, Lemp MA, Sullivan DA. The
International Workshop on Meibomian Gland Dysfunction: Executive Summary. Invest Ophthalmol
Vis Sci 2011;52:1922-1929.
95. Knop E, Knop N, Millar T, Obata H, Sullivan DA. The International Workshop on Meibomian
Gland Dysfunction: Report of the Subcommittee on Anatomy, Physiology, and Pathophysiology of
the Meibomian Gland. Invest Ophthalmol Vis Sci 2011;52:1938-1978.
96. Kam WR, Sullivan DA. Neurotransmitter activation of signaling pathways in human meibomian
gland epithelial cells. Invest Ophthalmol Vis Sci 2011;52:854-8548.
97. Morrison S, Sullivan DA, Sullivan BD, Sheardown H, Schmidt TA. Dose-dependent & synergistic
effects on proteoglycan 4 (PRG4) on boundary lubrication at a human cornea – polydimethylsiloxane
(PDMS) biointerface. Eye and Contact Lens 2012;38:27-35.
David A. Sullivan, Ph.D.
36
98. Sullivan DA, Hammitt KM, Schaumberg DA, Sullivan BD, Begley CG, Gjorstrup P, Garrigue J-S,
Nakamura M, Quentric Y, Barabino S, Dalton M, Novack GD. Report of the TFOS/ARVO
Symposium on global treatments for dry eye disease: An unmet need. Ocul Surf 2012;10:108-116.
99. Khandelwal P, Liu S, Sullivan DA. Dihydrotestosterone regulation of gene expression in human
meibomian gland and conjunctival epithelial cells. Mol Vis 2012;18:1055-1067.
100. Ding J, Sullivan DA. Aging and dry eye disease. Exp Gerontol 2012; 47:483-490.
101. Sahin A, Kam WR, Rahimi Darabad R, Topilow K, Sullivan DA. Regulation of leukotriene B4
secretion by human corneal, conjunctival and meibomian gland epithelial cells. Arch Ophthalmol
2012;130:1013-1018.
102. Davis RK, Doane MG, Knop E, Knop N, Dubielzig RR, Colitz CMH, Argüeso P, Sullivan DA.
Characterization of ocular gland morphology and tear composition of pinnipeds. Veterinary
Ophthalmology 2013;16:269-275.
103. Schmidt TA (co-first), Sullivan DA (co-first), Knop E, Richards SM, Knop N, Liu S, Sahin A,
Darabad RR, Morrison S, Kam WR, Sullivan BD. Transcription, translation and function of lubricin
at the ocular surface. JAMA Ophthalmol 2013;18:1-11.
104. Rahimi Darabad R, Suzuki T, Richards SM, Jensen R, Jakobiec FA, Zakka FR, Liu S, Sullivan DA.
Impact of estrogen absence on gene expression in the meibomian gland. Invest Ophthalmol Vis Sci
2013;54:987-998.
105. Liu S, Kam W, Ding J, Hatton MP, Sullivan DA. Effect of growth factors on the proliferation and
gene expression of human meibomian gland epithelial cells. Invest Ophthalmol Vis Sci 2013;
54:2541-2550.
106. Ding J, Kam WR, Dieckow J, Sullivan DA. The influence of 13-cis retinoic acid on human
meibomian gland epithelial cells. Invest Ophthalmol Vis Sci 2013;54:4341-4350.
107. Nichols JJ, Jones L, Nelson JD, Stapleton F, Sullivan DA, Willcox MDP, and the members of the
TFOS International Workshop on Contact Lens Discomfort. The TFOS International Workshop on
Contact Lens Discomfort: Introduction. Invest Ophthalmol Vis Sci 2013;54:TFOS1-6.
108. Nichols JJ, Willcox MDP, Bron AJ, Belmonte C, Ciolino CB, Craig JP, Dogru M, Foulks GN, Jones
L, Nelson JD, Nichols KK, Purslow C, Schaumberg DA, Stapleton F, Sullivan DA, and the
members of the TFOS International Workshop on Contact Lens Discomfort. The TFOS
International Workshop on Contact Lens Discomfort: Executive Summary. Invest Ophthalmol Vis
Sci 2013;54:TFOS7-13.
109. Liu Y, Kam WR, Ding J, Sullivan DA. Effect of azithromycin on lipid accumulation in immortalized
human meibomian gland epithelial cells. JAMA Ophthalmology 2014; 132:226-228.
110. Liu Y, Kam WR, Ding J, Sullivan DA. One man's poison is another man's meat: Using azithromycininduced phospholipidosis to promote ocular surface health. Toxicology 2014;320C:1-5.
David A. Sullivan, Ph.D.
37
111. Ding J, Sullivan DA. The effects of insulin-like growth factor-1 and growth hormone on human
meibomian gland epithelial cells. JAMA Ophthalmology 2014;132:593-599.
