ETA Industry‐sponsored Satellite Symposia

ETAIndustry‐sponsored
SatelliteSymposia
Saturday,6thSeptember
SantiagoRoom
16.00‐18.00 ETAINDUSTRY‐SPONSOREDSATELLITESYMPOSIUM1
PersonalizingManagementofHypothyroidism:OneSizeDoesNotFitAll
Sunday,7thSeptember
CompostelaRoom
07.00–08.00ETAINDUSTRY‐SPONSOREDSATELLITESYMPOSIUM2
TheFutureisNow:OptimizingTreatmentforYourRAI‐RDTCPatients
SantiagoRoom
13.00‐14.00ETAINDUSTRY‐SPONSOREDSATELLITESYMPOSIUM3
TransformedCareforAdvancedMedullaryThyroidCancer:
IncorporatingtheRightTreatmentsfortheRightPatientattheRightTime
SantiagoRoom
19.00‐20.30 ETAINDUSTRY‐SPONSOREDSATELLITESYMPOSIUM4
Anewtreatmentalternativefortargetedtherapyinmedullarythyroidcancer
Monday,8thSeptember
SantiagoRoom
13.00‐14.00ETAINDUSTRY‐SPONSOREDSATELLITESYMPOSIUM5
Hypothyroidism:NewDevelopmentsinThyroidSubstitutionTherapy Tuesday,9thSeptember
SantiagoRoom
13.00‐14.00ETAINDUSTRY‐SPONSOREDSATELLITESYMPOSIUM6
NewTrendsintheManagementofThyroidCancer
ProgrammeOverview‐Saturday,6thSeptember2014
Room25
08.15‐15.15
ADVANCEDTHYROID,NECKULTRASONOGRAPHY&ULTRASOUND‐ASSISTED
PROCEDURES
ObradoiroRoom
08.30‐15.30 ICCIDDWEST‐CENTRALEUROPEREGIONALMEETING
CompostelaRoom
09.00‐14.30
SPANISHSOCIETYSATELLITESYMPOSIUM
AvancesenelDiagnósticoyTratamientodeEnfermedadTiroidea/
AdvancesintheDiagnosisandTreatmentofThyroidDiseases
Room14
10.00‐15.30
BASICTHYROIDCOURSE
Hypothalamus‐pituitary‐thyroidaxisinhealthanddisease
SantiagoRoom
11.00‐13.50
ETA‐CRNMEETING
ControversiesinThyroidCancerManagement
SantiagoRoom
14.00‐15.00 TFIPATIENTFORUMANDAECAT
1
SantiagoRoom
16.00‐18.00 ETAINDUSTRY‐SPONSOREDSATELLITESYMPOSIUM1
PersonalizingManagementofHypothyroidism:OneSizeDoesNotFitAll
SantiagoRoom
18.00‐18.15 OPENINGCEREMONY
WelcomebyFurioPaciniandClaraAlvarez
SantiagoRoom
18.15‐19.00 THEEUROPEANTHYROIDJOURNALLECTURE
Chairperson: WilmarWiersinga,TheNetherlands
Editor‐in‐ChiefoftheEuropeanThyroidJournal
2
ScientificProgramme/Sunday,7thSeptember
CompostelaRoom
07.00–08.00ETAINDUSTRY‐SPONSOREDSATELLITESYMPOSIUM2
TheFutureisNow:OptimizingTreatmentforYourRAI‐RDTCPatients
SantiagoRoom
08.00‐10.00ORALSESSION1:TOPICHIGHLIGHTS(OP1‐OP6)
Chairpersons:FurioPacini,ItalyandClaraAlvarez,Spain
08.00‐08.20
OP01 AZEBRAFISHMODELOFNETRIN1DEFICIENCYREVEALSABNORMALTHYROID
MORPHOGENESISLINKEDTODEFECTIVECARDIOVASCULARDEVELOPMENT
RobertOpitz1,AchimTrubiroha1,IsabelleVandernoot1,Marc‐PhilipHitz2,RashaAbu‐Khudir2,
ValérieDésilets2,JohnnyDeladoëy2,GregorAndelfinger2,SabineCostagliola1
1Iribhm, Université Libre de Bruxelles, Brussels, Belgiu; 2Department of Pediatrics, Centre Hospitalier Universitaire Sainte
Justine,Montréal,Québec,Canada
08.20‐08.40
OP02ANALYSESOFAPHASE3,MULTICENTER,DOUBLE‐BLIND,PLACEBO‐
CONTROLLEDTRIALOFLENVATINIB(E7080)INPATIENTSWITH131‐I‐REFRACTORY
DIFFERENTIATEDTHYROIDCANCER(SELECT)
StevenI.Sherman1,MakotoTahara2,LoriWirth3,BruceRobinson4,MarciaF.Brose5,RossellaElisei6,
CorinaE.Dutcus7,BegoñadelasHeras8,JunmingZhu7,MouhammedAmirHabra1,KateNewbold9,
ManishaH.Shah10,AnaO.Hoff11,AndrewGGianoukakis12,NaomiKiyota13,MatthewH.Taylor14,
Sung‐BaeKim15,MonikaK.Krzyzanowska16,MartinSchlumberger17
1DepartmentofEndocrineNeoplasiaandHormonalDisorders,DivisionofInternalMedicine,TheUniversityofTexasM.D.
AndersonCancerCenter,Houston,TX,USA;2DepartmentofHeadandNeckMedicalOncologyNationalCancerCenterHospital
East,Kashiwa,Japan;3DepartmentofMedicine,MassachusettsGeneralHospital,Boston,MA,USA
4KollingInstituteofMedicalResearch,UniversityofSydney,NewSouthWales2006,Australia;5Departmentof
Otorhinolaryngology:HeadandNeckSurgery,AbramsonCancerCenteroftheUniversityofPennsylvania,Philadelphia,Pa,
USA;6EndocrineUnit,DepartmentofClinicalandExperimentalMedicine,UniversityofPisa,Pisa,Italy
7EisaiInc,WoodcliffLake,Nj,USA;8EisaiLtd,Hatfield,England,UK;9TheRoyalMarsdenHospitalNationalHealthService
Trust,London,England,UK;10DepartmentofInternalMedicine,TheOhioStateUniversityComprehensiveCancerCenter,
Columbus,Oh,USA;11InstitutoDoCancerdeSaoPaulo,UniversidadedeSaoPaulo,SaoPaulo,Brazil;12Divisionof
EndocrinologyandMetabolism,Harbor‐UclaMedicalCenter,Torrance,Ca,USA;13DepartmentofMedicalOncologyand
Hematology,KobeUniversityHospital,Kobe,Japan;14KnightCancerInstitute,OregonHealthandScienceUniversity,
Portland,Or,USA;15DepartmentofOncology,AsanMedicalCenter,UniversityofUlsanCollegeofMedicine,Seoul,Korea
16DivisionofMedicalOncology&Hematology,PrincessMargaretCancerCentre,Uhn610UniversityAvenue,Toronto,Ontario,
Canada;17DepartmentofNuclearMedicineandEndocrineOncology,GustaveRoussyandUniversitéParis‐Sud,Villejuif,
France
1
08.40‐09.00
OP03TARGETEDMUTATIONSINMCT10EXPANDTHESUBSTRATESPECTRUMTO
INCLUDET4
JörgJohannes1,UlrichSchweizer1,DoreenBraun1,KleinauGunnar2
1RheinischeFriedrich‐Wilhelms‐UniversitätBonn;InstitutFürBiochemieundMolekularbiologie
2Charité‐UniversitätsmedizinBerlin;InstitutFürExperimentellePädiatrischeEndokrinologie
09.00‐09.20
OP04THETARGETEDINACTIVATIONOFMEN1GENEEXACERBATESRET/PTC3‐
INDUCEDTHYROIDNEOPLASTICTRANSFORMATION
SamiaSelmi‐Ruby1,Maria‐JésusObregon2,JulietteDupayrat3,FrançoiseBorson‐Chazot3,Chang
Zhang3
1FacultédeMédecineRth‐LaennecCrclUmr1052;2InstitutodeInvestigationsBiomedicas;3Crcl‐Umr1052
09.20‐09.40
OP05 NEXTGENERATIONSEQUENCING(NGS)REVEALSAHIGHLYFREQUENT
MULTIGENICINVOLVEMENTINTHEPATHOGENESISOFCONGENITAL
HYPOTHYROIDISM
LucaPersani1,TizianadeFilippis2,GiuliaGelmini2,FedericaMarelli2,MariaCristinaVigone3,Mirella
Moro2,MariaCarolinaSalerno4,GiorgioRadetti5,GiovannaWeber6,FabianaGuizzardi2
1UniversityofMilanandIrccsIstitutoAuxologicoItaliano;2IrccsIstitutoAuxologicoItaliano;3SanRaffaeleHospital
4UniversityofNaples;5HospitalofBolzano;6SanRaffaeleHospitalandVita‐SaluteUniversity
09.40‐10.00
OP06SERUMMIRNASASANONINVASIVETOOLINTHEDIFFERENTIALDIAGNOSIS
OFTHYROIDNODULESINACAUCASIANPOPULATION
TaniaPilli1,SilviaCantara1,SebastianoGuidi2,CeveniniGabriele3,GiuliaBusonero1,Sandro
Cardianale1,FrancescoDotta1,FurioPacini1
1DepartmentofMedicine,SurgeryandNeuroscience,UniversityofSiena,Siena,Italy;2FondazioneUmbertoDIMarioOnlus,
ToscanaLifeSciences,Siena,Italy;3DepartmentofMedicalBiotechnologies,UniversityofSiena,Siena,Italy
10.00-10.30 COFFEE BREAK
SantiagoRoom
10.30‐12.00 SYMPOSIUM1:THYROIDANDTHEHEART
Chairpersons:GeorgeJ.Kahaly,GermanyandIgnacioBernabeu‐Moron,Spain
10.30‐11.00 Cardiovascularcomplications:toxicnodulesvsautoimmunethyroiddisease
BernadetteBiondi,Italy
11.00‐11.30 Cardiovascularmortalityandlong‐termoutcomesinthyroiddisease
ThomasBrix,Denmark
11.30‐12.00 Thyroidhormoneresistanceandcardiovasculardisease
CarlaMoran,UnitedKingdom
2
CompostelaRoom
10.30‐12.00SYMPOSIUM2:THYROIDHORMONEANDENERGYEXPENDITURE
Chairpersons:EricFliers,TheNetherlandsandMariaJesusObregon,Spain
10.30‐11.00 Mitochondrialactionsofthyroidhormone
GeraldCabello,France
11.00‐11.30 Centralrolesofthyroidhormonesignalinginbrownfatthermogenesis
MiguelLopez,Spain 11.30‐12.00 Thyroidhormoneandthermoregulation JensMittag,Sweden
PosterArea
12.00‐13.00 LUNCHANDPOSTERDISCUSSIONPO1(POSTERSP1‐P121)
PosterSession1:Graves’Orbitopathy
Chairperson:AlessandroAntonelli,Italy
PosterSession2:CardiovascularEffects
Chairperson:WarnerSimonides,TheNetherlands
PosterSession3:ThyroidandEnvironment1
Chairperson:EndreNagy,Hungary
PosterSession4:ThyroidinReproductionandDevelopment1
Chairperson:BijayVaidya,UnitedKingdom
PosterSession5:ThyroidFunctionandDevelopment
Chairperson:LucaPersani,Italy
PosterSession6:Hypothyroidism
Chairperson:JoaodeCastro,Portugal
PosterSession7:ThyroidCancerDiagnostics1
Chairperson:RoussankaKovatcheva,Bulgaria
PosterSession8:ThyroidCancerTherapeutics1
Chairperson:SophieLeboulleux,France
PosterSession9:MedullaryThyroidCancer
Chairperson:ValerianoLeite,Portugal
PosterSession10:GoiterandNodules1
Chairperson:MuratErdogan,Turkey
SantiagoRoom
13.00‐14.00ETAINDUSTRY‐SPONSOREDSATELLITESYMPOSIUM3
TransformedCareforAdvancedMedullaryThyroidCancer:
IncorporatingtheRightTreatmentsfortheRightPatientattheRightTime
3
14.00‐14.45 MEET‐THE‐EXPERT1‐4
Room14
14.00‐14.45 MTE1
CurrentStateofRituximabtherapyinthyroiddisease
MarioSalvi,ItalyandLaszloHegedüs,Denmark
CompostelaRoom
14.00‐14.45 MTE2
Geneticsandthyroid‐frombenchtobedside
TomaszBednarczuk,Poland
SantiagoRoom
14.00‐14.45 MTE3
Microcarcinoma:treatmentandfollowup
LauraFugazzola,Italy
Room25
14.00‐14.45 MTE4
Congenitalhypothyroidism
NadiaSchoenmakers,UnitedKingdom
14.45-15.-15 COFFEE BREAK
SantiagoRoom
15.15‐15.30 ETALISSITZKYPRIZEAWARD
SantiagoRoom
15.30‐17.30 ORALSESSION2:YOUNGINVESTIGATORSSESSION/CLINICAL(OP07‐OP14)
Chairpersons:PeterLaurberg,DenmarkandJacquesOrgiazzi,France
15.30‐15.45
OP07TELOMERASEPROMOTERMUTATIONS,EXPRESSIONANDLOCALIZATIONIN
DIFFERENTIATEDTHYROIDCANCER
MarinaMuzza1,CarlaColombo1,StefaniaRossi2,ValentinaCirello1,MichelaPerrino1,SimoneDe
Leo1,ElisaPignatti3,ManuelaSimoni3,GaetanoBulfamante2,LauraFugazzola1
1DepartmentofClinicalSciencesandCommunityHealth,UniversityofMilan;EndocrineUnit,FondazioneIrccsCa’Granda,
Milan;2DepartmentHealthSciences,UniversityofMilan;DivisionofPathology,SanPaoloHospital,Milan
3UnitandChairofEndocrinologyandMetabolism,DepartmentofBiomedical,MetabolicandNeuralSciences,Universityof
ModenaandReggioEmilia;DepartmentofMedicine,Endocrinology,MetabolismandGeriatrics,AziendaUslofModena
15.45‐16.00
OP08DUALGS‐GQVERSUSGQSELECTIVESIGNALLINGDEFECTSINCARBOXY‐
TERMINALTSHRMUTANTS:INVITROANDCLINICALCORRELATES
4
MartaGarcia1,JacquelinevanSande2,AinhoaIglesias1,HelèneBony‐Trifunovic3,MariaChueca4,
EricavandenAkker5,IsolinaRiaño6,CristinaLuzuriaga7,PatriciaCrock8,IsabelGonzález‐Casado9,
JacquesE.Dumont2,JoséC.Moreno1
1ThyroidMolecularLaboratory.InstituteforMedicalandMolecularGenetics(Ingemm).LaPazUniversityHospital.Madrid.
