ANTINUCLEAR ANTIBODY TESTING The ANA screen test (ANA) detects autoantibodies to multiple clinically relevant antibodies (SS-A, SS-B, Sm, RNP, SmRNP, Scl-70, Jo-1, Centromere B, Ribosomal P, and Chromatin). A negative result means that the patient’s serum shows no reactivity for these common antibodies associated with connective tissue diseases. The best assay for detection of anti-dsDNA is the separately ordered ADNA test. The ANA by IFA (NAB) assay is recommended if the ANA screen test is negative, but patient symptoms are compelling for SLE. Test Name Antinuclear Antibody Screen Antinuclear Antibody by IFA Antinuclear Antibody Screen with reflex to IFA (if screen is positive) Order Code ANA NAB ANA2 CPT Code 86038 86038 EXTRACTABLE NUCLEAR ANTIBODY TESTING ENA testing is recommended to follow-up a positive ANA screen. The following individual tests and panels are available: Test Name Centromere B Antibody Chromatin Antibody Jo-1 Antibody Ribosomal Protein Antibody RNP Antibody Scleroderma Antibody Smith Antibody SmRNP Antibody SS-A (Ro) Antibody SS-B (La) Antibody SS-A and SS-B Antibody Panel ENA 3 Antibody Panel ENA 5 Antibody Panel ENA 7 Antibody Panel ENA 11 Antibody Panel Order Code CENTB CHROM JO1 RIBOP RNP SCL70 SMITH SMRNP SSA SSB SSAB SMRN ENA5 ENA7 ENA10 CPT Code 86235 86235 86235 86235 86235 86235 86235 86235 86235 86235 86235 x2 86235 x3 86235 x5 86235 x7 86235 x10 Panels include the following components: SS-A (Ro) Antibody SS-B (La) Antibody Smith Antibody SmRNP Antibody RNP Antibody Jo-1 Antibody Scleroderma Antibody (Scl-70) Centromere B Antibody Chromatin Antibody Ribosomal Protein Antibody SSAB X X SMRN X X X ENA5 X X X X X ENA7 X X X X X X X ENA10 X X X X X X X X X X REV 2/4/2014
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