112. Sullivan DA, Liu Y, Kam WR, Ding J, Green KM, Shaffer SA, Hatton MP, Liu S. Serum-induced
differentiation of human meibomian gland epithelial cells. Invest Ophthalmol Vis Sci 2014; 55:38663877.
113. Samsom ML, Morrison S, Masala N, Sullivan BD, Sullivan DA, Sheardown H, Schmidt TA.
Characterization of full-length recombinant human Proteoglycan 4 as an ocular surface boundary
lubricant. Exp Eye Res 2014;127:14-19.
114. Rahimi Darabad R, Suzuki T, Richards SM, Barabino S, Jensen R, Jakobiec FA, Zakka FR, Sullivan
DA. Influence of estrogen deficiency on lacrimal gland gene expression. Exp Eye Res 2014;127:153160.
115. Ding J, Wirostko B, Sullivan DA. Human Growth hormone promotes corneal epithelial cell
migration in vitro. Cornea 2014; in press.
116. Liu Y, Kam WR, Ding J, Sullivan DA. Can tetracycline antibiotics duplicate the ability of
azithromycin to stimulate meibomian gland epithelial cell differentiation? Cornea 2014; in press.
117. Wirostko B, Rafii MJ, Sullivan DA, Morelli J, Ding J. Novel therapy to treat corneal epithelial
defects: a hypothesis with growth hormone. Ocul Surf 2014; in press.
Proceedings of Meetings:
118. Wira CR, Sullivan DA, Sandoe CP. Estrogen-mediated control of the secretory immune system in
the uterus of the rat. Ann NY Acad Sci 1983;409:534-551.
119. Sullivan DA, Wira CR. Estradiol regulation of secretory component in the rat uterus. Ann NY Acad
Sci 1983;409:882-884.
120. Sullivan DA, Allansmith MR. Androgen regulation of IgA levels in tears of rats. Protides Biol Fluids
1985;32:93-94.
121. Sullivan DA, Allansmith MR. Origin of IgA in tears of rats. Protides Biol Fluids 1985;32:89-91.
122. Stern JE, Sullivan DA, Wira CR. Secretory component in breast cancer: Correlations with patient age
and hormone receptor levels in primary breast tumors. Protides Biol Fluids 1985;32:579-581.
123. Gudmundsson OG, Sullivan DA, Bloch KJ, Allansmith MR. Immunoglobulins and secretory
component in rat tears and ocular adnexa. In: III International Symposium on Immunology and
Immunopathology of the Eye. New York, NY: Masson Publishing, Inc.; 1985. p. 287-290.
124. Sullivan DA, Hann LE. Endocrine regulation of the ocular secretory immune system. Adv Exp Med
Biol 1987;216:765-774.
David A. Sullivan, Ph.D.
38
125. Sullivan DA, Hann LE, Allansmith MR. The influence of age on the ocular secretory immune system
of the rat. Adv Exp Med Biol 1987;216:1395-1407.
126. Seo JK, Grant KE, Sullivan DA, Hanson DB, Bloch, KJ, Harmatz PR, Walker WA. Fluctuation in
biliary IgA content following cannulation of the common bile duct. Adv Exp Med Biol
1987;216:1133-1138.
127. Sullivan DA, Allansmith MR. Involvement of the hypothalamic-pituitary axis in the androgen
regulation of the ocular secretory immune system. In: Secchi AG, Fregona, IA, editors. Modern
Trends in Immunology and Immunopathology of the Eye. S.p.A.-Milano; 1989. p. 363-366.
128. Sullivan DA, Hann LE, Allansmith MR. The effect of aging on the ocular secretory immune system
of the rat. In: Secchi AG, Fregona, IA, editors. Modern Trends in Immunology and
Immunopathology of the Eye. S.p.A.-Milano; 1989. p. 367-370.
129. Ariga H, Vendramini AC, Soo C, Edwards J, Sullivan DA. Hormonal influence on autoimmune
expression in lacrimal tissue of MRL/Mp-lpr/lpr and NZB/NZW F1 mice. In: Advances in Mucosal
Immunology. London: Kluwer Academic Publishers; 1990. p. 520-521.
130. Sullivan DA, Yee L, Conner AS, Olivier, M, Hann, LE, Allansmith MR. Impact of antigenic
exposure on the developmental appearance of IgA-, IgG- and IgM-containing cells in the lacrimal
gland. In: Advances in Mucosal Immunology. London: Kluwer Academic Publishers; 1990. p. 518519.
131. Kelleher, RS, Hann LE, Edwards, JA, Sullivan, DA. Endocrine and neuropeptide control of
secretory component synthesis by acinar cells from the lacrimal gland. In: Advances in Mucosal
Immunology. London: Kluwer Academic Publishers; 1990. p. 522-523.