Spain;2InstituteofInterdisciplinaryResearch.UniversityofBrussels.Brussels.Belgium;3PediatricEndocrinologyand
Diabetes.NordHospital.Amiens,France;4PediatricEndocrinology.VirgendelCaminoHospital.Pamplona.Spain.
5PediatricEndocrinology.SophiaChildren’sHospital.ErasmusMedicalCenter.Rotterdam.TheNetherlands.
6Pediatric.CarmenandSeveroOchoaHospital.CangasdelNarcea.Spain;7Endocrinology.MarquésdeValdecillaUniversity
Hospital.Santander.Spain;8PediatricDiabetesandEndocrinology.JohnHunterChildren’sHospital.Newcastle.Australia.
9PediatricEndocrinology.LaPazUniversityHospital.Madrid.Spain.
16.00‐16.15
OP09IMAGE‐GUIDED,TUMORSTROMA‐TARGETEDI‐131THERAPYOF
HEPATOCELLULARCARCINOMA(HCC)USINGAHIF‐1‐SPECIFICSODIUMIODIDE
SYMPORTERGENESYSTEM
KerstinKnoop1,AndreaMMueller1,KathrinASchmohl1,NathalieSchwenk1,JanetteCarlsen2,
MarcusHacker2,BurkhardGoeke1,ErnstWagner3,PeterJNelson4,ChristineSpitzweg1
1DepartmentofInternalMedicineII,UniversityHospitalofMunich,Germany;2DepartmentofNuclearMedicine,University
HospitalofMunich,Germany;3DepartmentofPharmacy,CenterofDrugResearch,PharmaceuticalBiology‐Biotechnology,
Ludwig‐Maximilians‐University,Munich,Germany;4ClinicalBiochemistryGroup,MedicalPoliclinic,UniversityHospitalof
Munich,Germany
16.15‐16.30
OP10THECOACTIVATORTAZMODULATESTHEPHENOTYPICEXPRESSIONOF
NKX2.1MUTANTSINTHEBRAIN‐THYROID‐LUNGSYNDROME.
AmandaHerranz1,ChristianMartínMoya1,LucíaGarzón2,CarmenLuna3,NoemíNúñez4,Rogelio
Simón4,PilarSantisteban5,JoséCarlosMoreno1
1ThyroidMolecularLaboratory.InstituteforMedicalandMolecularGenetics(Ingemm),LaPazUniversityHospital,Madrid,
Spain;2PaediatricEndocrinology,12deOctubreUniversityHospital,Madrid,Spain;3PaediatricPneumologyandAllergy,12
deOctubreUniversityHospital,Madrid,Spain;4PaediatricNeurology,12deOctubreUniversityHospital,Madrid,Spain.
5PhysiopathologyofEndocrineandNervousSystem,BiomedicalResearchInstitute(Iib),SpanishCouncilforScientific
Research(Csic).Madrid,Spain.
16.30‐16.45
OP11EFFICACYANDTOXICITYOFVANDETANIBFORADVANCEDMEDULLARY
THYROIDCANCERTREATMENT,THEFRENCHEXPERIENCE
CecileChougnet1,MartinSchlumberger2,BorgetIsabelle3,TUTHYREFNetwork4
1HopitalSaintLouis
2DepartmentofNuclearMedicineandEndocrineOncology,GustaveRoussyandUniversitéParis‐Sud,Villejuif,France
3GustaveRoussy,UniversitéParis‐Sud,Villejuif,France
4Tuthyref
16.45‐17.00
OP12METHYLATIONPROFILINGREVEALSMARKERSSPECIFICTODISTINCTRET
MUTATIONSINMEDULLARYTHYROIDCARCINOMA
VeronikaMancikova1,EsmeraldaCastelblanco2,AgustínF.Fernández3,LucíaIngladaPérez4,Aguirre
DeCubas5,SaludBorrego6,XavierMatias‐Guiu7,MarioEncinas2,MarioF.Fraga3,MercedesRobledo4
1HereditaryEndocrineCancerGroup,SpanishNationalCancerResearchCentre(Cnio);2HospitalUniversitariArnaude
Vilanova,Lleida;3InstitutoUniversitariodeOncologíadelPrincipadodeAsturias,Oviedo;4HereditaryEndocrineCancer
Group,SpanishNationalCancerResearchCentre(Cnio);IsciiiCenterforBiomedicalResearchonRareDiseases(Ciberer)
5HereditaryEndocrineCancerGroup,SpanishNationalCancerResearchCentre(Cnio),Madrid,Spain;6HospitalVirgendel
Rocío,Sevilla;7DepartmentofPathology,UniversityHospitalArnaudeVilanova,UniversityofLleida,Irblleida
5
17.00‐17.15
OP13SPONTANEOUSABORTIONANDSTILLBIRTHARECOMMONINBOTH
HYPERTHYROIDISMANDHYPOTHYROIDISM:ADANISHPOPULATION‐BASEDSTUDY
OF1,028,045PREGNANCIES
StineLindingAndersen1,JørnOlsen2,ChunSenWu2,PeterLaurberg1
1AalborgUniversityHospital;2AarhusUniversity,Denmark
17.15‐17.30
OP14INCREASEDFATMASSRESULTSINHIGHERFREET3LEVELSINCHILDREN
PeteNTaylor1,NicholasTimpson2,JonathanTobias2,ColinDayan1
1InstituteofMolecular&ExperimentalMedicine;SchoolofMedicine;CardiffUniversity;2UniversityofBristol,UK
CompostelaRoom
15.30‐17.30 ORALSESSION3:MTCANDANAPLASTICCARCINOMA(OP15‐OP22)
Chairpersons:BarbaraJarzab,PolandandMercedesRobledo,Spain
15.30‐15.45
OP15AREDIFFERENCESINGENEEXPRESSIONPROFILEBETWEENTYPEOFRET
MUTATIONINMEDULLARYTHYROIDCANCERPRESENT?
