advanced skin rejuvenation EFFICACITE COMPAREE vs RETINOL CREAM BENCHMARKING vs RETINOL CREAM EFFET FILLER - DERMO-VOLUMATEUR FILLER EFFECT’- DERM-PLUMPING HUMAN SKIN – STIMULATION OF GAG PRODUCTION IN PAPILLAR DERMIS AFTER SIX DAYS EX VIVO Control Retinol cream Evaluation comparée de la molécule active du NovHyal ® Biotech G versus une crème rétinol commerciale sur peau humaine mature durant 6 jours. Mesure de la production des GAGs acides par coloration au bleu Alcian [Contrôle : peau sans produit]. Comparative evaluation of the active molecule of NovHyal® Biotech G versus a commercial retinol cream on human skin during 6 days. Staining of acid GAGs with Alcian blue. [Control: skin without any product] Untreated skin - Control Comment: low amounts of GAG (blue colour) mainly located around the DEJ Skin treated with Retinol Cream Comment: clear amounts of GAG mainly located around the DEJ GAGs production in 6 days: Skin treated with NAG6P 10g/L Comment: clear amounts of GAG well distributed in the entire papillar dermis NovHyal® Biotech G alone: boosted in the DEJ and homogeneously in the entire dermis Commercial retinol cream: increased only in DEJ HUMAN SKIN – STIMULATION OF GAG PRODUCTION IN PAPILLAR DERMIS AFTER TEN DAYS EX VIVO Test comparé de la molécule active du NovHyal® Biotech G versus une crème commerciale au retinol sur peau humaine mature durant 10 jours. Mesure de la production des GAGs acides par analyse d’image et quantification [Contrôle : peau sans produit]. Comparative evaluation of the active molecule of NovHyal® Biotech G versus a commercial retinol cream on human skin during 10 days. Quantification of acid GAGs by image analysis. [Control: skin without NovHyal® Biotech G] Control NAG6P 0.1 g/L NAG6P 1 g/L NAG6P 10g/L Retinol cream © Induchem 2012 (= NovHyal® Biotech G 0.4%) (= NovHyal® Biotech G 4%) GAGs synthesis in 10 days: NovHyal® Biotech G alone: +84% Commercial retinol cream: +109% advanced skin rejuvenation EFFET RAFFERMISSANT - LISSANT FIRMING’- SMOOTHING EFFECT HUMAN SKIN – REORGANIZATION AND RESTRUCTURING IN PAPILLAR DERMIS AFTER SIX DAYS EX VIVO Control Retinol cream Evaluation comparée du NovHyal® Biotech G seul versus une crème rétinol commerciale sur peau humaine mature durant 10 jours. Analyse anatomique de la jonction épidermo-dermique [Contrôle : peau sans produit]. Comparative evaluation of NovHyal® Biotech G alone versus a commercial retinol cream on human skin during 10 days. Skin anatomy analysis at the epidermis-dermis junction level. [Control: skin without product] Untreated skin - Control Comment: good epidermis structure but weak dermis epidermis junction Skin treated with Retinol Cream Comment: strong stimulation of the epidermis - signs of epidermic acanthosis Skin treated with NovHyal® Biotech G 0.4 % Comment: good epidermis structure and excellent dermis epidermis junction NovHyal® Biotech G alone: DEJ strengthened Commercial retinol cream: acanthosis Dermis-epidermis junction: EFFET REGENERATEUR REGENERATION EFFECT EX VIVO HUMAN SKIN – EXPRESSION OF CD44 RECEPTORS (hyaluronan receptor) IN THE BASAL LAYER EX VIVO AFTER TEN DAYS Control Retinol cream Evaluation comparée du NovHyal® Biotech G seul versus une crème rétinol commerciale sur peau humaine mature durant 10 jours. Quantification des récepteurs CD44 par marquage en immunofluorescence. [Contrôle : peau sans produit]. Comparative evaluation of NovHyal® Biotech G alone versus a commercial retinol cream on human skin during 10 days. Quantification of CD44 receptors by immunofluorescence labelling. [Control: skin without product]. Untreated skin - Control Comment: clear expression of CD44 receptors at the level of the basal layer Skin treated with Retinol Cream Comment: clear expression of CD44 receptors at the level of the basal layer CD 44 Expression: Skin treated with NovHyal® Biotech G 0.4 % Comment: very clear (enhanced) expression of CD44 receptors at the level of the basal layer NovHyal® Biotech G alone: high activation Commercial retinol cream: moderate activation Induchem AG - Industriestrasse 8a - CH-8604 Volketswil - Switzerland
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