132. Sullivan, DA, Hann, LE. Androgen regulation of the ocular secretory immune system. In: Advances
in Mucosal Immunology. London: Kluwer Academic Publishers; 1990. p. 250-254.
133. Sullivan DA, Hann LE, Yee L, Edwards JA, Soo C, Allansmith MR. Neural-immune interactions:
role of ocular innervation in the secretory immune system of the lacrimal gland. In: Advances in
Mucosal Immunology. London: Kluwer Academic Publishers; 1990. p. 524-525.
134. Cappeller WA, Bloch KJ, Sullivan DA, Carter EA, Harmatz PR. Dissociation of IR22 IgA myeloma
protein during hepatobiliary transfer after thermal injury in the rat. In: Advances in Mucosal
Immunology. London: Kluwer Academic Publishers; 1990. p. 586-587.
135. Kelleher RS, Hann LE, Edwards JA, Sullivan DA. Hormonal and neural modulation of secretory
component production by lacrimal gland acinar cells. In: Ocular Immunology Today. New York:
Elsevier Science Publishers; 1990. p. 289-292.
136. Sullivan DA, Hann LE, Soo C, Edwards JA, Allansmith. Influence of neural innervation on the
expression of the secretory immune system of the lacrimal gland. In: Ocular Immunology Today.
New York: Elsevier Science Publishers; 1990. p. 321-324.
David A. Sullivan, Ph.D.
39
137. Ariga H, Vendramini ACLM, Soo C, Edwards JA, Sullivan DA. Androgen treatment of autoimmune
disease in lacrimal glands of MRL/Mp-lpr/lpr and NZB/NZW F1 mice. In: Ocular Immunology
Today. New York: Elsevier Science Publishers; 1990. p. 95-98.
138. Sullivan DA, Soo C, Allansmith MR. Severe protein malnutrition: impact on tear IgA levels during
development and aging. In: Ocular Immunology Today. New York: Elsevier Science Publishers;
1990. p. 325-328.
139. Sullivan DA. Preface. Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical
Relevance. Sullivan DA, Bromberg BB, Cripps MM, Dartt DA, MacKeen DL, Mircheff AK,
Montgomery PC, Tsubota K, Walcott B, editors. New York: Plenum Press; 1994; pp. ix-x.
140. Rocha FJ, Kelleher RS, Edwards JA, Pena JDO, Ono M, Sullivan DA. Binding characteristics,
immunocytochemical location and hormonal regulation of androgen receptors in lacrimal tissue. Adv
Exp Med Biol 1994;350:157-160.
141. Sullivan DA, Ariga H, Vendramini AC, Rocha FJ, Ono M, Sato EH. Androgen-induced suppression
of autoimmune disease in lacrimal glands of mouse models of Sjögren's syndrome. Adv Exp Med
Biol 1994;350:683-690.
142. Rocha FJ, Sato EH, Sullivan BD, Sullivan DA. Comparative efficacy of androgen analogues in
suppressing lacrimal gland inflammation in a mouse model (MRL/lpr) of Sjögren's syndrome. Adv
Exp Med Biol 1994;350:697-700.
143. Lambert RW, Kelleher RS, Wickham LA, Gao J, Sullivan DA. Neural-endocrine control of secretory
component synthesis by lacrimal gland acinar cells: specificity, temporal characteristics and molecular
basis. Adv Exp Med Biol 1994;350:175-180.
144. Wickham LA, Huang Z, Lambert RW, Sullivan DA. Sialodacryoadenitis virus infection of rat
lacrimal gland acinar cells. Adv Exp Med Biol 1994;350:193-196.
145. Huang Z, Lambert RW, Wickham LA, Sullivan DA. Influence of the endocrine environment on
herpes virus infection in rat lacrimal gland acinar cells. Adv Exp Med Biol 1994;350:189-192.
146. Gao J, Lambert RW, Sullivan DA. Androgen regulation of secretory component mRNA levels in the
rat lacrimal gland. Adv Exp Med Biol 1994;350:219-224.
147. Ono M, Rocha FJ, Sato EH, Sullivan DA. Distribution and endocrine regulation of androgen
receptors in lacrimal glands of the MRL/lpr mouse model of Sjögren’s syndrome. In: Homma M.
Sugai S, Tojo T, Miyasaka N, Akizuki M, editors. Sjögren's Syndrome. State of the Art. Amsterdam,
Kugler Press 1994. p. 261-263.
148. Sullivan DA. Possible mechanisms involved in the reduced tear secretion in Sjögren’s syndrome. In:
Homma M. Sugai S, Tojo T, Miyasaka N, Akizuki M, editors. Sjögren's Syndrome. State of the Art.
Amsterdam, Kugler Press; 1994. p. 13-19.
David A. Sullivan, Ph.D.
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149. Sullivan DA, Huang Z, Lambert RW, Wickham LA, Ono M, Pena JDO, Gao J. Androgen regulation
of ocular mucosal- and auto-immunity. In: Szélenyi J, Berczi I, editors. Advances in
Psychoneuroimmunology. New York: Plenum Press; 1994. p. 213-222.