MalgorzataOczko‐Wojciechowska1,MichalSwierniak2,MalgorzataKowalska1,Tomasz
Tyszkiewicz1,AgnieszkaPawlaczek1,MichalJarzab3,DagmaraRusinek4,JadwigaZebracka‐Gala1,
AgnieszkaCzarniecka5,JolantaKrajewska6,BarbaraJarzab1
1MscMemorialCancerCenterandInstituteofOncology,GliwiceBranch,DepartmentofNuclearMedicineandEndocrine
Oncology;2MscMemorialCancerCenterandInstituteofOncology,GliwiceBranch,DepartmentofNuclearMedicineand
EndocrineOncology;GenomicMedicine;DepartmentofGenenalTransplantandLiverSurgery;MedicalUniversityofWarsaw
3MscMemorialCancerCenterandInstituteofOncology,GliwiceBranch,IIIRadiotherapyClinic;4MscMemorialCancerCenter
andInstituteofOncology,GliwiceBranch,Poland;DepartmentofNuclearMedicineandEndocrineOncology
5CentreofOncologyM.Sklodowska‐CurieMemorialInstituteGliwiceBranch;6M.Sklodowska‐CurieMemorialCancerCenter
andInstituteofOncology,GliwiceBranch
15.45‐16.00
OP16MILDHYPERCALCITONINEMIAINPATIENTSWITHBENIGNDISEASESOFTHE
THYROIDANDCALCIUMHOMEOSTASIS
JuergenKratzsch1,StefanKarger1,FriedhelmRaue2,JoachimFeldkamp3,SandraScheel3,Tanja
Diana4,NinaMattheis4,GeorgeJ.Kahaly4
1UniversityHospital,Leipzig;2PraxisProf.Raue&Colleagues,Heidelberg;3KlinikumBielefeld,Bielefeld;4JohannesGutenberg
UniversityMedicalCenter,Germany
16.00‐16.15
OP17DIVERGENTROLESOFFORKHEADFAMILYTRANSCRIPTIONFACTOR
PARALOGSINMEDULLARYTHYROIDCARCINOMA
MikaelNilsson1,ShawnLiang2,CamillaIngeson2,ThereseCarlsson2,JakobDahlberg3,Svante
Jansson3,AkifDemir4,HenrikFagman4
1SahlgrenskaCancerCenter,SahlgrenskaAcademy,UniversityofGothenburg,Gothenburg,Sweden;2SahlgrenskaCancer
Center,UniversityofGothenburg;3DepartmentofSurgery,SahlgrenskaUniversityHospital;4DepartmentofPathology,
SahlgrenskaUniversityHospital
16.15‐16.30
OP18EXOMESEQUENCINGREVEALSTHATSOS1GENEMUTATIONSCAUSEA
SYNDROMEWITHPHENOTYPICFEATURESOFMULTIPLEENDOCRINENEOPLASIA
TYPE2BBUTNOENDOCRINOPATHY
6
BijayVaidya0,MartinaOwens1,EmmaKivuva2,AliChakera3,PeterTurnpenny2,AndrewHattersley4,
AnthonyQuinn5,RichardCaswell6,HanaLangoAllen6,SianEllard7
1DepartmentofMolecularGenetics,RoyalDevon&ExeterHospital,Exeter,UK;2DepartmentofClinicalGenetics,RoyalDevon
&ExeterHospital,Exeter,UK;3DepartmentofEndocrinology,RoyalDevonandExeterHospital,Exeter,UK
4DepartmentofEndocrinology,RoyalDevonandExeterHospital,Exeter,Uk;InstituteofBiomedicalandClinicalScience,
UniversityofExeterMedicalSchool,Exeter,UK;5DepartmentofOphthalmology,RoyalDevonandExeterHospital,Exeter,UK
6InstituteofBiomedicalandClinicalScience,UniversityofExeterMedicalSchool,Exeter,UK;7DepartmentofMolecular
Genetics,RoyalDevon&ExeterHospital,Exeter,UK;InstituteofBiomedicalandClinicalScience,UniversityofExeterMedical
School,Exeter,UK
16.30‐16.45
OP19EFFICACYANDSAFETYOFVANDETANIBINAGGRESSIVEANDSYMPTOMATIC
MEDULLARYTHYROIDCANCER(MTC)–POST‐HOCANALYSISFROMTHEZETATRIAL
(NCT00410761)
MichaelKreissl1,OleHauch2,AlanWebster2,MartinSchlumberger3
1DepartmentofNuclearMedicine,CentralHospitalofAugsburg,Augsburg,Germany;2Astrazeneca,Macclesfield,UK
3InstitutGustaveRoussy,Villejuif,France
16.45‐17.00
OP20CLINICALIMPACTOFRETGENETICSCREENINGOFINTHEMANAGEMENTOF
MEDULLARYTHYROIDCARCINOMA(MTC)PATIENTS:20YEARSOFEXPERIENCE
FrancescaCasella1,AlessiaTacito1,RaffaeleCiampi1,EleonoraMolinaro1,LauraAgate1,Valeria
Bottici1,AntonioMatrone1,AgneseBiagini1,RossellaElisei1,CristinaRomei1
1SectionofEndocrinology,DepartmentofClinicalandExperimentalMedicine,UniversityofPisa,Pisa,Italy
17.00‐17.15
OP21REFERENCERANGEOFSERUMCALCITONININCHILDREN
MariaGraziaCastagna1,LauraFugazzola2,FabioMaino1,DanilaCovelli3,FaustaSestini1,Chiara
FerrarisFusarini4,CarloScapellato5,FrancescoMacchini6,GabrieleCevenini7,FurioPacini1
1SectionofEndocrinology,UniversityofSiena,Siena,Italy;2DepartmentofClinicalSciencesandCommunityHealth,University
ofMilan,Milan,Italy;EndocrineUnit,FondazionePoliclinicoIrccs,Milan,Italy;3SectionofEndocrinologyandDiabetology,
UniversityofMilan,Italy;4LaboratoryofClinicalPathology,UniversityofMilan,Italy;5LaboratoryofClinicalPathology,
UniversityofSiena,Siena,Italy;6SectionofPediatrics,UniversityofMilan,Italy;7SectionofSurgeryBioengineering,University
ofSiena,Siena,Italy
17.15‐17.30
OP22MOLECULARPROFILINGOFSPORADICMEDULLARYTHYROIDCARCINOMA
PATIENTSBYNEXTGENERATIONSEQUENCING
VeraTiedje1,SaskiaTing2,ThomasHerold3,KurtWernerSchmid2,DagmarFührer‐Sakel4
1DepartmentofEndocrinologyandMetabolism;UniversityofDuisburg‐Essen;2InstituteofPathology;UniversityHospital
Essen
3InstituteofPathology;UniversityHospitalEssen;GermanCancerConsortium(Dktk)Heidelberg;4Departmentof
EndocrinologyandMetabolism;UniversityHospitalEssen,Germany
17.30‐17.45 Break
SantiagoRoom
17.45‐18.30 ALDOPINCHERALECTUREPRIZE
Chairpersons:FurioPacini,ItalyandColinDayan,UnitedKingdom
7
SantiagoRoom
19.00‐20.30 ETAINDUSTRY‐SPONSOREDSATELLITESYMPOSIUM4
Anewtreatmentalternativefortargetedtherapyinmedullarythyroidcancer
8
ScientificProgramme/Monday,8thSeptember
SantiagoRoom
08.00‐09.30SYMPOSIUM3:
EPIDEMIOLOGYOFSPORADICANDFAMILIALTHYROIDCANCER
Chairpersons:MariaAlevizaki,GreeceandCristinaAlvarezEscola,Spain
08.00‐08.30 RegionalvariationinthyroidcancerincidenceinBelgium
AnnickvandenBruel,Belgium
08.30‐09.00 TimetrendofthyroidcancerinItaly
CristinaRomei,Italy
09.00‐09.30 Familialnon‐medullarythyroidcancer
MarcoCapezzone,Italy
CompostelaRoom
08.00‐09.30SYMPOSIUM4:GENEREGULATIONBYTHYROIDHORMONERECEPTORS
Chairpersons:AnaAranda,SpainandDuncanBassett,UnitedKingdom
08.00‐08.30 Thyroidhormoneandhypothalamicfunctions
BalázsGereben,Hungary
08.30‐09.00 NCORandSMRTinthyroidhormoneaction
AnthonyHollenberg,USA
09.00‐09.30 Nonclassicalregulationofgeneexpressionbythyroidhormone
LarsMoeller,Germany
09.30-10.00 COFFEE BREAK
10.00‐12.00ORALSESSION4:THYROIDAUTOIMMUNITY(OP23‐OP30)
Chairpersons:StefanoMariotti,Italy;MonicaMarazuela,Spain
10.00‐10.15
OP23FIRSTINTERNATIONALSTANDARDISATIONOFATSH‐RECEPTORSTIMULATING
AUTOANTIBODYBIOASSAY
TanjaDiana1,MarkusLehmann1,JasminFranken1,MichaelKanitz1,GeorgeJ.Kahaly1
1JohannesGutenbergUniversityMedicalCenter,Mainz,Germany
1
10.15‐10.30
OP24MECHANISMOFTSHRACTIVATIONBYTSHANDTHYROIDSTIMULATING
ANTIBODIES
JaneSanders1,RicardoNunezMiguel1,PaulSanders1,StuartYoung1,JadwigaFurmaniak1,Bernard
ReesSmith1
1FirsLaboratories,RsrLtd,UK
10.30‐10.45
OP25CHANGESOFSERUMTSHRECEPTORANTIBODIES(TRAB)LEVELSINPATIENTS
WITHGRAVES’DISEASE(GD)SUBMITTEDTORADIOIODINETHERAPY(RAI)
IreneCampi1,GuiaVannucchi1,DanilaCovelli1,SilviaTirelli2,RodariMarcello3,GiovannaPepe4,
ArturoChiti4,MarioSalvi1
1DepartmentofClinicalSciencesandCommunityHealth,FondazioneIrccsCa’GrandaOspedaleMaggiorePoliclinico
2LaboratoryMedicineUnit,FondazioneIrccsCa’GrandaOspedaleMaggiorePoliclinico;3DepartmentofNuclearMedicine,
HumanitasClinicalandResearchCenter,Rozzano;4DepartmentofNuclearMedicine,HumanitasClinicalandResearchCenter,
Rozzano.
10.45‐11.00
OP26THYROIDAUTOIMMUNITYISPREVALENTINPATIENTSWITHCELIACDISEASE
ANDTHEIRFIRSTDEGREERELATIVES–APROSPECTIVE,CONTROLLEDSTUDY
DetlefSchuppan1,MartinRosenthal1,MareikeRoth1,JessicaWillim1,ElisaKolbe1,TanjaDiana1,George
J.Kahaly1
1JohannesGutenbergUniversityMedicalCenter,Mainz,Germany
11.00‐11.15
OP27INCREASEDREGULATORYBLYMPHOCYTES(BREG)INPATIENTSWITH
HASHIMOTO’STHYROIDITISANDASSOCIATEDAUTOIMMUNEDISORDERS
IleniaGatto1,MariaGiuliaSantaguida2,GiorgioMangino1,SusannaCarlottaDelDuca2,CamillaVirili2,
LucillaGargano3,GiovannaRomeo1,MarcoCentanni4
1DeptofMedico‐SurgicalSciencesandBiotechnologies,“sapienza”UniversityofRome,Latina,Italy;2DeptofExperimental
Medicine“sapienza”UniversityofRome,Latina,Italy;3EndocrinologyUnit,SantaMariaGorettiHospital,AuslLatina,Latina,
Italy;4“sapienza”UniversityofRomeDeptofMedico‐SurgicalSciencesandBiotechnologiesLatina
11.15‐11.30
OP28GRAVES´DISEASEISASSOCIATEDWITHADEFECTIVEEXPRESSIONOFTHE
IMMUNEREGULATORYMOLECULEGALECTIN‐9INANTIGEN‐PRESENTINGDENDRITIC
CELLS
AnaMariaRamosLevi1,MiguelASampedro‐Núñez1,SandraCampos1,SusanaLeskela1,AnaSerrano1,
AnaRodriguez‐Muñoz1,RebecaMartínez1,HortensiadelaFuente1,RobertoGonzalez‐Amaro2,Monica
Marazuela1
1HospitalUniversitarioPrincesa.InstitutodeInvestigaciónPrincesa;2UniversidadSanLuisPotosi
11.30‐11.45
OP29FETALCELLMICROCHIMERISMANDHLA‐GSTATUSINALARGESERIESOF
AUTOIMMUNETHYROIDDISEASES
ValentinaCirello1,RobertaRizzo2,MilenaCrippa3,IreneCampi4,CarlaColombo1,GuiaVannucchi4,
AntoniaMaffini1,StefanoFerrero5,PalmaFinelli6,LauraFugazzola7
1DepartmentofClinicalSciencesandCommunityHealth,UniversityofMilan,Milan,Italy;2DepartmentofMedicalSciences,
SectionofMicrobiologyandMedicalGenetics,UniversityofFerrara,Ferrara,Italy;3LaboratoryofMedicalCytogeneticsand
MolecularGenetics,IstitutoAuxologicoItaliano,Milan,Italy;4EndocrineUnit,FondazionePoliclinicoIrccs,Milan,Italy
2
5DivisionofPathology,FondazionePoliclinicoIrccs,Milan,Italy;DepartmentofBiomedical,SurgicalandDentalSciences,
UniversityofMilan,MedicalSchool,Milan,Italy;6LaboratoryofMedicalCytogeneticsandMolecularGenetics,IstitutoAuxologico
Italiano,Milan,Italy;DepartmentofMedicalBiotechnologyandTranslationalMedicine,UniversityofMilan,Milan,Italy
7DepartmentofClinicalSciencesandCommunityHealth,UniversityofMilan,Milan,Italy;EndocrineUnit,FondazionePoliclinico
Irccs,Milan,Italy
11.45‐12.00
OP30GLYCOSYLATIONPATTERNANALYSISOFGLYCOPROTEINHORMONESAND
THEIRRECEPTORS
RicardoNunezMiguel1,JaneSanders1,PaulSanders1,StuartYoung1,JadwigaFurmaniak1,Bernard
ReesSmith1
1FirsLaboratories,RsrLtd,UK
CompostelaRoom
10.00‐12.00ORALSESSION5:TISSUESPECIFICACTIONSOFTHYROIDHORMONE(OP31‐OP38)
Chairpersons:RobinPeeters,TheNetherlandsandJuanBernal,Spain
10.00‐10.15
OP31ANALYSISOFTRANSCRIPTOMICLANDSCAPEENLIGHTENSTHEIMPACTOF
HYPOTHYROIDISMONNEUROGENESIS.
GhislaineMorvanDubois0,GothiéJeanDavid1,Clerget‐FroidevauxMarie‐Stephanie2,Duvernois‐
BerthetEvelyne3,RemaudSylvie3,DemeneixBarbara3
1Umr7221CnrsMnhn;2Umr7221cnrsMnhn;3Umr7221MnhnCnrs,France
10.15‐10.30
OP32NF‐KBSIGNALINGINTHEHYPOTHALAMUSISESSENTIALFORTHERESPONSEOF
THECENTRALHPTAXISTOACUTEINFLAMMATION.
