ECM-ProfilingTM Measuring samples the Nordic way ECM-ProfilingTM • A biomarker sample measurement package based on our Protein FingerPrintTM technology • These biomarkers help you in – Early assessment of efficacy – Diagnosis and prognosis of indications – Translational research in preclinal and clinal settings ECM-ProfilingTM • We can measure our biomarkers against Serum, Plasma, Urine, Synovial fluids and cell cultures in various models – – – – In vitro models Ex vivo models Various animal models Human clinical samples • Based on the samples, Nordic Bioscience delivers bioanalytical reports that can include – In depth analysis with benchmarking against known/public data – Benchmarking against other treatments for efficacy comparison – Prognosis and prediction analysis Lab services (Additional) • Preparation of protocols • Full logistic services e.g. Study-specific kit supplies with barcodes, requisition forms • Training of site staff in accordance with the laboratory manual • Integrated processing of laboratory data and reporting using a laboratory information management system (LIMS). • Project and data management • Scientific expertise in study design and data interpretation • Long-term storage of biological sample material, e.g. urine and serum, at -20C and -80C Protein FingerPrintTM • The combination of a signature protein from a given tissue and a pathology dependent protease results in the release of unique tissue degradation fragments that we call ProteinFingerPrintTM – ProteinFingerPrintTM have specific neoepitopes and are thus pathology specific – ProteinFingerPrintTM are tissue derived biomarkers quantifiable in Serum Enzyme Neoepitope specific antibody No binding x Neoepitope Non-cleaved Our accreditation & certifications • We have one of the only two CAP labs in Northern Europe/Scandinavia • ISO 9001 certified • GLP and GCP complied processes and services • 21 CFR (11) compliant lab information system List of Biomarkers Biomarker Description acADAMTS4 Measures the active form of ADAMTS4 ENDO Measurement of type XVIII collage degradation FNC Measurement of fibronectin turnover Nidogen Measurement of nidogen degradation by cats C2Mbeta Measures MMP-generated fragments of type II collagen, isomerized C-Col10 Measures circulating type X collagen C-Col18 Measures circulating type XVIII collagen PAR1x Measures the propeptide of the PAR1, which is released from the membrane bound receptor upon activation. PAR2x Measures the propeptide of the PAR2, which is released from the membrane bound receptor upon activation. PAR3x Measures the propeptide of the PAR3, which is released from the membrane bound receptor upon activation. PAR4x Measures the propeptide of the PAR4, which is released from the membrane bound receptor upon activation. acADAMTS5 Measures the active form of ADAMTS5 AGNx-1 Measures a aggrecanase fragment of aggrecan BGM Measures a MMP generated biglycan fragment List of Biomarkers Biomarker Description acCatK Measures the active form of cathepsin K VICM Measures a MMP generated citrullinated vimentin fragment CRPM Measures MMP generated CRP fragment ELM7 Measures a MMP-7 genated elastin fragment FMODx Measures a MMP generated fibromodulin fragment Tau-A Measures an ADAM10 generated Tau fragment SerumC1M Measures a MMP-generated fragment of type I collagen huP1NP Measures the N-terminal pro-peptide of type I collagen, which is released when type I collagen is released to the ECM. C2Malpha Measures MMP-generated fragments of type II collagen acMMP13 Measures the active form of MMP13 Serum C3M Measures a MMP-generated fragment of type III collagen P4NP-7S Measures the release of the 7S domain of type IV collagen. It is suggested that this is a measure of type IV collagen formation Pro-C5 Measures the C-terminal pro-peptide of type III collagen, which is released when type V collagen is released to the ECM. Is specific for the cleavage site C5M Measures a MMP-generated fragment of type V collagen List of Biomarkers Biomarker Description C6M Measures MMP generated type VI collagen fragments VCANM Measures a MMP generated versican fragment IC6 Measures the N-terminal pro-peptide of type VI collagen, which is released when type VI collagen is released to the ECM huPro-C3 Measures the N-terminal pro-peptide of type III collagen, which is released when type III collagen is released to the ECM. Cleavage site specific LAM Measures a MMP and HNE generated laminin fragment TIM Measures a MMP generated titin fragment Tau-C Measures an Caspase generated Tau fragment acMMP3 Measures the active form of MMP3 acMMP9 Measures the active form of MMP9 Cit-C2 Measures MMP degraded and citrullinated type II colagen EL-NE Measures a HNE genated elastin fragment TIM2 Measures a MMP generated titin fragment MLC3-C Measures a caspase generated MLC3 fragment
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