Programme Saturday 23 August 2014 15:00 - 18:00 ARRIVAL AND REGISTRATION ATC Registration Desk 18:00 - 18:15 Welcome and Opening Remarks ATC Auditorium 18:15 - 19:45 Session 1 Chair: Eileen Furlong, EMBL Heidelberg, Germany ATC Auditorium 18:15 - 18:45 Epigenome: a manual for genome function and utilisation Hendrik Stunnenberg NCMLS, Radboud University Nijmegen, The Netherlands 18:45 - 19:05 Regulation of genomic accessibility Gerald Crabtree Stanford University, United States of America 19:05 - 19:25 Chromatin and antisense transcript dynamics underlying quantitative gene reguation Caroline Dean John Innes Centre, United Kingdom 19:25 - 19:45 NAP1-Mediated Linker Histone Eviction is a critical step for decompaction and transcription of higher-order chromatin Robert Roeder The Rockefeller University, United States of America 19:45 - 21:30 DINNER EMBL Canteen 21:30 - 23:00 WELCOME RECEPTION ATC Roof Top Lounge 11th EMBL Conference: Transcription and Chromatin Sunday 24 August 2014 09:00 - 12:40 Session 2 Chair: Cigall Kadoch, Dana-Farber Cancer Institute & Harvard Medical School, USA ATC Auditorium 09:00 - 09:20 Decoding transcriptional regulation in Drosophila Alexander Stark IMP, Austria 09:20 - 09:40 Switching genes on and off during hematopoiesis Douglas Higgs University of Oxford, United Kingdom 09:40 - 09:55 Three-dimensional properties of enhancer interactions during embryonic development Eileen Furlong EMBL Heidelberg, Germany 09:55 - 10:10 Predictive polymer modelling reveals coupled fluctuations in chromosome conformation and transcription Luca Giorgetti Institut Curie, CNRS UMR3215/INSERM U934, Paris, France 10:10 - 10:25 Three dimensional chromatin architecture correlates with two opposite transcription factors, which contributes to the cell specificity Yasuharu Kanki The University of Tokyo, Japan 10:25 - 10:45 Managing remote (regulatory) relationships: chromosomal folding versus genomic distances Francois Spitz EMBL Heidelberg, Germany 10:45 - 11:15 COFFEE BREAK ATC Foyer Programme 11:15 - 11:35 Biogenesis and mechanism of action of eRNAs Ramin Shiekhattar University of Miami, United States of America 11:35 - 11:50 Essential role of enhancer transcription in H3K4me1/2 deposition at de novo enhancers Minna Kaikkonen University of Eastern Finland, A.I.Virtanen Institute, Finland 11:50 - 12:05 A dynamic promoter nucleosome architecture at highly expressed genes in yeast David Shore University of Geneva, Switzerland 12:05 - 12:20 Enhancer malfunction in cancer Ali Shilatifard Stowers Institute for Medical Research, United States of America 12:20 - 12:40 Non-coding transcription at cis-regulatory elements: evidence for active and domain-wide suppression Gioacchino Natoli European Institute of Oncology (IEO), Italy 12:40 - 14:30 LUNCH EMBL Canteen 14:30 - 17:00 POSTER SESSION 1 ATC Helix A and B 17:00 - 19:20 Session 3 Chair: Ali Shilatifard, Stowers Institute for Medical Research, United States of America ATC Auditorium 17:00 - 17:20 Modulating the nucleosome barrier to transcription Steven Henikoff F. Hutchinson Cancer Research Center and H. Hughes Medical Institute, United States of America 11th EMBL Conference: Transcription and Chromatin 17:20 - 17:40 Novel epigenetic signatures of wild type and mutant p53 transcriptional activity Shelley Berger University of Pennsylvania, United States of America 17:40 - 17:55 Regulatory Architecture of Nucleosome Sliding and Ejection by Sth1/RSC Cedric Clapier Howard Hughes Medical Institute, United States of America 17:55 - 18:10 Suppression of non-functional RNAs: keeping TBP out of trouble Marc Timmers University Medical