EmmelydeVries1,RonnyHaenold2,SigrunHorn2,EricFliers1,FalkWeih2,HeikeHeuer3,AnitaBoelen1
1AcademicMedicalCenter;2LeibnizInstituteforAgeResearch‐FritzLipmannInstitute(Fli);3LeibnizInstituteforAgeResearch
‐FritzLipmannInstitute(Fli),Jena;LeibnizResearchInstituteforEnvironmentalMedicine,Dusseldorf
10.30‐10.45
OP33RE‐EXPRESSIONOFTYPE1IODOTHYRONINEDEIODINASEREDUCES
PROLIFERATIONINRENALCANCERCELLS
PiotrPopławski1,AgnieszkaPiekiełko‐Witkowska1
1CentreofPostgraduateMedicalEducation,DepartmentofBiochemistryandMolecularBiology,Poland
10.45‐11.00
OP34EFFECTSOFTHYROIDHORMONEDERIVATIVESONINVITROCHONDROGENESIS
JanineMartitz1,PeterHofmann2,AlexandraDeichsel2,PetraSeemann2,LutzSchomburg1
1InstituteforExperimentalEndocrinology;2ChariteBerlin,Germany
11.00‐11.15
OP35DIFFERENTIALEFFECTSOFCHRONIC,INTRAHYPOTHALAMICTHYROID
HORMONEADMINISTRATIONINTHEVENTROMEDIALANDPARAVENTRICULAR
NUCLEUS
ZhiZhang1,EwoutFoppen1,PeterBisschop1,AnitaBoelen1,AndriesKalsbeek2,EricFliers1
1AcademicMedicalCentre;2AcademicMedicalCentre;NetherlandsInstituteforNeuroscience(Nin)
3
11.15‐11.30
OP36CARDIACREGENERATIONANDTHYROIDHORMONE:ASTUDYIN
METAMORPHOSINGXENOPUSLAEVIS
CélineVivien1,LindseyMarshall1,LouisePéricard1,FabriceGirardot1,BarbaraDemeneix2,Laurent
Coen1
1UmrCnrs7221,DépartementRégulations,DéveloppementEtDiversitéMoléculaire,MuséumNationalD'histoireNaturelle–
Paris;2UmrCnrs7221,DépartementRégulations,DéveloppementEtDiversitéMoléculaire,MuséumNationalD'histoire
Naturelle
11.30‐11.45
OP37THYROIDHORMONET3ISAMITOGENICANDANTIAPOPTOTICFACTORINRAT
GRANULOSACELLSANDFOLLICLES
CeciliaVergaFalzacappa1,VirginiaDiPaolo2,ClaudiaMangialardo3,AlessandraScamporrino1,
ValentinaAndriollo1,IleniaCammarata1,SilviaMisiti1,RitaCanipari2,MarcoCentanni4
1ExperimentalMedicineDepartment,Sapienza,UniversityofRome;2DepartmentofAnatomy,Histology,ForensicMedicineand
Orthopedic,SectionofHistology,Sapienza;3DeptofMedico‐SurgicalSciencesandBiotechnologies,“sapienza”Universityof
Rome,Latina,Italy;4“Sapienza”UniversityofRomeDeptofMedico‐SurgicalSciencesandBiotechnologiesLatina
11.45‐12.00
OP38ANEWGENEPREDISPOSINGTOCONGENITALHYPOTHYROIDISM
AngelaPascarella1,GiuseppeFerrandino2,MariaBasile2,OlgaSpadaro1,FulvioD'Angelo2,Chiara
D'Ambrosio3,AndreaScaloni3,MarioDeFelice2,RobertoDiLauro1,GabriellaDeVita1,Elena
Amendola1
1DipartimentoDIMedicinaMolecolareEBiotecnologieMediche,Universita’FedericoII,Napoli,Italia
2IstitutoDIRicercheGeneticheG.Salvatore,BiogemS.C.Ar.L,ArianoIrpino,Avellino,Italia
3Proteomics&MassSpectrometryLaboratory,Ispaam,NationalResearchCouncil PosterArea
12.00‐13.00LUNCHANDPOSTERDISCUSSIONPO2(POSTERSP122‐238)
PosterSession13:Graves’OrbitopathyandAutoimmunity
Chairperson:Marie‐ChristineMany,Belgium
PosterSession14:HeartandThyroid
Chairperson:FabioMonzani,Italy
PosterSession15:SubclinicalThyroidDiseaseandHypothyroidism
Chairperson:PeteTaylor,UnitedKingdom
PosterSession16:ThyroidandEnvironment2
Chairperson:MassimoTonacchera,Italy
PosterSession17:ThyroidCancerDiagnostics2
Chairperson:StéphaneBardet,France
PosterSession18:ThyroidCancerPathogenesis1
Chairperson:TheraLinks,TheNetherlands
PosterSession19:ThyroidCancerTherapeutics2
Chairperson:AntoninoBelfiore,Italy
PosterSession20:ThyroidHormoneAvailabilityandAction
Chairperson:GeorgBrabant,Germany
PosterSession21:ThyroidinReproductionandDevelopment2
Chairperson:KrisPoppe,Belgium
4
PosterSession22:CaseReports2
Chairperson:MilosSarkovic,Serbia
PosterSession23:GoiterandNodules2
Chairperson:LaurenceDuPasquier‐Fediaevsky,France
SantiagoRoom
13.00‐14.00ETAINDUSTRY‐SPONSOREDSATELLITESYMPOSIUM5
Hypothyroidism:NewDevelopmentsinThyroidSubstitutionTherapy 14.00-14.15 COFFEE BREAK
14.15‐15.00MEET‐THE‐EXPERT5‐8
SantiagoRoom
14.15‐15.00 MTE5
NewinsightsintoGraves’disease
MicheleMarino,Italy
Room14
14.15‐15.00 MTE6
Structure&FunctionRelationshipofTHtransporters
UlrichSchweizer,Germany
CompostelaRoom
14.15‐15.00 MTE7
Guidelinesformanagementofsubclinicalhypothyroidisminpregnancy
JohnLazarus,UnitedKingdom
Room25
14.15‐15.00 MTE8
VertebratemodelsforstudyingTHmetabolismandaction
VeerleDarras,Belgium
SantiagoRoom
15.00‐17.00ORALSESSION6:THYROIDCANCERDIAGNOSTICS(OP39‐OP46)
Chairpersons:EfisioPuxedduItalyandManuelPuigDomingo,Spain
15.00‐15.15
OP39ISANINCREASEINTHYROIDNODULEVOLUMEAPREDICTOROFMALIGNANCY?
HirotoshiNakamura1,MitsuyoshiHirokawa1,MinoruKihara1,AkihiroMiwa1,AkiraMiyauchi1
1KumaHospital,Japan
15.15‐15.30
OP40MOLECULARTESTINGOFROUTINEAIR‐DRIEDFINENEEDLEASPIRATION(FNA)
SMEARSIMPROVESPRE‐SURGICALDIAGNOSISANDSUPPORTSTHEHISTOLOGICAL
IDENTIFICATIONOFFOLLICULARCARCINOMAS
MarkusEszlinger1,SimonettaPiana2,AnjaMoll1,EileenBoesenberg1,RalfPaschke1
1DivisionofEndocrinologyandNephrology,UniversityofLeipzig,Leipzig,Germany;2PathologyUnit,ArcispedaleSantaMaria
Nuova‐Irccs,ReggioEmilia,Italy
5
15.30‐15.45
OP41RE‐EVALUATIONGTHEMALIGNANCYRISKOFTHYROIDFOLLICULAR
NEOPLASMS:ATWO‐YEARSTUDYON598CASES
BénédicteRoyer1,ClaudeBigorgne2,GillesRuss3,AgnèsRouxel2,MarieBienvenu4
1CentredePathologieEtD'imagerie;2CentredePathologieEtD'imagerie;LaPitié‐SalpêtrièreHospital;3CentredePathologieEt
D'imagerie;LaPitié‐SalpêtrièreHospital;PierreandMarieCurieUniversity;4CentredePathologieEtD'imagerie;Cochin
Hospital
15.45‐16.00
OP42DIAGNOSTICPERFORMANCEOFELASTOGRAPHYINCYTOLOGICALLY
INDETERMINATETHYROIDNODULES
FrancescaGarino1,MaurilioDeandrea1,FedericoRagazzoni1,AlbertoMormile1,NicolaPalestini2,
MilenaFreddi2,GuidoGasparri2,ManuelaMotta3,DonatellaPacchioni4,PaoloPieroLimone1
1DepartmentofEndocrinology,DiabetesandMetabolism,AoMauriziano;2DepartmentofSurgery,ScuGeneralSurgeryIII,Aou
CittàDellaSaluteEDellaScienza;3DepartmentofDiagnosticandClinicalPathology,AoMauriziano
4DepartmentofLaboratoryMedicine,ScuDiagnosticAnatomyandHistopathology,AouCittàDellaSaluteEDellaScienza
16.00‐16.15
OP43PREDICTIVEVALUEOFHIGHSENSITIVETHYROGLOBULINASSAY(USTG)AND
NECKULTRASONOGRAPHY(US)ATTHETIMEOFREMNANTABLATIONONLT‐4
THERAPYINPATIENTSWITHLOWANDINTERMEDIATERISKDIFFERENTIATED
THYROIDCANCER(DTC)
AntonioMatrone1,CarlaGambale1,EleonoraMolinaro1,LauraAgate1,ValeriaBottici1,AgneseBiagini1,
DavidViola1,PaoloVitti1,RossellaElisei1
1UniversityofPisa,EndocrineUnit‐DepartmentofClinicalandExperimentalMedicine,Pisa,Italy
16.15‐16.30
OP44LOCALLYINVASIVEPAPILLARYTHYROIDCARCINOMAINVOLVINGA
FUNCTIONINGRECURRENTLARYNGEALNERVEEXCLUSIVELYMAYBETREATEDBY
SHAVINGTECHNIQUEWITHMACROSCOPICRESIDUALTUMORFOLLOWEDBYHIGH‐
DOSERADIOIODINETHERAPY
HyoungShinLee1,KangDaeLee1,JunWoongSong2,GiYunNam2,SungWonKim2,SeonMiBaek3,
HyoSangPark3
1DepartmentofOtolaryngology‐HeadandNeckSurgery,KosinUniversityCollegeofMedicine;2KosinUniversityCollegeof
Medicine;3SharingandHappinessHospital
16.30‐16.45
OP45MOLECULARTESTINGOFRESIDUALTHINPREPMATERIALINCREASES
SENSITIVITYANDALLOWSMOLECULARDIAGNOSTICSFORCYTOLOGICALLYNON‐
DIAGNOSTICSAMPLES
JeffreyKrane1,MarkusEszlinger2,EdmundCibas1,RalfPaschke2
1DepartmentofPathology,BrighamandWomen'sHospital,HarvardMedicalSchool,Boston,MA,USA;2DivisionofEndocrinology
andNephrology,UniversityofLeipzig,Leipzig,Germany
16.45‐17.00
OP46PREDICTIVEVALUEOFULTRASENSITIVESERUMTGATABLATIONIN
DIFFERENTIATEDTHYROIDCANCERPATIENTS
SilviaMemmo1,MariaGraziaCastagna1,ValentinaBelardini1,FabioMaino1,CarlaFioravanti1,Fausta
Sestini1,GabrieleCevenini2,FurioPacini1
1SectionofEndocrinology,UniversityofSiena,Siena,Italy;2SectionofSurgeryBioengineering,UniversityofSiena,Siena,Italy
6
CompostelaRoom
15.00‐17.00ORALSESSION7:THYROIDHORMONETRANSPORTERSANDDEIODINASES(OP47‐
OP54)
Chairpersons:LutzSchomburg,GermanyandEdwardVisser,TheNetherlands
15.00‐15.15
OP47STRONGINDUCTIONOFDEIODINASESBYNOVELSELENOCOMPOUNDS
MetteStoedter1,ElenaIbanez2,KostjaRenko3,JanineMartitz1,EddyRijntjes4,NicolePietschmann3,
AlfonsoCalvo2,JuanA.Palop2,SanmartinGrijalbaCarmen2,LutzSchomburg1
1InstituteforExperimentalEndocrinology
2UniversidaddeNavarra
3ChariteBerlin
4InstitutFürExperimentelleEndokrinologie,Charité‐UniversitätsmedizinBerlin,Germany
15.15‐15.30
OP48THR92ALAD2‐POLYMORPHISMDETERMINESREDUCEDT4‐INDUCED
APOPTOSISINMUSCLESTEMCELLS
MonicaDentice1,CristinaLuongo1,RaffaeleAmbrosio1,TommasoPorcelli1,DanielaDiGirolamo1,
FaustaAlfano1,MariaAngelaDeStefano1,DomenicoSalvatore1
1DepartmentofClinicalMedicineandSurgery,UniversityofNaples“federicoII,Italy
15.30‐15.45
OP49FIRSTINSIGHTSINTOLAT2AST2TRANSPORTERANDITSSTRUCTURE‐
FUNCTIONRELATIONSHIPS
AnitaKinne1,KatrinHinz2,MelanieWittner2,JosefKöhrle3,GerdKrause2
1Leibniz‐InstitutFürMolekularePharmakologie(Fmp),Berlin,Germany;2Leibniz‐InstitutFürMolekularePharmakologie(Fmp)
3InstitutFürExperimentelleEndokrinologie,Charité‐UniversitätsmedizinBerlin,Germany
15.45‐16.00
OP50NOVELTHYROIDHORMONETRANSPORTERS:LAT3ANDLAT4MEDIATE
CELLULARIODOTHYRONINEEFFLUX
ChantalZevenbergen1,EdwardVisser1,RobinPeeters1,AnitaKinne2,GerdKrause2,MarcelMeima1,
TheoVisser1
1ErasmusUniversityMedicalCenter,Rotterdam,TheNetherlands;2Leibniz‐InstitutFürMolekularePharmakologie(Fmp),
Germany
16.00‐16.15
OP51NEWINSIGHTSINTOTHEMECHANISMOFDEIODINASE3
UlrichSchweizer1,DoreenBraun,ChristineSchlicker3,JosefKöhrle4,ClemensSteegborn5
1RheinischeFriedrich‐Wilhelms‐UniversitätBonn;InstitutFürBiochemieundMolekularbiologie;2RheinischeFriedrich‐
Wilhelms‐UniversitätBonn;InstitutFürBiochemieundMolekularbiologie;3Ruhr‐UniversityBochum;4InstitutFür
ExperimentelleEndokrinologie,Charité‐UniversitätsmedizinBerlin,Germany;5UniversityofBayreuth
16.15‐16.30
OP52FUNCTIONALCHARACTERISTICSOFMCT8ORTHOLOGS:INSIGHTSFROM
HUMAN,MOUSEANDZEBRAFISH
SimoneKersseboom0,RamonaE.A.vanHeerebeek1,FranciscoJ.Arjona2,W.EdwardVisser1,RobinP.