150. Sullivan DA, Rocha FJ, Sato EH. Influence of androgen therapy on lacrimal autoimmune disease in
a mouse model of Sjögren's syndrome. Adv Exp Med Biol 1995;371B:1199-1202.
151. Lambert RW, Gao J, Kelleher RS, Wickham LA, Sullivan DA. Neural, endocrine and immune
regulation of secretory component production by lacrimal gland acinar cells. Adv Exp Med Biol
1995;371A:221-224.
152. Wickham LA, Huang Z, Lambert RW, Sullivan DA. Herpes- and corona-virus infection of rat
lacrimal acinar cells. Adv Exp Med Biol 1995;371B:999-1002.
153. Sullivan DA. Preface. Lacrimal Gland, Tear Film and Dry Eye Syndromes 2. Basic Science and
Clinical Relevance. Sullivan DA, Dartt DA, Meneray MM, editors. New York: Plenum Press; 1998;
pp. v-vi.
154. Sullivan DA, Wickham LA, Rocha EM, Kelleher RS, Silveira LA, Toda I. Influence of gender, sex
steroid hormones and the hypothalamic-pituitary axis on the structure and function of the lacrimal
gland. Adv Exp Med Biol 1998;438:11-42.
155. Sullivan DA, Rocha EM, Ullman MD, Krenzer KL, Gao J, Toda I, Dana MR, Bazzinotti D, Silveira
LA, Wickham LA. Androgen regulation of the meibomian gland. Adv Exp Med Biol 1998;438:327331.
156. Wickham LA, Rocha AM, Gao J, Krenzer KL, Silveira LA, Toda I, Sullivan DA. Identification and
hormonal control of sex steroid receptors in the eye. Adv Exp Med Biol 1998;438:95-100.
158. Toda I, Wickham LA, Rocha EM, Silveira LA, Sullivan DA. Gender- and androgen-related impact
on the expression of proto-oncogenes and apoptotic factors in lacrimal and salivary glands of mouse
models of Sjögren’s syndrome. Adv Exp Med Biol 1998;438:447-452.
159. Rocha EM, Wickham LA, Huang Z, Toda I, Gao J, Silveira LA, Sullivan DA. Presence and
testosterone influence on the levels of anti- and pro-inflammatory cytokines in lacrimal tissues of a
mouse model of Sjögren’s syndrome. Adv Exp Med Biol 1998;438:485-491.
150. Sullivan DA. Preface. Lacrimal Gland, Tear Film and Dry Eye Syndromes 3. Basic Science and
Clinical Relevance. Sullivan DA, Tsubota K, Dartt DA, Stern ME, Sullivan RM, Bromberg BB,
editors. New York: Kluwer Academic/Plenum Press; 2002; p. xi.
160. Sullivan DA, Yamagami H, Liu M, Steagall RJ, Schirra F, Suzuki T, Krenzer KL, Cermak JM,
Sullivan RM, Richards S, Schaumberg DA, Dana MR, Sullivan BD. Sex steroids, the meibomian
gland and evaporative dry eye. Adv Exp Med Biol 2002;506:389-399.
161. Richards SM, Liu M, Sullivan BD, Sullivan DA. Gender-related differences in gene expression of the
lacrimal gland. Adv Exp Med Biol 2002;506:121-127.
David A. Sullivan, Ph.D.
41
162. Liu M, Richards SM, Schirra F, Yamagami H, Sullivan BD, Sullivan DA. Identification of androgenregulated genes in the lacrimal gland. Adv Exp Med Biol 2002;506:129-135.
163. Sullivan BD, Evans JE, Dana MR, Sullivan DA. Impact of androgen deficiency on the lipid profiles
in human meibomian gland secretions. Adv Exp Med Biol 2002;506:449-458.
164. Sullivan BD, Cermak JM, Sullivan RM, Papas AS, Evans JE, Dana MR, Sullivan DA. Correlations
between nutrient intake and the polar lipid profiles of meibomian gland secretions in women with
Sjögren’s syndrome. Adv Exp Med Biol 2002;506:441-447.
165. Steagall RJ, Yamagami H, Wickham LA, Sullivan DA. Androgen control of gene expression in the
rabbit meibomian gland. Adv Exp Med Biol 2002;506:465-476.
166. Yamagami H, Richards SM, Sullivan BD, Liu M, Steagall RJ, Sullivan DA. Gender-associated
differences in gene expression of the meibomian gland. Adv Exp Med Biol 2002;506:459-463.
167. Yamagami H, Schirra F, Liu M, Richards SM, Sullivan BD, Sullivan DA. Androgen influence on
gene expression in the meibomian gland. Adv Exp Med Biol 2002;506:477-481.