Center Utrecht, The Netherlands 18:10 - 18:25 Regulation of H2A.Z deposition by T108 phosphorylation Ann Ehrenhofer-Murray Humboldt-Universität zu Berlin, Germany 18:25 - 18:40 Heterochromatin assembly and dynamics on the single molecule level Beat Fierz EPFL, Switzerland 18:40 - 19:00 The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription at expressed genes Laszlo Tora IGBMC, France 19:00 - 19:20 Genomic and structural basis for regulation of cardiogenesis by heterotypic transcription factors Benoit Bruneau Gladstone Institutes, United States of America 19:20 - 21:30 DINNER EMBL Canteen 21:30 - 23:00 AFTER-DINNER DRINKS ATC Roof Top Lounge Programme Monday 25 August 2014 09:00 - 12:40 Session 4 Chair: Denis Duboule, EPFL and University of Lausanne, Switzerland ATC Auditorium 09:00 - 09:20 Structural basis of transcription initiation and regulation Patrick Cramer Gene Center and Ludwig-Maximilians-Universität München, Germany 09:20 - 09:40 Structure-function studies of RNA polymerase I and III transcription Christoph Müller EMBL Heidelberg, Germany 09:40 - 09:55 Temporal dynamics of enhancer transcription and promoter activation in cellular state change Albin Sandelin University of Copenhagen, Denmark 09:55 - 10:10 Tyrosine phosphorylation of RNA Polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells Jean-Christophe Andrau CNRS, France 10:10 - 10:25 The TFIID subunit TAF4 directs pre-initiation complex formation and HNF4A promoter occupancy to activate post-natal hepatocyte gene expression Irwin Davidson IGBMC, France 10:25 - 10:45 GAGA Factor maintains promoters in nucleosome-free conformation and allows promoter-proximal pausing John Lis Cornell University, United States of America 10:45 - 11:15 COFFEE BREAK ATC Foyer 11th EMBL Conference: Transcription and Chromatin 11:15 - 11:35 Organisation of chromatin and the transcription machinery across the yeast genome Frank Pugh Penn State University, United States of America 11:35 - 11:50 Reconstitution of transcriptionally active human core Mediator complex reveals a pivotal role of the MED14 subunit Murat Cevher Rockefeller University, United States of America 11:50 - 12:05 Divergent transcription initiates from core promoters at the edges of open chromatin Scott Lacadie The Max Delbrück Center for Molecular Medicine, Germany 12:05 - 12:20 Drosophila TRF2 is a preferential core promoter regulator Tamar Juven-Gershon Bar-Ilan University, Israel 12:20 - 12:40 Histone variants and their chaperones: helping regulate gene expression Geneviève Almouzni Institut Curie/CNRS, France 12:40 - 14:30 LUNCH ATC Foyer 14:30 - 17:00 POSTER SESSION 2 ATC Helix A and B 17:00 - 19:20 Session 5 Chair: Marc Timmers, University Medical Centre Utrecht, The Netherlands ATC Auditorium 17:00 - 17:20 KRAB’n’KAP: epigenetic control of the genetic self, sort-of-self and un-self Didier Trono EPFL, Switzerland Programme 17:20 - 17:40 Targeted function of Polycomb-Group complexes Robert Kingston Massachusetts General Hospital, United States of America 17:40 - 17:55 The function of histone H2A monoubiquitination in Polycomb repression Jürg Müller Max-Planck Institute of Biochemistry, Germany 17:55 - 18:10 Polycomb-like Proteins in Cell Cycle Control Adrian Bracken Trinity College Dublin, Ireland 18:10 - 18:25 A role for poised enhancers during Drosophila pattern formation Nina Koenecke Stowers Institute for Medical Research, United States of America 18:25 - 18:40 Transcriptional activation without chromatin marking in developmentally regulated genes Silvia Pérez Center for Genomic Regulation (CRG), Spain 18:40 - 19:00 H3K27 methylation and PRC2 