Peeters1,TheoJ.Visser1
1ErasmusUniversityMedicalCenter;2RadboudUniversityNijmegen,TheNetherlands
7
16.30‐16.45
OP53HYPOTHALAMICTHYROIDHORMONESENSINGREGULATESTORPOR
INDUCTION.
EvaK.Wirth1,MonjaWillershäuser2,FranziskaMeyer1,EddyRijntjes3,MarcKlein4,ArnaudAgin5,
MartinHrabědeAngelis6,JosefKöhrle3,MartinKlingenspor2,JanRozman7,UlrichSchweizer8
1InstitutFürExperimentelleEndokrinologie,ChariteUniversitätsmedizinBerlin;2MolecularNutritionalMedicine,Else‐Kröner
FreseniusCenter,TechnischeUniversitätMünchen;3InstitutFürExperimentelleEndokrinologie,Charité‐Universitätsmedizin
Berlin,Germany;4ServiceD’endocrinologie,CentreHospitalierEtUniversitairedeNancy;5IcubeUmr7357,Universitéde
Strasbourg/Cnrs;6GermanMouseClinic,InstituteofExperimentalGenetics,HelmholtzZentrumMünchen;CenterofLifeand
FoodSciencesWeihenstephan,TechnischeUniversitätMünchen,;GermanCenterforDiabetesResearch,Neuherberg
7MolecularNutritionalMedicine,Else‐KrönerFreseniusCenter,TechnischeUniversitätMünchen;GermanMouseClinic,Institute
ofExperimentalGenetics,HelmholtzZentrumMünchen;GermanCenterforDiabetesResearch,Neuherberg
8RheinischeFriedrich‐Wilhelms‐UniversitätBonn;InstitutFürBiochemieundMolekularbiologie
16.45‐17.00
OP54THYROIDHORMONEDEGRADINGENZYMETYPE3DEIODINASE(D3)ISPRESENT
INHUMANNEUTROPHILS
AnnevanderSpek1,MonicaDentice2,DomenicoSalvatore3,EricFliers1,AnitaBoelen1
1AcademicMedicalCentre,TheNetherlands;2DepartmentofClinicalMedicineandSurgery,UniversityofNaples“federicoII
3UniversitàDINapoli"FedericoII",Italy
8
ScientificProgramme/Tuesday,9thSeptember
SantiagoRoom
08.00‐09.30SYMPOSIUM5:THYROIDDISEASEDURINGPREGNANCYANDCHILDHOOD
Chairpersons:MarekNiedziela,PolandandJoseMoreno,Spain
08.00‐08.30 Iodinedeficiencyinpregnancyandneurodevelopment MargaretRayman,UnitedKingdom
08.30‐09.00 Graves'diseaseinchildren
JulianeLeger,France
09.00‐09‐30 Thyroiddiseaseduringpregnancyandchildhood
FrançoiseBorson‐Chazot,France CompostelaRoom
08.00‐09.30SYMPOSIUM6:PATHOLOGICALFUNCTIONSOFMCT8
Chairpersons:HeikeHeuer,GermanyandCarlosDieguez,Spain
08.00‐08.30 RoleofMCT8inthebrain JuanBernal,Spain 08.30‐09.00 MCT8andmetabolism
CaterinadiCosmo,Italy
09.00‐09‐30 TherapeuticoptionsforMCT8patients
TheoVisser,TheNetherlands
09.30‐10.00COFFEEBREAK
SantiagoRoom
10.00‐12.00ORALSESSION8:HYPERTHYROIDISMANDORBITOPATHY(OP55‐OP62)
Chairpersons:LuigiBartalena,ItalyandFernandoCordido
10.00‐10.15
OP55DIAGNOSISANDMANAGEMENTOFGRAVES’DISEASEINEUROPE‐RESULTSOF
ASURVEYAMONGMEMBERSOFTHEEUROPEANTHYROIDASSOCIATION(ETA)
LuigiBartalena1,HenryB.Burch2,GeorgeJ.Kahaly3
1
1UniversityofInsubria,Varese,Italy;2UniformedServicesUniversityoftheHealthSciences;3JohannesGutenbergUniversity
MedicalCenter,Dept.ofMedicineI,Mainz,Germany
10.15‐10.30
OP56THYROIDSTIMULATINGAUTOANTIBODIESARECLINICALLYUSEFULAND
PREDICTIVEINGRAVES’DISEASE‐APROSPECTIVETRIAL
GeorgeJ.Kahaly1,MichaelKanitz1,ElisaKolbe1,NinaMatheis1,TanjaDiana1
1JohannesGutenbergUniversityMedicalCenter,Mainz,Germany
10.30‐10.45
OP57EFFECTSOFTRIIODOTHYRONINEONBONEMARROWANDSPLENIC
GRANULOCYTESANDMONOCYTESPOPULATIONS
FlaviaBloise1,FelipeLeiteOliveira2,HuilaFonseca2,SamueldosSantosValença2,Radovan
Borojevic2,CarmenCabanelasPazos‐Moura3,ValériadeMello‐Coelho2
1InstituteofBiomedicalSciences;InstituteofBiophysicsCarlosChagasFilho.FederalUniversityofRiodeJaneiro;Academic
MedicalCentral.UniversityofAmsterdam;Capes;2InstituteofBiomedicalSciences;3InstituteofBiophysicsCarlosChagas
Filho
10.45‐11.00
OP58THYROXINE‐INDUCEDCHANGESOFTHEPLASMAPROTEOME–ASTUDYOF
EXPERIMENTALHYPERTHYROIDISMINHUMANS
BeatriceEngelmann1,Anna‐LuiseDirk2,ElkeHammer3,AlexanderIwen2,HenriWallaschofski4,Uwe
Völker3,GeorgHomuth3,GeorgBrabant2
1InterfacultyInstituteforGeneticsandFunctionalGenomics,UniversityofGreifwald;2ExperimentalandClinical
Endocrinology,UniversityofLuebeck;3InterfacultyInstituteforGeneticsandFunctionalGenomics,UniversityofGreifswald
4InterfacultyInstituteforGeneticsandFunctionalGenomics
11.00‐11.15
OP59DECREASEOFGLUT4ANDT3ANDINCREASEOFNOX2AREINVOLVEDINTHE
OXIDATIVESTRESSOFEYEMUSCULARCELLSANDORBITALADIPOCYTESINGRAVES’
ORBITOPATHY
VanRegemorterElliott1,JulieCraps2,JorisVirginie1,BehetsCatherine1,BenoîtLengelé2,Baldeschi
Lelio1,ChantalDaumerie3,Marie‐ChristineMany2
1Ucl;2UniversitéCatholiquedeLouvain,MorphologieExpérimentale;3CliniquesUniversitairesSaint‐Luc;Université
CatholiquedeLouvain
11.15‐11.30
OP60ROLEOFALTERNATETSHRLIGANDSANDBINDINGPROTEINS(TSHR‐BP)IN
GRAVES’ORBITOPATHY(GO)
MohdShazliDraman1,FionaGrennan‐Jones1,LeiZhang1,PeteNTaylor1,DanielMorris2,Carol
Lane2,ColinDayan1,MarianLudgate1
1InstituteofMolecular&ExperimentalMedicine;SchoolofMedicine;CardiffUniversity
2DepartmentofOphthalmology;UniversityHospitalofWales
11.30‐11.45
OP61THEEFFECTOFRITUXIMAB(RTX)ANDINTRAVENOUSMETHYLPREDNISOLONE
(IVMP)ONTSH‐RECEPTORANTIBODIES(TRAB)ANDTHECXCL‐10CHEMOKINEIN
PATIENTSWITHACTIVEGRAVES’ORBITOPATHY(GO).
GuiaVannucchi1,IreneCampi2,DanilaCovelli2,PFallahi3,STirelli4,ADiDomenicoantonio3,Nicola
Currò5,DavideDazzi6,AlessandroAntonelli3,MarioSalvi2
1EndocrineUnit,FondazionePoliclinicoIrccs,Milan,Italy;2EndocrineUnit,FondazioneIrccsCàGranda,Milan
3DepartmentofClinicalandExperimentalMedicine,UniversityofPisa;4LaboratoryMedicineUnit,FondazioneCa’Granda
Irccs
2
5Ophthalmology4,FondazioneCa’GrandaIrccs
6InternalMedicine5,OspedaleDIFidenza,Fidenza,Italy
11.45‐12.00
OP62 FORKHEADTRANSCRIPTIONFACTORS;POSSIBLETARGETSFORTHERAPYIN
GO?
LeiZhang1,FionaRuge2,MohdShazliDraman1,FionaGrennan‐Jones1,CarolLane3,ColinDayan1,
MarianLudgate1
1InstituteofMolecular&ExperimentalMedicine;SchoolofMedicine;CardiffUniversity;2Cardiff‐PekingCancerInstitute;
SchoolofMedicine;CardiffUniversity;3DepartmentofOphthalmology;UniversityHospitalofWales
Compostelaroom
10.00‐12.00ORALSESSION9:THYROIDCANCERPATHOGENESIS(OP63‐OP70)
Chairpersons:ChrisMcCabe,UnitedKingdomandPilarSantisteban,Spain
10.00‐10.15
OP63ANOVELMODULATOROFCELLINVASIONANDMETASTASIS
RachelWatkins1,VickiSmith1,NeilSharma1,MartinRead1,PerkinKwan1,RachelFletcher1,Vikki
Poole1,WarapornImruetaicharoenchoke1,KristienBoelaert1,JayneFranklyn1,ChristopherMcCabe1
1UniversityofBirmingham,UnitedKingdom
10.15‐10.30
OP64ANINTRONICDELETIONINPHOSPHOLIPASE‐CΒ1(PLCΒ1)ASSOCIATEDWITH
EUTHYROIDMULTINODULARGOITRE(MNG)ANDRISKOFPROGRESSINGTO
PAPILLARYTHYROIDCANCER(PTC)
IoannisLadas1,FionaGrennan‐Jones1,AmeenBakhsh1,LeiZhang1,AnnadeLloyd1,Denise
Zwanziger2,DagmarFuhrer‐Sakel2,MarianLudgate1
1CardiffUniversity,ThyroidResearchGroup,InstituteofMolecularandExperimentalMedicine,Cardiff,UnitedKingdom
2KlinikFurEndokrinologie,Universitatsklinikum,Essen,Germany
10.30‐10.45
OP65SELECTIVEKILLINGANDSUBSEQUENTSENESCENCEINDUCTION:ADOUBLE
ACTIONFORANAPLASTICTHYROIDCANCERTHERAPY.
