Curriculum vitae Univ.‐Prof. Dr. rer. nat. Dr. med. habil. Mirko HH Schmidt W2‐Professor of Anatomy and Biochemistry Date of birth 06 July 1973 Gender Male Nationality German Business contact Institute for Microanatomy and Neurobiology Johannes Gutenberg University, School of Medicine Bldg. 708, Room 2.006 Langenbeckstr. 1 D‐55131 Mainz Phone 06131 17‐8071 Mirko.Schmidt@unimedizin‐mainz.de EDUCATION 1993 ‐ 1998 Studies of Biochemistry at the University of Bochum 1998 Diploma in Biochemistry (Supervisors: Anton Posch & Monika Raulf‐Heimsoth) 1999 ‐ 2001 Studies of Human Medicine at the University of Lübeck 1998 ‐ 2001 PhD thesis at the Institute for Biochemistry (Supervisor: Stefan Anemüller) and the Cli‐
nic of Surgery (Supervisor: Michael Duchrow) at the University of Lübeck 2001 Awarded the title Dr. rer. nat. (PhD) PROFESSIONAL EXPERIENCE 2001 ‐ 2003 Postdoctoral Fellow at the Hermelin Brain Tumor Center at the Henry Ford Hospital Detroit, MI, USA (Supervisor: Oliver Bogler) 2003 ‐ 2007 Senior‐Postdoctoral Fellow at the Institute of Biochemistry II of Goethe University, School of Medicine, Frankfurt am Main (Supervisor: Ivan Dikic) 2009 Habilitation and venia legendi in Biochemistry at Goethe University, School of Medi‐
cine, Frankfurt am Main (Supervisors: Ivan Dikic & Werner Müller‐Esterl) 2009 Awarded the titles Privatdozent (lecturer) and Dr. med. habil. (lecturer of medicine) 2007 ‐ 2012 Independent PI of the research group “Molecular Signal Transduction” at the Institute of Neurology (Edinger Institute) of Goethe University, School of Medicine, Frankfurt am Main (Director: Karl‐Heinz Plate) Since 2012 Associate Professor for Anatomy and Biochemistry, PI of the research group “Mole‐
cular Signal Transduction” at the Institute for Microanatomy and Neurobiology (Director: Robert Nitsch) at Johannes Gutenberg University, School of Medicine, Mainz Since 2012 Deputy Director of the Institute for Microanatomy and Neurobiology 2012 Awarded the title University Professor RESEARCH INTERESTS Molecular Signal Transduction Processes in  Neurobiology  Vascular Biology  Molecular Oncology AWARDS AND HONOURS 2003 Long‐term fellow of the European Molecular Biology Organization 2004 Fellow of the Paul and Ursula Klein Foundation 2005 Lecture Award at the Roche Meeting for “Leading bioscientists of the next decade” in Basel, Switzerland 2005 Adolf Messer Young Investigators Award 2007 Start‐Up Fund of the Excellence Cluster Cardiopulmonary System 2007 Best poster at the annual meeting of the DGP, Bonn 2010 Funding of outstanding young investigators of Goethe‐University Frankfurt am Main 2011 Best poster at the annual meeting of the Excellence Cluster Cardiopulmonary System (ECCPS), Bad Nauheim 2012 DGP meridol price, Vienna, Austria 10 MOST IMPORTANT PUBLICATIONS 1. Iva Nikolić, Nevenka Dudvarski Stanković, Frank Bicker, Jeannette Meister, Helene Braun, Khader Awwad, Jan Baumgart, Kirsten Simon, Serge C. Thal, Chinmoy Patra, Patrick N. Harter, Karl H. Plate, Felix B. Engel, Stefanie Dimmeler, Johannes A. Eble, Michel Mittelbronn, Michael K. Schäfer, Benno Jungblut, Emmanouil Chavakis, Ingrid Fleming & Mirko HH Schmidt (2013) EGFL7 ligates endothelial V3 integrin to enhance vessel formation. Blood 121 (15), 3041‐3050. 2. Virginia Guarani, Gianluca Deflorian, Claudio A. Franco, Marcus Krüger, Li‐Kun Phng, Katie Bentley, Louise Toussaint, Franck Dequiedt, Raul Mostoslavsky, Mirko HH Schmidt, Barbara Zimmermann, Ralf P. Brandes, Marina Mione, Christoph H. Westphal, Thomas Braun, Andreas M. Zeiher, Holger Gerhardt, Stefanie Dimmeler & Michael Potente (2011) Acetylation‐dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature 473 (7346), 234‐238. 3. Mirko HH Schmidt*, Frank Bicker, Iva Nikolic, Jeannette Meister, Tanja Babuke, Srdjan Picuric, Werner Müller‐Esterl, Karl H. Plate & Ivan Dikic* (2009) Epidermal growth factor‐like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. Nat Cell Biol 11 (7), 873‐880. *Equal contribution 4. Bülent Sargin, Chunaram Choudhary, Nicola Crosetto, Mirko HH Schmidt, Marion Rensinghoff, Christine Thiessen, Lara Tickenbrock, Joachim Schwäble, Christian Brandts, Benjamin August, Steffen Koschmieder, Sinivasa Rao Baudi, Wolfgang E. Berdel, Carsten Müller‐Tidow, Ivan Dikic & Hubert Serve (2007) Flt3‐dependent transformation by inactivating c‐Cbl mutations in AML. Blood 110 (3), 1004‐
1012. 5. Mirko HH Schmidt, Koraljka Husnjak, Iwona Szymkiewicz, Kaisa Haglund & Ivan Dikic (2006) Cbl escapes Cdc42 mediated inhibition by downregulation of the adaptor moleculePix. Oncogene 25 (21), 3071‐
3078. 6. Mirko HH Schmidt & Ivan Dikic (2005) The Cbl interactome and its functions. Nat Rev Mol Cell Biol 6 (12), 907‐919. 7. Mirko HH Schmidt, Ivan Dikic & Oliver Bogler (2005) Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities. Journal of Biological Chemistry 280 (5), 3414‐3425. 8. Mirko HH Schmidt, Daniela Hoeller, Jiuhong Yu, Frank B. Furnari, Webster K. Cavenee, Ivan Dikic & Oliver Bogler (2004) Alix/AIP1 antagonizes EGFR downregulation by the Cbl‐SETA/CIN85 complex. Mol Cell Biol 24 (20), 8981‐8993. 9. Mirko HH Schmidt, Baihua Chen, Lisa M. Randazzo & Oliver Bogler (2003) SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion. J Cell Sci 116 (14), 2845‐2855. 10. Mirko H. H. Schmidt, Frank B. Furnari, Webster K. Cavenee & Oliver Bogler (2003) Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization. PNAS 100 (11), 6505‐6510. 

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