168. Suzuki T, Sullivan BD, Liu M, Schirra F, Richards SM, Yamagami H, Sullivan DA. Estrogen and
progesterone effects on the morphology of the mouse meibomian gland. Adv Exp Med Biol
2002;506:483-488.
169. Schaumberg DA, Sullivan DA, Dana MR. Epidemiology of dry eye syndrome. Adv Exp Med Biol
2002;506:989-998.
170. Sullivan RM, Cermak JM, Papas AS, Dana MR, Sullivan DA. Economic and quality of life impact of
dry eye symptoms in women with Sjögren's syndrome. Adv Exp Med Biol 2002;506:1183-1188.
171. Bijlsma WR, Tonino BAR, Richards SM, Liu M, Sullivan BD, Sullivan DA. Androgen influence on
lymphocyte gene expression. Adv Exp Med Biol 2002;506:143-151.
172. Sullivan DA, Sullivan BD, Evans JE, Schirra F, Yamagami H, Liu M, Richards SM, Suzuki T,
Schaumberg DA, Sullivan RM, Dana MR. Androgen deficiency, meibomian gland dysfunction and
evaporative dry eye. Ann NY Acad Sci 2002;966:211-222.
173. Suzuki T, Schaumberg DA, Sullivan BD, Liu M, Richards SM, Sullivan RM, Dana MR, Sullivan DA.
Do estrogen and progesterone play a role in the dry eye of Sjögren's syndrome? Ann NY Acad Sci
2002;966:223-225.
174. Sullivan DA, Stern ME. Preface, 4th International Conference on the Lacrimal Gland Tear Film and
Dry Eye Syndromes: Basic Science and Clinical Relevance. Ocul Surf 2005; 3 (1) Suppl:S7.
175. Sullivan DA. The endocrine system and the meibomian glands. Proceedings of the Meibom-2000
Symposium on the Meibomian Glands, 2008; in press.
Reviews, Editorials and Chapters:
David A. Sullivan, Ph.D.
42
176. Wira CR, Sullivan DA. Effect of estradiol and progesterone on the secretory immune system in the
female genital tract. In: Leavitt WW, editor. Hormones and Cancer. New York: Plenum Press; 1982.
p. 99-111.
177. Allansmith MR, Sullivan DA. Books on cornea-external diseases. Ophthalmol 1983;Suppl 229-230.
178. Sullivan DA. Endocrine control of the ocular secretory immune system. In: Berczi, I, editor.
Hormones and Immunity. Lancaster, England: MTP Press Limited; 1987. p. 54-92.
179. Sullivan DA, Hann LE. Mechanisms involved in the endocrine regulation of the ocular secretory
immune system. In: Hadden JW, Masek K, Nistico G, editors. Interactions among Central Nervous
System, Neuroendocrine and Immune Systems. Rome, Italy: Pythagora Press; 1989. p. 395-428.
180. Sullivan DA. Hormonal influence on the secretory immune system of the eye. In: Freier S, ed. The
Neuroendocrine-Immune Network. Boca Raton, FL: CRC Press; 1990. p. 199-238.
181. Sullivan DA, Sato EH. Potential therapeutic approach for the hormonal treatment of lacrimal gland
dysfunction in Sjögren's syndrome. Clin Immunol Immunopath 1992;64:9-16.
182. Sullivan DA. Endocrine effects on mucosal immune function. In: Walker WA, Harmatz PR, Wershil
BK, editors. Immunophysiology of the Gut. Orlando, FL: Academic Press; 1993. p. 165-170.
183. Sullivan DA. Research report of the SSF 1992-3 fellowship winner, Zhiyan Huang, MD. The
Moisture Seekers 1993;11:1,5.
184. Sullivan DA, Sato EH: Immunology of the lacrimal gland. In Albert DM, Jakobiec, FA, editors.
Principles and Practice of Ophthalmology: Basic Sciences. Philadelphia, PA: WB Saunders Company;
1994. p. 479-486.
185. Sullivan DA. Ocular mucosal immunity. In: Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee J,
Bienenstock J, editors. Handbook of Mucosal Immunology. Orlando, FL: Academic Press; 1994. p.
569-597.
186. Sullivan DA, Ono M. New research insights into the physiological basis and potential treatment for
dry eye in Sjögren's syndrome. Journal of the Eye, 1994;11:1187-1195.
187. Sullivan DA, Wickham LA, Rocha EM, Silveira LA, Toda I. Role of sex steroid hormones in the
expression and possible treatment of dry eye in Sjögren’s syndrome. In: The Moisture Seekers
Newsletter, 1996:14:1,3,4.
188. Sullivan DA, Wickham LA, Krenzer KL, Rocha EM, Toda I. Aqueous tear deficiency in Sjögren’s
syndrome: Possible causes and potential treatment. In: Pleyer U, Hartmann C, Sterry W, editors.