ElisaStellariaGrassi1,ValeriaVezzoli1,IreneNegri1,GiovanniVitale2,LucaPersani2
1Dept.ofClinicalSciences&CommunityHealth,UniversityofMilan;2Dept.ofClinicalSciences&CommunityHealth,
UniversityofMilan;DivisionofEndocrineandMetabolicDiseases&Lab.ofEndocrineandMetabolicResearch,IrccsIstituto
AuxologicoItaliano
10.45‐11.00
OP66THEFIRSTREPORTEDMUTATIONSINTHEPITUITARYTUMOR‐
TRANSFORMINGGENE(PTTG)BINDINGFACTOR(PBF)
WarapornImruetaicharoenchoke1,MartinRead1,JoelSmith1,VickiSmith1,BhavikaModasia1,Vikki
Poole1,RachelWatkins1,JayneFranklyn1,KristienBoelaert1,ChristopherMcCabe1
1UniversityofBirmingham,UnitedKingdom
11.00‐11.15
OP67CLM29ANDCLM3,TWOTYROSINEKINASEINHIBITORS,HAVE
ANTINEOPLASTICACTIVITYINVITROINPRIMARYCULTURESFROMANAPLASTIC
THYROIDCANCER,OBTAINEDFROMFINENEEDLEASPIRATION.
3
AldaCorrado1,PoupakFallahi1,SilviaMartinaFerrari1,GuidoBocci1,ConcettinaLaMotta1,Gabriele
Materazzi1,AndreaDiDomenicantonio1,RomanoDanesi1,FedericoDaSettimo1,PaoloMiccoli1,
AlessandroAntonelli0
1UniversityofPisa,Italy
11.15‐11.30
OP68ESTROGENANDPROGESTERONRECEPTORSEXPRESSIONINDIFFERENTIATED
THYROIDCANCER:AROLEINTHERISKSTRATIFICATIONOFTHYROIDTUMORS
SimoneDeLeo1,MichelaPerrino1,CarlaColombo1,StefaniaRossi2,DelfinaTosi2,Leonardo
Vicentini3,GaetanoBulfamante2,LauraFugazzola1,GuiaVannucchi1
1Endocrinology,FondazioneCa’GrandaIrccs,UniversityofMilan,Italy;2PathologyUnit,OspedaleSanPaolo,Universityof
Milan;3EndocrineSurgeryUnit,FondazioneIrccsCàGranda,Milan
11.30‐11.45
OP69INSULINRESISTANCE:ANOTHERRISKFACTORTHATINCREASESTHERISKOF
RECURRENCEINPATIENTSWITHTHYROIDCANCER?
FabianPitoia1,ErikaAbelleira1,FernandaBueno1,CarolinaUrciuoli1
1HospitaldeClinicas‐UniversityofBuenosAires
11.45‐12.00
OP70GENETICPREDISPOSITIONTOPAPILLARYTHYROIDCANCER
DorotaKula1,DariaHandkiewicz‐Junak1,MichalKalemba1,ZbigniewPuch1,MalgorzataKowalska1,
MonikaKowal1,TomaszTyszkiewicz1,RenataCyplinska1,JoannaPolanska2,BarbaraJarzab1
1MariaSklodowska‐CurieMemorialCancerCenterandInstituteofOncology;2SilesianUniversityofTechnology,Poland
PosterArea
12.00‐13.00
LUNCHANDPOSTERDISCUSSION3(POSTERS239‐367)
PosterSession24:ThyroidAutoimmunity
Chairperson:MarianLudgate,UnitedKingdom
PosterSession25:Hyperthyroidism
Chairperson:PatriceRodien,France
PosterSession26:NovelActionsofThyroidHormone
Chairperson:HeikeBiebermann,Germany
PosterSession27:PaediatricsandPregnancy
Chairperson:JulianeLeger,France
PosterSession28:ThyroidCancerDiagnostics3
Chairperson:LeonidasDuntas,Greece
PosterSession29:ThyroidCancerDiagnostics4
Chairperson:TaniaPilli,Italy
PosterSession30:ThyroidCancerPathogenesis2
Chairperson:KalliopiPaizaitou‐Panayiotou,Greece
PosterSession31:ThyroidHormoneandGeneExpression
Chairperson:BarbaraDemeneix,France
PosterSession32:CaseReports3
Chairperson:ValentinFadayev,Russia
PosterSession33:ThyroidCancerTherapeutics3
Chairperson:RolandGärtner,Germany
4
PosterSession34:ThyroidCancerTherapeutics4
Chairperson:MatthiasSchott,Germany
PosterSession35:BiochemicalandMetabolicParameters
Chairperson:TomaszBednarczuk,Poland
SantiagoRoom
13.00‐14.00ETAINDUSTRY‐SPONSOREDSATELLITESYMPOSIUM6
NewTrendsintheManagementofThyroidCancer
14.00-14.45 MEET-THE-EXPERT 9-12
SantiagoRoom
14.00‐14.45 MTE9
ManagementofFollicularneoplasms
PaoloVitti,Italy
CompostelaRoom
14.00‐14.45 MTE10
Thyroidhormonesandbones
GrahamWilliams,UnitedKingdom
Room14
14.00‐14.45 MTE11
Nuclearmedicineimaginginthyroiddisease
MarkusLuster,Germany
Room25
14.00‐14.45 MTE12
Non‐thyroidalillness
AnitaBoelen,TheNetherlands
14.45-15.00 COFFEE BREAK
SantiagoRoom
15.00‐17.00ORALSESSION10:CLINICALTHYROIDOLOGY(OP71‐OP78)
Chairpersons:PhilippeCaron,FranceandJuanCarlosGalofré,Spain
15.00‐15.15
OP71SUBCLINICALHYPOTHYROIDISMANDTHERISKOFNON‐FATALANDFATAL
STROKE:ANINDIVIDUALPARTICIPANTANALYSIS
LayalChaker1,ChristineBaumgartner2,WendyJ.P.denElzen3,M.ArfanIkram4,ManuelR.Blum2,
StephanJ.L.Bakker5,AbbasDehghan6,ChristianeDrechsler7,RobertN.Luben8,AlbertHofman6,
MarileenL.P.Portegies6,MarcoMedici1,GiorgioIervasi9,Tinh‐HaiCollet2,AlexandraBrenmer10,
ChristophWanner11,MassimoIacoviello12,RobinP.Dullaart5,JoséA.Sgarbi13,GrazianoCeresini14,
RudiG.Westendorp15,J.WouterJukema16,MisaImaizumi17,JayneA.Franklyn18,DouglasC.
5
Bauer19,AnneR.Cappola20,JohnP.Walsh21,SalmanRazvi22,Kay‐TeeKhaw8,HenryVölzke23,
OscarH.Franco6,JacobijnGussekloo3,NicolasRodondi2,RobinP.Peeters1
1DepartmentofInternalMedicine,ThyroidCenter,ErasmusMedicalCenter,Rotterdam,TheNetherlands
2DepartmentofAmbulatoryCareandCommunityMedicine,UniversityofLausanne,Lausanne,Switzerland
3DepartmentofEpidemiologyDepartmentsofPublicHealthandPrimaryCare;LeidenUniversityMedicalCenter,Leiden,the
Netherlands;4DepartmentofNeurology,ErasmusUniversityMedicalCenter,Rotterdam,TheNetherlands;Departmentof
Radiology,ErasmusUniversityMedicalCenter,Rotterdam,TheNetherlands;DepartmentofEpidemiology,Erasmus
UniversityMedicalCenter,Rotterdam,TheNetherlands;5DepartmentofInternalMedicine,UniversityofGroningen,University
MedicalCenterGroningen,TheNetherlands;6DepartmentofEpidemiology,ErasmusUniversityMedicalCenter,Rotterdam,
TheNetherlands;7DepartmentofMedicine,DivisionofNephrology,UniversityHospitalofWürzburg,Germany
8DepartmentofPublicHealthandPrimaryCare,UniversityofCambridge,Cambridge,England;9NationalCouncilResearch
InstituteofClinicalPhysiology,Pisa,Italy;10SchoolofPopulationHealth,UniversityofWesternAustralia,Crawley
11DepartmentofMedicine,DivisionofNephrologyandScientificDirector,ClinicalTrialUnit,UniversityHospitalofWürzburg,
Germany;12CardiologyUnit,DepartmentofEmergencyandOrganTransplantation,UniversityofBari,Italy
13DivisionofEndocrinology,DepartmentofMedicine,FederalUniversityofSaoPaulo,Brazil;DivisionofEndocrinology,
FaculdadedeMedicinadeMarília,Marília,Brazil;14FacoltaDIMedicinaEChirurgia,DepartmentofClinicaland
ExperimentalMedicine,Parma,Italy;15DepartmentofEpidemiologyndGerontologyandGeriatrics,LeidenUniversityMedical
Center,Leiden,theNetherlands;NetherlandsConsortiumforHealthyAgeing,Leiden;16DepartmentofCardiology,Leiden
UniversityMedicalCentre,Leiden,TheNetherlands;17DepartmentofClinicalStudies,RadiationEffectsResearchFoundation,
Nagasaki,Japan;18SchoolofClinicalandExperimentalMedicine,CollegeofMedicalandDentalSciences,Universityof
Birmingham,Birmingham,England;19DepartmentsofMedicine,Epidemiology,andBiostatisticsandMedicineuniversityof
California,SanFrancisco;20DivisionofEndocrinology,Diabetes,andMetabolism,DepartmentofMedicine,SchoolofMedicine,
UniversityofPennsylvania,Philadelphia;21DepartmentofEndocrinologyandDiabetes,SirCharlesGairdnerHospital,
Nedlands,WesternAustralia;22DepartmentofEndocrinology,GatesheadHealthFoundationNHSTrust,Gateshead,England
23InstituteforCommunityMedicine,Clinical‐EpidemiologicalResearch,UniversityofGreifswald,Greifswald,Germany
15.15‐15.30
OP72MILDHYPERTHYROIDISMLEADSTOINCREASEDCONNECTIVITYINTEMPORAL
LOBESTRUCTURES:ARESTINGSTATEFMRISTUDY
Anna‐LuiseDirk1,MartinGöttlich2,MarcusHeldmann2,AnnaGoebel2,GeorgBrabant1,ThomasF.