epigenetically transmit a memory of repression across generations and in development Susan Strome University of California, Santa Cruz, United States of America 19:00 - 19:20 Polycomb Complexes Danny Reinberg HHMI at NYU School of Medicine, United States of America 19:20 - 21:30 DINNER EMBL Canteen 21:30 - 23:00 AFTER-DINNER DRINKS ATC Roof Top Lounge 11th EMBL Conference: Transcription and Chromatin Tuesday 26 August 2014 09:00 - 13:00 Session 6 Chair: Geneviève Almouzni, Institut Curie, France ATC Auditorium 09:00 - 09:20 Transcriptional dynamics in the precellular Drosophila Embryo Michael Levine UC Berkeley, United States of America 09:20 - 09:35 The BAF chromatin remodelling complex is a regulator of mouse embryo lineage specification Maryna Panamarova WT\CR UK Gurdon Institute, United Kingdom 09:35 - 09:50 Polycomb component Cbx4 inhibits the expression of non-epidermal lineage genes and controls progenitor cells differentiation in the developing epidermis Vladimir Botchkarev University of Bradford, United Kingdom 09:50 - 10:05 Atrx and Daxx promote heterochromatin formation at retrotransposons in mouse ES cells Gunnar Schotta LMU Munich, Germany 10:05 - 10:20 Hi-jacking of regulatory landscapes at Hox gene clusters Denis Duboule EPFL and University of Geneva, Switzerland 10:20 - 10:40 Transcriptional regulation of cardiac cell fate Laurie Boyer Massachusetts Institute of Technology, United States of America 10:40 - 11:10 COFFEE BREAK ATC Foyer Programme 11:10 - 11:30 Central and peripheral clocks: the regulation of circadian gene expression by systemic cues Ueli Schibler University of Geneva, Switzerland 11:30 - 11:45 Cell fate specification through chromatin remodelling by the pioneer transcription factor Pax7 Jacques Drouin IRCM-MONTREAL, Canada 11:45 - 12:00 Signalling modules in transcriptional super-enhancers Denes Hnisz Whitehead Institute, United States of America 12:00 - 12:15 TRIM24 acts as a transcriptional co-activator of the androgen receptor during prostate cancer progression Anna Groner Dana-Farber Cancer Institute, United States of America 12:15 - 12:35 The evolution of mammalian tissue transcriptomes Henrik Kaessmann University of Lausanne, Switzerland 12:35 - 14:30 LUNCH ATC Foyer 14:30 - 17:00 POSTER SESSION 3 ATC Helix A and B 17:00 - 19:00 Session 7 Chair: Michael Levine, UC Berkeley, United States of America ATC Auditorium 17:00 - 17:20 Transcription and nuclear organisation during early development: chicken and egg Wendy Bickmore MRC Human Genetics Unit, United Kingdom 11th EMBL Conference: Transcription and Chromatin 17:20 - 17:35 Relieving Polycomb-mediated repressive chromatin facilitates breast tumorigenesis Raphaël Margueron Institut Curie/INSERM U934/CNRS UMR3215, France 17:35 - 17:50 ADP-ribosylation of histones: A reversible modification of specific amino acid residues Michael Hottiger University of Zurich, Switzerland 17:50 - 18:05 Mechanisms of transcriptional regulation in the p53 network Joaquin Espinosa HHMI / University of Colorado Boulder, United States of America 18:05 - 18:20 Dynamic analysis of Polycomb-mSWI/SNF (BAF) opposition Cigall Kadoch Dana-Farber Cancer Institute & Harvard Medical School, United States of America 18:20 - 18:40 Unveiling Polycomb functions in stem cells and cancer Luciano Di Croce Centre for Genomic Regulation/ICREA, Spain 18:40 - 19:00 Novel epigenetic modification pathways Tony Kouzarides Gurdon Institute, University of Cambridge, United Kingdom 19:00 - 19:15 Closing Remarks ATC Auditorium 19:30 - 01:00 DINNER AND PARTY EMBL Canteen and ATC Foyer
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