Oculodermal Diseases - Immunology of Bullous Oculo-Muco-Cutaneous Disorders. Buren, The
Netherlands: Aeolus Press; 1997. p. 95-152.
189. Sullivan DA. Sex hormones and Sjögren’s syndrome. J Rheumatol 1997;24 (Suppl 50):17-32.
David A. Sullivan, Ph.D.
43
190. Sullivan DA, Wickham LA, Toda I, Rocha EM, Krenzer KL, Dana MR. Gender and dry eye. In:
Research to Prevent Blindness Science Writers Seminar. New York: Research to Prevent Blindness; 1997. p.
57-60.
191. Zierhut M, Elson CO, Forrester JV, Kijlstra A, Kraehenbuhl J-P, Sullivan DA. Mucosal immunology
and the eye. Immunol Today 1998;19:148-150.
192. Sullivan DA. Ocular mucosal immunity. In: Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee J,
Bienenstock J, editors. Handbook of Mucosal Immunology, 2nd Edition. Orlando, FL: Academic
Press; 1999. p. 1241-1281.
193. Sullivan DA, Wickham LA, Rocha EM, Krenzer KL, Sullivan BD, Steagall R, Cermak JM, Dana MR,
Ullman MD, Sato EH, Gao J, Rocha FJ, Ono M, Silveira LA, Lambert RW, Kelleher RS, Tolls BD,
Toda I. Androgens and dry eye in Sjögren’s syndrome. Ann NY Acad Sci 1999;876:312-324.
194. Sullivan DA. Immunology of the lacrimal gland and tear film. In Pleyer U, Zierhut M, BehrensBaumann W, editors. Developments in Ophthalmology: Immuno-Ophthalmology. Basel,
Switzerland: Karger; 1999. p. 39-53.
195. Dartt DA, Sullivan DA. Wetting of the ocular surface. In Albert DM, Jakobiec, FA, editors.
Principles and Practice of Ophthalmology, 2nd Edition. Philadelphia, PA: WB Saunders Company;
2000. vol. 2, p. 960-981.
196. Sullivan DA. Ocular secretory immune system: lacrimal gland and conjunctiva. In Zierhut M,
Forrester JV, editors. Mucosal Immunology and Ocular Diseases. Buren, The Netherlands: Aeolus
Press; 2000. p. 53-91.
197. Dana MR, Sullivan DA, Parke AL. Toward optimal health: the experts discuss dry eye syndrome.
Interview by Jodi Godfrey Meisler. J Womens Health Gend Based Med 2001;10:725-729.
198. Sullivan DA, Schaumberg DA, Schirra F, Suzuki T, Liu M, Richards SM, Sullivan RM, Dana MR,
Sullivan BD. Hormone therapy for dry eye. Rev Ophthalmol 2002;9:73-76.
199. Zierhut M, Dana MR, Stern ME, Sullivan DA. Immunology of the Lacrimal Gland and Ocular Tear
Film. Trends Immunol 2002;23:333-335.
200. Sullivan DA. Androgen deficiency and dry eye syndromes. Arch Soc Espanola Oftalmologia.
2004;79:49-50.
201. Sullivan DA. Tearful relationships? Sex, hormones and aqueous-deficient dry eye. Ocular Surface
2004;2:92-123.
202. Sullivan DA. Sex and sex steroid influences on dry eye syndrome. In: Pflugfelder SC, Beuerman RW,
Stern ME, editors. Dry Eye and Ocular Surface Disorders. New York City, NY: Marcel Dekker, Inc.
2004;165-190.
David A. Sullivan, Ph.D.
44
203. O'Sullivan NL, Montgomery PC, Sullivan DA. Ocular mucosal immunity. In: Ogra PL, Mestecky J,
Lamm ME, Strober W, McGhee J, Bienenstock J, editors. Handbook of Mucosal Immunology, 3rd
Edition. Orlando, FL: Academic Press;2004;86:1477-1496.
204. Sullivan DA, Schaumberg DA, Schirra F, Suzuki T, Liu M, Richards SM, Sullivan RM, Dana MR,
Sullivan BD. Sex, sex steroids and dry eye syndromes. In Zierhut M, Stern ME, Sullivan DA, eds.
Immunology of the Lacrimal Gland, Tear Film and Ocular Surface. London, Great Britain: Taylor &
Francis, 2005. pp. 161-181.
205. Sullivan DA. Endocrine Markers in the diagnosis of dry eye syndromes. Diagnostic Template 11
(http://www.tearfilm.org/dewsreport/), Appendix of Methodologies to diagnose and monitor dry
eye disease, Report of the International Dry Eye WorkShop (DEWS), Volume 5, Number 2, 2007.
206. Abelson MB, Sullivan DA, Ousler GWIII, Smith L, Maffei C. What you missed at the TFOS
Meeting: A thorough update on the latest research in corneal and external disease. Rev Ophthalmol
2007;14(12):56-61.