Muente2
1ExperimentalandClinicalEndocrinology,UniversityofLuebeck;2DepartmentofNeurology,UniversityofLuebeck,Germany
15.30‐15.45
OP73EUTHYROIDANDHYPERTHYROIDHAVEINCREASEDRISKOF
CEREBROVASCULAREVENTSAFTER131IODINETREATMENT–ACOHORTSTUDYOF
MORETHAN5000TREATEDPATIENTS
JeppeLerchelaCour1,LarsThorbjoernJensen2,BIrteNygaard3
1SectionofClinicalPhysiology,DepartmentofDiagnostics,GlostrupHospital,UniversityofCopenhagen
2DepartmentofClinicalPhysiologyandNuclearMedicine,HerlevHospital,UniversityofCopenhagen;SectionofClinical
Physiology,DepartmentofDiagnostics,GlostrupHospital,UniversityofCopenhagen
3DepartmentofEndocrinology,HerlevHospital
15.45‐16.00
OP74LOWSERUMTHYROTROPINLEVELANDDURATIONOFSUPPRESSIONASA
PREDICTOROFMAJOROSTEOPOROTICFRACTURES–THEOPENTHYROREGISTER
COHORT
AnneSofieLaulund1,BoAbrahamsen2,HenrikLøvendahlJørgensen3,MadsNybo4,ThomasHeiberg
Brix1,LaszloHegedüs1
1DepartmentofEndocrinologyandMetabolism,OdenseUniversityHospital
2ResearchCentreforAgingandOsteoporosis,OdenseUniversityHospital
3DepartmentofClinicalBiochemistry,BispebjergHospital
4DepartmentofClinicalBiochemistryandPharmacology,OdenseUniversityHospital
6
16.00‐16.15
OP75RANDOMISEDCONTROLLEDPRE‐CLINICALTRIALOFTRI‐IODOTHYRONINE
(T3)ANDHYDROCORTISONEREPLACEMENTINSEPTICSHOCK.
MatthewMaiden1,MarianneChapman1,TimKuchel2,DavidTorpy1,IainClarke3,GuyLudbrook1
1RoyalAdelaideHospital;UniversityofAdelaide;2Sahmri;3MonashUniversity
16.15‐16.30
OP76BIRTHDEFECTSAFTERTHEUSEOFTHEANTITHYROIDDRUGS(ATDS)
METHIMAZOLE/CARBIMAZOLE(MMI/CMZ)ANDPROPYLTHIOURACIL(PTU)IN
PREGNANCY:HIGHRISKISCONFINEDTOABRIEFTIMEWINDOWOFPREGNANCY.
PeterLaurberg1,StineLindingAndersen1
1AalborgUniversityHospital
16.30‐16.45
OP77EVALUATIONTHEASSOCIATIONOFPOLYMORPHISMSINDIO1ANDDIO2
GENESWITHMENTAL,BIOCHEMICALPARAMETERSANDQUALITYOFLIFEIN
WOMENWITHPRIMARYHYPOTHYROIDISM
ValentinFadeyev1,MeruertMadiyarova1,TatyanaMorgunova1
1I.M.SechenovFirstMoscowStateMedicalUniversity,DepartmentofEndocrinology,Russia
16.45‐17.00
OP78LONG‐TERMSELENIUMSUPPLEMENTATIONANDTHYROTROPININDANISH
SENIORS.RESULTSFROMARANDOMISEDCONTROLLEDTRIAL.
KristianWinther1,FrederikCold2,SteenJoopBonnema1,SørenCold2,BirgitDebrabant3,Mads
Nybo4,LaszloHegedüs1
1DepartmentofEndocrinologyandMetabolism,OdenseUniversityHospital,Denmark;2DepartmentofOncology,Odense
UniversityHospital,Denmark;3DepartmentofEpidemiology,BiostatisticsandBiodemography,UniversityofSouthern
Denmark,Odense,Denmark;4DepartmentofClinicalBiochemistry,OdenseUniversityHospital,Denmark
CompostelaRoom
15.00‐17.00ORALSESSION11:YOUNGINVESTIGATORSSESSION/BASIC(OP79‐OP86)
Chairpersons:TheoVisser,TheNetherlandsandJosefKöhrle,Germany
15.00‐15.15
OP79BIOSYNTHESISOF3‐IODOTHYRONAMINEFROMTHYROXINEININTESTINAL
TISSUE
CarolinHöfig1,TiloWuensch2,InaLehmphul3,HanneloreDaniel4,UlrichSchweizer5,JensMittag6,
JosefKöhrle3
1KarolinskaInstitutet,DepartmentofCell&MolecularBiology,Sweden;InstitutFürExperimentelleEndokrinologie,Charité‐
UniversitätsmedizinBerlin,Germany;2KarolinskaInstitutet,DepartmentofCell&MolecularBiology,Sweden;ZielResearch
CenterofNutritionandFoodScience,AbteilungBiochemie,TechnischeUniversitätMünchen,Germany
3InstitutFürExperimentelleEndokrinologie,Charité‐UniversitätsmedizinBerlin,Germany
4ZielResearchCenterofNutritionandFoodScience,AbteilungBiochemie,TechnischeUniversitätMünchen,Germany
5InstitutFürBiochemieundMolekularbiologie,RheinischeFriedrich‐Wilhelms‐UniversitätBonn,Germany
6KarolinskaInstitutet,DepartmentofCell&MolecularBiology,Sweden
15.15‐15.30
OP80REGULATIONOFEMBRYONICTHYROIDGROWTHBYMESENCHYMALFGF10
COINCIDINGWITHFUNCTIONALDIFFERENTIATION
ShawnLiang1,HenrikFagman2,MikaelNilsson1
7
1SahlgrenskaCancerCenter,SahlgrenskaAcademy,UniversityofGothenburg,Gothenburg,Sweden
2DepartmentofClinicalPathologyandGenetics,SahlgrenskaUniversityHospital,Gothenburg,Sweden
15.30‐15.45
OP81IDENTIFICATIONOFMIR‐146B‐3PASAKEYPLAYERINTHYROIDCANCER
DEDIFFERENTIATION
LeónWert‐Lamas1,GarcilasoRiesco1,PilarSantisteban2
1IibAlbertoSols.Csic‐Uam;2InstitutodeInvestigacionesBiomédicas(Csic‐Uam),Spain
15.45‐16.00
OP82INVIVODISSECTIONOFTHEROLEOFGLIS3TRANSCRIPTIONFACTORINTHE
HYPOTHALAMIC‐PITUITARY‐THYROIDAXIS
FedericaMarelli1,FrancoCotelli2,LucaPersani3
1IrccsIstitutoAuxologicoItaliano;2UniversityofMilan;3IrccsIstitutoAuxologicoItaliano;UniversityofMilan,Italy
16.00‐16.15
OP83THEEFFECTOFDEIODINASETYPE3KNOCKDOWNONZEBRAFISHEYE
DEVELOPMENT.
AnneM.Houbrechts1,EniseBagci2,MarjoleinHeijlen1,DriesKnapen3,VeerleM.Darras1
1LaboratoryofComparativeEndocrinology,KuLeuven,Belgium;2SystemicPhysiological&EcotoxicologicalResearch,Ua,
Belgium;3SystemicPhysiological&EcotoxicologicalResearch,Ua,Belgium;VeterinaryPhysiologyandBiochemistry,Ua,
Belgium
16.15‐16.30
OP84CHARACTERIZATIONOFCHICKENTHYROIDHORMONETRANSPORTERS
NeleBourgeois1,StijnL.J.VanHerck1,JokeDelbaere1,ChantalZevenbergen2,SimoneKersseboom2,
VeerleM.Darras1,TheoJ.Visser2
1LaboratoryofComparativeEndocrinology,KuLeuven,Belgium
2DepartmentofInternalMedicine,ErasmusUniversityMedicalCenter,3015GeRotterdam,TheNetherlands
16.30‐16.45
OP85IMPACTOFTHYROIDHORMONESONERΑ‐DEPENDENTACTIONSINTHE
HYPOTHALAMUS
LarissaFaustino1,KhatunaGagnidze2,TaniaMOrtiga‐Carvalho3,DonaldPfaff2
1UniversidadeFederalDoRiodeJaneiro;TheRockefellerUniversity;2TheRockefellerUniversity;3UniversidadeFederalDo
RiodeJaneiro
16.45‐17.00
OP86ROLEOFTHENADPHOXIDASENOX4INBRAFV600E‐DEPENDENT
DOWNREGULATIONOFNIS.
AzouziNaïma1,CaillouxJérémy1,BoichardAmélie2,AbirAlGhuzlan3,DanaHartl3,Martin
Schlumberger4,AmezianeElHassaniRabii5,CorinneDupuy0
1UniversitéParis‐Sud11;Umr8200Cnrs;InstitutGustaveRoussy;2InstitutGustaveRoussy;3GustaveRoussy,UniversitéParis‐
Sud,Villejuif,France;4DepartmentofNuclearMedicineandEndocrineOncology,GustaveRoussyandUniversitéParis‐Sud,
Villejuif,France;5Ubrm,CentreNationaldeL’energie,desSciencesEtdesTechniquesNucléaires,Rabat,
SantiagoRoom
17.00‐17.45ETAPRIZELECTURE
Chairpersons:FurioPacini,ItalyandColinDayan,UnitedKingdom
Iodine,thyroidautoimmunityandcancer
8
SantiagoRoom
18.00‐19.15 GENERALASSEMBLY(FORETAMEMBERSONLY)
9
ScientificProgramme/Wednesday,10thSeptember
CompostelaRoom
07.45‐08.45 SHORT‐CALLABSTRACTS
Chairpersons: Furio Pacini, Italy; Colin Dayan, United Kingdom CompostelaRoom
08.45‐10.15SYMPOSIUM7:THYROIDHORMONEREPLACEMENT
Chairpersons: Jean Louis Wemeau, France and Francesco Trimarchi, Italy 08.45‐09.15 Risks of thyroid hormone replacement Simon Pearce, United Kingdom 09.15‐09.45 Trends in thyroid hormone prescribing, malabsorption and intolerance of thyroid hormone Salvatore Benvenga, Italy 09.45‐10.15 T3 vs T4 therapy Colin Dayan, United Kingdom Room 25 08.45‐10.15SYMPOSIUM8:DVANCEDTHYROIDTUMORS:
STEPSBEFORETARGETTHERAPY
Chairpersons: Laurence Leenhardt, France and Javier Aller Pardo, Spain 08.45‐09.15 Outcome of metastatic thyroid cancer Cosimo Durante, Italy 09.15‐09.45 The future of imaging evaluation of target lesions TBD 09.45‐10.15 Evaluation of the ratio benefices/QoL under TKI treatment Kate Newbold, United Kingdom 10.15‐10.30COFFEEBREAK
1
Compostela Room 10.30‐12.30ORALSESSION12:THYROIDCANCERTHERAPY(OP87‐OP94)
Chairpersons: Rossella Elisei, Italy and Garcilaso Riesco‐Eizaguirre, Spain 10.30‐10.45 OP87EXPLORATORYANALYSISOFOUTCOMESFORPATIENTSWITHLOCALLY
ADVANCEDORMETASTATICRADIOACTIVEIODINE‐REFRACTORYDIFFERENTIATED
THYROIDCANCER(RAI‐RDTC)RECEIVINGOPEN‐LABELSORAFENIBPOST‐
PROGRESSIONONTHEPHASEIIIDECISIONTRIAL
MartinSchlumberger1,ChristopherNutting2,BarbaraJarzab3,RossellaElisei4,SalvatoreSiena5,Lars
Bastholt6,ChristelledelaFouchardiere7,FurioPacini8,RalfPaschke9,YoungKeeShong10,StevenI
Sherman11,JohannesWASmit12,JohnChung13,ChristianKappeler14,IstvanMolnar13,MarciaS
Brose15
1GustaveRoussy;2RoyalMarsdenHospital;3MariaSklodowska‐CurieMemorialCancerCentreandInstituteofOncology
4DepartmentofClinicalandExperimentalMedicine,UniversityofPisa;5OspedaleNiguardaCa'Granda;6OdenseUniversity
Hospital;7ConsortiumCancerThyroïdien,HospicesCivils‐CentreAnticancéreux;8UnitofEndocrinology,UniversityofSiena
9DepartmentforEndocrinologyandNephrology,LeipzigUniversity;10AsanMedicineCenter,UniversityofUlsanCollegeof
Medicine;11TheUniversityofTexasMDAndersonCancerCenter;12DepartmentofInternalMedicine,RadboudUniversity
MedicalCenter;13BayerHealthcarePharmaceuticals;14BayerPharmaAG;15DepartmentofOtorhinolaryngology:Headand
NeckSurgery,AbramsonCancerCenteroftheUniversityofPennsylvania
10.45‐11.00
OP88FOLLICULAR(FVPTC)VSCLASSICAL(CVPTC)VARIANTOFPAPILLARTHYROID
CANCER:CORRELATIONOFTHEOUTCOMEAFTER12YEARSOFFOLLOWUP
CarlottaGiani1,LiborioTorregrossa2,EleonoraMolinaro1,AndreaCacciatoInsilla2,LauraAgate1,
DavidViola1,LucianaPuleo1,GabrieleMaterazzi2,IvoMarchetti3,PaoloMiccoli2,GiancarloDi
Coscio3,PaoloVitti1,FulvioBasolo2,RossellaElisei1
1EndocrineUnit,DepartmentofClinicalandExperimentalMedicine,UniversityofPisa,Pisa,Italy
2DepartmentofSurgical,MedicalandMolecularPathologyoftheClinicalArea,UniversityofPisa,Pisa,Italy
3DepartmentofTranslationalResearchandNewTechnologiesinMedicineandSurgeons,UniversityofPisa,Pisa,Italy
11.00‐11.15
OP89CONSERVATIVEVSRADICALSURGICALMANAGEMENTINCHILDRENWITH
DIFFERENTIATEDTHYROIDCANCER:MULTICENTRICSTUDY
ClaudioSpinelli1,PaoloMiccoli1,AlessandroInserra2,GianniBisogno3,GiovanniCecchetto3,Poupak
Fallahi1,AlessandroAntonelli0
1UniversityofPisa;2“bambinoGesù”PediatricHospital;3UniversityofPadova,Italy
11.15‐11.30
OP90PROGNOSTICVALUEOFMICROSCOPICLYMPHNODEINVOLVEMENTIN
PATIENTSWITHPAPILLARYTHYROIDCANCER
StephaneBardet1,RenaudCiappuccini1,ElskeQuak1,Jean‐PierreRame1,DavidBlanchard1,
DominiqueDeRaucourt1,EmmanuelBabin2,Jean‐JacquesMichels1,DominiqueVaur1,Natacha
Heutte3
1CentreFrancoisBaclesse;2Chu;3UniversitédeBasse‐Normandie,France
11.30‐11.45
OP91METASTATICTHYROIDCANCERUNRESPONSIVETOCONVENTIONALTHERAPY
TREATEDWITHSORAFENIB“OFF‐LABEL”:ANUPDATEOFOUR6YEARSOF
EXPERIENCE
2
VirginiaCappagli1,ValeriaBottici1,EleonoraMolinaro1,LauraAgate1,DavidViola1,LauraValerio1,
PaoloPiaggi2,SalvatoreMazzeo3,ValentinaBattaglia3,BenedettaPontilloContillo3,PaoloVitti1,
RossellaElisei1
1EndocrineUnit,DepartmentofClinicalandExperimentalMedicine,UniversityofPisa,Pisa,Italy;2DepartmentOfEnergyand
SystemsEngineering,UniversityofPisa;3DepartmentforIntegratedActivityRadiology,VascularandInterventional
Radiology,NuclearMedicine;UniversityofPisa,Pisa,Italy
11.45‐12.00
OP92DIFFERENTIALGENEEXPRESSIONINFOLLICULARTHYROIDCARCINOMAS
SHOWINGDIFFERENTDEGREESOFINVASIVENESS
RicardoCelestino1,TorfinnNome2,AnaPestana3,EvaSigstad4,RagnhildA.Lothe5,TrineBjøro6,
ManuelSobrinho‐Simões7,RolfI.Skotheim2,PaulaSoares8
1InstituteofMolecularPathologyandImmunologyoftheUniversityofPorto(Ipatimup),Porto,Portugal;SchoolofAllied
HealthSciencesEstsp,PolytechnicofPorto,Porto,Portugal;2DepartmentofCancerPrevention,InstituteforCancerResearch,
NorwegianRadiumHospital,OsloUniversityHospital,Oslo;CentreforCancerBiomedicine,FacultyofMedicine,Universityof
Oslo,Oslo,Norway;3InstituteofMolecularPathologyandImmunologyoftheUniversityofPorto(Ipatimup),Porto,Portugal;
InstituteofBiomedicalSciencesofUniversityofPorto,Porto,Portugal;4DepartmentofPathology,NorwegianRadium
Hospital,OsloUniversityHospital,Oslo,Norway;5DepartmentofCancerPrevention,InstituteforCancerResearch,Norwegian
RadiumHospital,OsloUniversityHospital,Oslo;CentreforCancerBiomedicine,FacultyofMedicine,UniversityofOslo,Oslo,
Norway;DepartmentofMolecularBiosciences,UniversityofOslo,Oslo,Norway;6DepartmentofMedicalBiochemistry,
NorwegianRadiumHospital,OsloUniversityHospital,Oslo,Norway;InstituteofClinicalMedicine,UniversityofOslo,Oslo,
Norway;7InstituteofMolecularPathologyandImmunologyoftheUniversityofPorto(Ipatimup),Porto,Portugal;Medical
Faculty,UniversityofPorto,Porto,Portugal;DepartmentofPathology,CentroHospitalardeSãoJoão,Porto,Portugal
8InstituteofMolecularPathologyandImmunologyoftheUniversityofPorto(Ipatimup),Porto,Portugal;MedicalFaculty,
UniversityofPorto,Porto,Portugal
12.00‐12.15
OP93SURGICALSTRATEGYINLOWADVANCEDDIFFERENTIATEDTHYROIDCANCER
STAGEDT1N0M0‐RESULTSOFAPILOTFEASIBILITYSTUDY
AgnieszkaCzarniecka1,StanislawPoltorak1,AleksanderSacher1,AdamMaciejewski1,Jolanta
Krajewska1,MichalJarzab1,EwaStobiecka1,EwaZembala‐Nozynska1,EwaChmielik1,Dagmara
Rusinek1,MonikaKowal1,MalgorzataOczko‐Wojciechowska1,DariaHandkiewicz‐Junak1,Barbara
Jarzab1
1CentreofOncologyM.Sklodowska‐CurieMemorialInstituteGliwiceBranch,Poland
12.15‐12.30
OP94PERCUTANEOUSTREATMENTOFBONEMETASTASESFROMDIFFERENTIATED
THYROIDCARCINOMAS:RESULTSFROMACOHORTOF23PATIENTS
FrançoiseBonichon0,CazzatoRobertoLuigi1,BuyXavier2,GodbertYann3,HenriquesdeFigueiredo
Bénédicte4,PointillartVincent5,PalussiereJean6
1DeptofDiagnosticImagingandInterventionalRadiologyUniversitàCampusBio‐MedicoDIRomaViaAlvarodelPortillo,
200Rome;2DepartmentofInterventionalRadiology,InstitutBergonié,229CoursdeL'argonne,33076,BordeauxCedex,
France;3DepartmentofNuclearMedicine,InstitutBergonié,229CoursdeL'argonne,33076,BordeauxCedex,France
4DepartmentofRadiotherapy,InstitutBergonié,229CoursdeL'argonne,33076,BordeauxCedex,France
5SpinalSurgeryUnit,DepartmentofOrthopaedics,UniversityHospitalofBordeaux,PlaceAmélieRabaLéon,33076,
Bordeaux,France;6DepartmentofInterventionalRadiology,InstitutBergonié,229CoursdeL'argonne,33076,Bordeaux
Cedex,France,
Room 25 10.30‐12.30ORALSESSION13:GENEEXPRESSION(OP95‐OP102)
Chairperson: Riccardo Zucchi, Italy and Joao Anselmo, Portugal 3
10.30‐10.45
OP95THETRANSCRIPTIONFACTORNRF2CONTROLSANTIOXIDANTRESPONSES
ANDIMPACTSTHYROID‐SPECIFICGENEEXPRESSIONANDHANDLINGOFEXCESS
IODINE
PanosZiros1,IoannisHabeos2,DionysiosChartoumpekis3,MichailMpakakis2,IreneMamali2,
StavroulaManolakou1,IoannisLilis2,NikolaosPapachristou2,VenetsanaKyriazopoulou2,Thomas
Kensler3,DionysiosPapachristou2,GerasimosSykiotis1
1LausanneUniversityHospital
2UniversityofPatrasMedicalSchool
3UniversityofPittsburgh
10.45‐11.00
OP96THENUCLEARCOREPRESSORNCORISANESSENTIALMEDIATOROFTHEANTI‐
TUMORIGENICANDANTI‐METASTATICACTIONSOFTHETHYROIDHORMONE
RECEPTORß
OlaiaMartinez‐Iglesias1,RosaMartin‐Orozco1,ElviraAlonso‐Merino1,JuanPedroVelasco‐Martín2,
JavierRegadera2,JosePalacios3,PilarGonzález‐Peramato4,AnaAranda1
1InstitutodeInvestigacionesBiomédicas;2UniversidadAutónomadeMadrid;3HospitalRamónYCajal;4HospitalLaPaz
11.00‐11.15
OP97BEHAVIORALANDMETABOLICEFFECTSOF3‐IODOTHYROACETICACID:ROLE
OFHISTAMINE
MariaElenaManni1,AlessandroSaba2,AnnunziatinaLaurino1,RiccardoDonzelli2,GraziaChiellini2,
RiccardoZucchi2,LauraRaimondi1
1UniversityofFlorence;2UniversityofPisa,Italy
11.15‐11.30
OP98IDENTIFICATIONOFANINTRA‐MOLECULARDISULFIDEBRIDGEESSENTIAL
FORTHECOVALENTANDFUNCTIONALINTERACTIONBETWEENDUOX2ANDITS
PARTNERDUOXA2
CarréAurore1,LouzadaRuy2,AmezianeElHassaniRabii3,CorinneDupuy0
1UniversitéParis‐Sud11;Umr8200Cnrs;InstitutGustaveRoussy
2LaboratóriodeFisiologiaEndócrinaDorisRosenthal;UniversidadeFederalDoRiodeJaneiro
3Ubrm,CentreNationaldeL’energie,desSciencesEtdesTechniquesNucléaires,Rabat,
11.30‐11.45
OP99THYROIDHORMONESREDUCETHETGFΒ‐DEPENDENTACTIONS,ALLEVIATING
FIBROTICRESPONSES
ElviraAlonso‐Merino1,RosaMartin‐Orozco1,LidiaRuízLlorente1,LuisFernandaFanjulRodríguez1,
OlaiaMartinez‐Iglesias1,JuanPedroVelasco‐Martín2,JavierRegadera2,AnaAranda1
1InstitutodeInvestigacionesBiomédicas
2UniversidadAutónomadeMadrid
11.45‐12.00
OP100THYROMIMETICACTIONOF3,5‐T2INDIET‐INDUCEDOBESEMICE
JulikaLietzow1,WenkeJonas2,PriyavathiDhandapani1,JosefKöhrle1
1InstitutFürExperimentelleEndokrinologie,Charité‐UniversitätsmedizinBerlin,Germany
2GermanInstituteofHumanNutrition(Dife),Nuthetal,Germany
12.00‐12.15
OP101SELENIUMINCREASESTHYROTROPHIN‐INDUCEDNISEXPRESSIONTHROUGH
APE1‐DEPENDENTREGULATIONOFPAX8BINDINGACTIVITY
4
SuzanaLeoni1,AnaSastre‐Perona2,PilarSantisteban1,AntonioDelaVieja3
1InstitutodeInvestigacionesBiomédicas(Csic‐Uam);2InstitutodeInvestigacionesBiomédicas(Csic‐Uam)‐Madrid
3InstitutodeSaludCarlosIII(ÁreadeBiologíaCelularYDesarrollo,CentroNacionaldeMicrobiología),Spain
12.15‐12.30
OP1023‐IODOTHYROACETICACIDINDUCESGENERALIZEDITCHAND
HYPERSENSITIVITYTONOXIUSHEATSTIMULIINMOUSE
AnnunziatinaLaurino1,FrancescoResta1,RiccardoZucchi2,LauraRaimondi1
1UniversityofFlorence;2UniversityofPisa,Italy
Compostela Room 12.30‐13.00 YOUNGINVESTIGATORAWARDS,POSTERPRIZES,JACKROBBINSPRIZE
ANDCLOSINGCEREMONY
President, Furio Pacini, Italy & Secretary, Colin Dayan, United Kingdom 5

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