207. Sullivan DA. Historical Perspective: Tear Film & Ocular Surface Society Conferences. Ocul Surf
2011;9:2.
208. Nichols KK, Foulks GN, Bron AJ, Sullivan DA. Meibomian gland dysfunction: What is it, why does
it occur, and how do I treat it? Ophthalmology Management, Optometric Management and Contact
Lens Spectrum 2011.
209. Gomes JA, Rocha EM, Freitas D, Sullivan DA. Workshop sobre Disfunção das Glândulas
Meimobius. Arq Bras Oftalmol 2011;74:157-160.
210. Sullivan DA. New approaches and challenges for the treatment of dry eye disease. Frontiers Dry Eye
2012;7:48-49.
211. Efron N, Brennan NA, Bright FV, Glasgow BJ, Jones LW, Sullivan DA, Tomlinson A, Zhang J. 2. Contact
lens care and ocular surface homeostasis. Cont Lens Anterior Eye 2013;36 Suppl 1:S9-13.
212. Liu Y, Ding J, Sullivan DA. An additional explanation for azithromycin’s efficacy in treating
meibomian gland dysfunction. Brit J Ophthalmol, Published Online First: 19 August 2014
Books:
213. Sullivan DA, Bromberg BB, Cripps MM, Dartt DA, MacKeen DL, Mircheff AK, Montgomery PC,
Tsubota K, Walcott B, editors. Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science
and Clinical Relevance. New York: Plenum Press; 1994.
214. Sullivan DA, Dartt DA, Meneray MM, editors. Lacrimal Gland, Tear Film and Dry Eye Syndromes
2. Basic Science and Clinical Relevance. New York: Plenum Press; 1998.
215. Sullivan DA, Tsubota K, Dartt DA, Stern ME, Sullivan RM, Bromberg BB, editors. Lacrimal Gland,
Tear Film and Dry Eye Syndromes 3. Basic Science and Clinical Relevance. New York: Kluwer
Academic/Plenum Press; 2002.
David A. Sullivan, Ph.D.
45
216. Zierhut M, Stern ME, Sullivan DA, eds. Immunology of the Lacrimal Gland, Tear Film and Ocular
Surface. London, Great Britain: Taylor & Francis, 2005.
Thesis:
Sullivan DA. Pulmonary immaturity in the respiratory distress syndrome and glucocorticoid induced
acceleration of lung maturation [M.S. project]. Minneapolis, MN: University of Minnesota Medical
School; 1975.
Sullivan DA. The role of estradiol in the regulation of the secretory immune system of the female
reproductive tract [Ph.D. dissertation]. Hanover, NH: Dartmouth Medical School; 1980.
Patents:
1.
Ocular Androgen Therapy in Sjögren’s Syndrome. Patent No. 5,620,921, Issued 4/15/97.
2.
Ocular Therapy in Sjögren’s Syndrome Using Topically Applied Androgens or TGF-b. Patent No.
5,688,765, Issued 11/18/97.
3.
Ocular Therapy in Keratoconjunctivitis Sicca Using Topically Applied Androgens or TGF-b. Patent
No. 5,958,912, Issued 9/28/99.
4.
Ocular Therapy in Keratoconjunctivitis Sicca Using Topically Applied Androgens or TGF-b. Patent
No. 6,107,289, Issued 8/22/00.
5.
Sullivan B, Schmidt TA, Sullivan DA. Therapeutic replenishment and enrichment of ocular surface
lubrication. Pub. No. WO/2009/137217.
6.
Sullivan B, Schmidt TA, Sullivan DA. Therapeutic modulation of ocular surface lubrication. Pub.
No. WO/2009/137602.
7.
Sullivan B, Schmidt TA, Sullivan DA. Ophthalmic device, and method of use thereof, for increasing
ocular boundary lubrication. Patent No. 12,940,454, Issued 6/13.
8.
Sullivan B, Schmidt TA, Sullivan DA. Replenishment and enrichment of ocular surface lubrication.
Pub. No. WO/2011/050287.
9.
Sullivan B, Schmidt TA, Truitt E, Truitt NBJ, Sullivan DA. Application and uses of PRG4 and
therapeutic modulation thereof. Pub. No. WO/2010/135736.
10.
Truitt E, Sullivan B, Sullivan DA. Therapeutic modulation of vaginal epithelium boundary
lubrication. Pub. No. WO/2010/083239.
11.
Sullivan B, Schmidt TA, Sullivan DA. Ophthalmic device, and method of use thereof, for increasing
ocular boundary lubrication. Patent No. 14/032,233, Issued 9/14.
Abstracts:
David A. Sullivan, Ph.D.
46
Articles submitted by November 2014 1.
Liu Y, Sullivan DA, Lost EO, Kopchick JJ, Ding J. Regulation of mouse meibomian gland size by the
growth hormone/insulin-like growth factor-1 axis. To be submitted, January 2015.
2.
Kam WR, Rahimi Darabad R, Suzuki T, Sullivan DA. Suppressive effects of 17β-estradiol on
immortalized human meibomian gland epithelial cells. To be submitted, January 2015.
3.
Sullivan DA, Cermak JM, Sullivan RM, Papas AS, Dana MR, Krenzer KL. Comparative signs and
symptoms of dry eye in primary and secondary Sjögren’s syndrome and meibomian gland disease. To
be submitted, January 2015.
Abstracts to be converted to original articles 4.
Sullivan DA, Richards SM. Sex and endocrine influence on surfactant protein gene expression in
ocular and salivary tissues.
5.
Rocha EM, Sullivan BD, Toda I, Wickham, LA, Silveira LA, Sullivan DA. Sex and androgen effects
on cytokine mRNA levels in lacrimal tissues of mouse models of Sjögren’s syndrome.
6
Sullivan DA, Richards SM. Mechanism(s) involved in the androgen-induced suppression of lacrimal
gland inflammation in Sjögren’s syndrome.
7.
Sahin A, Kam WR, Rahimi Darabad R, Sullivan DA. Lipopolysaccharide induction of proinflammatory gene expression in human corneal, conjunctival and meibomian gland epithelial cells.
8.
Kam WR, Rahimi Darabad R, Sullivan DA. Membrane steroid receptors are expressed by human
meibomian gland epithelial cells.
9.
Sullivan DA, Rahimi Darabad, Liu S, Kam WR. Are mice relevant models for understanding sexrelated differences in the human meibomian gland?
Part IV: Personal Narrative
I am a Ph.D. graduate of Dartmouth Medical School (Hanover, NH), an Associate Professor in the
Department of Ophthalmology at Harvard Medical School and a Senior Scientist at the Schepens Eye
Research Institute (SERI; Boston, MA). During the past 32 years, my research has focused upon the
interrelationships between sex, sex steroids and dry eye disease, and has led to authorship on over 200
scientific articles and 11 patents, as well as to the development of potential therapies for aqueous-deficient
and evaporative dry eye disease. I have continually been awarded research grants from NIH throughout
my career, and have served as a preceptor for 28 postdoctoral fellows. I have been invited to give
presentations at numerous international meetings on ophthalmology, immunology, endocrinology and
autoimmunity, as well as at various medical institutions, around the world. I was recently awarded The
Carel C. Koch Memorial Medal Award from the American Academy of Optometry for “outstanding
contributions to the enhancement and development of relationships between optometry and other
professions.”
David A. Sullivan, Ph.D.
47
I am a Founder, recent President, and current Chairman of the Board of Directors of the Tear Film &
Ocular Surface Society (TFOS), a non-profit organization, which was created to advance the research,
literacy, and educational aspects of the scientific field of the tear film and ocular surface throughout the
world. I have organized 7 International Conferences, overseen the awarding of more than 200 Young
Investigator Awards, and organized the TFOS International Workshops on Dry Eye (“DEWS”),
Meibomian Gland Dysfunction and Contact Lens Discomfort. These global Workshops involved the
efforts of 50 to 80 scientific and clinical experts, each required 2 to 3 years to complete, and all led to the
publication of major reports. Through TFOS I have helped to promote increased international awareness
of external eye diseases, enhance governmental funding for tear film and ocular surface research, stimulate
the development of therapeutic drugs and diagnostic devices, and influence the design and conduct of
clinical trials of novel treatments for ocular surface disorders. My efforts for TFOS are voluntary, and I
receive no compensation from this Society. TFOS has a distribution to ~5,000 basic scientists, clinical
researchers and industry representatives in more than 80 countries.
Within SERI I have served as the Head of the Research Council (i.e. Faculty Senate), the Director of
the Center for Corneal and External Eye Disease Research, the Head of the Immunology Unit, and the
Leader of the Immunity, Inflammation and Transplantation Focus Group. I also chaired the SERI
Technology Transfer Committee for over 10 years, and helped to create the Joint Clinical Research Center
of SERI and the Massachusetts Eye & Ear Infirmary, and the SERI Corporate Alliance Program.
Outside SERI I have chaired the Medical and Scientific Advisory Board of the Sjögren's Syndrome
Foundation, and was recently a Co-Chair of the Cornea Program Committee of the Association for
Research in Vision and Ophthalmology. I have acted as a reviewer for research grant proposals for NIH,
the Concerted Action Program of the Ministry of Education of Flanders and the USA Veterans
Administration, served on the Fellowship Review Panel for the Fight for Sight Research Division of the
National Society to Prevent Blindness, and assisted as an editorial referee for many ophthalmic, immune
and endocrine journals.

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JOHN M. TYSON 1st Assistant Director D.G.A.

A list of available Wills and Probate Documents